Overview
SCIENTIFIC SCORE
Questionable
Based on 20 Researches
6.7
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B-6 (as Pyridoxine Hydrochloride)
10 mg
588%
Calcium (as Calcium Carbonate)
60 mg
5%
Melatonin
5 mg
*
Top Medical Research Studies
8
Melatonin may reduce migraine frequency
We explored whether melatonin can effectively prevent migraines by analyzing data from 25 randomized controlled trials, involving nearly 4,500 participants.
The findings suggested that taking 3 mg of oral melatonin at bedtime could reduce the frequency of migraine days and had a favorable response rate compared to a placebo.
Notably, melatonin was regarded as one of the better options when considering overall effectiveness and tolerability. These results highlight melatonin's potential as a helpful preventive treatment for those struggling with episodic migraines.
The findings suggested that taking 3 mg of oral melatonin at bedtime could reduce the frequency of migraine days and had a favorable response rate compared to a placebo.
Notably, melatonin was regarded as one of the better options when considering overall effectiveness and tolerability. These results highlight melatonin's potential as a helpful preventive treatment for those struggling with episodic migraines.
Read More
5
We explored the potential of melatonin as an acute treatment for migraines in children and adolescents aged 4 to 17 years. Our study involved a randomized trial where participants were given either a high or a low dose of melatonin to see which worked better to relieve migraine pain.
The results revealed that both dosages led to some level of pain reduction, though the difference wasn't significant. The high-dose group saw an average pain reduction of 2.7 cm on a scale, while the low-dose group reported a 2.3 cm reduction, a difference that wasn't statistically meaningful.
We also observed a fairly high dropout rate from the study, which could impact our findings on effectiveness. Interestingly, we found that taking a higher dose of melatonin and napping afterward seemed to correlate with better migraine relief. Overall, while melatonin shows promise as a treatment, we must continue our investigation to establish clearer benefits.
The results revealed that both dosages led to some level of pain reduction, though the difference wasn't significant. The high-dose group saw an average pain reduction of 2.7 cm on a scale, while the low-dose group reported a 2.3 cm reduction, a difference that wasn't statistically meaningful.
We also observed a fairly high dropout rate from the study, which could impact our findings on effectiveness. Interestingly, we found that taking a higher dose of melatonin and napping afterward seemed to correlate with better migraine relief. Overall, while melatonin shows promise as a treatment, we must continue our investigation to establish clearer benefits.
Read More
9
We explored the role of melatonin in preventing migraines in adults through a detailed analysis of three relevant studies. By comparing melatonin against a placebo and standard treatments like amitriptyline and valproate, we aimed to assess its effectiveness and safety for those suffering from migraines.
Our findings revealed that melatonin provided significant benefits compared to a placebo. Specifically, we observed a higher rate of responders, meaning more people experienced relief from their migraines when using melatonin. The therapy significantly reduced the frequency and duration of migraine attacks, lessened the severity of headaches, and decreased the need for pain-relief medication.
However, melatonin didn’t show a significant advantage over established migraine treatments like amitriptyline or valproate. Importantly, common side effects such as drowsiness and fatigue did not occur more frequently in those taking melatonin compared to other groups. Overall, melatonin appears to be a promising option for migraine prevention, particularly for those looking for alternatives to traditional medications.
Our findings revealed that melatonin provided significant benefits compared to a placebo. Specifically, we observed a higher rate of responders, meaning more people experienced relief from their migraines when using melatonin. The therapy significantly reduced the frequency and duration of migraine attacks, lessened the severity of headaches, and decreased the need for pain-relief medication.
However, melatonin didn’t show a significant advantage over established migraine treatments like amitriptyline or valproate. Importantly, common side effects such as drowsiness and fatigue did not occur more frequently in those taking melatonin compared to other groups. Overall, melatonin appears to be a promising option for migraine prevention, particularly for those looking for alternatives to traditional medications.
Read More
Most Useful Reviews
9
Effective treatment
This product is great; it significantly helps with my migraines and fibromyalgia.
Read More
7.5
Improved sleep quality
2 people found this helpful
Countermeasures against nightmares with migraine: I often experience nightmares due to my migraines. My doctor mentioned this as a symptom. I tried melatonin, which seemed effective; my sleep deepened, and I noticed fewer nightmares.
Read More
7.5
Helps me rest
They are excellent and help me rest while reducing my migraines.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 20 Researches
6.7
- All Researches
9
We conducted a study to explore how melatonin can help reduce migraine headaches in children who do not have sleep disorders. In our clinical trial, we included 55 children aged between five to 15 years. The participants were divided into two groups: one group received propranolol only, while the other was treated with propranolol plus melatonin for three months.
After evaluating the results, we observed that the children taking melatonin alongside propranolol experienced a notable decrease in headache frequency compared to those who only took propranolol. About three months into the treatment, there was a significant difference in how well the two groups responded—many more children in the melatonin group reported positive effects from the treatment. Additionally, parents of these children were more satisfied with the results than those in the control group.
Importantly, we found no significant side effects from either treatment group, and the intensity of disability caused by the headaches remained similar between the two groups. Overall, it appears that adding melatonin could be a useful strategy for managing migraine headaches in children without sleep issues.
After evaluating the results, we observed that the children taking melatonin alongside propranolol experienced a notable decrease in headache frequency compared to those who only took propranolol. About three months into the treatment, there was a significant difference in how well the two groups responded—many more children in the melatonin group reported positive effects from the treatment. Additionally, parents of these children were more satisfied with the results than those in the control group.
Importantly, we found no significant side effects from either treatment group, and the intensity of disability caused by the headaches remained similar between the two groups. Overall, it appears that adding melatonin could be a useful strategy for managing migraine headaches in children without sleep issues.
Read More
9
Melatonin reduces migraine frequency
We conducted a randomized, double-blind clinical trial to examine the effects of melatonin on migraine attacks. In this study, 60 patients experiencing episodic migraines were divided into two groups. One group received 3 mg of melatonin, while the other received a placebo, both along with a standard treatment of propranolol over two months.
Throughout the follow-up period, we assessed the frequency, duration, and severity of migraine attacks. We found that those taking melatonin experienced a notable reduction in both the frequency and duration of their migraine events compared to the placebo group. While the severity of pain did not show a significant difference between the two groups, the overall impact on attack frequency and duration was promising.
Importantly, both treatments were similarly safe, with only a slight incidence of side effects observed. This suggests that melatonin could serve as an effective preventive option for adults suffering from episodic migraines when used alongside other standard therapies.
Throughout the follow-up period, we assessed the frequency, duration, and severity of migraine attacks. We found that those taking melatonin experienced a notable reduction in both the frequency and duration of their migraine events compared to the placebo group. While the severity of pain did not show a significant difference between the two groups, the overall impact on attack frequency and duration was promising.
Importantly, both treatments were similarly safe, with only a slight incidence of side effects observed. This suggests that melatonin could serve as an effective preventive option for adults suffering from episodic migraines when used alongside other standard therapies.
Read More
9
We explored the role of melatonin in preventing migraines in adults through a detailed analysis of three relevant studies. By comparing melatonin against a placebo and standard treatments like amitriptyline and valproate, we aimed to assess its effectiveness and safety for those suffering from migraines.
Our findings revealed that melatonin provided significant benefits compared to a placebo. Specifically, we observed a higher rate of responders, meaning more people experienced relief from their migraines when using melatonin. The therapy significantly reduced the frequency and duration of migraine attacks, lessened the severity of headaches, and decreased the need for pain-relief medication.
However, melatonin didn’t show a significant advantage over established migraine treatments like amitriptyline or valproate. Importantly, common side effects such as drowsiness and fatigue did not occur more frequently in those taking melatonin compared to other groups. Overall, melatonin appears to be a promising option for migraine prevention, particularly for those looking for alternatives to traditional medications.
Our findings revealed that melatonin provided significant benefits compared to a placebo. Specifically, we observed a higher rate of responders, meaning more people experienced relief from their migraines when using melatonin. The therapy significantly reduced the frequency and duration of migraine attacks, lessened the severity of headaches, and decreased the need for pain-relief medication.
However, melatonin didn’t show a significant advantage over established migraine treatments like amitriptyline or valproate. Importantly, common side effects such as drowsiness and fatigue did not occur more frequently in those taking melatonin compared to other groups. Overall, melatonin appears to be a promising option for migraine prevention, particularly for those looking for alternatives to traditional medications.
Read More
8
We explored how melatonin can help in preventing migraines through a systematic review of randomized controlled trials. By analyzing seven studies that involved 1,283 participants, we compared the effects of melatonin to standard migraine treatments and placebo groups.
Our findings suggest that melatonin can significantly reduce both the frequency and severity of migraine attacks. However, the effectiveness seemed to depend on the dosage, and there are still questions about the best approach to take.
Beyond migraine relief, we also noted intriguing hints that melatonin might assist with weight control, indicating further avenues for research. As melatonin continues to gain popularity for various uses, including sleep disorders, its potential as a migraine preventative is a significant development worth considering.
Our findings suggest that melatonin can significantly reduce both the frequency and severity of migraine attacks. However, the effectiveness seemed to depend on the dosage, and there are still questions about the best approach to take.
Beyond migraine relief, we also noted intriguing hints that melatonin might assist with weight control, indicating further avenues for research. As melatonin continues to gain popularity for various uses, including sleep disorders, its potential as a migraine preventative is a significant development worth considering.
Read More
8
We investigated how melatonin might alleviate migraine symptoms by looking at the biological processes involved. Our study specifically examined the effects of melatonin in rats experiencing migraine-like pain stimulated by nitroglycerin.
To understand its mechanisms, we used various antagonists—blocking specific melatonin receptors in the process. This approach allowed us to observe changes in pain behavior, levels of certain pain-related substances, and the activation of mast cells linked to migraines.
Our findings revealed that melatonin significantly reduced mechanical pain sensitivity and decreased the levels of CGRP, a protein associated with migraine pain. It also seemed to calm the activation of mast cells in the meninges, which play a role in headache conditions. Notably, these effects were largely cancelled when we used specific receptor blockers, indicating that its benefits primarily stem from the MT2 receptor, while there may still be a role for the MT1 receptor.
Overall, this research sheds light on melatonin's potential as a therapeutic option for migraines, highlighting its influence on pain pathways and mast cell activity.
To understand its mechanisms, we used various antagonists—blocking specific melatonin receptors in the process. This approach allowed us to observe changes in pain behavior, levels of certain pain-related substances, and the activation of mast cells linked to migraines.
Our findings revealed that melatonin significantly reduced mechanical pain sensitivity and decreased the levels of CGRP, a protein associated with migraine pain. It also seemed to calm the activation of mast cells in the meninges, which play a role in headache conditions. Notably, these effects were largely cancelled when we used specific receptor blockers, indicating that its benefits primarily stem from the MT2 receptor, while there may still be a role for the MT1 receptor.
Overall, this research sheds light on melatonin's potential as a therapeutic option for migraines, highlighting its influence on pain pathways and mast cell activity.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective treatment
This product is great; it significantly helps with my migraines and fibromyalgia.
Read More
7.5
Improved sleep quality
2 people found this helpful
Countermeasures against nightmares with migraine: I often experience nightmares due to my migraines. My doctor mentioned this as a symptom. I tried melatonin, which seemed effective; my sleep deepened, and I noticed fewer nightmares.
Read More
7.5
Helps me rest
They are excellent and help me rest while reducing my migraines.
Read More
2
Side effects noted
2 people found this helpful
I can sleep well, even if I take a quarter dose. I liked it and continued using it. However, I always wake up with a headache, which is disappointing. I think it varies by individual, especially for those prone to migraines.
Read More
Frequently Asked Questions
9
Effective treatment
This product is great; it significantly helps with my migraines and fibromyalgia.
2
Side effects noted
2 people found this helpful
I can sleep well, even if I take a quarter dose. I liked it and continued using it. However, I always wake up with a headache, which is disappointing. I think it varies by individual, especially for those prone to migraines.
7.5
Helps me rest
They are excellent and help me rest while reducing my migraines.
7.5
Improved sleep quality
2 people found this helpful
Countermeasures against nightmares with migraine: I often experience nightmares due to my migraines. My doctor mentioned this as a symptom. I tried melatonin, which seemed effective; my sleep deepened, and I noticed fewer nightmares.
8
We explored how melatonin can help in preventing migraines through a systematic review of randomized controlled trials. By analyzing seven studies that involved 1,283 participants, we compared the effects of melatonin to standard migraine treatments and placebo groups.
Our findings suggest that melatonin can significantly reduce both the frequency and severity of migraine attacks. However, the effectiveness seemed to depend on the dosage, and there are still questions about the best approach to take.
Beyond migraine relief, we also noted intriguing hints that melatonin might assist with weight control, indicating further avenues for research. As melatonin continues to gain popularity for various uses, including sleep disorders, its potential as a migraine preventative is a significant development worth considering.
Our findings suggest that melatonin can significantly reduce both the frequency and severity of migraine attacks. However, the effectiveness seemed to depend on the dosage, and there are still questions about the best approach to take.
Beyond migraine relief, we also noted intriguing hints that melatonin might assist with weight control, indicating further avenues for research. As melatonin continues to gain popularity for various uses, including sleep disorders, its potential as a migraine preventative is a significant development worth considering.
9
We conducted a study to explore how melatonin can help reduce migraine headaches in children who do not have sleep disorders. In our clinical trial, we included 55 children aged between five to 15 years. The participants were divided into two groups: one group received propranolol only, while the other was treated with propranolol plus melatonin for three months.
After evaluating the results, we observed that the children taking melatonin alongside propranolol experienced a notable decrease in headache frequency compared to those who only took propranolol. About three months into the treatment, there was a significant difference in how well the two groups responded—many more children in the melatonin group reported positive effects from the treatment. Additionally, parents of these children were more satisfied with the results than those in the control group.
Importantly, we found no significant side effects from either treatment group, and the intensity of disability caused by the headaches remained similar between the two groups. Overall, it appears that adding melatonin could be a useful strategy for managing migraine headaches in children without sleep issues.
After evaluating the results, we observed that the children taking melatonin alongside propranolol experienced a notable decrease in headache frequency compared to those who only took propranolol. About three months into the treatment, there was a significant difference in how well the two groups responded—many more children in the melatonin group reported positive effects from the treatment. Additionally, parents of these children were more satisfied with the results than those in the control group.
Importantly, we found no significant side effects from either treatment group, and the intensity of disability caused by the headaches remained similar between the two groups. Overall, it appears that adding melatonin could be a useful strategy for managing migraine headaches in children without sleep issues.
4
We examined the fascinating link between melatonin and migraine, focusing on how this hormone might help alleviate migraines. Melatonin, primarily produced by the pineal gland, is known for helping our bodies adjust to changes in the environment, such as light and food intake. It plays a significant role in regulating various brain structures associated with migraine attacks.
Through our analysis of numerous studies, we discovered that melatonin appears to have a potential effect on migraine severity and occurrence, especially in women at different stages of their menstrual cycle who suffer from migraines. While melatonin is naturally found in various foods and can be taken as a supplement, we noted its promising role as a complementary therapy due to its minimal side effects and low risk of interaction with other medications.
However, we must acknowledge that factors like hormonal phases may influence the effectiveness of melatonin, complicating efforts to determine its isolated effects on migraines. Overall, our exploration into melatonin and its relationship with migraines offers a hopeful perspective, particularly for individuals sensitive to conventional treatments or those on multiple medications.
Through our analysis of numerous studies, we discovered that melatonin appears to have a potential effect on migraine severity and occurrence, especially in women at different stages of their menstrual cycle who suffer from migraines. While melatonin is naturally found in various foods and can be taken as a supplement, we noted its promising role as a complementary therapy due to its minimal side effects and low risk of interaction with other medications.
However, we must acknowledge that factors like hormonal phases may influence the effectiveness of melatonin, complicating efforts to determine its isolated effects on migraines. Overall, our exploration into melatonin and its relationship with migraines offers a hopeful perspective, particularly for individuals sensitive to conventional treatments or those on multiple medications.
4
We explored the role of melatonin in helping to prevent migraines, particularly in pediatric cases. In the reviewed studies, five different investigations were conducted looking at its effectiveness for migraine management. While we found that melatonin showed promise in some instances, it’s crucial to highlight that one study reported negative effects, which affects the overall perception of its benefit as a standalone treatment.
The effectiveness of melatonin appears inconsistent, reflecting the need for further exploration. Since the current evidence includes a mixture of results, we acknowledge that reliance solely on melatonin isn’t fully supported yet.
Overall, although melatonin could potentially help some individuals combat migraines, caution is warranted due to the mixed outcomes in the existing literature. More rigorous studies are necessary to clarify its role and determine the best approach for using melatonin in migraine treatment.
The effectiveness of melatonin appears inconsistent, reflecting the need for further exploration. Since the current evidence includes a mixture of results, we acknowledge that reliance solely on melatonin isn’t fully supported yet.
Overall, although melatonin could potentially help some individuals combat migraines, caution is warranted due to the mixed outcomes in the existing literature. More rigorous studies are necessary to clarify its role and determine the best approach for using melatonin in migraine treatment.
9
Melatonin reduces migraine frequency
We conducted a randomized, double-blind clinical trial to examine the effects of melatonin on migraine attacks. In this study, 60 patients experiencing episodic migraines were divided into two groups. One group received 3 mg of melatonin, while the other received a placebo, both along with a standard treatment of propranolol over two months.
Throughout the follow-up period, we assessed the frequency, duration, and severity of migraine attacks. We found that those taking melatonin experienced a notable reduction in both the frequency and duration of their migraine events compared to the placebo group. While the severity of pain did not show a significant difference between the two groups, the overall impact on attack frequency and duration was promising.
Importantly, both treatments were similarly safe, with only a slight incidence of side effects observed. This suggests that melatonin could serve as an effective preventive option for adults suffering from episodic migraines when used alongside other standard therapies.
Throughout the follow-up period, we assessed the frequency, duration, and severity of migraine attacks. We found that those taking melatonin experienced a notable reduction in both the frequency and duration of their migraine events compared to the placebo group. While the severity of pain did not show a significant difference between the two groups, the overall impact on attack frequency and duration was promising.
Importantly, both treatments were similarly safe, with only a slight incidence of side effects observed. This suggests that melatonin could serve as an effective preventive option for adults suffering from episodic migraines when used alongside other standard therapies.
5
We embarked on a journey to explore the effectiveness of melatonin in preventing migraines among children and adolescents aged 10 to 17. Our study involved a rigorous method, where we conducted a randomized, double-blind trial comparing melatonin doses (3 mg and 6 mg) against a placebo for migraine prevention.
Participants had been experiencing headaches frequently before joining the study, and after an initial single-blind placebo phase, they were assessed for eligibility based on their headache patterns. Although our primary goal was to see a reduction in headache days during the treatment phase, we ultimately found no significant evidence that melatonin outperformed the placebo.
Notably, while we did observe a decrease in headache days overall, this improvement wasn't clearly linked to melatonin use, particularly since a considerable amount of data was missing. Importantly, melatonin was well accepted by participants with no serious side effects reported. This leads us to reflect on how future studies might better structure their enrollment to enhance the clarity of results, especially by considering those already on migraine treatments.
Participants had been experiencing headaches frequently before joining the study, and after an initial single-blind placebo phase, they were assessed for eligibility based on their headache patterns. Although our primary goal was to see a reduction in headache days during the treatment phase, we ultimately found no significant evidence that melatonin outperformed the placebo.
Notably, while we did observe a decrease in headache days overall, this improvement wasn't clearly linked to melatonin use, particularly since a considerable amount of data was missing. Importantly, melatonin was well accepted by participants with no serious side effects reported. This leads us to reflect on how future studies might better structure their enrollment to enhance the clarity of results, especially by considering those already on migraine treatments.
References
- Nelakuditi B, Dandamudi BJ, Dimaano KAM, Shah N, AlQassab O, et al. Efficacy of Melatonin as a Promising Intervention for Migraine Prevention: A Systematic Review of Randomized Control Trials. Cureus. 2024;16:e72559. doi:10.7759/cureus.72559
- Kilinc E, Torun IE, Baranoglu Kilinc Y, Töre F. Proposed receptor-mediated mechanisms of melatonin in nitroglycerin-induced migraine-like hyperalgesic conditions in rats. J Nutr Biochem. 2025;136:109800. doi:10.1016/j.jnutbio.2024.109800
- Togha M, Noormohammadi M, Ghorbani Z, Karimzadeh F, Bathaie SZ. Serum melatonin levels and in a sample of Iranian patients with migraine. Sci Rep. 2024;14:22883. doi:10.1038/s41598-024-73278-y
- Fayyazi A, Abbasian P, Hosseini SMS, Mohammadi Y, Bazmamoum H. Efficacy of Melatonin Administration in Reducing Headaches in Children with Migraines without Sleep Disorders. Iran J Child Neurol. 2024;18:57. doi:10.22037/ijcn.v18i3.42197
- Mehramiri A, Shalilahmadi D, Mohamadianinejad SE, Kouti L, Hosseinpour Y. The Effect of Melatonin on Reducing the Frequency and Severity of Migraine Attacks: A Double-Blind, Randomized Clinical Trial. Iran J Med Sci. 2024;49:313. doi:10.30476/ijms.2023.97782.2965
- Aydın T, Ayça S, Yurdakul K, Elevli M. Melatonin Levels in Children with Migraine. Neurol India. 2024;72:74. doi:10.4103/ni.ni_1108_21
- Farzin K, Kheiltash A, Tafakhori A, Nakhjiri NE, Sabet MS, et al. The effectiveness of agomelatine on headache severity and frequency in episodic migraine without aura; a parallel randomized controlled trial study. BMC Neurol. 2024;24:2. doi:10.1186/s12883-023-03516-9
- Tao H, Wan Q, Sun M, Cai K, Song Y, et al. Involvement of Plasma Melatonin in Medication-Overuse Headache: A Cross-Sectional Study. Clin Neuropharmacol. 2024;47:12. doi:10.1097/WNF.0000000000000573
- Gelfand AA, Allen IE, Grimes B, Irwin S, Qubty W, et al. Melatonin for migraine prevention in children and adolescents: A randomized, double-blind, placebo-controlled trial after single-blind placebo lead-in. Headache. 2023;63:1314. doi:10.1111/head.14600
- Fayyazi A, Abdollahi A, Moradi A, Bazmamoun H. Administration in Efficacy of Melatonin Reducing Headaches in Children With Migraines and Sleep Disorders: A Randomized Clinical Trial Study. Iran J Child Neurol. 2022;16:55. doi:10.22037/ijcn.v17i2.37918
- Puliappadamb HM, Maiti R, Mishra A, Jena M, Mishra BR. Efficacy and Safety of Melatonin as Prophylaxis for Migraine in Adults: A Meta-analysis. J Oral Facial Pain Headache. 2022;36:207–219. doi:10.11607/ofph.3211
- Zduńska A, Cegielska J, Domitrz I. The Pathogenetic Role of Melatonin in Migraine and Its Theoretic Implications for Pharmacotherapy: A Brief Overview of the Research. Nutrients. 2022;14. doi:10.3390/nu14163335
- Moreno-Ajona D, Villar-Martínez MD, Goadsby PJ. Emerging Targets for Migraine Treatment. Neurol India. 2021;69:S98. doi:10.4103/0028-3886.315989
- Yamanaka G, Kanou K, Takamatsu T, Takeshita M, Morichi S, et al. Complementary and Integrative Medicines as Prophylactic Agents for Pediatric Migraine: A Narrative Literature Review. J Clin Med. 2021;10. doi:10.3390/jcm10010138
- Song TJ, Kim BS, Chu MK. Therapeutic role of melatonin in migraine prophylaxis: Is there a link between sleep and migraine?. Prog Brain Res. 2020;255:343. doi:10.1016/bs.pbr.2020.05.014
- Gelfand AA, Ross AC, Irwin SL, Greene KA, Qubty WF, et al. Melatonin for Acute Treatment of Migraine in Children and Adolescents: A Pilot Randomized Trial. Headache. 2020;60:1712. doi:10.1111/head.13934
- Liampas I, Siokas V, Brotis A, Vikelis M, Dardiotis E. Endogenous Melatonin Levels and Therapeutic Use of Exogenous Melatonin in Migraine: Systematic Review and Meta-Analysis. Headache. 2020;60:1273. doi:10.1111/head.13828
- Tseng PT, Yang CP, Su KP, Chen TY, Wu YC, et al. The association between melatonin and episodic migraine: A pilot network meta-analysis of randomized controlled trials to compare the prophylactic effects with exogenous melatonin supplementation and pharmacotherapy. J Pineal Res. 2020;69:e12663. doi:10.1111/jpi.12663
- Wells RE, Beuthin J, Granetzke L. Complementary and Integrative Medicine for Episodic Migraine: an Update of Evidence from the Last 3 Years. Curr Pain Headache Rep. 2019;23:10. doi:10.1007/s11916-019-0750-8
- Long R, Zhu Y, Zhou S. Therapeutic role of melatonin in migraine prophylaxis: A systematic review. Medicine (Baltimore). 2019;98:e14099. doi:10.1097/MD.0000000000014099
