Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
USERS' SCORE
Good
Based on 9 Reviews
8.1
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Magnesium (as Magnesium Oxide)
250 mg
60%
Top Medical Research Studies
9
We conducted a systematic review and meta-analysis exploring how dietary magnesium (Mg) intake connects with depression among adults. By reviewing data from over 63,000 individuals, we found that those with the highest magnesium intake had a 34% lower chance of experiencing depression compared to those with the lowest intake.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk.
Read More
8
This study examined how magnesium deficiency relates to depression in adults aged 20 to 60. By using the National Health and Nutrition Examination Survey data from 2005 to 2018, we analyzed the magnesium depletion score (MDS) while assessing depression through the Patient Health Questionnaire-9.
Our findings reveal a positive association: as the MDS increases, so does the likelihood of depression. Each one-unit rise in MDS raises the odds of depression. However, results varied with different MDS levels. While these results are promising, further research is necessary to understand the underlying mechanisms better.
Our findings reveal a positive association: as the MDS increases, so does the likelihood of depression. Each one-unit rise in MDS raises the odds of depression. However, results varied with different MDS levels. While these results are promising, further research is necessary to understand the underlying mechanisms better.
Read More
8
We examined the role of magnesium levels in relation to depressive symptoms through a comprehensive analysis of data from Taiwan's Nutrition and Health Survey. Involving 2,196 participants, we employed logistic and linear regression methods to assess these relationships.
Our findings revealed that higher magnesium levels correlated with fewer depressive symptoms. Interestingly, this connection was stronger in individuals with elevated C-reactive protein (CRP) levels, suggesting that inflammation influences how magnesium affects mood.
Overall, maintaining adequate magnesium levels might be beneficial, especially for those dealing with inflammation.
Our findings revealed that higher magnesium levels correlated with fewer depressive symptoms. Interestingly, this connection was stronger in individuals with elevated C-reactive protein (CRP) levels, suggesting that inflammation influences how magnesium affects mood.
Overall, maintaining adequate magnesium levels might be beneficial, especially for those dealing with inflammation.
Read More
Most Useful Reviews
7.5
Helps relieve depression
23 people found this helpful
Magnesium is essential for the body, aiding in vital functions such as energy metabolism and muscle contraction. It is particularly beneficial for the heart, managing blood pressure and cholesterol levels. Combined with vitamin B6, it alleviates stress and improves mood. I take one tablet at night, and it relaxes me, relieving my headaches associated with dystonia. The small, round tablets produced no gastrointestinal side effects, and I highly recommend this magnesium supplement.
Read More
9
Calms teenage depression
1 people found this helpful
We take magnesium as a family to combat aggression and depression. My eldest son, who is under stress at work, has become calmer. My 14-year-old daughter overcame adolescent depression with it, and my youngest, diagnosed with ADHD, shows reduced aggression. I'm very pleased with the results.
Read More
9
Improves stress management
This magnesium is excellent! On my neurologist's advice, I ordered this brand, and the dosage is adequate. After starting it, my sleep improved, and I've found it indispensable for managing stress and depression. The small tablets are easy to ingest, and the price is very reasonable.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
- All Researches
9.5
Magnesium and Vitamin D effective for depression
We explored the effectiveness of magnesium coupled with vitamin D in easing depressive symptoms among individuals with long-COVID. Our study involved 60 participants suffering from mild to moderate depression, hypomagnesemia, and vitamin D deficiency.
Over four months, those who received both magnesium and vitamin D showed significant improvements in their depression scores compared to those who only took vitamin D. Specifically, a notable 73% of the magnesium group achieved significant relief, positioning this combination as a promising treatment for depression linked to long-COVID.
Mild side effects were noted but did not lead to any withdrawals, indicating the safety of this treatment option.
Over four months, those who received both magnesium and vitamin D showed significant improvements in their depression scores compared to those who only took vitamin D. Specifically, a notable 73% of the magnesium group achieved significant relief, positioning this combination as a promising treatment for depression linked to long-COVID.
Mild side effects were noted but did not lead to any withdrawals, indicating the safety of this treatment option.
Read More
9
We conducted a systematic review and meta-analysis exploring how dietary magnesium (Mg) intake connects with depression among adults. By reviewing data from over 63,000 individuals, we found that those with the highest magnesium intake had a 34% lower chance of experiencing depression compared to those with the lowest intake.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk.
Read More
8
We examined how various nutrient patterns affect depressive symptoms in older adults through a detailed study involving over 1,000 participants.
By evaluating nutrient intake and depressive symptoms over more than 15 years, we found that those with a diet high in magnesium and several other nutrients had significantly lower odds of experiencing depressive symptoms.
This suggests that nutrients, particularly magnesium, might play a crucial role in supporting mental health in older adults.
By evaluating nutrient intake and depressive symptoms over more than 15 years, we found that those with a diet high in magnesium and several other nutrients had significantly lower odds of experiencing depressive symptoms.
This suggests that nutrients, particularly magnesium, might play a crucial role in supporting mental health in older adults.
Read More
8
Magnesium deficiency correlates with depression
This study examined the relationship between magnesium deficiency, measured by the Magnesium Depletion Score (MDS), and depression among U.S. adults. We analyzed data from the National Health and Nutrition Examination Survey, focusing on those with moderate to severe depression.
Our findings revealed a significant link—higher MDS scores led to an increased risk of depression. Specifically, for each unit rise in MDS, the chance of developing depression increased by 13%. Interestingly, those with severe magnesium deficiency saw a staggering 58% rise in depression likelihood. This suggests that improving magnesium levels could be beneficial for both preventing and treating depression.
Our findings revealed a significant link—higher MDS scores led to an increased risk of depression. Specifically, for each unit rise in MDS, the chance of developing depression increased by 13%. Interestingly, those with severe magnesium deficiency saw a staggering 58% rise in depression likelihood. This suggests that improving magnesium levels could be beneficial for both preventing and treating depression.
Read More
8
This study examined how magnesium deficiency relates to depression in adults aged 20 to 60. By using the National Health and Nutrition Examination Survey data from 2005 to 2018, we analyzed the magnesium depletion score (MDS) while assessing depression through the Patient Health Questionnaire-9.
Our findings reveal a positive association: as the MDS increases, so does the likelihood of depression. Each one-unit rise in MDS raises the odds of depression. However, results varied with different MDS levels. While these results are promising, further research is necessary to understand the underlying mechanisms better.
Our findings reveal a positive association: as the MDS increases, so does the likelihood of depression. Each one-unit rise in MDS raises the odds of depression. However, results varied with different MDS levels. While these results are promising, further research is necessary to understand the underlying mechanisms better.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Helps relieve depression
23 people found this helpful
Magnesium is essential for the body, aiding in vital functions such as energy metabolism and muscle contraction. It is particularly beneficial for the heart, managing blood pressure and cholesterol levels. Combined with vitamin B6, it alleviates stress and improves mood. I take one tablet at night, and it relaxes me, relieving my headaches associated with dystonia. The small, round tablets produced no gastrointestinal side effects, and I highly recommend this magnesium supplement.
Read More
9
Calms teenage depression
1 people found this helpful
We take magnesium as a family to combat aggression and depression. My eldest son, who is under stress at work, has become calmer. My 14-year-old daughter overcame adolescent depression with it, and my youngest, diagnosed with ADHD, shows reduced aggression. I'm very pleased with the results.
Read More
9
Improves stress management
This magnesium is excellent! On my neurologist's advice, I ordered this brand, and the dosage is adequate. After starting it, my sleep improved, and I've found it indispensable for managing stress and depression. The small tablets are easy to ingest, and the price is very reasonable.
Read More
9
Highly recommended aid
Magnesium is crucial for our health, and its absence is easily felt. Following my neurologist's recommendation, I chose this brand, and it significantly improved my sleep, serving as a crucial aid in coping with stress and depression. The tablets are easy to swallow, and the price is appealing.
Read More
7.5
Improves sleep quality
1 people found this helpful
Neurologists support magnesium's role in treating anxiety and depression. It can be effective in managing sleep disorders, especially for those with anxiety. The quality of this supplement is excellent! Since I began taking it, my sleep has improved significantly. The dark glass packaging is also a plus. I definitely recommend this product!
Read More
Frequently Asked Questions
9
Highly recommended aid
Magnesium is crucial for our health, and its absence is easily felt. Following my neurologist's recommendation, I chose this brand, and it significantly improved my sleep, serving as a crucial aid in coping with stress and depression. The tablets are easy to swallow, and the price is appealing.
9
Calms teenage depression
1 people found this helpful
We take magnesium as a family to combat aggression and depression. My eldest son, who is under stress at work, has become calmer. My 14-year-old daughter overcame adolescent depression with it, and my youngest, diagnosed with ADHD, shows reduced aggression. I'm very pleased with the results.
7.5
Essential for mental health
1 people found this helpful
Magnesium significantly benefits bone growth, heart health, and mental well-being. It can alleviate muscle cramps and reduce joint pain. I recognise signs of magnesium deficiency, such as fatigue and anxiety. Since taking this supplement, I feel it is vital for my health and mental state, particularly in managing my depression.
7.5
Alleviates stress symptoms
The quality of this magnesium is top-notch! It positively impacts my nervous system, relieving fatigue and depressive feelings. I recommend taking it during meals, and the tablets are small and easy to swallow.
7.5
Helps relieve depression
23 people found this helpful
Magnesium is essential for the body, aiding in vital functions such as energy metabolism and muscle contraction. It is particularly beneficial for the heart, managing blood pressure and cholesterol levels. Combined with vitamin B6, it alleviates stress and improves mood. I take one tablet at night, and it relaxes me, relieving my headaches associated with dystonia. The small, round tablets produced no gastrointestinal side effects, and I highly recommend this magnesium supplement.
9
Improves stress management
This magnesium is excellent! On my neurologist's advice, I ordered this brand, and the dosage is adequate. After starting it, my sleep improved, and I've found it indispensable for managing stress and depression. The small tablets are easy to ingest, and the price is very reasonable.
9
We conducted a systematic review and meta-analysis exploring how dietary magnesium (Mg) intake connects with depression among adults. By reviewing data from over 63,000 individuals, we found that those with the highest magnesium intake had a 34% lower chance of experiencing depression compared to those with the lowest intake.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk.
9.5
Magnesium and Vitamin D effective for depression
We explored the effectiveness of magnesium coupled with vitamin D in easing depressive symptoms among individuals with long-COVID. Our study involved 60 participants suffering from mild to moderate depression, hypomagnesemia, and vitamin D deficiency.
Over four months, those who received both magnesium and vitamin D showed significant improvements in their depression scores compared to those who only took vitamin D. Specifically, a notable 73% of the magnesium group achieved significant relief, positioning this combination as a promising treatment for depression linked to long-COVID.
Mild side effects were noted but did not lead to any withdrawals, indicating the safety of this treatment option.
Over four months, those who received both magnesium and vitamin D showed significant improvements in their depression scores compared to those who only took vitamin D. Specifically, a notable 73% of the magnesium group achieved significant relief, positioning this combination as a promising treatment for depression linked to long-COVID.
Mild side effects were noted but did not lead to any withdrawals, indicating the safety of this treatment option.
8
Magnesium deficiency correlates with depression
This study examined the relationship between magnesium deficiency, measured by the Magnesium Depletion Score (MDS), and depression among U.S. adults. We analyzed data from the National Health and Nutrition Examination Survey, focusing on those with moderate to severe depression.
Our findings revealed a significant link—higher MDS scores led to an increased risk of depression. Specifically, for each unit rise in MDS, the chance of developing depression increased by 13%. Interestingly, those with severe magnesium deficiency saw a staggering 58% rise in depression likelihood. This suggests that improving magnesium levels could be beneficial for both preventing and treating depression.
Our findings revealed a significant link—higher MDS scores led to an increased risk of depression. Specifically, for each unit rise in MDS, the chance of developing depression increased by 13%. Interestingly, those with severe magnesium deficiency saw a staggering 58% rise in depression likelihood. This suggests that improving magnesium levels could be beneficial for both preventing and treating depression.
4
We explored the impact of micronutrients on major depressive disorder (MDD) and recurrent depression (rMDD) using genetic data. Our comprehensive analysis, drawing from a large dataset, indicated weak evidence that certain micronutrients like magnesium could influence depression outcomes.
While iron, copper, and vitamin D showed some promise for protective benefits, the evidence surrounding magnesium was mixed, leaving us uncertain about its true effect. Importantly, we found no strong causal links for other micronutrients, signaling the need for further research into their potential risks and benefits.
While iron, copper, and vitamin D showed some promise for protective benefits, the evidence surrounding magnesium was mixed, leaving us uncertain about its true effect. Importantly, we found no strong causal links for other micronutrients, signaling the need for further research into their potential risks and benefits.
7
We explored the impact of antioxidant supplements on depression by analyzing data from 52 studies involving over 4,000 participants. Our findings indicate that supplements like magnesium and others significantly improve depressive symptoms and anxiety levels.
This supports the idea that incorporating antioxidants can enhance conventional treatment for depression. However, we also noted the limitations due to diverse populations and measurement scales, which might affect the overall interpretation.
Nonetheless, our research highlights the potential benefits of antioxidant supplements in mental health treatment.
This supports the idea that incorporating antioxidants can enhance conventional treatment for depression. However, we also noted the limitations due to diverse populations and measurement scales, which might affect the overall interpretation.
Nonetheless, our research highlights the potential benefits of antioxidant supplements in mental health treatment.
References
- Serefko A, Lachowicz-Radulska J, Szopa A, Herbet M, Czylkowska A, et al. The Novel Imipramine-Magnesium Complex Exerts Antidepressant-like Activity in Mice Subjected to the Forced Swim Test and the Tail Suspension Test. Molecules. 2025;30. doi:10.3390/molecules30030519
- Bardinet J, Pouchieu C, Chuy V, Merle B, Pellay H, et al. Association between nutrient patterns and odds of depressive symptomatology: a population-based cohort of older adults followed during 15-y. Eur J Nutr. 2025;64:88. doi:10.1007/s00394-025-03597-x
- Rodríguez-Morán M, Guerrero-Romero F, Barragán-Zuñiga J, Gamboa-Gómez CI, Weyman-Vela Y, et al. Combined oral supplementation with magnesium plus vitamin D alleviates mild to moderate depressive symptoms related to long-COVID: an open-label randomized, controlled clinical trial. Magnes Res. 2024;37:49. doi:10.1684/mrh.2024.0535
- Zhao W, Jin H. Magnesium depletion score and depression: a positive correlation among US adults. Front Public Health. 2024;12:1486434. doi:10.3389/fpubh.2024.1486434
- Carnegie RE, Zheng J, Borges MC, Jones HJ, Wade KH, et al. Micronutrients and Major Depression: A Mendelian Randomisation Study. Nutrients. 2024;16. doi:10.3390/nu16213690
- Cai Z, She J, Liu X, Li R, Guo S, et al. Associations between magnesium depletion score and depression among individuals aged 20 to 60 years. J Trace Elem Med Biol. 2024;86:127543. doi:10.1016/j.jtemb.2024.127543
- Strodl E, Bambling M, Parnam S, Ritchie G, Cramb S, et al. Probiotics and magnesium orotate for the treatment of major depressive disorder: a randomised double blind controlled trial. Sci Rep. 2024;14:20841. doi:10.1038/s41598-024-71093-z
- Hajhashemy Z, Shirani F, Askari G. Dietary Magnesium Intake in Relation to Depression in Adults: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis of Epidemiologic Studies. Nutr Rev. 2025;83:217. doi:10.1093/nutrit/nuae056
- Abdelmoneam AH, Khafagy GM, Elbeh KA, Hasan MDA. Impact of Magnesium and Ferritin Deficiency on Depression Among Adolescent Students. J Prim Care Community Health. 2024;15:21501319241252570. doi:10.1177/21501319241252570
- Chou MH, Yang YK, Wang JD, Lin CY, Lin SH. Elevated C-Reactive Protein Levels Modify the Effect of Magnesium on Depressive Symptoms: A Population-Based Study. Nutrients. 2023;15. doi:10.3390/nu15071560
- Chou MH, Yang YK, Wang JD, Lin CY, Lin SH. The Association of Serum and Dietary Magnesium with Depressive Symptoms. Nutrients. 2023;15. doi:10.3390/nu15030774
- Li Z, Chen K, Shao Q, Lu H, Zhang X, et al. Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress. J Neuroinflammation. 2023;20:16. doi:10.1186/s12974-023-02696-y
- Wang H, Jin M, Xie M, Yang Y, Xue F, et al. Protective role of antioxidant supplementation for depression and anxiety: A meta-analysis of randomized clinical trials. J Affect Disord. 2023;323:264. doi:10.1016/j.jad.2022.11.072
- Saba S, Faizi F, Sepandi M, Nehrir B. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery. Magnes Res. 2022;35:62. doi:10.1684/mrh.2022.0503
- Abiri B, Sarbakhsh P, Vafa M. Randomized study of the effects of vitamin D and/or magnesium supplementation on mood, serum levels of BDNF, inflammation, and SIRT1 in obese women with mild to moderate depressive symptoms. Nutr Neurosci. 2022;25:2123. doi:10.1080/1028415X.2021.1945859
- Miller ES, Sakowicz A, Roy A, Wang A, Yang A, et al. Is peripartum magnesium sulfate associated with a reduction in postpartum depressive symptoms?. Am J Obstet Gynecol MFM. 2021;3:100407. doi:10.1016/j.ajogmf.2021.100407
