Overview
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.9
USERS' SCORE
Good
Based on 7 Reviews
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B-12 (as Cyanocobalamin)
5,000 mcg
208,330%
Top Medical Research Studies
8
We explored a novel oral delivery system using vitamin B12, fucoidan, and concanavalin A to enhance insulin effectiveness for diabetes management. This smart nanosystem targets inflammation while regulating blood glucose levels efficiently. Our findings indicated that when tested on type I diabetic mice, the nanosystem significantly lowered blood sugar and reduced inflammatory markers, such as TNF-α and interleukin-6. Notably, the system ensures safe and effective delivery, presenting a promising alternative to traditional insulin methods.
Read More
8
We explored how vitamin B12 might protect against nerve damage caused by diabetes. In a research study, diabetic rats received B12 supplements for four months. By examining their brains, we found that B12 reduced nerve cell death and supported healthy brain functions, even under diabetic conditions. The treatment improved important markers related to nerve support and minimized harmful inflammatory responses. This suggests that vitamin B12 could be a valuable addition for helping diabetic patients maintain better brain health.
Read More
9
We explored the effectiveness of vitamin B12 in treating diabetic ocular nerve palsy, a complication that can occur in people with diabetes. In a recent study, fifty individuals with this condition were divided into two groups. One group received steroid treatments while the other was treated with vitamin B12 injections.
After assessing ocular movements at three points during treatment, we observed a notable improvement in those receiving vitamin B12 compared to those receiving steroids. Specifically, the vitamin B12 group showed an enhancement of eye movements by an average of 1.04, while the steroid group had a lesser improvement of 0.75. This difference was statistically significant, suggesting that vitamin B12 may be more effective in aiding recovery of eye movement in these patients.
Importantly, treating diabetic neuropathy with vitamin supplementation not only addresses possible nutritional deficiencies but could also improve overall quality of life for patients. This study highlights the potential benefits of vitamin B12 therapy, making it an appealing option for individuals dealing with the effects of diabetic-related nerve issues.
After assessing ocular movements at three points during treatment, we observed a notable improvement in those receiving vitamin B12 compared to those receiving steroids. Specifically, the vitamin B12 group showed an enhancement of eye movements by an average of 1.04, while the steroid group had a lesser improvement of 0.75. This difference was statistically significant, suggesting that vitamin B12 may be more effective in aiding recovery of eye movement in these patients.
Importantly, treating diabetic neuropathy with vitamin supplementation not only addresses possible nutritional deficiencies but could also improve overall quality of life for patients. This study highlights the potential benefits of vitamin B12 therapy, making it an appealing option for individuals dealing with the effects of diabetic-related nerve issues.
Read More
Most Useful Reviews
7.5
Increased energy levels
5 people found this helpful
Vital! Few people know that a lack of this vitamin can lead to serious consequences. My mother takes metformin for diabetes, and the instructions note a decrease in B12 as a side effect. I recently decided to ensure she receives this vitamin, but it was unavailable in pharmacies. Thankfully, I found it on Ayherb. After two weeks of taking it, my mother became more active and cheerful, no longer sleeping during the day. Her skin looks healthier, and she’s more alert and has better hearing. We are thrilled with the improvement. Look after your elderly relatives; they might have a deficiency!
Read More
10
Essential for diabetes
Excellent! This vitamin is essential for individuals with insulin resistance and type 2 diabetes. Hypoglycaemic medications deplete B12 stores, making supplementation crucial. It should be taken in courses for optimal effect.
Read More
9
Recommended for diabetics
Excellent product! It’s particularly beneficial for those experiencing vitamin B12 deficiency, especially when taking diabetes medications that reduce B12 levels in the body. I recommend pairing it with N-complex. I will attach a picture of the product.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.9
- All Researches
9
We explored the effectiveness of vitamin B12 in treating diabetic ocular nerve palsy, a complication that can occur in people with diabetes. In a recent study, fifty individuals with this condition were divided into two groups. One group received steroid treatments while the other was treated with vitamin B12 injections.
After assessing ocular movements at three points during treatment, we observed a notable improvement in those receiving vitamin B12 compared to those receiving steroids. Specifically, the vitamin B12 group showed an enhancement of eye movements by an average of 1.04, while the steroid group had a lesser improvement of 0.75. This difference was statistically significant, suggesting that vitamin B12 may be more effective in aiding recovery of eye movement in these patients.
Importantly, treating diabetic neuropathy with vitamin supplementation not only addresses possible nutritional deficiencies but could also improve overall quality of life for patients. This study highlights the potential benefits of vitamin B12 therapy, making it an appealing option for individuals dealing with the effects of diabetic-related nerve issues.
After assessing ocular movements at three points during treatment, we observed a notable improvement in those receiving vitamin B12 compared to those receiving steroids. Specifically, the vitamin B12 group showed an enhancement of eye movements by an average of 1.04, while the steroid group had a lesser improvement of 0.75. This difference was statistically significant, suggesting that vitamin B12 may be more effective in aiding recovery of eye movement in these patients.
Importantly, treating diabetic neuropathy with vitamin supplementation not only addresses possible nutritional deficiencies but could also improve overall quality of life for patients. This study highlights the potential benefits of vitamin B12 therapy, making it an appealing option for individuals dealing with the effects of diabetic-related nerve issues.
Read More
8
B12 in multi-nutrient diabetes study
We explored how a combination of nutrients, including B12, impacts people with diabetic neuropathy. In a study with 73 individuals suffering from type 2 diabetes, participants were split into two groups: one received the combination of nutrients while the other received a placebo for six months.
Our findings revealed that this nutrient blend significantly improved pain levels, vibration perception, and B12 levels in participants. However, it’s important to note that the overall efficacy of B12 in this context is just part of a broader treatment approach rather than a standalone solution.
Our findings revealed that this nutrient blend significantly improved pain levels, vibration perception, and B12 levels in participants. However, it’s important to note that the overall efficacy of B12 in this context is just part of a broader treatment approach rather than a standalone solution.
Read More
8
We investigated how gastrectomy impacts the risk of type 2 diabetes in gastric cancer survivors. Analyzing data from over 150,000 patients, we observed that those who underwent total gastrectomy had a higher chance of developing diabetes, especially if they didn't take vitamin B12 supplements. Surprisingly, patients who had subtotal gastrectomy enjoyed a lower risk of diabetes. Furthermore, B12 supplementation appeared to shield those who underwent total gastrectomy from heightened diabetes risk. This highlights the importance of monitoring and managing vitamin levels post-surgery.
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8
We examined the relationship between B vitamin intake and the risk of developing type 2 diabetes (T2D) through a large study in Shanghai. Using data from nearly 45,000 adults, we found that higher consumption of B vitamins, particularly B1, B2, B6, B9, and B12, was linked to a lower risk of T2D.
Our analysis also suggested that inflammation played a mediating role in this effect. While we did not find a significant link with B3, vitamin B6 was notably influential in reducing T2D risk. Overall, incorporating these B vitamins in our diet may help mitigate T2D, at least in part, through controlling inflammation.
Our analysis also suggested that inflammation played a mediating role in this effect. While we did not find a significant link with B3, vitamin B6 was notably influential in reducing T2D risk. Overall, incorporating these B vitamins in our diet may help mitigate T2D, at least in part, through controlling inflammation.
Read More
8
We explored a novel oral delivery system using vitamin B12, fucoidan, and concanavalin A to enhance insulin effectiveness for diabetes management. This smart nanosystem targets inflammation while regulating blood glucose levels efficiently. Our findings indicated that when tested on type I diabetic mice, the nanosystem significantly lowered blood sugar and reduced inflammatory markers, such as TNF-α and interleukin-6. Notably, the system ensures safe and effective delivery, presenting a promising alternative to traditional insulin methods.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Increased energy levels
5 people found this helpful
Vital! Few people know that a lack of this vitamin can lead to serious consequences. My mother takes metformin for diabetes, and the instructions note a decrease in B12 as a side effect. I recently decided to ensure she receives this vitamin, but it was unavailable in pharmacies. Thankfully, I found it on Ayherb. After two weeks of taking it, my mother became more active and cheerful, no longer sleeping during the day. Her skin looks healthier, and she’s more alert and has better hearing. We are thrilled with the improvement. Look after your elderly relatives; they might have a deficiency!
Read More
10
Essential for diabetes
Excellent! This vitamin is essential for individuals with insulin resistance and type 2 diabetes. Hypoglycaemic medications deplete B12 stores, making supplementation crucial. It should be taken in courses for optimal effect.
Read More
9
Recommended for diabetics
Excellent product! It’s particularly beneficial for those experiencing vitamin B12 deficiency, especially when taking diabetes medications that reduce B12 levels in the body. I recommend pairing it with N-complex. I will attach a picture of the product.
Read More
9
Strongly recommended
I take this separately as I have diabetes or insulin resistance. Those who take glucophage or metformin should note that vitamins are depleted rapidly. Hence, I make sure to replenish with this supplement. I rate it five stars as it is a properly selected health supplement. This is key to longevity and wellbeing.
Read More
9
Miracle for diabetes
Miracle! This product has worked wonders for my mother, who has type 2 diabetes.
Read More
Frequently Asked Questions
7.5
Increased energy levels
5 people found this helpful
Vital! Few people know that a lack of this vitamin can lead to serious consequences. My mother takes metformin for diabetes, and the instructions note a decrease in B12 as a side effect. I recently decided to ensure she receives this vitamin, but it was unavailable in pharmacies. Thankfully, I found it on Ayherb. After two weeks of taking it, my mother became more active and cheerful, no longer sleeping during the day. Her skin looks healthier, and she’s more alert and has better hearing. We are thrilled with the improvement. Look after your elderly relatives; they might have a deficiency!
10
Essential for diabetes
Excellent! This vitamin is essential for individuals with insulin resistance and type 2 diabetes. Hypoglycaemic medications deplete B12 stores, making supplementation crucial. It should be taken in courses for optimal effect.
9
Strongly recommended
I take this separately as I have diabetes or insulin resistance. Those who take glucophage or metformin should note that vitamins are depleted rapidly. Hence, I make sure to replenish with this supplement. I rate it five stars as it is a properly selected health supplement. This is key to longevity and wellbeing.
9
Miracle for diabetes
Miracle! This product has worked wonders for my mother, who has type 2 diabetes.
9
Recommended for diabetics
Excellent product! It’s particularly beneficial for those experiencing vitamin B12 deficiency, especially when taking diabetes medications that reduce B12 levels in the body. I recommend pairing it with N-complex. I will attach a picture of the product.
7.5
Relieved numbness
I purchased B12 to help improve the side effects of mild diabetes in my family. My toes often feel numb, and I heard that B12 could enhance this particular issue. I am hopeful it will provide some relief.
7.5
Likes strawberry flavour
Great B-12 tablets! My father, aged 64 and with diabetes, takes one tablet each day. He finds them pleasant, especially since he usually dislikes supplements. He enjoys the strawberry flavour and appreciates that the tablet can be taken without water. I will certainly purchase this Vitamin B-12 again for him.
8
B12 in multi-nutrient diabetes study
We explored how a combination of nutrients, including B12, impacts people with diabetic neuropathy. In a study with 73 individuals suffering from type 2 diabetes, participants were split into two groups: one received the combination of nutrients while the other received a placebo for six months.
Our findings revealed that this nutrient blend significantly improved pain levels, vibration perception, and B12 levels in participants. However, it’s important to note that the overall efficacy of B12 in this context is just part of a broader treatment approach rather than a standalone solution.
Our findings revealed that this nutrient blend significantly improved pain levels, vibration perception, and B12 levels in participants. However, it’s important to note that the overall efficacy of B12 in this context is just part of a broader treatment approach rather than a standalone solution.
8
We explored how vitamin B12 might protect against nerve damage caused by diabetes. In a research study, diabetic rats received B12 supplements for four months. By examining their brains, we found that B12 reduced nerve cell death and supported healthy brain functions, even under diabetic conditions. The treatment improved important markers related to nerve support and minimized harmful inflammatory responses. This suggests that vitamin B12 could be a valuable addition for helping diabetic patients maintain better brain health.
7
We explored the relationship between high serum vitamin B12 levels and diabetes, particularly focusing on how vitamin B12 supplementation might affect this condition. In our retrospective study, we gathered data from 3,511 patients over one year who were found to have elevated B12 levels above the normal limit of 771 pg/mL.
A significant finding from our analysis was that 53.2% of patients with high B12 levels were also diagnosed with diabetes and had been using vitamin B12 as part of their treatment regimen. This suggests that there may be a potential link between vitamin B12 supplementation and diabetes management.
Furthermore, we observed a positive correlation between elevated B12 levels and specific laboratory results, indicating that patients’ age and other liver-related parameters could play a role in these outcomes. However, we did not find compelling evidence that vitamin B12 directly improves diabetes symptoms or controls blood sugar levels independently.
Overall, while high serum vitamin B12 is often associated with diabetes in those using it as a supplementary treatment, more detailed investigations are needed to fully understand the implications for diabetes management. Most notably, we found that many comorbid conditions were benign, primarily among Saudi patients aged 50-70.
A significant finding from our analysis was that 53.2% of patients with high B12 levels were also diagnosed with diabetes and had been using vitamin B12 as part of their treatment regimen. This suggests that there may be a potential link between vitamin B12 supplementation and diabetes management.
Furthermore, we observed a positive correlation between elevated B12 levels and specific laboratory results, indicating that patients’ age and other liver-related parameters could play a role in these outcomes. However, we did not find compelling evidence that vitamin B12 directly improves diabetes symptoms or controls blood sugar levels independently.
Overall, while high serum vitamin B12 is often associated with diabetes in those using it as a supplementary treatment, more detailed investigations are needed to fully understand the implications for diabetes management. Most notably, we found that many comorbid conditions were benign, primarily among Saudi patients aged 50-70.
8
We conducted a thorough examination of a clinical trial that looked at how vitamin B12, alongside an herbal treatment called the Tangbi Formula, impacts patients with diabetic distal symmetric polyneuropathy (DSPN). This multicenter trial was designed to compare a group receiving both treatments to another group that received a placebo combined with vitamin B12. This setup helped us assess the actual effectiveness of the herbal combination on the symptoms of this condition.
After 24 weeks of treatment, we observed a significant decrease in the Michigan Diabetic Neuropathy Score (MDNS) among those taking the Tangbi Formula, pointing to improvements in their symptoms. In addition, changes in the visual-analogue scale (VAS) and the Toronto clinical scoring system (TCSS) also revealed positive results when comparing the two groups. However, it’s important to note that nerve conduction velocities did not show significant changes in either group, suggesting that the effects of vitamin B12 alone may be difficult to ascertain within this study’s context.
Overall, this research shines a light on how combining herbal medicines with conventional treatment can be beneficial for patients suffering from DSPN, though it does limit our ability to fully evaluate the specific effects of vitamin B12 in isolation.
After 24 weeks of treatment, we observed a significant decrease in the Michigan Diabetic Neuropathy Score (MDNS) among those taking the Tangbi Formula, pointing to improvements in their symptoms. In addition, changes in the visual-analogue scale (VAS) and the Toronto clinical scoring system (TCSS) also revealed positive results when comparing the two groups. However, it’s important to note that nerve conduction velocities did not show significant changes in either group, suggesting that the effects of vitamin B12 alone may be difficult to ascertain within this study’s context.
Overall, this research shines a light on how combining herbal medicines with conventional treatment can be beneficial for patients suffering from DSPN, though it does limit our ability to fully evaluate the specific effects of vitamin B12 in isolation.
4
We conducted a thorough examination on the prevalence of vitamin B12 deficiency among patients with type 2 diabetes who have been on metformin therapy. Our study involved 260 participants who had been using this medication for over a year. We took blood samples to measure their vitamin B12 levels and assessed various factors that might influence these levels.
Interestingly, we found that about 36.54% of patients were vitamin B12 deficient. The deficiency seemed more common in women, particularly those aged between 41 to 50 years, and in individuals with a longer history of diabetes. However, we did not find a clear connection between the dosage of metformin or the duration of treatment and vitamin B12 levels.
Therefore, while it is evident that vitamin B12 deficiency is a significant concern for more than a third of individuals taking metformin, our findings suggest that increasing the metformin dosage or extending the treatment duration does not necessarily lead to greater deficiency risks. This highlights the importance of routinely checking vitamin B12 levels in diabetic patients on metformin to prevent potential complications, ensuring they maintain a better quality of life.
Interestingly, we found that about 36.54% of patients were vitamin B12 deficient. The deficiency seemed more common in women, particularly those aged between 41 to 50 years, and in individuals with a longer history of diabetes. However, we did not find a clear connection between the dosage of metformin or the duration of treatment and vitamin B12 levels.
Therefore, while it is evident that vitamin B12 deficiency is a significant concern for more than a third of individuals taking metformin, our findings suggest that increasing the metformin dosage or extending the treatment duration does not necessarily lead to greater deficiency risks. This highlights the importance of routinely checking vitamin B12 levels in diabetic patients on metformin to prevent potential complications, ensuring they maintain a better quality of life.
References
- Didangelos T, Karlafti E, Kotzakioulafi E, Giannoulaki P, Kontoninas Z, et al. Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy. Nutrients. 2024;16. doi:10.3390/nu16183045
- Kim G, Han KD, Cho SH, Oh R, Lee YB, et al. Association between gastrectomy and the risk of type 2 diabetes in gastric cancer survivors: A nationwide cohort study. Diabetes Metab. 2024;50:101569. doi:10.1016/j.diabet.2024.101569
- Zhu Y, Ying T, Xu M, Chen Q, Wu M, et al. Joint B Vitamin Intake and Type 2 Diabetes Risk: The Mediating Role of Inflammation in a Prospective Shanghai Cohort. Nutrients. 2024;16. doi:10.3390/nu16121901
- Gautam S, Mittal C, Ranjan A, Singh G. Association of Diabetic Peripheral Neuropathy with Micronutrients. J Assoc Physicians India. 2024;72:65. doi:10.59556/japi.72.0493
- Zhou J, Ma H, Guan M, Feng J, Dong X, et al. Anti-inflammatory Fucoidan-ConA oral insulin nanosystems for smart blood glucose regulation. Int J Pharm. 2024;659:124250. doi:10.1016/j.ijpharm.2024.124250
- Hakola L, Mramba LK, Uusitalo U, Andrén Aronsson C, Hummel S, et al. Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study. Eur J Nutr. 2024;63:1329. doi:10.1007/s00394-024-03346-6
- Suryavanshi U, Angadi KK, Reddy VS, Reddy GB. Neuroprotective role of vitamin B12 in streptozotocin-induced type 1 diabetic rats. Chem Biol Interact. 2024;387:110823. doi:10.1016/j.cbi.2023.110823
- N I, Shyam Kumar S. The Effectiveness of Steroid Versus Vitamin Therapy in the Improvement of Extraocular Movements in Patients With Diabetic Cranial Nerve Palsy: A Comparative Study. Cureus. 2024;16:e75656. doi:10.7759/cureus.75656
- Abu-Zahab ZA, Qureshi H, Adham GM, Elzefzafy WM, Zalam SS, et al. Frequency of comorbid diseases with high serum Vitamin B12 levels in patients attending King Salman Medical City (KSAMC), at Madinah. Int J Health Sci (Qassim). 2025;19:15.
- Zhao X, An X, Cui Y, Dong L, Fang Z, et al. TangBi Formula for Painful Diabetic Distal Symmetric Polyneuropathy: A Multicenter, Randomized, Double-Blind, Placebo-Controlled and Parallel-Group Trial. J Diabetes. 2025;17:e70045. doi:10.1111/1753-0407.70045
- Asghar S, Tanvir H, Riaz A, Ejaz MH, Akram M, et al. Prevalence of Vitamin B12 Deficiency in Patients With Type 2 Diabetes Mellitus on Metformin Therapy: A Cross-Sectional Study. Cureus. 2024;16:e72184. doi:10.7759/cureus.72184
