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SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
USERS' SCORE
Good
Based on 2 Reviews
8.3
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B-6 (as Pyridoxine Hydrochloride)
10 mg
588%
Calcium (as Calcium Carbonate)
60 mg
5%
Melatonin
5 mg
*
Top Medical Research Studies
9
Melatonin reduces reflux esophagitis damage
Melatonin protects against experimental reflux esophagitis.
Study focused on melatonin's effects
We explored how melatonin can protect the esophagus from reflux esophagitis (RE), a condition where stomach contents flow back into the esophagus, often causing painful inflammation. In our research with rats, we found that melatonin pretreatment resulted in significantly fewer bleeding lesions and lower levels of harmful lipid peroxidation typically caused by RE.
Additionally, melatonin helped replenish important antioxidants in the esophagus, suggesting its potential to neutralize free radicals that contribute to tissue damage. As we delved into the immune response, we observed that melatonin decreased the levels of certain pro-inflammatory cytokines, like TNF-alpha and IL-6, while keeping the levels of the anti-inflammatory cytokine IL-10 steady.
Interestingly, when we tested a melatonin receptor blocker, luzindole, we discovered that this approach did not hinder melatonin's protective effects. This indicates that melatonin works its magic in a receptor-independent way as well, not just through its antioxidant properties but also by modulating inflammation. Overall, we found that melatonin could be a beneficial ally for those suffering from reflux esophagitis, providing insights for future treatment strategies.
Additionally, melatonin helped replenish important antioxidants in the esophagus, suggesting its potential to neutralize free radicals that contribute to tissue damage. As we delved into the immune response, we observed that melatonin decreased the levels of certain pro-inflammatory cytokines, like TNF-alpha and IL-6, while keeping the levels of the anti-inflammatory cytokine IL-10 steady.
Interestingly, when we tested a melatonin receptor blocker, luzindole, we discovered that this approach did not hinder melatonin's protective effects. This indicates that melatonin works its magic in a receptor-independent way as well, not just through its antioxidant properties but also by modulating inflammation. Overall, we found that melatonin could be a beneficial ally for those suffering from reflux esophagitis, providing insights for future treatment strategies.
Read More
8
Melatonin protects esophageal barriers
Melatonin protects the esophageal epithelial barrier by suppressing the transcription, expression and activity of myosin light chain kinase through ERK1/2 signal transduction.
Highly relevant protection insights
We investigated how melatonin impacts the esophageal barrier, particularly in the context of gastroesophageal reflux disease (GERD). Our research revealed that dilated intercellular spaces (DIS) contribute to reflux issues, where melatonin appears to offer protective benefits.
Through several experiments, including the evaluation of esophageal epithelial samples from GERD patients using transmission electron microscopy, we observed that melatonin significantly helped maintain the integrity of the esophageal barrier. We noted that melatonin reduced the activity of a protein called myosin light chain kinase (MLCK), which is linked to maintaining cell connections.
Additionally, our tests with the Het-1A cell line showed that when pretreated with melatonin, these cells displayed improved barrier functions against acid exposure. Both the permeability of the cells and the activity of MLCK decreased, indicating melatonin's protective mechanism operates through the ERK1/2 signaling pathway.
These findings suggest that melatonin could be a valuable addition to treatment options for those suffering from GERD, offering a potential way to protect esophageal health and reduce symptoms effectively.
Through several experiments, including the evaluation of esophageal epithelial samples from GERD patients using transmission electron microscopy, we observed that melatonin significantly helped maintain the integrity of the esophageal barrier. We noted that melatonin reduced the activity of a protein called myosin light chain kinase (MLCK), which is linked to maintaining cell connections.
Additionally, our tests with the Het-1A cell line showed that when pretreated with melatonin, these cells displayed improved barrier functions against acid exposure. Both the permeability of the cells and the activity of MLCK decreased, indicating melatonin's protective mechanism operates through the ERK1/2 signaling pathway.
These findings suggest that melatonin could be a valuable addition to treatment options for those suffering from GERD, offering a potential way to protect esophageal health and reduce symptoms effectively.
Read More
8
Melatonin's protective role identified
Melatonin Regulates lncRNA NEAT1/miR-138-5p/HIF-1α Axis through MOV10 to Affect Acid-Related Esophageal Epithelial Cell Pyroptosis.
Moderately relevant to reflux treatment
We explored the impact of melatonin (MT) on inflammation in the esophagus, specifically in the context of gastroesophageal reflux disease (GERD), which is often linked to acid-related damage. Our study delved into how melatonin might influence the cellular processes involved when the esophagus becomes inflamed due to acid exposure.
Using a model that mimicked the acidic environment induced by deoxycholic acid (DCA), we observed changes in the activities of several important proteins and molecules related to inflammatory responses. Notably, the study revealed that melatonin seems to work by modulating a specific axis involving molecules such as MOV10, lncRNA NEAT1, and HIF-1α, which are all significant players in the body’s inflammatory processes.
We found that in the presence of DCA, levels of inflammatory markers increased, while the levels of protective miR-138-5p decreased. Melatonin treatment notably reversed these trends, suggesting that it may offer protective effects against esophageal damage by inhibiting these inflammatory pathways. Overall, our findings highlight melatonin's potential as a therapeutic agent for managing acid-induced esophageal inflammation.
Using a model that mimicked the acidic environment induced by deoxycholic acid (DCA), we observed changes in the activities of several important proteins and molecules related to inflammatory responses. Notably, the study revealed that melatonin seems to work by modulating a specific axis involving molecules such as MOV10, lncRNA NEAT1, and HIF-1α, which are all significant players in the body’s inflammatory processes.
We found that in the presence of DCA, levels of inflammatory markers increased, while the levels of protective miR-138-5p decreased. Melatonin treatment notably reversed these trends, suggesting that it may offer protective effects against esophageal damage by inhibiting these inflammatory pathways. Overall, our findings highlight melatonin's potential as a therapeutic agent for managing acid-induced esophageal inflammation.
Read More
Most Useful Reviews
8.8
Improvement noted
I’m a fan of Natrol products and normally take 1 mg of melatonin for sleep. However, I read that 5 mg for 30 days can help with reflux, and I experienced significant improvement. I'd definitely recommend it, but I suggest researching it first.
Read More
5.5
Effective for reflux
I bought this after seeing it featured on a Paleo blog, as it's claimed to be beneficial for sleep and reflux esophagitis. I'm trying it for my mother, who suffers from reflux esophagitis.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.7
9
Melatonin enhances GERD treatment effectiveness
Is the Addition of Sublingual Melatonin to Omeprazole Superior to Omeprazole Alone in the Management of Gastroesophageal Reflux Disease Symptoms: A Clinical Trial.
Study shows positive melatonin impact
We explored whether adding sublingual melatonin to the common reflux medication omeprazole could enhance symptom relief for individuals suffering from gastroesophageal reflux disease (GERD). In this randomized double-blind clinical trial involving 78 patients, half received omeprazole along with melatonin, while the other half had omeprazole with a placebo.
After four weeks of treatment, we observed significant improvements in the melatonin group. Participants reported reductions in heartburn and epigastric pain, contributing to a lower score on the Frequency Scale for Symptoms of GERD. Additionally, quality of life assessments indicated a notable enhancement for those taking melatonin compared to those on placebo.
Importantly, we found that adverse events were similar between the two groups, with no serious side effects reported. These findings suggest that sublingual melatonin may indeed offer valuable benefits alongside traditional proton pump inhibitors in managing GERD symptoms more effectively.
After four weeks of treatment, we observed significant improvements in the melatonin group. Participants reported reductions in heartburn and epigastric pain, contributing to a lower score on the Frequency Scale for Symptoms of GERD. Additionally, quality of life assessments indicated a notable enhancement for those taking melatonin compared to those on placebo.
Importantly, we found that adverse events were similar between the two groups, with no serious side effects reported. These findings suggest that sublingual melatonin may indeed offer valuable benefits alongside traditional proton pump inhibitors in managing GERD symptoms more effectively.
Read More
9
Melatonin reduces reflux damage
Esophagoprotection mediated by exogenous and endogenous melatonin in an experimental model of reflux esophagitis.
Study confirms melatonin's benefits
We explored the role of melatonin in protecting the esophagus from damage caused by acid reflux. Our study compared melatonin, both from supplements and the amino acid L-tryptophan, to common treatments like pantoprazole and ranitidine. The research utilized a model of reflux esophagitis in rats, where we induced gastric reflux and then observed the impact of our treatments on esophageal damage.
Just four hours post-reflux induction, we noted significant mucosal damage, accompanied by swelling and an influx of white blood cells. Notably, both melatonin and L-tryptophan led to a reduction in the extent of lesions and improved blood flow to the esophagus. Furthermore, when plasma melatonin levels were lowered through pineal gland removal, the damage worsened. However, administering melatonin or L-tryptophan helped mitigate this effect.
We also found that blocking melatonin's action with a specific receptor antagonist negated these protective effects. Additional experiments showed that factors associated with inflammation were reduced with melatonin's use, suggesting it not only protects the tissue but also decreases harmful inflammatory responses. Overall, we concluded that melatonin effectively safeguards against acid reflux-induced damage by triggering specific bodily responses that enhance tissue health and reduce inflammation.
Just four hours post-reflux induction, we noted significant mucosal damage, accompanied by swelling and an influx of white blood cells. Notably, both melatonin and L-tryptophan led to a reduction in the extent of lesions and improved blood flow to the esophagus. Furthermore, when plasma melatonin levels were lowered through pineal gland removal, the damage worsened. However, administering melatonin or L-tryptophan helped mitigate this effect.
We also found that blocking melatonin's action with a specific receptor antagonist negated these protective effects. Additional experiments showed that factors associated with inflammation were reduced with melatonin's use, suggesting it not only protects the tissue but also decreases harmful inflammatory responses. Overall, we concluded that melatonin effectively safeguards against acid reflux-induced damage by triggering specific bodily responses that enhance tissue health and reduce inflammation.
Read More
9
Melatonin reduces reflux esophagitis damage
Melatonin protects against experimental reflux esophagitis.
Study focused on melatonin's effects
We explored how melatonin can protect the esophagus from reflux esophagitis (RE), a condition where stomach contents flow back into the esophagus, often causing painful inflammation. In our research with rats, we found that melatonin pretreatment resulted in significantly fewer bleeding lesions and lower levels of harmful lipid peroxidation typically caused by RE.
Additionally, melatonin helped replenish important antioxidants in the esophagus, suggesting its potential to neutralize free radicals that contribute to tissue damage. As we delved into the immune response, we observed that melatonin decreased the levels of certain pro-inflammatory cytokines, like TNF-alpha and IL-6, while keeping the levels of the anti-inflammatory cytokine IL-10 steady.
Interestingly, when we tested a melatonin receptor blocker, luzindole, we discovered that this approach did not hinder melatonin's protective effects. This indicates that melatonin works its magic in a receptor-independent way as well, not just through its antioxidant properties but also by modulating inflammation. Overall, we found that melatonin could be a beneficial ally for those suffering from reflux esophagitis, providing insights for future treatment strategies.
Additionally, melatonin helped replenish important antioxidants in the esophagus, suggesting its potential to neutralize free radicals that contribute to tissue damage. As we delved into the immune response, we observed that melatonin decreased the levels of certain pro-inflammatory cytokines, like TNF-alpha and IL-6, while keeping the levels of the anti-inflammatory cytokine IL-10 steady.
Interestingly, when we tested a melatonin receptor blocker, luzindole, we discovered that this approach did not hinder melatonin's protective effects. This indicates that melatonin works its magic in a receptor-independent way as well, not just through its antioxidant properties but also by modulating inflammation. Overall, we found that melatonin could be a beneficial ally for those suffering from reflux esophagitis, providing insights for future treatment strategies.
Read More
9
Melatonin shows promise for GERD
Melatonin for the treatment of gastroesophageal reflux disease.
Melatonin's effects not isolated
We looked into the potential of melatonin as a treatment for gastroesophageal reflux disease (GERD). The research highlighted how melatonin, produced in greater quantities by our gut than the pineal gland, plays a vital role in gastrointestinal (GI) health. In some animal studies, melatonin has proven to protect against esophageal lesions and can assist with other digestive issues.
In a clinical trial, combining melatonin with other natural supplements outperformed a common heartburn medication called omeprazole. However, the unique impact of melatonin alone had not been specifically tested before. We followed a 64-year-old woman who wished to move away from prescription medications due to osteoporosis concerns. She had experienced recurring GERD symptoms after trying to stop using a proton pump inhibitor (PPI).
We observed that after a 40-day course of a mixture including 6 mg of melatonin, she could discontinue her PPI without any symptoms returning. Interestingly, reducing her melatonin dosage led to a return of symptoms, suggesting it was essential for her relief. This study indicates that melatonin, especially when combined with supportive nutrients, may be significant in managing GERD symptoms. Yet, since this was part of a blend, we can't say with absolute certainty how much of the success came strictly from melatonin alone.
In a clinical trial, combining melatonin with other natural supplements outperformed a common heartburn medication called omeprazole. However, the unique impact of melatonin alone had not been specifically tested before. We followed a 64-year-old woman who wished to move away from prescription medications due to osteoporosis concerns. She had experienced recurring GERD symptoms after trying to stop using a proton pump inhibitor (PPI).
We observed that after a 40-day course of a mixture including 6 mg of melatonin, she could discontinue her PPI without any symptoms returning. Interestingly, reducing her melatonin dosage led to a return of symptoms, suggesting it was essential for her relief. This study indicates that melatonin, especially when combined with supportive nutrients, may be significant in managing GERD symptoms. Yet, since this was part of a blend, we can't say with absolute certainty how much of the success came strictly from melatonin alone.
Read More
8
Melatonin's protective role identified
Melatonin Regulates lncRNA NEAT1/miR-138-5p/HIF-1α Axis through MOV10 to Affect Acid-Related Esophageal Epithelial Cell Pyroptosis.
Moderately relevant to reflux treatment
We explored the impact of melatonin (MT) on inflammation in the esophagus, specifically in the context of gastroesophageal reflux disease (GERD), which is often linked to acid-related damage. Our study delved into how melatonin might influence the cellular processes involved when the esophagus becomes inflamed due to acid exposure.
Using a model that mimicked the acidic environment induced by deoxycholic acid (DCA), we observed changes in the activities of several important proteins and molecules related to inflammatory responses. Notably, the study revealed that melatonin seems to work by modulating a specific axis involving molecules such as MOV10, lncRNA NEAT1, and HIF-1α, which are all significant players in the body’s inflammatory processes.
We found that in the presence of DCA, levels of inflammatory markers increased, while the levels of protective miR-138-5p decreased. Melatonin treatment notably reversed these trends, suggesting that it may offer protective effects against esophageal damage by inhibiting these inflammatory pathways. Overall, our findings highlight melatonin's potential as a therapeutic agent for managing acid-induced esophageal inflammation.
Using a model that mimicked the acidic environment induced by deoxycholic acid (DCA), we observed changes in the activities of several important proteins and molecules related to inflammatory responses. Notably, the study revealed that melatonin seems to work by modulating a specific axis involving molecules such as MOV10, lncRNA NEAT1, and HIF-1α, which are all significant players in the body’s inflammatory processes.
We found that in the presence of DCA, levels of inflammatory markers increased, while the levels of protective miR-138-5p decreased. Melatonin treatment notably reversed these trends, suggesting that it may offer protective effects against esophageal damage by inhibiting these inflammatory pathways. Overall, our findings highlight melatonin's potential as a therapeutic agent for managing acid-induced esophageal inflammation.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.3
8.8
Improvement noted
I’m a fan of Natrol products and normally take 1 mg of melatonin for sleep. However, I read that 5 mg for 30 days can help with reflux, and I experienced significant improvement. I'd definitely recommend it, but I suggest researching it first.
5.5
Effective for reflux
I bought this after seeing it featured on a Paleo blog, as it's claimed to be beneficial for sleep and reflux esophagitis. I'm trying it for my mother, who suffers from reflux esophagitis.
