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SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.4
USERS' SCORE
Good
Based on 4 Reviews
8.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%
Saturated Fat
0 g
0%
Trans Fat
0 g
**
Polyunsaturated Fat
0.5 g
**
Monounsaturated Fat
0 g
**
Cholesterol
10 mg
3%
Omega-3 Fish Oil
1000 mg
**
EPA (Eicosapentaenoic Acid)
180 mg
**
DHA (Docosahexaenoic Acid)
120 mg
**
Top Medical Research Studies
9
Omega-3 aids hypothyroid cognition
The effect of omega-3 on cognition in hypothyroid adult male rats.
Supports omega-3 as treatment
We set out to investigate how hypothyroidism affects cognitive function and whether omega-3 could provide a helpful boost in adult male rats. The study involved thirty rats, split into three groups: one as a control, another experiencing hypothyroidism, and the last group receiving omega-3 treatment.
The findings were quite striking. Rats with induced hypothyroidism showed significant memory problems, including difficulties in spatial learning and retention in various tests. These deficits were accompanied by lower levels of important brain chemicals and noticeable structural damage in the hippocampus, a key area for memory.
However, when we provided omega-3 supplements to one group, there was a remarkable turnaround. Those rats not only saw improvements in their memory but also regained some brain health. Omega-3 helped boost antioxidant levels, lessen structural issues in the brain, and reduce the expression of a protein linked to these damages.
All in all, our research suggests that omega-3 may serve as a protective ally against the cognitive challenges posed by hypothyroidism. This offers an exciting avenue for potential treatments that could benefit not just rats but perhaps humans facing similar hormonal challenges.
The findings were quite striking. Rats with induced hypothyroidism showed significant memory problems, including difficulties in spatial learning and retention in various tests. These deficits were accompanied by lower levels of important brain chemicals and noticeable structural damage in the hippocampus, a key area for memory.
However, when we provided omega-3 supplements to one group, there was a remarkable turnaround. Those rats not only saw improvements in their memory but also regained some brain health. Omega-3 helped boost antioxidant levels, lessen structural issues in the brain, and reduce the expression of a protein linked to these damages.
All in all, our research suggests that omega-3 may serve as a protective ally against the cognitive challenges posed by hypothyroidism. This offers an exciting avenue for potential treatments that could benefit not just rats but perhaps humans facing similar hormonal challenges.
Read More
8
Eicosapentaenoic acid supports hypothyroidism
Effect of eicosapentaenoic acid ethyl ester on hypothyroid function.
High relevance to hypothyroidism research
We aimed to investigate how eicosapentaenoic acid ethyl ester, a form of omega-3 fatty acid derived from fish oil, influences thyroid function in patients with hypothyroidism. Interestingly, while it has generally been observed that plasma free fatty acid (FFA) levels remain normal in hypothyroid individuals, our findings indicated that some patients exhibited elevated FFA concentrations. This was compelling, as those with higher FFA levels showed milder symptoms of thyroid dysfunction compared to others with lower levels.
To delve deeper, we tested the effects of eicosapentaenoic acid in an animal model using hypothyroid rats. By administering eicosapentaenoic acid ethyl ester to these rats, we observed that it effectively inhibited the decline of thyroid hormone levels caused by a substance called MMI. Additionally, we noted that it positively influenced the structure of the thyroid follicles in these rats.
Our study suggests that eicosapentaenoic acid may not only support thyroid function but could also have potential benefits for managing conditions related to hypothyroidism. This opens up exciting possibilities for further research into natural treatments for thyroid health.
To delve deeper, we tested the effects of eicosapentaenoic acid in an animal model using hypothyroid rats. By administering eicosapentaenoic acid ethyl ester to these rats, we observed that it effectively inhibited the decline of thyroid hormone levels caused by a substance called MMI. Additionally, we noted that it positively influenced the structure of the thyroid follicles in these rats.
Our study suggests that eicosapentaenoic acid may not only support thyroid function but could also have potential benefits for managing conditions related to hypothyroidism. This opens up exciting possibilities for further research into natural treatments for thyroid health.
Read More
9
Omega 3 aids testicular function
Omega 3 fatty acids preserve testicular function by ameliorating BPF-induced dysthyroidism: role of p53/Bcl-2 signaling and proton pump activities.
Study identifies omega 3 impact.
We explored the impact of omega 3 fatty acids (O3FA) on hypothyroidism triggered by bisphenol F (BPF), a chemical known to disrupt endocrine functions. The study involved 20 male Wistar rats, divided into groups to either receive BPF, O3FA, or a combination of both for a duration of 28 days. This design helped us assess the protective effects of O3FA against hypothyroidism-related testicular dysfunction.
Our findings revealed that both low and high doses of O3FA were effective in improving various indicators of reproductive health. Specifically, we observed enhancements in sperm quality and hormone levels, including testosterone and luteinizing hormone. Additionally, O3FA increased antioxidant defenses and reduced harmful markers associated with oxidative stress.
On a cellular level, we noted that O3FA countered BPF's adverse effects on critical processes in the body, including energy production and apoptosis (cell death). This was linked to restoring a balance between proteins that promote cell survival and those that trigger cell death. Overall, the study underscores the potential of omega 3 fatty acids as a therapeutic intervention for testicular dysfunction arising from hypothyroidism.
Our findings revealed that both low and high doses of O3FA were effective in improving various indicators of reproductive health. Specifically, we observed enhancements in sperm quality and hormone levels, including testosterone and luteinizing hormone. Additionally, O3FA increased antioxidant defenses and reduced harmful markers associated with oxidative stress.
On a cellular level, we noted that O3FA countered BPF's adverse effects on critical processes in the body, including energy production and apoptosis (cell death). This was linked to restoring a balance between proteins that promote cell survival and those that trigger cell death. Overall, the study underscores the potential of omega 3 fatty acids as a therapeutic intervention for testicular dysfunction arising from hypothyroidism.
Read More
Most Useful Reviews
9.5
Miraculous skin improvement
My first omega-3, recommended by my endocrinologist, needed for my hypothyroidism. Initially, my skin was extremely dry and sensitive, but after taking Omega for about a month, I noticed a significant improvement. My skin now remains better hydrated even after washing. I take two capsules daily after meals. I previously tried Finnish and Norwegian omega, but I prefer this one, despite the large capsule size. Highly recommend it!
Read More
8.8
Consistent therapy support
Good dosage and composition. I take it regularly to support my treatment for hypothyroidism.
Read More
8.8
Effective and reliable
This omega is excellent, providing good dosage without belching or heartburn. It was prescribed for my hypothyroidism. I've been taking it consistently, trying different brands, and am pleased with the quality products available.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.4
9
Omega 3 aids testicular function
Omega 3 fatty acids preserve testicular function by ameliorating BPF-induced dysthyroidism: role of p53/Bcl-2 signaling and proton pump activities.
Study identifies omega 3 impact.
We explored the impact of omega 3 fatty acids (O3FA) on hypothyroidism triggered by bisphenol F (BPF), a chemical known to disrupt endocrine functions. The study involved 20 male Wistar rats, divided into groups to either receive BPF, O3FA, or a combination of both for a duration of 28 days. This design helped us assess the protective effects of O3FA against hypothyroidism-related testicular dysfunction.
Our findings revealed that both low and high doses of O3FA were effective in improving various indicators of reproductive health. Specifically, we observed enhancements in sperm quality and hormone levels, including testosterone and luteinizing hormone. Additionally, O3FA increased antioxidant defenses and reduced harmful markers associated with oxidative stress.
On a cellular level, we noted that O3FA countered BPF's adverse effects on critical processes in the body, including energy production and apoptosis (cell death). This was linked to restoring a balance between proteins that promote cell survival and those that trigger cell death. Overall, the study underscores the potential of omega 3 fatty acids as a therapeutic intervention for testicular dysfunction arising from hypothyroidism.
Our findings revealed that both low and high doses of O3FA were effective in improving various indicators of reproductive health. Specifically, we observed enhancements in sperm quality and hormone levels, including testosterone and luteinizing hormone. Additionally, O3FA increased antioxidant defenses and reduced harmful markers associated with oxidative stress.
On a cellular level, we noted that O3FA countered BPF's adverse effects on critical processes in the body, including energy production and apoptosis (cell death). This was linked to restoring a balance between proteins that promote cell survival and those that trigger cell death. Overall, the study underscores the potential of omega 3 fatty acids as a therapeutic intervention for testicular dysfunction arising from hypothyroidism.
Read More
9
Omega-3 aids hypothyroid cognition
The effect of omega-3 on cognition in hypothyroid adult male rats.
Supports omega-3 as treatment
We set out to investigate how hypothyroidism affects cognitive function and whether omega-3 could provide a helpful boost in adult male rats. The study involved thirty rats, split into three groups: one as a control, another experiencing hypothyroidism, and the last group receiving omega-3 treatment.
The findings were quite striking. Rats with induced hypothyroidism showed significant memory problems, including difficulties in spatial learning and retention in various tests. These deficits were accompanied by lower levels of important brain chemicals and noticeable structural damage in the hippocampus, a key area for memory.
However, when we provided omega-3 supplements to one group, there was a remarkable turnaround. Those rats not only saw improvements in their memory but also regained some brain health. Omega-3 helped boost antioxidant levels, lessen structural issues in the brain, and reduce the expression of a protein linked to these damages.
All in all, our research suggests that omega-3 may serve as a protective ally against the cognitive challenges posed by hypothyroidism. This offers an exciting avenue for potential treatments that could benefit not just rats but perhaps humans facing similar hormonal challenges.
The findings were quite striking. Rats with induced hypothyroidism showed significant memory problems, including difficulties in spatial learning and retention in various tests. These deficits were accompanied by lower levels of important brain chemicals and noticeable structural damage in the hippocampus, a key area for memory.
However, when we provided omega-3 supplements to one group, there was a remarkable turnaround. Those rats not only saw improvements in their memory but also regained some brain health. Omega-3 helped boost antioxidant levels, lessen structural issues in the brain, and reduce the expression of a protein linked to these damages.
All in all, our research suggests that omega-3 may serve as a protective ally against the cognitive challenges posed by hypothyroidism. This offers an exciting avenue for potential treatments that could benefit not just rats but perhaps humans facing similar hormonal challenges.
Read More
9
Omega-3s protect developing brains
Anti-apoptotic role of omega-3-fatty acids in developing brain: perinatal hypothyroid rat cerebellum as apoptotic model.
Supports omega-3 benefits in hypothyroidism
We investigated the potential benefits of omega-3 fatty acids in a model of hypothyroidism. This study used a group of pregnant and lactating rats whose offspring experienced thyroid hormone deficiency due to induced hypothyroidism.
We found that supplementing the mothers with omega-3 fatty acids, specifically a blend of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), significantly altered the levels of apoptosis—cell death—occurring in the developing brains of their pups.
Our results demonstrated that omega-3 supplementation reduced DNA fragmentation and the activation of a protein linked to apoptosis, suggesting that these fatty acids play a protective role. They appeared to counteract the effects of hypothyroidism by bringing back the balance of pro-and anti-apoptotic proteins in the cerebellum.
Notably, omega-3 fatty acids helped restore vital signaling pathways that connect to cell survival without interfering with thyroid hormone-responsive gene expression. This highlights the complex role omega-3s could play in brain health during critical developmental phases, especially under stress such as thyroid hormone deficiency.
We found that supplementing the mothers with omega-3 fatty acids, specifically a blend of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), significantly altered the levels of apoptosis—cell death—occurring in the developing brains of their pups.
Our results demonstrated that omega-3 supplementation reduced DNA fragmentation and the activation of a protein linked to apoptosis, suggesting that these fatty acids play a protective role. They appeared to counteract the effects of hypothyroidism by bringing back the balance of pro-and anti-apoptotic proteins in the cerebellum.
Notably, omega-3 fatty acids helped restore vital signaling pathways that connect to cell survival without interfering with thyroid hormone-responsive gene expression. This highlights the complex role omega-3s could play in brain health during critical developmental phases, especially under stress such as thyroid hormone deficiency.
Read More
9
Eicosapentaenoic Acid supports brain development
Anti-apoptotic role of omega-3-fatty acids in developing brain: perinatal hypothyroid rat cerebellum as apoptotic model.
Effectiveness of EPA treatment analyzed
We investigated the role of eicosapentaenoic acid (EPA), an omega-3 fatty acid, in the context of hypothyroidism and its effects on brain development. Our study used a rat model where hypothyroidism was induced, allowing us to examine how EPA influences neuronal health during this critical phase of development.
Through our research, we found that supplementing EPA, along with docosahexaenoic acid (DHA), significantly reduced signs of neuronal apoptosis, which is a controlled process of cell death that can be detrimental when excessive. Specifically, we observed decreases in DNA fragmentation and activation of an important mediator of cell death—caspase-3—in the cerebella of hypothyroid pups.
One of the key findings highlighted that EPA helped counteract increases in a pro-apoptotic protein called Bax. At the same time, levels of protective proteins, such as Bcl-2 and Bcl-x(L), were restored, which are crucial in promoting cell survival. Additionally, EPA supplementation normalized several important signaling pathways affected by thyroid hormone deficiency, which play vital roles in neuronal health.
Overall, our findings contribute valuable insight into how eicosapentaenoic acid can offer protective benefits for brain development during periods of stress caused by hypothyroidism, illuminating potential therapeutic pathways for ongoing investigations.
Through our research, we found that supplementing EPA, along with docosahexaenoic acid (DHA), significantly reduced signs of neuronal apoptosis, which is a controlled process of cell death that can be detrimental when excessive. Specifically, we observed decreases in DNA fragmentation and activation of an important mediator of cell death—caspase-3—in the cerebella of hypothyroid pups.
One of the key findings highlighted that EPA helped counteract increases in a pro-apoptotic protein called Bax. At the same time, levels of protective proteins, such as Bcl-2 and Bcl-x(L), were restored, which are crucial in promoting cell survival. Additionally, EPA supplementation normalized several important signaling pathways affected by thyroid hormone deficiency, which play vital roles in neuronal health.
Overall, our findings contribute valuable insight into how eicosapentaenoic acid can offer protective benefits for brain development during periods of stress caused by hypothyroidism, illuminating potential therapeutic pathways for ongoing investigations.
Read More
9
DHA promotes brain development in hypothyroidism
Anti-apoptotic role of omega-3-fatty acids in developing brain: perinatal hypothyroid rat cerebellum as apoptotic model.
Study highlights DHA's protective role
We explored the effects of docosahexaenoic acid (DHA), a type of omega-3 fatty acid, in a study designed to understand its role in overcoming hypothyroidism-induced neuronal apoptosis, especially during crucial cerebellar development. Our research involved supplementing pregnant and lactating rats with a mixture of DHA and eicosapentaenoic acid (EPA) while inducing hypothyroidism using methimazole.
By examining the cerebellum of pups at postnatal day 16, we observed that DHA supplementation significantly curbed DNA fragmentation and reduced caspase-3 activation, both markers of cell death. This protective effect seemed linked to DHA's ability to lower levels of pro-apoptotic proteins like Bax, which typically rise when thyroid hormones are deficient.
Furthermore, we found that omega-3 fatty acids boosted levels of protective proteins like Bcl-2 and Bcl-x(L), which are usually suppressed in hypothyroid conditions. DHA also helped restore important signaling pathways impacted by hypothyroidism, such as phospho-AKT, phospho-ERK, and phospho-JNK, without affecting myelin basic protein levels, which are responsive to thyroid hormones.
Overall, our findings suggest that omega-3 fatty acids, particularly DHA, have a significant anti-apoptotic role in the developing brain during periods of thyroid hormone deficiency.
By examining the cerebellum of pups at postnatal day 16, we observed that DHA supplementation significantly curbed DNA fragmentation and reduced caspase-3 activation, both markers of cell death. This protective effect seemed linked to DHA's ability to lower levels of pro-apoptotic proteins like Bax, which typically rise when thyroid hormones are deficient.
Furthermore, we found that omega-3 fatty acids boosted levels of protective proteins like Bcl-2 and Bcl-x(L), which are usually suppressed in hypothyroid conditions. DHA also helped restore important signaling pathways impacted by hypothyroidism, such as phospho-AKT, phospho-ERK, and phospho-JNK, without affecting myelin basic protein levels, which are responsive to thyroid hormones.
Overall, our findings suggest that omega-3 fatty acids, particularly DHA, have a significant anti-apoptotic role in the developing brain during periods of thyroid hormone deficiency.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.6
9.5
Miraculous skin improvement
My first omega-3, recommended by my endocrinologist, needed for my hypothyroidism. Initially, my skin was extremely dry and sensitive, but after taking Omega for about a month, I noticed a significant improvement. My skin now remains better hydrated even after washing. I take two capsules daily after meals. I previously tried Finnish and Norwegian omega, but I prefer this one, despite the large capsule size. Highly recommend it!
Read More
8.8
Consistent therapy support
Good dosage and composition. I take it regularly to support my treatment for hypothyroidism.
8.8
Essential vitamin synergy
Omega is a staple for us. We take it alongside vitamin D for better absorption, which is beneficial for managing hypothyroidism. If you found my experience helpful, click yes!
8.8
Effective and reliable
This omega is excellent, providing good dosage without belching or heartburn. It was prescribed for my hypothyroidism. I've been taking it consistently, trying different brands, and am pleased with the quality products available.
