5/15/2025
Last update
5/15/2025
Overview
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6
USERS' SCORE
Good
Based on 1 Review
8.4
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Biotin
10,000 mcg
33,333%
Top Medical Research Studies
4
Low-dose biotin effects minimal
We set out to investigate how low-dose biotin supplements, specifically those containing less than 300μg per day, might affect thyroid hormone levels in patients with hypothyroidism. Our approach included a detailed evaluation of 57 patients who were receiving thyroxine and also taking biotin supplements for a period ranging from 10 to 60 days.
Throughout the study, we measured the levels of thyroid-stimulating hormone (TSH) and free T4 (FT4) while the patients were on biotin and again 10 days after they stopped taking the supplement. As a control, we compared these findings to those of 31 age-matched individuals who were also being treated for hypothyroidism but were not using biotin.
Our analysis suggests that any changes observed in thyroid hormone profiles due to low-dose biotin supplementation are not clinically significant. In most cases, these changes do not warrant any adjustments to the patient's thyroid medication.
Overall, while our findings contribute to understanding the relationship between biotin and thyroid hormone levels, it appears that low-dose biotin may not play a crucial role in the treatment of hypothyroidism. Larger, more comprehensive studies would be beneficial to explore this phenomenon further.
Throughout the study, we measured the levels of thyroid-stimulating hormone (TSH) and free T4 (FT4) while the patients were on biotin and again 10 days after they stopped taking the supplement. As a control, we compared these findings to those of 31 age-matched individuals who were also being treated for hypothyroidism but were not using biotin.
Our analysis suggests that any changes observed in thyroid hormone profiles due to low-dose biotin supplementation are not clinically significant. In most cases, these changes do not warrant any adjustments to the patient's thyroid medication.
Overall, while our findings contribute to understanding the relationship between biotin and thyroid hormone levels, it appears that low-dose biotin may not play a crucial role in the treatment of hypothyroidism. Larger, more comprehensive studies would be beneficial to explore this phenomenon further.
Read More
8
We examined the complex interaction between biotin treatment and thyroid function in a unique case of a child with both trisomy 21 and partial biotinidase deficiency. The study shed light on how biotin supplementation—needed for treating biotinidase deficiency—can interfere with thyroid hormone assessments. This interference led to a misleading "normal" thyroid-stimulating hormone (TSH) result early in the infant’s life, which delayed the diagnosis of congenital hypothyroidism.
After pausing biotin treatment for just four days and retesting, we discovered a significantly elevated TSH level. This prompted us to initiate treatment with levothyroxine—a common medication for hypothyroidism. Initially, we used tablet form but soon transitioned to an oral solution to address dosing challenges that arose with the tablets. Interestingly, this switch improved our ability to manage TSH levels effectively.
While this case emphasizes the importance of precise laboratory testing in the context of biotin treatment, it does not establish any direct benefit of biotin for managing hypothyroidism itself. Overall, our findings highlight the need for careful monitoring and adjustments in treatment approaches for those with additional health challenges, such as trisomy 21 and biotinidase deficiency.
After pausing biotin treatment for just four days and retesting, we discovered a significantly elevated TSH level. This prompted us to initiate treatment with levothyroxine—a common medication for hypothyroidism. Initially, we used tablet form but soon transitioned to an oral solution to address dosing challenges that arose with the tablets. Interestingly, this switch improved our ability to manage TSH levels effectively.
While this case emphasizes the importance of precise laboratory testing in the context of biotin treatment, it does not establish any direct benefit of biotin for managing hypothyroidism itself. Overall, our findings highlight the need for careful monitoring and adjustments in treatment approaches for those with additional health challenges, such as trisomy 21 and biotinidase deficiency.
Read More
Most Useful Reviews
7.5
Hair management support
25 people found this helpful
My hair falls out more than I'd like due to hypothyroidism. However, as long as I take my biotin, it is manageable and reduces shedding. I love the Natrol brand, and their strawberry flavour is lovely, making it easy to take. If you have trouble sleeping, their Melatonin is also wonderful.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6
- All Researches
8
We examined the complex interaction between biotin treatment and thyroid function in a unique case of a child with both trisomy 21 and partial biotinidase deficiency. The study shed light on how biotin supplementation—needed for treating biotinidase deficiency—can interfere with thyroid hormone assessments. This interference led to a misleading "normal" thyroid-stimulating hormone (TSH) result early in the infant’s life, which delayed the diagnosis of congenital hypothyroidism.
After pausing biotin treatment for just four days and retesting, we discovered a significantly elevated TSH level. This prompted us to initiate treatment with levothyroxine—a common medication for hypothyroidism. Initially, we used tablet form but soon transitioned to an oral solution to address dosing challenges that arose with the tablets. Interestingly, this switch improved our ability to manage TSH levels effectively.
While this case emphasizes the importance of precise laboratory testing in the context of biotin treatment, it does not establish any direct benefit of biotin for managing hypothyroidism itself. Overall, our findings highlight the need for careful monitoring and adjustments in treatment approaches for those with additional health challenges, such as trisomy 21 and biotinidase deficiency.
After pausing biotin treatment for just four days and retesting, we discovered a significantly elevated TSH level. This prompted us to initiate treatment with levothyroxine—a common medication for hypothyroidism. Initially, we used tablet form but soon transitioned to an oral solution to address dosing challenges that arose with the tablets. Interestingly, this switch improved our ability to manage TSH levels effectively.
While this case emphasizes the importance of precise laboratory testing in the context of biotin treatment, it does not establish any direct benefit of biotin for managing hypothyroidism itself. Overall, our findings highlight the need for careful monitoring and adjustments in treatment approaches for those with additional health challenges, such as trisomy 21 and biotinidase deficiency.
Read More
4
Low-dose biotin effects minimal
We set out to investigate how low-dose biotin supplements, specifically those containing less than 300μg per day, might affect thyroid hormone levels in patients with hypothyroidism. Our approach included a detailed evaluation of 57 patients who were receiving thyroxine and also taking biotin supplements for a period ranging from 10 to 60 days.
Throughout the study, we measured the levels of thyroid-stimulating hormone (TSH) and free T4 (FT4) while the patients were on biotin and again 10 days after they stopped taking the supplement. As a control, we compared these findings to those of 31 age-matched individuals who were also being treated for hypothyroidism but were not using biotin.
Our analysis suggests that any changes observed in thyroid hormone profiles due to low-dose biotin supplementation are not clinically significant. In most cases, these changes do not warrant any adjustments to the patient's thyroid medication.
Overall, while our findings contribute to understanding the relationship between biotin and thyroid hormone levels, it appears that low-dose biotin may not play a crucial role in the treatment of hypothyroidism. Larger, more comprehensive studies would be beneficial to explore this phenomenon further.
Throughout the study, we measured the levels of thyroid-stimulating hormone (TSH) and free T4 (FT4) while the patients were on biotin and again 10 days after they stopped taking the supplement. As a control, we compared these findings to those of 31 age-matched individuals who were also being treated for hypothyroidism but were not using biotin.
Our analysis suggests that any changes observed in thyroid hormone profiles due to low-dose biotin supplementation are not clinically significant. In most cases, these changes do not warrant any adjustments to the patient's thyroid medication.
Overall, while our findings contribute to understanding the relationship between biotin and thyroid hormone levels, it appears that low-dose biotin may not play a crucial role in the treatment of hypothyroidism. Larger, more comprehensive studies would be beneficial to explore this phenomenon further.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Hair management support
25 people found this helpful
My hair falls out more than I'd like due to hypothyroidism. However, as long as I take my biotin, it is manageable and reduces shedding. I love the Natrol brand, and their strawberry flavour is lovely, making it easy to take. If you have trouble sleeping, their Melatonin is also wonderful.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Angelopoulos N, Paparodis RD, Androulakis I, Anagnostis P, Boniakos A, et al. The clinical significance of low dose biotin supplements (<300μg/day) in the treatment of patients with hypothyroidism: crucial or overestimated?. Thyroid Res. 2023;16:18. 10.1186/s13044-023-00162-8
- Feldt MM. Delayed Diagnosis of Congenital Hypothyroidism in a Child with Trisomy 21 and Biotinidase Deficiency and Successful Use of Levothyroxine Sodium Oral Solution. Case Rep Endocrinol. 2020;2020:8883969. 10.1155/2020/8883969
