' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 16 Researches
7.6
USERS' SCORE
Excellent
Based on 4 Reviews
9.2
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%
Saturated Fat
0 g
0%
Trans Fat
0 g
**
Polyunsaturated Fat
0.5 g
**
Monounsaturated Fat
0 g
**
Cholesterol
10 mg
3%
Omega-3 Fish Oil
1000 mg
**
EPA (Eicosapentaenoic Acid)
180 mg
**
DHA (Docosahexaenoic Acid)
120 mg
**
Top Medical Research Studies
9
Eicosapentaenoic acid benefits hypertension
5,6-diHETE lactone (EPA-L) mediates hypertensive microvascular dilation by activating the endothelial GPR-PLC-IP signaling pathway.
Clear focus on hypertension treatment
We investigated the impact of eicosapentaenoic acid (EPA) on hypertension, a condition characterized by elevated blood pressure that can lead to serious health issues. The study focused on a special compound called 5,6-diHETE lactone (EPA-L), derived from EPA, which we observed to promote better blood vessel function. This compound was tested on hypertensive rats and showed a significant reduction in blood pressure.
Interestingly, we found that the way EPA-L works isn’t through increasing levels of nitric oxide like some may expect. Instead, we discovered that it triggers a unique signaling pathway involving G-protein-coupled receptors. This pathway activates key cellular processes in the endothelial cells lining our blood vessels, allowing them to relax and dilate, thereby contributing to lower blood pressure. In vitro experiments on human endothelial cells confirmed these findings, providing further evidence for the effectiveness of EPA-L.
Overall, our research positions EPA-L as a promising metabolite from eicosapentaenoic acid, demonstrating potential benefits in managing hypertension and promoting vascular health.
Interestingly, we found that the way EPA-L works isn’t through increasing levels of nitric oxide like some may expect. Instead, we discovered that it triggers a unique signaling pathway involving G-protein-coupled receptors. This pathway activates key cellular processes in the endothelial cells lining our blood vessels, allowing them to relax and dilate, thereby contributing to lower blood pressure. In vitro experiments on human endothelial cells confirmed these findings, providing further evidence for the effectiveness of EPA-L.
Overall, our research positions EPA-L as a promising metabolite from eicosapentaenoic acid, demonstrating potential benefits in managing hypertension and promoting vascular health.
Read More
8
Eicosapentaenoic acid lowers blood pressure
Vasodilation and blood pressure-lowering effect mediated by 5,6-EEQ lactone in 5/6 nephrectomy hypertensive rats.
High relevance to hypertension treatment
We examined the impact of eicosapentaenoic acid (EPA) lactone on hypertension, particularly in a model where rats undergo a 5/6 nephrectomy. This condition is known to induce high blood pressure and related vascular dysfunction. Our research involved administering the EPA lactone to these hypertensive rats over five days while measuring their blood pressure, kidney function, and other relevant health metrics.
Through our study, we found that the EPA lactone significantly lowered blood pressure. It achieved this by promoting improved dilation of the blood vessels, which is essential for maintaining healthy circulation. Notably, the mechanism involved calcium-dependent potassium channels in the endothelium, contributing to better vessel relaxation and function.
Our findings suggest that the EPA lactone may hold promise as a dietary supplement for individuals dealing with hypertension, particularly those experiencing issues related to microvascular dysfunction. This study enhances our understanding of how this specific metabolite can play a role in managing high blood pressure effectively.
Through our study, we found that the EPA lactone significantly lowered blood pressure. It achieved this by promoting improved dilation of the blood vessels, which is essential for maintaining healthy circulation. Notably, the mechanism involved calcium-dependent potassium channels in the endothelium, contributing to better vessel relaxation and function.
Our findings suggest that the EPA lactone may hold promise as a dietary supplement for individuals dealing with hypertension, particularly those experiencing issues related to microvascular dysfunction. This study enhances our understanding of how this specific metabolite can play a role in managing high blood pressure effectively.
Read More
7
Eicosapentaenoic Acid benefits cardiac health
Eicosapentaenoic Acid Ameliorates Cardiac Fibrosis and Tissue Inflammation in Spontaneously Hypertensive Rats.
High relevance to hypertension treatment
In our investigation, we delved into the effects of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, on hypertension and its associated heart problems. To understand its impact, we used twelve-week-old spontaneously hypertensive rats, which mimic the conditions seen in humans with high blood pressure.
The rats were divided into two groups, with one group fed a diet enriched with EPA while the other received a standard diet for 20 weeks. Our findings revealed something promising: those on the EPA-enriched diet showed a marked reduction in cardiac fibrosis, a condition where heart tissue becomes stiff and less functional. This was significant, as it also contributed to improved diastolic function, even though blood pressure continued to rise.
However, it’s important to note that EPA did not seem to affect the thickening of the heart muscle, known as hypertrophy. We also found evidence that EPA treatment increased certain factors that typically indicate an anti-inflammatory response, such as M2 macrophages and interleukin-10 levels.
Overall, we observed that EPA appears to prevent further complications related to heart function during sustained high blood pressure, positioning it as a potentially innovative treatment strategy for managing hypertensive heart disease.
The rats were divided into two groups, with one group fed a diet enriched with EPA while the other received a standard diet for 20 weeks. Our findings revealed something promising: those on the EPA-enriched diet showed a marked reduction in cardiac fibrosis, a condition where heart tissue becomes stiff and less functional. This was significant, as it also contributed to improved diastolic function, even though blood pressure continued to rise.
However, it’s important to note that EPA did not seem to affect the thickening of the heart muscle, known as hypertrophy. We also found evidence that EPA treatment increased certain factors that typically indicate an anti-inflammatory response, such as M2 macrophages and interleukin-10 levels.
Overall, we observed that EPA appears to prevent further complications related to heart function during sustained high blood pressure, positioning it as a potentially innovative treatment strategy for managing hypertensive heart disease.
Read More
Most Useful Reviews
9.5
Effective against hypertension
Omega-3 Fish Oil works brilliantly! I prescribe it to my patients with cardiovascular issues, including hypertension and arrhythmias. It's important to remember that individuals may have a specific intolerance to the components of the medication.
Read More
9.5
Hypertension relief
This product works perfectly for hypertension and heart issues, even among the elderly.
Read More
8.8
Cholesterol reduction
Omega-3 polyunsaturated fatty acids from cold water fish are crucial for the secondary prevention of coronary heart disease, especially in those over 50 or with hypertension. They help lower cholesterol, triglycerides, and inhibit platelet aggregation. I've observed that this combination stabilises cholesterol plaques and enhances antihypertensive therapy, ultimately reducing the risk of sudden death in coronary heart disease patients.
Read More
Most Recommended Products for Hypertension
Thorne Ultimate-E®
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 1 Reviews
9.5
American Health Ester-C With Citrus Bioflavonoids
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Very Good
Based on 1 Reviews
8.8
NOW Foods Potassium Citrate
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Very Good
Based on 14 Reviews
8.7
Medical Researches
SCIENTIFIC SCORE
Most Likely Effective
Based on 16 Researches
7.6
9
Eicosapentaenoic acid benefits hypertension
5,6-diHETE lactone (EPA-L) mediates hypertensive microvascular dilation by activating the endothelial GPR-PLC-IP signaling pathway.
Clear focus on hypertension treatment
We investigated the impact of eicosapentaenoic acid (EPA) on hypertension, a condition characterized by elevated blood pressure that can lead to serious health issues. The study focused on a special compound called 5,6-diHETE lactone (EPA-L), derived from EPA, which we observed to promote better blood vessel function. This compound was tested on hypertensive rats and showed a significant reduction in blood pressure.
Interestingly, we found that the way EPA-L works isn’t through increasing levels of nitric oxide like some may expect. Instead, we discovered that it triggers a unique signaling pathway involving G-protein-coupled receptors. This pathway activates key cellular processes in the endothelial cells lining our blood vessels, allowing them to relax and dilate, thereby contributing to lower blood pressure. In vitro experiments on human endothelial cells confirmed these findings, providing further evidence for the effectiveness of EPA-L.
Overall, our research positions EPA-L as a promising metabolite from eicosapentaenoic acid, demonstrating potential benefits in managing hypertension and promoting vascular health.
Interestingly, we found that the way EPA-L works isn’t through increasing levels of nitric oxide like some may expect. Instead, we discovered that it triggers a unique signaling pathway involving G-protein-coupled receptors. This pathway activates key cellular processes in the endothelial cells lining our blood vessels, allowing them to relax and dilate, thereby contributing to lower blood pressure. In vitro experiments on human endothelial cells confirmed these findings, providing further evidence for the effectiveness of EPA-L.
Overall, our research positions EPA-L as a promising metabolite from eicosapentaenoic acid, demonstrating potential benefits in managing hypertension and promoting vascular health.
Read More
9
Eicosapentaenoic acid's role in hypertension
Resolvin E1/ChemR23 Protects Against Hypertension and Vascular Remodeling in Angiotensin II-Induced Hypertensive Mice.
Study relevance moderately established
We explored the impact of Resolvin E1 (RvE1)—a compound derived from eicosapentaenoic acid—on hypertension and the corresponding vascular changes associated with it. This research utilized a model where hypertension was induced in mice through a substance called angiotensin II. We administered RvE1 via injection to see how it affected both blood pressure and blood vessel integrity.
Our findings showed that RvE1 could lower high blood pressure and reduce certain harmful changes in the blood vessels. Specifically, it lessened the thickening of artery walls and decreased the buildup of scar tissue in these areas. These improvements were linked to RvE1’s ability to reduce the presence of immune cells that can cause inflammation, which is crucial in the development of hypertension.
We noted that RvE1 works by activating specific cellular pathways that help mediate immune responses and cell growth. Interestingly, levels of RvE1 were found to be lower in patients suffering from hypertension, suggesting that restoring this compound could have therapeutic benefits.
In summary, RvE1 derived from eicosapentaenoic acid shows promise as a potential treatment avenue for managing hypertension and its associated vascular challenges by promoting a healthy resolution of inflammation and regulating cell behavior.
Our findings showed that RvE1 could lower high blood pressure and reduce certain harmful changes in the blood vessels. Specifically, it lessened the thickening of artery walls and decreased the buildup of scar tissue in these areas. These improvements were linked to RvE1’s ability to reduce the presence of immune cells that can cause inflammation, which is crucial in the development of hypertension.
We noted that RvE1 works by activating specific cellular pathways that help mediate immune responses and cell growth. Interestingly, levels of RvE1 were found to be lower in patients suffering from hypertension, suggesting that restoring this compound could have therapeutic benefits.
In summary, RvE1 derived from eicosapentaenoic acid shows promise as a potential treatment avenue for managing hypertension and its associated vascular challenges by promoting a healthy resolution of inflammation and regulating cell behavior.
Read More
9
Eicosapentaenoic Acid Improves Kidney Health
EPA-Enriched Phospholipids Alleviate Renal Interstitial Fibrosis in Spontaneously Hypertensive Rats by Regulating TGF-β Signaling Pathways.
Relevant effects on hypertension observed
We set out to investigate how eicosapentaenoic acid (EPA) enriched in phospholipids—termed EPA-PL—affects hypertension and kidney health, particularly in spontaneously hypertensive rats (SHRs). Our research focused on understanding whether dietary EPA-PL could provide protective benefits against kidney damage associated with chronic high blood pressure.
Over three weeks, we treated SHRs with EPA-PL and observed a significant reduction in blood pressure. This drop in blood pressure appeared to be linked to its regulation of the renin-angiotensin system, an important player in blood pressure management. In addition to improved blood pressure, we found notable improvements in kidney function. Measurements of plasma creatinine, blood urea nitrogen, and 24-hour proteinuria showed that EPA-PL treatment led to less kidney dysfunction.
Further investigation into the microscopic structure of the kidneys revealed that EPA-PL helps alleviate renal injury and tubulointerstitial fibrosis, conditions that are often detrimental in hypertensive kidney disease. Mechanistically, we observed that the treatment inhibited a protein called TGF-β, while also affecting other important pathways related to cell survival and inflammatory responses, leading to less oxidative stress in the kidneys.
Overall, our findings suggest that EPA-PL holds promising potential as a therapeutic approach for preventing and alleviating the damaging effects of hypertension on kidney health.
Over three weeks, we treated SHRs with EPA-PL and observed a significant reduction in blood pressure. This drop in blood pressure appeared to be linked to its regulation of the renin-angiotensin system, an important player in blood pressure management. In addition to improved blood pressure, we found notable improvements in kidney function. Measurements of plasma creatinine, blood urea nitrogen, and 24-hour proteinuria showed that EPA-PL treatment led to less kidney dysfunction.
Further investigation into the microscopic structure of the kidneys revealed that EPA-PL helps alleviate renal injury and tubulointerstitial fibrosis, conditions that are often detrimental in hypertensive kidney disease. Mechanistically, we observed that the treatment inhibited a protein called TGF-β, while also affecting other important pathways related to cell survival and inflammatory responses, leading to less oxidative stress in the kidneys.
Overall, our findings suggest that EPA-PL holds promising potential as a therapeutic approach for preventing and alleviating the damaging effects of hypertension on kidney health.
Read More
8
Eicosapentaenoic acid and hypertension
Association Between Circulating Fatty Acids and Blood Pressure: A Review.
Relevant to hypertension management
We observed that eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, plays an interesting role in managing high blood pressure (hypertension). This naturally occurring fatty acid is recognized for its potential benefits in reducing blood pressure levels, particularly in those struggling with hypertension.
In our exploration of the latest findings, we noted that several studies suggest EPA could positively influence blood pressure through various mechanisms. These include reducing inflammation and improving vascular function, which are both significant factors in managing hypertension. It seems that consuming EPA could serve as a dietary recommendation for those aiming to lower their blood pressure.
However, it’s important to be aware that the existing research around EPA's effectiveness is still evolving. While some fatty acids are associated with a reduction in blood pressure, the overall relationship is not absolutely conclusive, and further studies are still needed to fully understand how EPA interacts with blood pressure management.
We encourage a balanced approach that also considers other lifestyle factors, such as diet and physical activity, when looking at how fatty acids like EPA can fit into a hypertension management plan.
In our exploration of the latest findings, we noted that several studies suggest EPA could positively influence blood pressure through various mechanisms. These include reducing inflammation and improving vascular function, which are both significant factors in managing hypertension. It seems that consuming EPA could serve as a dietary recommendation for those aiming to lower their blood pressure.
However, it’s important to be aware that the existing research around EPA's effectiveness is still evolving. While some fatty acids are associated with a reduction in blood pressure, the overall relationship is not absolutely conclusive, and further studies are still needed to fully understand how EPA interacts with blood pressure management.
We encourage a balanced approach that also considers other lifestyle factors, such as diet and physical activity, when looking at how fatty acids like EPA can fit into a hypertension management plan.
Read More
8
Eicosapentaenoic acid benefits hypertension
Association between dietary intake of omega-3 polyunsaturated fatty acids and all-cause and cardiovascular mortality among hypertensive adults: Results from NHANES 1999-2018.
High relevance to hypertension research.
We conducted an exploration into the effects of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, on hypertension and overall mortality rates. The study examined data from nearly 27,000 hypertensive individuals using dietary information collected from 10 NHANES cycles spanning nearly two decades.
Throughout the research, we observed that individuals who increased their consumption of omega-3 fatty acids, particularly those derived from plant sources and fish, demonstrated a notable decrease in both all-cause and cardiovascular mortality. Specifically, higher intake of EPA was linked to a lower risk of cardiovascular death, indicating this nutrient could play a beneficial role for individuals managing hypertension.
Our findings suggest that dietary inclusion of omega-3s, especially EPA, ALA, and DPA, may offer important health advantages, paving the way for potential dietary strategies to lower the risks associated with hypertension. By encouraging higher omega-3 consumption, we could help individuals reduce their overall mortality risk related to heart health.
Throughout the research, we observed that individuals who increased their consumption of omega-3 fatty acids, particularly those derived from plant sources and fish, demonstrated a notable decrease in both all-cause and cardiovascular mortality. Specifically, higher intake of EPA was linked to a lower risk of cardiovascular death, indicating this nutrient could play a beneficial role for individuals managing hypertension.
Our findings suggest that dietary inclusion of omega-3s, especially EPA, ALA, and DPA, may offer important health advantages, paving the way for potential dietary strategies to lower the risks associated with hypertension. By encouraging higher omega-3 consumption, we could help individuals reduce their overall mortality risk related to heart health.
Read More
User Reviews
USERS' SCORE
Excellent
Based on 4 Reviews
9.2
9.5
Effective against hypertension
Omega-3 Fish Oil works brilliantly! I prescribe it to my patients with cardiovascular issues, including hypertension and arrhythmias. It's important to remember that individuals may have a specific intolerance to the components of the medication.
9.5
Hypertension relief
This product works perfectly for hypertension and heart issues, even among the elderly.
8.8
Cholesterol reduction
Omega-3 polyunsaturated fatty acids from cold water fish are crucial for the secondary prevention of coronary heart disease, especially in those over 50 or with hypertension. They help lower cholesterol, triglycerides, and inhibit platelet aggregation. I've observed that this combination stabilises cholesterol plaques and enhances antihypertensive therapy, ultimately reducing the risk of sudden death in coronary heart disease patients.
Read More
8.8
Vascular expansion
Fish oil, or Omega-3, is vital for numerous body functions. Most food sources provide insufficient amounts, leading to the need for supplements. It helps expand blood vessels, enhancing blood flow and preventing arterial hypertension. This positively affects heart function, reduces the risk of arrhythmias and atherosclerosis, and even regulates mood, benefiting both heart and mental health.
Read More
