Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7
USERS' SCORE
Good
Based on 3 Reviews
8.6
Supplement Facts
Serving Size: 1 Gummy
Amount Per Serving
%DV
Calories
10
Total Carbohydrate
2 g
1%*
Total Sugars
2 g
**
Includes 2 g Added Sugars
4%*
Melatonin
1 mg
**
Top Medical Research Studies
9
We explored the potential of melatonin as a treatment for H1N1 flu infection. In our study, we found that melatonin, a powerful antioxidant and anti-inflammatory compound, could significantly protect against the flu in both laboratory tests and in living mice.
Our findings showed that higher local levels of melatonin in the nose and lungs correlated with lower death rates from the virus. In fact, melatonin-deficient mice had much higher mortality rates, which were notably reduced when treated with melatonin.
We discovered that melatonin primarily works by targeting mast cells, which are important players in the body’s immune response. By suppressing the activation of these cells after H1N1 infection, melatonin helps control the release of inflammatory proteins, leading to less damage in lung tissue. This mechanism highlights how melatonin treatment can prevent serious lung injury caused by the virus, opening up new avenues for post-flu recovery strategies.
Our findings showed that higher local levels of melatonin in the nose and lungs correlated with lower death rates from the virus. In fact, melatonin-deficient mice had much higher mortality rates, which were notably reduced when treated with melatonin.
We discovered that melatonin primarily works by targeting mast cells, which are important players in the body’s immune response. By suppressing the activation of these cells after H1N1 infection, melatonin helps control the release of inflammatory proteins, leading to less damage in lung tissue. This mechanism highlights how melatonin treatment can prevent serious lung injury caused by the virus, opening up new avenues for post-flu recovery strategies.
Read More
4
Melatonin's limited effect on flu immunity
We conducted a randomized open-label trial to explore how melatonin might influence our immune response to the flu vaccine. Our team grouped adults who were set to receive the flu shot into two categories: one that received 5 mg of melatonin and another that served as the control group. We assessed their immune responses through various tests two to three weeks after getting vaccinated.
With a total of 108 participants involved, our baseline assessment—which included sleep quality—showed similar characteristics across both groups. Unfortunately, when we looked at the effectiveness of melatonin, we found no significant difference in the overall immune response. The seroconversion rates and specific antibody levels remained largely the same between those who took melatonin and those who did not.
However, we did discover something intriguing: individuals taking melatonin had a higher increase in certain immune cell markers. Specifically, there was a notable rise in co-expression of interferon gamma and granzyme B, which play important roles in our immune defense. Although this finding is interesting, the overall impact of melatonin on the flu vaccine response appears limited, warranting further research with larger sample sizes to understand its full potential and any connections to our body’s natural rhythms.
With a total of 108 participants involved, our baseline assessment—which included sleep quality—showed similar characteristics across both groups. Unfortunately, when we looked at the effectiveness of melatonin, we found no significant difference in the overall immune response. The seroconversion rates and specific antibody levels remained largely the same between those who took melatonin and those who did not.
However, we did discover something intriguing: individuals taking melatonin had a higher increase in certain immune cell markers. Specifically, there was a notable rise in co-expression of interferon gamma and granzyme B, which play important roles in our immune defense. Although this finding is interesting, the overall impact of melatonin on the flu vaccine response appears limited, warranting further research with larger sample sizes to understand its full potential and any connections to our body’s natural rhythms.
Read More
8
We explored how melatonin can help address energy exhaustion caused by the Influenza A virus (IAV) in patients suffering from acute exacerbation of chronic obstructive pulmonary disease (AECOPD). In our investigation, we found that individuals with IAV-induced AECOPD showed a significant increase in resting energy expenditure, indicating a heightened metabolic strain.
Our research focused on primary COPD bronchial epithelial cells infected with IAV. We discovered that these cells experienced early and severe energy shortages, with notable damage to their mitochondria—the cell’s powerhouses. Notably, there was a shift from efficient energy production through oxidative phosphorylation (OXPHOS) to less efficient glycolysis, further compounding the issue.
We were pleased to see that melatonin treatment effectively reversed many of these adverse effects. It prompted improvements in mitochondrial function and helped restore ATP levels, which are crucial for energy. By targeting the specific pathways impacted by IAV, such as the OMA1-OPA1-S pathway, melatonin showed considerable promise in improving the clinical outcomes for COPD patients affected by IAV.
These findings suggest that melatonin could be a valuable therapeutic strategy for those suffering from AECOPD triggered by influenza. As we continue to unravel the complexities of viral infections in chronic pulmonary conditions, melatonin may shine as a supportive treatment option.
Our research focused on primary COPD bronchial epithelial cells infected with IAV. We discovered that these cells experienced early and severe energy shortages, with notable damage to their mitochondria—the cell’s powerhouses. Notably, there was a shift from efficient energy production through oxidative phosphorylation (OXPHOS) to less efficient glycolysis, further compounding the issue.
We were pleased to see that melatonin treatment effectively reversed many of these adverse effects. It prompted improvements in mitochondrial function and helped restore ATP levels, which are crucial for energy. By targeting the specific pathways impacted by IAV, such as the OMA1-OPA1-S pathway, melatonin showed considerable promise in improving the clinical outcomes for COPD patients affected by IAV.
These findings suggest that melatonin could be a valuable therapeutic strategy for those suffering from AECOPD triggered by influenza. As we continue to unravel the complexities of viral infections in chronic pulmonary conditions, melatonin may shine as a supportive treatment option.
Read More
Most Useful Reviews
9
Soothing relief
Melatonin Gummies have become a hit in our household! Not only do the kids adore the fruity flavours, but these gummies also work wonders. The Melatonin provides soothing relief, particularly during cold and flu season, making them a parent's go-to choice for helping children feel better.
Read More
9
Faster sleep
I was advised by my son's paediatrician to purchase quality melatonin gummies from iHerb to help him fall asleep quicker. I had never really heard of them before. I am amazed that they actually work! I only need to give him one 1mg gummy before bed, ideally 20 minutes before lights out. Before we discovered these gummies, he took about an hour to sleep. Now he is out within roughly 15 minutes. The first night he tried them, he fell asleep so quickly that I was in shock. By the third night, I was convinced. He has now been using them for a few months, and they have greatly improved his sleep.
Read More
9
Restored sleep
Our two-year-old went through a significant sleep regression, going to sleep at 11pm and waking at 4-5am. After giving him one of these gummies, he was asleep by 6:30pm and didn’t wake until 6:30am. Initially, we thought it might just be a fluke, but after a couple of months, he consistently sleeps for 11-12 hours when he has his melatonin. These gummies are simply amazing!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7
- All Researches
9
We explored the potential of melatonin as a treatment for H1N1 flu infection. In our study, we found that melatonin, a powerful antioxidant and anti-inflammatory compound, could significantly protect against the flu in both laboratory tests and in living mice.
Our findings showed that higher local levels of melatonin in the nose and lungs correlated with lower death rates from the virus. In fact, melatonin-deficient mice had much higher mortality rates, which were notably reduced when treated with melatonin.
We discovered that melatonin primarily works by targeting mast cells, which are important players in the body’s immune response. By suppressing the activation of these cells after H1N1 infection, melatonin helps control the release of inflammatory proteins, leading to less damage in lung tissue. This mechanism highlights how melatonin treatment can prevent serious lung injury caused by the virus, opening up new avenues for post-flu recovery strategies.
Our findings showed that higher local levels of melatonin in the nose and lungs correlated with lower death rates from the virus. In fact, melatonin-deficient mice had much higher mortality rates, which were notably reduced when treated with melatonin.
We discovered that melatonin primarily works by targeting mast cells, which are important players in the body’s immune response. By suppressing the activation of these cells after H1N1 infection, melatonin helps control the release of inflammatory proteins, leading to less damage in lung tissue. This mechanism highlights how melatonin treatment can prevent serious lung injury caused by the virus, opening up new avenues for post-flu recovery strategies.
Read More
8
We explored how melatonin can help address energy exhaustion caused by the Influenza A virus (IAV) in patients suffering from acute exacerbation of chronic obstructive pulmonary disease (AECOPD). In our investigation, we found that individuals with IAV-induced AECOPD showed a significant increase in resting energy expenditure, indicating a heightened metabolic strain.
Our research focused on primary COPD bronchial epithelial cells infected with IAV. We discovered that these cells experienced early and severe energy shortages, with notable damage to their mitochondria—the cell’s powerhouses. Notably, there was a shift from efficient energy production through oxidative phosphorylation (OXPHOS) to less efficient glycolysis, further compounding the issue.
We were pleased to see that melatonin treatment effectively reversed many of these adverse effects. It prompted improvements in mitochondrial function and helped restore ATP levels, which are crucial for energy. By targeting the specific pathways impacted by IAV, such as the OMA1-OPA1-S pathway, melatonin showed considerable promise in improving the clinical outcomes for COPD patients affected by IAV.
These findings suggest that melatonin could be a valuable therapeutic strategy for those suffering from AECOPD triggered by influenza. As we continue to unravel the complexities of viral infections in chronic pulmonary conditions, melatonin may shine as a supportive treatment option.
Our research focused on primary COPD bronchial epithelial cells infected with IAV. We discovered that these cells experienced early and severe energy shortages, with notable damage to their mitochondria—the cell’s powerhouses. Notably, there was a shift from efficient energy production through oxidative phosphorylation (OXPHOS) to less efficient glycolysis, further compounding the issue.
We were pleased to see that melatonin treatment effectively reversed many of these adverse effects. It prompted improvements in mitochondrial function and helped restore ATP levels, which are crucial for energy. By targeting the specific pathways impacted by IAV, such as the OMA1-OPA1-S pathway, melatonin showed considerable promise in improving the clinical outcomes for COPD patients affected by IAV.
These findings suggest that melatonin could be a valuable therapeutic strategy for those suffering from AECOPD triggered by influenza. As we continue to unravel the complexities of viral infections in chronic pulmonary conditions, melatonin may shine as a supportive treatment option.
Read More
4
Melatonin's limited effect on flu immunity
We conducted a randomized open-label trial to explore how melatonin might influence our immune response to the flu vaccine. Our team grouped adults who were set to receive the flu shot into two categories: one that received 5 mg of melatonin and another that served as the control group. We assessed their immune responses through various tests two to three weeks after getting vaccinated.
With a total of 108 participants involved, our baseline assessment—which included sleep quality—showed similar characteristics across both groups. Unfortunately, when we looked at the effectiveness of melatonin, we found no significant difference in the overall immune response. The seroconversion rates and specific antibody levels remained largely the same between those who took melatonin and those who did not.
However, we did discover something intriguing: individuals taking melatonin had a higher increase in certain immune cell markers. Specifically, there was a notable rise in co-expression of interferon gamma and granzyme B, which play important roles in our immune defense. Although this finding is interesting, the overall impact of melatonin on the flu vaccine response appears limited, warranting further research with larger sample sizes to understand its full potential and any connections to our body’s natural rhythms.
With a total of 108 participants involved, our baseline assessment—which included sleep quality—showed similar characteristics across both groups. Unfortunately, when we looked at the effectiveness of melatonin, we found no significant difference in the overall immune response. The seroconversion rates and specific antibody levels remained largely the same between those who took melatonin and those who did not.
However, we did discover something intriguing: individuals taking melatonin had a higher increase in certain immune cell markers. Specifically, there was a notable rise in co-expression of interferon gamma and granzyme B, which play important roles in our immune defense. Although this finding is interesting, the overall impact of melatonin on the flu vaccine response appears limited, warranting further research with larger sample sizes to understand its full potential and any connections to our body’s natural rhythms.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Soothing relief
Melatonin Gummies have become a hit in our household! Not only do the kids adore the fruity flavours, but these gummies also work wonders. The Melatonin provides soothing relief, particularly during cold and flu season, making them a parent's go-to choice for helping children feel better.
Read More
9
Faster sleep
I was advised by my son's paediatrician to purchase quality melatonin gummies from iHerb to help him fall asleep quicker. I had never really heard of them before. I am amazed that they actually work! I only need to give him one 1mg gummy before bed, ideally 20 minutes before lights out. Before we discovered these gummies, he took about an hour to sleep. Now he is out within roughly 15 minutes. The first night he tried them, he fell asleep so quickly that I was in shock. By the third night, I was convinced. He has now been using them for a few months, and they have greatly improved his sleep.
Read More
9
Restored sleep
Our two-year-old went through a significant sleep regression, going to sleep at 11pm and waking at 4-5am. After giving him one of these gummies, he was asleep by 6:30pm and didn’t wake until 6:30am. Initially, we thought it might just be a fluke, but after a couple of months, he consistently sleeps for 11-12 hours when he has his melatonin. These gummies are simply amazing!
Read More
Frequently Asked Questions
9
Faster sleep
I was advised by my son's paediatrician to purchase quality melatonin gummies from iHerb to help him fall asleep quicker. I had never really heard of them before. I am amazed that they actually work! I only need to give him one 1mg gummy before bed, ideally 20 minutes before lights out. Before we discovered these gummies, he took about an hour to sleep. Now he is out within roughly 15 minutes. The first night he tried them, he fell asleep so quickly that I was in shock. By the third night, I was convinced. He has now been using them for a few months, and they have greatly improved his sleep.
9
Restored sleep
Our two-year-old went through a significant sleep regression, going to sleep at 11pm and waking at 4-5am. After giving him one of these gummies, he was asleep by 6:30pm and didn’t wake until 6:30am. Initially, we thought it might just be a fluke, but after a couple of months, he consistently sleeps for 11-12 hours when he has his melatonin. These gummies are simply amazing!
9
Soothing relief
Melatonin Gummies have become a hit in our household! Not only do the kids adore the fruity flavours, but these gummies also work wonders. The Melatonin provides soothing relief, particularly during cold and flu season, making them a parent's go-to choice for helping children feel better.
9
We explored the potential of melatonin as a treatment for H1N1 flu infection. In our study, we found that melatonin, a powerful antioxidant and anti-inflammatory compound, could significantly protect against the flu in both laboratory tests and in living mice.
Our findings showed that higher local levels of melatonin in the nose and lungs correlated with lower death rates from the virus. In fact, melatonin-deficient mice had much higher mortality rates, which were notably reduced when treated with melatonin.
We discovered that melatonin primarily works by targeting mast cells, which are important players in the body’s immune response. By suppressing the activation of these cells after H1N1 infection, melatonin helps control the release of inflammatory proteins, leading to less damage in lung tissue. This mechanism highlights how melatonin treatment can prevent serious lung injury caused by the virus, opening up new avenues for post-flu recovery strategies.
Our findings showed that higher local levels of melatonin in the nose and lungs correlated with lower death rates from the virus. In fact, melatonin-deficient mice had much higher mortality rates, which were notably reduced when treated with melatonin.
We discovered that melatonin primarily works by targeting mast cells, which are important players in the body’s immune response. By suppressing the activation of these cells after H1N1 infection, melatonin helps control the release of inflammatory proteins, leading to less damage in lung tissue. This mechanism highlights how melatonin treatment can prevent serious lung injury caused by the virus, opening up new avenues for post-flu recovery strategies.
8
We explored how melatonin can help address energy exhaustion caused by the Influenza A virus (IAV) in patients suffering from acute exacerbation of chronic obstructive pulmonary disease (AECOPD). In our investigation, we found that individuals with IAV-induced AECOPD showed a significant increase in resting energy expenditure, indicating a heightened metabolic strain.
Our research focused on primary COPD bronchial epithelial cells infected with IAV. We discovered that these cells experienced early and severe energy shortages, with notable damage to their mitochondria—the cell’s powerhouses. Notably, there was a shift from efficient energy production through oxidative phosphorylation (OXPHOS) to less efficient glycolysis, further compounding the issue.
We were pleased to see that melatonin treatment effectively reversed many of these adverse effects. It prompted improvements in mitochondrial function and helped restore ATP levels, which are crucial for energy. By targeting the specific pathways impacted by IAV, such as the OMA1-OPA1-S pathway, melatonin showed considerable promise in improving the clinical outcomes for COPD patients affected by IAV.
These findings suggest that melatonin could be a valuable therapeutic strategy for those suffering from AECOPD triggered by influenza. As we continue to unravel the complexities of viral infections in chronic pulmonary conditions, melatonin may shine as a supportive treatment option.
Our research focused on primary COPD bronchial epithelial cells infected with IAV. We discovered that these cells experienced early and severe energy shortages, with notable damage to their mitochondria—the cell’s powerhouses. Notably, there was a shift from efficient energy production through oxidative phosphorylation (OXPHOS) to less efficient glycolysis, further compounding the issue.
We were pleased to see that melatonin treatment effectively reversed many of these adverse effects. It prompted improvements in mitochondrial function and helped restore ATP levels, which are crucial for energy. By targeting the specific pathways impacted by IAV, such as the OMA1-OPA1-S pathway, melatonin showed considerable promise in improving the clinical outcomes for COPD patients affected by IAV.
These findings suggest that melatonin could be a valuable therapeutic strategy for those suffering from AECOPD triggered by influenza. As we continue to unravel the complexities of viral infections in chronic pulmonary conditions, melatonin may shine as a supportive treatment option.
References
- Lee RU, Watson NL, Glickman GL, White L, Isidean SD, et al. A randomized clinical trial of the impact of melatonin on influenza vaccine: Outcomes from the melatonin and vaccine response immunity and chronobiology study (MAVRICS). Hum Vaccin Immunother. 2024;20:2419742. doi:10.1080/21645515.2024.2419742
- Wei YY, Ye JJ, Zhang DW, Hu L, Wu HM, et al. Melatonin Rescues Influenza A Virus-Induced Cellular Energy Exhaustion via OMA1-OPA1-S in Acute Exacerbation of COPD. J Pineal Res. 2024;76:e12991. doi:10.1111/jpi.12991
- Huo C, Tang Y, Li X, Han D, Gu Q, et al. Melatonin alleviates lung injury in H1N1-infected mice by mast cell inactivation and cytokine storm suppression. PLoS Pathog. 2023;19:e1011406. doi:10.1371/journal.ppat.1011406
