We investigated the clinical safety and performance of a new magnesium scaffold known as DREAMS 3G. This innovative treatment aims to match the effectiveness of drug-eluting stents in coronary interventions.
Over one year, a total of 116 patients were monitored, showing promising results with minimal lumen loss and no adverse events like cardiac death or major thrombosis. Despite a few revascularization interventions, the scaffold appears to be a viable alternative.
Overall, our findings support its potential use in heart treatments.
Read More
9
Magnesium nanoparticles enhance clotting time
Effect of Biofunctional Green Synthesized MgO-Nanoparticles on Oxidative-Stress-Induced Tissue Damage and Thrombosis.
We investigated the effects of magnesium oxide nanoparticles, created using fruit extract, on blood clotting and oxidative stress. Our experiments showed that these nanoparticles significantly extended clotting time, indicating an anticoagulant effect. They also effectively reduced damage to red blood cells and various tissues in laboratory tests, helping to restore their function. Importantly, we found these nanoparticles non-toxic, suggesting they could be a promising treatment option for oxidative stress-related conditions without adverse side effects. However, further research is needed to fully understand their potential in clinical applications.
Read More
8
Magnesium scaffolds lower clotting risks
A novel stent flow chamber system demonstrates reduced thrombogenicity of bioresorbable magnesium scaffolds.
We aimed to examine how bioresorbable magnesium scaffolds influence blood clotting. Using a cutting-edge stent flow chamber system, we compared the thrombogenicity of various stents, including the Magmaris magnesium scaffold and a prototype called DREAMS 3G.
Our findings indicated that the Magmaris scaffold exhibited significantly lower thrombogenicity than traditional stainless steel stents. Impressively, the DREAMS 3G prototype demonstrated even further reductions in clotting risks, suggesting it could enhance patient safety.
This study highlights the potential of magnesium-based scaffolds in improving cardiovascular treatments.
Read More
Most Useful Reviews
7
Lowers blood pressure
1 people found this helpful
I noticed a positive effect on my blood pressure after discovering the link between magnesium deficiency and hypertension. Initially on the verge of high blood pressure, it has stabilised around 130, which is quite nice!
Read More
2
Not effective treatment
2 people found this helpful
Magnesium Glycinate is somewhat challenging to acquire, but it's been essential for me for over two years. My previous brand helped manage my blood pressure effectively, even at a low dose. Unfortunately, this brand did not have the same impact on my blood clot condition. The price is reasonable, and 200mg is a suitable starting dose for those with magnesium deficiency, though one must be cautious not to exceed the recommended amount. I am not entirely disheartened by this brand as there may be various reasons for its ineffectiveness for me. While this supplement didn't meet my needs, it could potentially benefit others. A significant advantage is that it is vegetarian-friendly.
Read More
6
Eases discomfort effectively
1 people found this helpful
Magnesium glycinate chelate is easily absorbed without causing an upset stomach. It supports healthy physical functioning, relieving stress and discomfort, as well as aiding the heart and blood vessels to maintain circulation and blood pressure. Its natural ingredients contribute to overall well-being.
We investigated the effects of magnesium oxide nanoparticles, created using fruit extract, on blood clotting and oxidative stress. Our experiments showed that these nanoparticles significantly extended clotting time, indicating an anticoagulant effect. They also effectively reduced damage to red blood cells and various tissues in laboratory tests, helping to restore their function. Importantly, we found these nanoparticles non-toxic, suggesting they could be a promising treatment option for oxidative stress-related conditions without adverse side effects. However, further research is needed to fully understand their potential in clinical applications.
Read More
8
Magnesium intake reduces RVO risk
Sufficient Magnesium Intake Reduces Retinal Vein Occlusion Risk: National Health and Nutrition Examination Survey Analysis.
We explored whether magnesium intake could influence the risk of retinal vein occlusion (RVO), a leading cause of vision loss. Our analysis involved over 16,000 participants from a national health survey.
We discovered that sufficient magnesium intake was linked to a significant 64% reduced risk of RVO.
This finding was especially relevant for adults under 60, those with hypertension, and individuals without glaucoma. Further studies are needed to confirm magnesium's preventive benefits for RVO.
Read More
8
Effective clay-based hemostatic sponge
An Antibacterial, Antioxidant Adherent Sponge Constructed for Control of Arterial Bleeding Via Gallic Acid-Mediated Robust Assembly of Fibrous Clay in Collagen.
We examined a new sponge made from clay and collagen to control severe bleeding. Integrating palygorskite clay with collagen using gallic acid created a sponge that resists particle shedding and provides strong adhesion.
In our tests, this sponge demonstrated impressive results, reducing blood loss to 632 mg and achieving hemostasis in just 151 seconds, outperforming traditional gauze and even a well-known product called QuikClot.
With added antibacterial and antioxidant properties, this sponge could significantly enhance emergency bleeding management.
Read More
8
Magnesium scaffolds lower clotting risks
A novel stent flow chamber system demonstrates reduced thrombogenicity of bioresorbable magnesium scaffolds.
We aimed to examine how bioresorbable magnesium scaffolds influence blood clotting. Using a cutting-edge stent flow chamber system, we compared the thrombogenicity of various stents, including the Magmaris magnesium scaffold and a prototype called DREAMS 3G.
Our findings indicated that the Magmaris scaffold exhibited significantly lower thrombogenicity than traditional stainless steel stents. Impressively, the DREAMS 3G prototype demonstrated even further reductions in clotting risks, suggesting it could enhance patient safety.
This study highlights the potential of magnesium-based scaffolds in improving cardiovascular treatments.
Read More
8
Bioresorbable stents' advancements noted
Coronary bioresorbable metallic stents: Advancements and future perspectives.
We explored the evolution of bioresorbable metallic stents as alternatives to traditional stents which can lead to complications like thrombosis and inflammation.
While bioresorbable polymeric stents face challenges, materials like zinc and magnesium show promise.
Specifically, magnesium-based stents have demonstrated successful absorption within a year and low rates of complications.
Continuing research will be essential to refine these innovations for better clinical outcomes.
I noticed a positive effect on my blood pressure after discovering the link between magnesium deficiency and hypertension. Initially on the verge of high blood pressure, it has stabilised around 130, which is quite nice!
Read More
2
Not effective treatment
2 people found this helpful
Magnesium Glycinate is somewhat challenging to acquire, but it's been essential for me for over two years. My previous brand helped manage my blood pressure effectively, even at a low dose. Unfortunately, this brand did not have the same impact on my blood clot condition. The price is reasonable, and 200mg is a suitable starting dose for those with magnesium deficiency, though one must be cautious not to exceed the recommended amount. I am not entirely disheartened by this brand as there may be various reasons for its ineffectiveness for me. While this supplement didn't meet my needs, it could potentially benefit others. A significant advantage is that it is vegetarian-friendly.
Read More
6
Eases discomfort effectively
1 people found this helpful
Magnesium glycinate chelate is easily absorbed without causing an upset stomach. It supports healthy physical functioning, relieving stress and discomfort, as well as aiding the heart and blood vessels to maintain circulation and blood pressure. Its natural ingredients contribute to overall well-being.
Read More
7.5
Good for aging bones
It's beneficial for my bones, especially in later life, and for managing high blood pressure as well.
Read More
7.5
Calms before sleep
Great value and quality! I feel calm after taking this before sleep. It also lowers blood pressure and relaxes the body—an excellent ingredient.
Read More
Frequently Asked Questions
A blood clot is a mass of blood that changes from a liquid to a gel, effectively forming a plug that can stop bleeding. This natural process, known as coagulation, is critical for preventing excessive blood loss when you sustain an injury. Blood clots can occur in various areas of the body, typically at the site of a wound, but they can also form within blood vessels without an obvious injury, which may lead to serious health complications.
While blood clots are essential for healing, they can pose significant health risks if they form inappropriately. For example, a deep vein thrombosis (DVT) occurs when a clot forms in a deep vein, usually in the legs, and can travel to the lungs, causing a life-threatening condition called a pulmonary embolism. Risk factors for blood clots include prolonged immobility, certain medical conditions, and the use of specific medications, among others. It’s important to recognize the symptoms of abnormal clotting, such as swelling, pain, and redness in the affected area, and seek medical attention if they occur.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Based on user reviews, the timeframe for noticing results from magnesium glycinate supplementation appears to vary. Some users have reported positive effects on their blood pressure and overall well-being shortly after starting to take the supplement, with one user mentioning a stabilization of their blood pressure around 130 shortly after beginning use (Read Review). However, others have expressed that they did not see the desired effects on their specific blood clot condition, suggesting that individual results may differ significantly (Read Review).
Users generally recommend giving yourself some time to assess the supplement's effectiveness, as it may be beneficial for different individuals in varied ways. One reviewer indicated that magnesium glycinate had been a staple for them over two years, hinting that consistent use might lead to gradual improvements in blood pressure and circulation health (Read Review). Therefore, it might be wise to expect anywhere from a few weeks to a couple of months before determining if this supplement is working for your blood clot condition.
The evidence surrounding magnesium's role in managing blood clot risks is quite impactful. Research indicates that magnesium deficiency can enhance platelet activity and promote quicker clotting, consequently increasing the likelihood of thrombosis and strokes [8]. Interestingly, some studies have also pointed to the potential of magnesium-based scaffolds, such as the Magmaris, in reducing the thrombogenicity when used in cardiovascular treatments. These scaffolds demonstrated lower rates of complications compared to traditional metal stents, suggesting that magnesium may play a role in enhancing patient safety by minimizing clotting risks [3][6].
Furthermore, the exploration of magnesium nanoparticles revealed their capacity to extend clotting time, hinting at potential anticoagulant properties [16]. This intersection of magnesium and blood clot management represents a promising area of research; however, continued investigation is necessary to fully harness these findings for clinical applications. As studies advance, they may further clarify the mechanisms by which magnesium influences blood clot dynamics and ultimately lead to more effective therapeutic strategies.
Based on user reviews, many individuals have reported meaningful improvements in their symptoms after supplementing with magnesium glycinate. Several users noted a positive impact on blood pressure, with one reviewer sharing that their blood pressure stabilized around 130 after starting the supplement (Read Review). Other testimonials highlight the supplement's ability to support overall physical health, with users mentioning reduced stress and discomfort, increased calmness, and better circulation without causing stomach upset (Read Review; Read Review).
Additionally, some users emphasized the importance of consistent use over time, noting personal benefits such as enhanced bone health and effective management of high blood pressure (Read Review). However, it’s essential to clarify that individual results can vary significantly, as one user experienced no improvement in their blood clot condition despite previous success with a different brand (Read Review). Thus, while many users find magnesium glycinate beneficial for various symptoms, potential users should be mindful that individual responses may differ.
Users have reported varying experiences with magnesium supplements, particularly in relation to blood clot conditions. Many have noted that magnesium glycinate can be effective in managing blood pressure, often suggesting a starting dose of around 200mg for those with magnesium deficiency. One user specifically highlighted how a low dose of their previous magnesium brand helped manage their blood pressure effectively, yet their current brand did not show the same result for their blood clot condition, indicating that effectiveness might vary by brand and individual response Read Review.
Additionally, it appears that magnesium glycinate is well-tolerated, as users report it does not typically cause stomach upset and may contribute to overall physical well-being Read Review. While many users emphasize the importance of not exceeding recommended doses, some anecdotal evidence suggests that magnesium can have a calming effect and may aid in relaxation and overall heart health, which could indirectly support those managing clotting issues Read Review. However, personal results can vary, and it is essential to consult a healthcare provider for tailored advice.
7
Lowers blood pressure
1 people found this helpful
I noticed a positive effect on my blood pressure after discovering the link between magnesium deficiency and hypertension. Initially on the verge of high blood pressure, it has stabilised around 130, which is quite nice!
2
Not effective treatment
2 people found this helpful
Magnesium Glycinate is somewhat challenging to acquire, but it's been essential for me for over two years. My previous brand helped manage my blood pressure effectively, even at a low dose. Unfortunately, this brand did not have the same impact on my blood clot condition. The price is reasonable, and 200mg is a suitable starting dose for those with magnesium deficiency, though one must be cautious not to exceed the recommended amount. I am not entirely disheartened by this brand as there may be various reasons for its ineffectiveness for me. While this supplement didn't meet my needs, it could potentially benefit others. A significant advantage is that it is vegetarian-friendly.
6
Eases discomfort effectively
1 people found this helpful
Magnesium glycinate chelate is easily absorbed without causing an upset stomach. It supports healthy physical functioning, relieving stress and discomfort, as well as aiding the heart and blood vessels to maintain circulation and blood pressure. Its natural ingredients contribute to overall well-being.
7.5
Calms before sleep
Great value and quality! I feel calm after taking this before sleep. It also lowers blood pressure and relaxes the body—an excellent ingredient.
7.5
Good for aging bones
It's beneficial for my bones, especially in later life, and for managing high blood pressure as well.
8
MAGT1 deficiency increases thrombosis risk
MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice.
We studied how a lack of magnesium transporter 1 (MAGT1) impacts blood clot formation and the risk of stroke. Using various laboratory and animal models, we observed that MAGT1 deficiency leads to enhanced platelet activity and quicker clotting. This deficiency resulted in faster artery blockage and severe brain damage during strokes. Interestingly, restoring magnesium levels or blocking certain channels helped normalize platelet behavior. Overall, we found that MAGT1's function is crucial for vascular health, indicating its deficiency could elevate risks for thrombosis and ischemic stroke.
8
Magnesium scaffolds lower clotting risks
A novel stent flow chamber system demonstrates reduced thrombogenicity of bioresorbable magnesium scaffolds.
We aimed to examine how bioresorbable magnesium scaffolds influence blood clotting. Using a cutting-edge stent flow chamber system, we compared the thrombogenicity of various stents, including the Magmaris magnesium scaffold and a prototype called DREAMS 3G.
Our findings indicated that the Magmaris scaffold exhibited significantly lower thrombogenicity than traditional stainless steel stents. Impressively, the DREAMS 3G prototype demonstrated even further reductions in clotting risks, suggesting it could enhance patient safety.
This study highlights the potential of magnesium-based scaffolds in improving cardiovascular treatments.
7
Magnesium scaffold safe and effective
Comparison of acute versus stable coronary syndrome in patients treated with the Magmaris scaffold: Two-year results from the Magmaris Multicenter Italian Registry.
We examined the effectiveness of the Magmaris magnesium scaffold on patients with stable coronary artery disease (SCAD) and acute coronary syndrome (ACS) over two years. By looking at data from the Magmaris Multicenter Italian Registry, we found that the rates of target lesion failure and scaffold thrombosis remained low for both groups. Specifically, TLF was 7.4% for SCAD and 8.8% for ACS patients, with scaffold thrombosis observed at 0% and 1.8%, respectively. Overall, the findings suggest that this magnesium scaffold is safe and effective.
9
Magnesium nanoparticles enhance clotting time
Effect of Biofunctional Green Synthesized MgO-Nanoparticles on Oxidative-Stress-Induced Tissue Damage and Thrombosis.
We investigated the effects of magnesium oxide nanoparticles, created using fruit extract, on blood clotting and oxidative stress. Our experiments showed that these nanoparticles significantly extended clotting time, indicating an anticoagulant effect. They also effectively reduced damage to red blood cells and various tissues in laboratory tests, helping to restore their function. Importantly, we found these nanoparticles non-toxic, suggesting they could be a promising treatment option for oxidative stress-related conditions without adverse side effects. However, further research is needed to fully understand their potential in clinical applications.
References
Kim J, Kim M, Lee CS, Choi EY. Sufficient Magnesium Intake Reduces Retinal Vein Occlusion Risk: National Health and Nutrition Examination Survey Analysis. Nutrients. 2025;17. doi:10.3390/nu17071285
Guo X, Zeng X, He Y, Zhang X, Shi W, et al. An Antibacterial, Antioxidant Adherent Sponge Constructed for Control of Arterial Bleeding Via Gallic Acid-Mediated Robust Assembly of Fibrous Clay in Collagen. ACS Appl Mater Interfaces. 2025;17:16489. doi:10.1021/acsami.4c19209
Müller M, Ludwig L, Englert H, Riedl KA, Müller MC, et al. A novel stent flow chamber system demonstrates reduced thrombogenicity of bioresorbable magnesium scaffolds. Sci Rep. 2024;14:26691. doi:10.1038/s41598-024-77266-0
Zhang J, Chen Z, Rao L, He Y. Coronary bioresorbable metallic stents: Advancements and future perspectives. J Cardiol. 2025;85:69. doi:10.1016/j.jjcc.2024.08.003
Włodarczak A, Rola P, Włodarczak S, Szudrowicz M, Giniewicz K, et al. Two-Year Outcomes for Patients with Non-ST-Elevation Acute Coronary Syndrome Treated with Magmaris and Absorb Bioresorbable Scaffolds in Large-Vessel Lesions. J Pers Med. 2024;14. doi:10.3390/jpm14050540
Galli S, Troiano S, Palloshi A, Rapetto C, Pisano F, et al. Comparison of acute versus stable coronary syndrome in patients treated with the Magmaris scaffold: Two-year results from the Magmaris Multicenter Italian Registry. Cardiovasc Revasc Med. 2023;57:53. doi:10.1016/j.carrev.2023.06.022
Włodarczak A, Rola P, Barycki M, Furtan Ł, Łanocha M, et al. Mid-term safety and efficacy of magnesium bioresorbable vascular scaffolds - magmaris in diabetic population. 2-Years outcome in acute coronary syndrome cohort. Diab Vasc Dis Res. 2023;20:14791641231188705. doi:10.1177/14791641231188705
Gotru SK, Mammadova-Bach E, Sogkas G, Schuhmann MK, Schmitt K, et al. MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice. Arterioscler Thromb Vasc Biol. 2023;43:1494. doi:10.1161/ATVBAHA.122.318115
Haude M, Wlodarczak A, van der Schaaf RJ, Torzewski J, Ferdinande B, et al. A new resorbable magnesium scaffold for de novo coronary lesions (DREAMS 3): one-year results of the BIOMAG-I first-in-human study. EuroIntervention. 2023;19:e414. doi:10.4244/EIJ-D-23-00326
Wlodarczak A, Montorsi P, Torzewski J, Bennett J, Starmer G, et al. One- and two-year clinical outcomes of treatment with resorbable magnesium scaffolds for coronary artery disease: the prospective, international, multicentre BIOSOLVE-IV registry. EuroIntervention. 2023;19:232. doi:10.4244/EIJ-D-22-01069
Haude M, Wlodarczak A, van der Schaaf RJ, Torzewski J, Ferdinande B, et al. Safety and performance of the third-generation drug-eluting resorbable coronary magnesium scaffold system in the treatment of subjects with de novo coronary artery lesions: 6-month results of the prospective, multicenter BIOMAG-I first-in-human study. EClinicalMedicine. 2023;59:101940. doi:10.1016/j.eclinm.2023.101940
Pompei G, Campo G, Ruggiero R, Maffeo D, Sgura F, et al. Long-term outcomes of patients treated with sirolimus-eluting resorbable magnesium scaffolds: Insights from the SHERPA-MAGIC study. Int J Cardiol. 2023;383:1. doi:10.1016/j.ijcard.2023.04.029
Fedele G, Castiglioni S, Maier JAM, Locatelli L. The Effects of Sirolimus and Magnesium on Primary Human Coronary Endothelial Cells: An In Vitro Study. Int J Mol Sci. 2023;24. doi:10.3390/ijms24032930
Tonai K, Katayama S, Koyama K, Sata N, Tomioka Y, et al. Association between hypomagnesemia and coagulopathy in sepsis: a retrospective observational study. BMC Anesthesiol. 2022;22:359. doi:10.1186/s12871-022-01903-2
Seguchi M, Aytekin A, Lenz T, Nicol P, Alvarez-Covarrubias HA, et al. Challenges of the newer generation of resorbable magnesium scaffolds: Lessons from failure mechanisms of the past generation. J Cardiol. 2023;81:179. doi:10.1016/j.jjcc.2022.09.003
Venkatappa MM, Udagani C, Hanumegowda SM, Pramod SN, Venkataramaiah S, et al. Effect of Biofunctional Green Synthesized MgO-Nanoparticles on Oxidative-Stress-Induced Tissue Damage and Thrombosis. Molecules. 2022;27. doi:10.3390/molecules27165162