Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.2
USERS' SCORE
Good
Based on 44 Reviews
8.2
Supplement Facts
Serving Size: 1 Gummy
Amount Per Serving
%DV
Calories
10
Total Carbohydrate
2 g
1%*
Total Sugars
2 g
**
Includes 2 g Added Sugars
4%*
Melatonin
1 mg
**
Top Medical Research Studies
8
We investigated the role of melatonin in enhancing synaptic development in mouse models of autism. Through long-term oral administration over 28 days, melatonin improved social interactions and dendritic spine density in genetically modified mice.
Importantly, we found that melatonin's benefits are linked to the activation of a specific signaling pathway in the brain. However, when this pathway was blocked, the positive effects of melatonin on synaptic function were diminished. Overall, our findings highlight melatonin's promise for addressing certain autism-related challenges.
Importantly, we found that melatonin's benefits are linked to the activation of a specific signaling pathway in the brain. However, when this pathway was blocked, the positive effects of melatonin on synaptic function were diminished. Overall, our findings highlight melatonin's promise for addressing certain autism-related challenges.
Read More
8
Melatonin shows positive effects on sleep
We explored the impact of melatonin on sleep disturbances in children with autism spectrum disorder (ASD) through a retrospective study, using parent surveys for insights.
Interestingly, about 8% of children in the study received melatonin, especially those with more severe symptoms. The results showed high adherence, with around 86% experiencing better sleep onset.
Additionally, over a quarter reported improved daytime behaviors. Despite some mild side effects, parents generally viewed melatonin as a safe and effective option for their children's sleep issues.
Interestingly, about 8% of children in the study received melatonin, especially those with more severe symptoms. The results showed high adherence, with around 86% experiencing better sleep onset.
Additionally, over a quarter reported improved daytime behaviors. Despite some mild side effects, parents generally viewed melatonin as a safe and effective option for their children's sleep issues.
Read More
8
We explored melatonin's potential to impact neurodevelopment in autism by using stem cells from children with autism. In our study, we differentiated these cells into dopaminergic neurons and tested the effects of melatonin on their growth and function. We discovered that, without melatonin, these neurons showed reduced growth and mitochondrial dysfunction.
However, when melatonin was added, we observed significant improvements in neuron growth and mitochondrial health. Melatonin appears to enhance calcium signaling crucial for development. Nevertheless, further research is needed to confirm these findings and their practical applications for autism treatment.
However, when melatonin was added, we observed significant improvements in neuron growth and mitochondrial health. Melatonin appears to enhance calcium signaling crucial for development. Nevertheless, further research is needed to confirm these findings and their practical applications for autism treatment.
Read More
Most Useful Reviews
10
Sleep aid
It helps tremendously; I give it 5 stars! This product aids my 5-year-old son who has level 3 autism. Without it, he struggles to sleep.
Read More
10
Life-saving product
This product has saved my life with my twin boys who have autism. I'm not sure what I would do without it.
Read More
10
Family sleep restored
My children had significant sleep issues, common in many with autism. The doctor recommended melatonin, and after trying iHerb’s gummies, our family's sleep drastically improved. In less than an hour, my husband and I were sleeping soundly. It's incredible how quickly they work — putting my kids to bed within twenty minutes. I look forward to ordering more for my husband to see if they help him too. Thanks, iHerb.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.2
- All Researches
8
We examined the link between insomnia and Autism Spectrum Disorder (ASD), particularly how melatonin can help manage sleep issues in affected children. The analysis, conducted by a team of experts, emphasized the importance of understanding sleep challenges to improve treatment outcomes for both kids and their caregivers.
Encouragingly, melatonin has been found to be both effective and safe for managing insomnia associated with ASD, particularly in prolonged-release forms. Although promising, more research is needed to further validate these findings and improve sleep management strategies.
Encouragingly, melatonin has been found to be both effective and safe for managing insomnia associated with ASD, particularly in prolonged-release forms. Although promising, more research is needed to further validate these findings and improve sleep management strategies.
Read More
8
Melatonin helps autistic zebrafish models
We explored the impact of Nomo1 deficiency on behavior in zebrafish, which mimics aspects of neuropsychiatric disorders, including autism. The study demonstrated that these zebrafish exhibited abnormal brain development and various neuropsychiatric symptoms.
Notably, we found that treating these fish with melatonin not only restored normal locomotor activity but also reduced repetitive behaviors and addressed inflammation in the brain. This suggests that melatonin could be a promising therapeutic option for managing neuropsychiatric conditions linked to NOMO1 deficiency.
Notably, we found that treating these fish with melatonin not only restored normal locomotor activity but also reduced repetitive behaviors and addressed inflammation in the brain. This suggests that melatonin could be a promising therapeutic option for managing neuropsychiatric conditions linked to NOMO1 deficiency.
Read More
8
We investigated the role of melatonin in enhancing synaptic development in mouse models of autism. Through long-term oral administration over 28 days, melatonin improved social interactions and dendritic spine density in genetically modified mice.
Importantly, we found that melatonin's benefits are linked to the activation of a specific signaling pathway in the brain. However, when this pathway was blocked, the positive effects of melatonin on synaptic function were diminished. Overall, our findings highlight melatonin's promise for addressing certain autism-related challenges.
Importantly, we found that melatonin's benefits are linked to the activation of a specific signaling pathway in the brain. However, when this pathway was blocked, the positive effects of melatonin on synaptic function were diminished. Overall, our findings highlight melatonin's promise for addressing certain autism-related challenges.
Read More
8
Melatonin shows positive effects on sleep
We explored the impact of melatonin on sleep disturbances in children with autism spectrum disorder (ASD) through a retrospective study, using parent surveys for insights.
Interestingly, about 8% of children in the study received melatonin, especially those with more severe symptoms. The results showed high adherence, with around 86% experiencing better sleep onset.
Additionally, over a quarter reported improved daytime behaviors. Despite some mild side effects, parents generally viewed melatonin as a safe and effective option for their children's sleep issues.
Interestingly, about 8% of children in the study received melatonin, especially those with more severe symptoms. The results showed high adherence, with around 86% experiencing better sleep onset.
Additionally, over a quarter reported improved daytime behaviors. Despite some mild side effects, parents generally viewed melatonin as a safe and effective option for their children's sleep issues.
Read More
8
We conducted a detailed look into sleep-related rhythmic movement disorder (SR-RMD) in children, involving data from 66 patients at a UK hospital.
Our assessment included questionnaires to explore autism traits and behavioral impacts. Notably, families reported the burden of sleeplessness and concerns for their children's safety.
Intriguingly, many parents noted improvements in their children’s sleep after administering extended-release melatonin, suggesting this could be a viable treatment option in the future.
Our assessment included questionnaires to explore autism traits and behavioral impacts. Notably, families reported the burden of sleeplessness and concerns for their children's safety.
Intriguingly, many parents noted improvements in their children’s sleep after administering extended-release melatonin, suggesting this could be a viable treatment option in the future.
Read More
User Reviews
USERS' SCORE
Good
Based on 44 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
10
Sleep aid
It helps tremendously; I give it 5 stars! This product aids my 5-year-old son who has level 3 autism. Without it, he struggles to sleep.
Read More
10
Life-saving product
This product has saved my life with my twin boys who have autism. I'm not sure what I would do without it.
Read More
10
Family sleep restored
My children had significant sleep issues, common in many with autism. The doctor recommended melatonin, and after trying iHerb’s gummies, our family's sleep drastically improved. In less than an hour, my husband and I were sleeping soundly. It's incredible how quickly they work — putting my kids to bed within twenty minutes. I look forward to ordering more for my husband to see if they help him too. Thanks, iHerb.
Read More
9
Deep sleep achieved
This product is wonderful for ensuring quality sleep! As a mother of a child with autism and epilepsy, I was initially hesitant to give him such drugs, but poor sleep disrupted our routine. I take it and give it to him about an hour before bedtime. Now we both enjoy deep sleep and wake up refreshed, with no drowsiness during the day.
Read More
9
Pleasant taste
I have been using this product to help my child with autism fall asleep. It tastes great and he enjoys it. It's made from organic non-GMO ingredients and is of high quality. He typically falls asleep within 30 minutes.
Read More
Frequently Asked Questions
9
Anxiety reduction
My daughter with autism has never slept through the night and used to take 3-4 hours to fall asleep. Since trying these melatonin gummies, she falls asleep within 30 minutes. I appreciate this product as it's easy to use, has a great flavour, and helps alleviate her anxiety about falling asleep. A fantastic product!
9
Significant improvement
We've used this to establish a sleep pattern for our 11-year-old with autism, who usually stays up half the night. He adores the taste, and with all-natural ingredients, the gummies are perfect for him. I've noticed massive improvements in his sleep and behaviour since using them—thank you for such an amazing benefit!
10
Family sleep restored
My children had significant sleep issues, common in many with autism. The doctor recommended melatonin, and after trying iHerb’s gummies, our family's sleep drastically improved. In less than an hour, my husband and I were sleeping soundly. It's incredible how quickly they work — putting my kids to bed within twenty minutes. I look forward to ordering more for my husband to see if they help him too. Thanks, iHerb.
9
Deep sleep achieved
This product is wonderful for ensuring quality sleep! As a mother of a child with autism and epilepsy, I was initially hesitant to give him such drugs, but poor sleep disrupted our routine. I take it and give it to him about an hour before bedtime. Now we both enjoy deep sleep and wake up refreshed, with no drowsiness during the day.
9
Highly recommended aid
My pediatrician recommended this melatonin for my son with autism who suffers from severe sleeping problems. They taste great and are easy for kids to take; we often cut them in half. I’ve tried them occasionally, and they work effectively. I intend to keep ordering them regularly.
8
Melatonin shows positive effects on sleep
We explored the impact of melatonin on sleep disturbances in children with autism spectrum disorder (ASD) through a retrospective study, using parent surveys for insights.
Interestingly, about 8% of children in the study received melatonin, especially those with more severe symptoms. The results showed high adherence, with around 86% experiencing better sleep onset.
Additionally, over a quarter reported improved daytime behaviors. Despite some mild side effects, parents generally viewed melatonin as a safe and effective option for their children's sleep issues.
Interestingly, about 8% of children in the study received melatonin, especially those with more severe symptoms. The results showed high adherence, with around 86% experiencing better sleep onset.
Additionally, over a quarter reported improved daytime behaviors. Despite some mild side effects, parents generally viewed melatonin as a safe and effective option for their children's sleep issues.
7
We examined the sleep struggles faced by children with autism through an engaging survey completed by parents. The findings revealed that insomnia is particularly common, impacting both the children and their families significantly.
A notable number of parents suggested that melatonin might be beneficial for addressing their children's sleep disturbances, reporting effectiveness around 60-70%. However, further research is necessary to explore the various causes of restless sleep and to understand the best interventions for these families.
A notable number of parents suggested that melatonin might be beneficial for addressing their children's sleep disturbances, reporting effectiveness around 60-70%. However, further research is necessary to explore the various causes of restless sleep and to understand the best interventions for these families.
8
We investigated the role of melatonin in enhancing synaptic development in mouse models of autism. Through long-term oral administration over 28 days, melatonin improved social interactions and dendritic spine density in genetically modified mice.
Importantly, we found that melatonin's benefits are linked to the activation of a specific signaling pathway in the brain. However, when this pathway was blocked, the positive effects of melatonin on synaptic function were diminished. Overall, our findings highlight melatonin's promise for addressing certain autism-related challenges.
Importantly, we found that melatonin's benefits are linked to the activation of a specific signaling pathway in the brain. However, when this pathway was blocked, the positive effects of melatonin on synaptic function were diminished. Overall, our findings highlight melatonin's promise for addressing certain autism-related challenges.
7
Melatonin improves liver function in autism
We explored a study that examined how melatonin might help alleviate liver issues in a mouse model of autism known as BTBR. The researchers looked at various liver-related problems, including oxidative stress and inflammation, comparing the BTBR mice to healthy controls.
They found that BTBR mice had significant liver development issues and an increase in harmful markers. After administering melatonin, there were notable improvements in liver structure and function in the autistic mice. This suggests that melatonin could have beneficial effects on managing some health complications associated with autism.
They found that BTBR mice had significant liver development issues and an increase in harmful markers. After administering melatonin, there were notable improvements in liver structure and function in the autistic mice. This suggests that melatonin could have beneficial effects on managing some health complications associated with autism.
5
We explored the effects of melatonin supplements, physical exercise, and their combination on sleep quality in children with autism spectrum disorder (ASD). Sixty-two children participated, assigned to groups receiving cycling, melatonin, both, or a placebo.
Results showed improvements in sleep efficiency and duration for all intervention groups, while the placebo did not yield significant changes. However, when comparing the groups, we found no notable differences between the effectiveness of melatonin and exercise, indicating both interventions could help alike.
Results showed improvements in sleep efficiency and duration for all intervention groups, while the placebo did not yield significant changes. However, when comparing the groups, we found no notable differences between the effectiveness of melatonin and exercise, indicating both interventions could help alike.
References
- Bruni O, Biggio G, Malorgio E, Nobili L. Insomnia in children affected by autism spectrum disorder: The role of melatonin in treatment. Sleep Med. 2024;119:511. doi:10.1016/j.sleep.2024.05.046
- Rezzani R, Gianò M, Pinto D, Rinaldi F, van Noorden CJF, et al. Hepatic Alterations in a BTBR T + Itpr3tf/J Mouse Model of Autism and Improvement Using Melatonin via Mitigation Oxidative Stress, Inflammation and Ferroptosis. Int J Mol Sci. 2024;25. doi:10.3390/ijms25021086
- Zhang Q, Li F, Li T, Lin J, Jian J, et al. Nomo1 deficiency causes autism-like behavior in zebrafish. EMBO Rep. 2024;25:570. doi:10.1038/s44319-023-00036-y
- Wang L, Xu M, Wang Y, Wang F, Deng J, et al. Melatonin improves synapse development by PI3K/Akt signaling in a mouse model of autism spectrum disorder. Neural Regen Res. 2024;19:1618. doi:10.4103/1673-5374.387973
- Tse ACY, Lee PH, Sit CHP, Poon ET, Sun F, et al. Comparing the Effectiveness of Physical Exercise Intervention and Melatonin Supplement in Improving Sleep Quality in Children with ASD. J Autism Dev Disord. 2024;54:4456. doi:10.1007/s10803-023-06172-7
- Sadeh H, Meiri G, Zigdon D, Ilan M, Faroy M, et al. Adherence to treatment and parents' perspective about effectiveness of melatonin in children with autism spectrum disorder and sleep disturbances. Child Adolesc Psychiatry Ment Health. 2023;17:123. doi:10.1186/s13034-023-00669-w
- Joels H, Benny A, Sharpe A, Postigo B, Joseph B, et al. Sleep related rhythmic movement disorder: phenotypic characteristics and treatment response in a paediatric cohort. Sleep Med. 2023;112:21. doi:10.1016/j.sleep.2023.09.020
- Dong S, Kifune T, Kato H, Wang L, Kong J, et al. Effects of melatonin on dopaminergic neuron development via IP3-mediated mitochondrial Ca regulation in autism spectrum disorder. Biochem Biophys Res Commun. 2023;681:7. doi:10.1016/j.bbrc.2023.09.050
- Bernardi K, Prono F, Bruni G, Panerai S, Ferri R, et al. Sleep disturbances in subjects with autism spectrum disorder: A parental perspective. Sleep Med. 2023;110:220. doi:10.1016/j.sleep.2023.08.020
- Horsnell J, Mangar S, Dimitriou D, Halstead EJ. Parental Experiences of Melatonin Administration to Manage Sleep Disturbances in Autistic Children and Adolescent in the UK. Healthcare (Basel). 2023;11. doi:10.3390/healthcare11121780
