We examined the connection between dietary magnesium and cardiovascular disease, focusing on how magnesium intake or serum levels relate to heart health. Over the last couple of decades, numerous studies have shown that low magnesium levels are associated with several heart-related issues, including high blood pressure, heart attacks, and even heart failure.
Our insights reveal that even mild or moderate magnesium deficiencies can trigger physiological and metabolic changes that may heighten cardiovascular risks. When magnesium levels are insufficient, we see a rise in inflammation, oxidative stress, and issues with how fats are processed in the body, which can lead to serious heart problems.
Furthermore, we noted that many individuals often consume less magnesium than what is recommended, particularly those who do not regularly eat whole grains, legumes, or green vegetables. This widespread lack of magnesium is concerning, as it could be a significant factor influencing heart disease in the general population.
Read More
9
Magnesium may help arterial health
Mitigation of arteriosclerosis through transcriptional regulation of ferroptosis and lipid metabolism by magnesium.
We investigated how magnesium impacts cardiovascular health, particularly its role in a condition known as arteriosclerosis. This disease can lead to serious heart complications, but recent studies revealed magnesium's potential benefits.
In a series of experiments involving human cells and animal models, we discovered that magnesium effectively reduces a process called ferroptosis, which is linked to the progression of arteriosclerosis. It appears that magnesium ions play a vital role by preventing certain proteins from breaking down. This action promotes the expression of protective proteins while reducing harmful components that contribute to the disease.
Notably, our animal tests highlighted that biodegradable magnesium stents not only hinder ferroptosis but also slow down the advancement of arteriosclerosis. This suggests that magnesium-based treatments could offer a promising avenue for combating cardiovascular diseases effectively.
Read More
8
Magnesium linked to cardiovascular health
Upper normal serum magnesium is associated with a reduction in incident death from fatal heart failure, coronary heart disease and stroke in non-dialysis patients with CKD stages 4 and 5.
We examined how magnesium levels in the blood could influence the risk of death from cardiovascular issues in patients with advanced chronic kidney disease (CKD). Our study tracked 1,271 individuals with CKD stages 4 and 5 over a decade, focusing on those who had not previously experienced major heart-related events.
We discovered that higher serum magnesium concentrations were linked to lower risks of dying from conditions like heart failure, coronary heart disease, and stroke. By stratifying patients based on their magnesium levels, we found that those in the highest group experienced significantly better outcomes.
This suggests that maintaining adequate magnesium levels might be important for protecting cardiovascular health in these patients. While it’s just one piece of the puzzle, our findings highlight the potential benefits of magnesium as a factor worth considering in the management of cardiovascular risks.
Read More
Most Useful Reviews
9
Reduced heart disease risk
3 people found this helpful
Magnesium is an essential trace element that we obtain solely through food, capable of reducing the risk of ischaemic heart disease and arterial hypertension, as well as preventing strokes. It normalises blood pressure, alleviates muscle spasms, and prevents blood vessel constriction, while also serving as a natural anti-stress agent. Magnesium has a calming effect on the nervous system during periods of anxiety and depression, protecting it from stress. By increasing magnesium intake, one can reduce the frequency and intensity of migraines, enhancing overall cardiovascular health.
Read More
9
Improved heart health
7 people found this helpful
Chelated magnesium is a vital supplement that can significantly enhance your quality of life, alleviating irritability and chronic fatigue. It is essential for athletes who lose magnesium during training and for office workers who experience active brain activity. This trace element is crucial for those with heart and vascular issues; it helps maintain potassium and sodium balance, preventing oedema and hypertensive crises. Magnesium is also beneficial in angina pectoris, as it relaxes the coronary vessels, easing seizures and improving myocardial nutrition to help avoid heart attacks. Additionally, it's recommended for vegetative-vascular dystonia, increasing stress resilience, and is safe for pregnant women, especially in the first trimester when the baby’s nervous system develops.
Read More
7.5
Eased nervousness
Frankly, I have noticed a significant easing of my nervousness after use.
We investigated how magnesium impacts cardiovascular health, particularly its role in a condition known as arteriosclerosis. This disease can lead to serious heart complications, but recent studies revealed magnesium's potential benefits.
In a series of experiments involving human cells and animal models, we discovered that magnesium effectively reduces a process called ferroptosis, which is linked to the progression of arteriosclerosis. It appears that magnesium ions play a vital role by preventing certain proteins from breaking down. This action promotes the expression of protective proteins while reducing harmful components that contribute to the disease.
Notably, our animal tests highlighted that biodegradable magnesium stents not only hinder ferroptosis but also slow down the advancement of arteriosclerosis. This suggests that magnesium-based treatments could offer a promising avenue for combating cardiovascular diseases effectively.
Read More
8
Magnesium linked to cardiovascular health
Upper normal serum magnesium is associated with a reduction in incident death from fatal heart failure, coronary heart disease and stroke in non-dialysis patients with CKD stages 4 and 5.
We examined how magnesium levels in the blood could influence the risk of death from cardiovascular issues in patients with advanced chronic kidney disease (CKD). Our study tracked 1,271 individuals with CKD stages 4 and 5 over a decade, focusing on those who had not previously experienced major heart-related events.
We discovered that higher serum magnesium concentrations were linked to lower risks of dying from conditions like heart failure, coronary heart disease, and stroke. By stratifying patients based on their magnesium levels, we found that those in the highest group experienced significantly better outcomes.
This suggests that maintaining adequate magnesium levels might be important for protecting cardiovascular health in these patients. While it’s just one piece of the puzzle, our findings highlight the potential benefits of magnesium as a factor worth considering in the management of cardiovascular risks.
Read More
8
Magnesium linked to heart health
Models based on dietary nutrients predicting all-cause and cardiovascular mortality in people with diabetes.
We explored the connection between dietary magnesium intake and cardiovascular disease, particularly in people living with diabetes. This study analyzed data from a large group of over 5,000 individuals who participated in the National Health and Nutrition Examination Survey over nearly two decades.
By utilizing advanced statistical methods, researchers identified key dietary factors that could predict long-term mortality risks. Notably, they found that higher intakes of dietary fiber and magnesium were associated with a decreased risk of both all-cause and cardiovascular-related deaths among people with diabetes. The analysis revealed a clear trend: as magnesium intake increased, the risk of cardiovascular mortality decreased.
The study suggests that incorporating more magnesium-rich foods could play a vital role in managing heart health for those with diabetes. By making informed dietary choices, individuals may enhance their longevity and reduce the risk of serious health complications.
Read More
8
Magnesium impacts blood sugar control
Serum magnesium, not calcium, is inversely associated with abnormal HbA1c concentrations in adults with coronary artery disease.
We explored the connections between magnesium (Mg), calcium (Ca), and abnormal levels of HbA1c—a key marker for blood sugar management—in adults with coronary artery disease (CAD). Our research involved a substantial group of 11,934 patients, allowing us to gain valuable insights into how these minerals impact cardiovascular health.
Our findings reveal a noteworthy association: higher serum magnesium levels appear to be linked to lower HbA1c concentrations. Specifically, patients with higher magnesium levels showed a significant decrease in the likelihood of having abnormal HbA1c readings. In contrast, calcium levels did not demonstrate a similar beneficial effect; they were not associated with abnormal HbA1c levels at all.
Interestingly, we also noted that while magnesium correlates with better fasting blood glucose outcomes, higher calcium levels were actually associated with worse results. Additionally, our analysis indicated that inflammation, as gauged by a specific blood marker, didn't mediate the relationship between magnesium and HbA1c. This suggests that magnesium might play a direct role in blood sugar regulation, separate from inflammation's influence.
Overall, our study highlights magnesium's potential importance in managing blood sugar levels among individuals with heart disease, pointing to a promising area for future research and potential dietary considerations.
Read More
8
Magnesium's impact on HFpEF mortality
Propensity score matched cohort study on magnesium supplementation and mortality in critically ill patients with HFpEF.
We explored how magnesium supplementation affects mortality rates in patients with heart failure with preserved ejection fraction (HFpEF), a subset of heart failure where treatment options are limited. The study analyzed data from the MIMIC-IV database, focusing on patients from 2008 to 2019. Using a technique called propensity score matching, we aimed to create a balanced comparison between those who received magnesium supplements and those who did not.
Our primary focus was on the 28-day all-cause mortality rate, along with secondary analyses of ICU stays, one-year mortality, and overall hospitalization duration. In total, we evaluated 1,970 patients, splitting them evenly between the magnesium and non-magnesium groups. The outcomes were striking: magnesium intake was associated with a significant reduction in mortality within the first 28 days, particularly benefiting older adults, women, and individuals with hypertension.
While magnesium supplementation showed promise in reducing mortality and also improved longer-term outcomes, we noted that it was linked to longer stays in both ICU and hospital settings. Interestingly, we found that blood urea nitrogen levels may play a role in mediating the relationship between magnesium intake and mortality, suggesting a more complex interaction at play.
This research highlights the potential of magnesium as a valuable treatment for those grappling with HFpEF, especially certain at-risk groups. As we consider these findings, further research is needed to explore magnesium's effects more thoroughly and understand its full implications for patient care.
Magnesium is an essential trace element that we obtain solely through food, capable of reducing the risk of ischaemic heart disease and arterial hypertension, as well as preventing strokes. It normalises blood pressure, alleviates muscle spasms, and prevents blood vessel constriction, while also serving as a natural anti-stress agent. Magnesium has a calming effect on the nervous system during periods of anxiety and depression, protecting it from stress. By increasing magnesium intake, one can reduce the frequency and intensity of migraines, enhancing overall cardiovascular health.
Read More
9
Improved heart health
7 people found this helpful
Chelated magnesium is a vital supplement that can significantly enhance your quality of life, alleviating irritability and chronic fatigue. It is essential for athletes who lose magnesium during training and for office workers who experience active brain activity. This trace element is crucial for those with heart and vascular issues; it helps maintain potassium and sodium balance, preventing oedema and hypertensive crises. Magnesium is also beneficial in angina pectoris, as it relaxes the coronary vessels, easing seizures and improving myocardial nutrition to help avoid heart attacks. Additionally, it's recommended for vegetative-vascular dystonia, increasing stress resilience, and is safe for pregnant women, especially in the first trimester when the baby’s nervous system develops.
Read More
7.5
Eased nervousness
Frankly, I have noticed a significant easing of my nervousness after use.
Read More
7.5
Better cardiovascular function
After taking this supplement, I observed improved sleep, reduced stress, and better functioning of my cardiovascular system. I highly recommend it to anyone experiencing magnesium deficiency.
Read More
7.5
Effective for stress
2 people found this helpful
I had a great experience sourcing magnesium from this site, although all previous chelated options were out of stock. This time, I chose glycinate, known for its bioavailability and assimilation, particularly beneficial for those with anaemia by addressing deficiencies in vitamin B, vitamin C, and magnesium. Unlike citrate, it does not stimulate bowel movements and effectively calms the nervous system, combating stress and anxiety. It serves as a supplementary treatment for heart disease, diabetes, insomnia, and inflammation. The capsules are large, but my 10-year-old can swallow them easily; for my 5-year-old, I mix it with water. After taking it, my family felt significant improvements in sleep and stress levels within a week.
Read More
Frequently Asked Questions
Cardiovascular disease (CVD) is a broad term that encompasses a range of heart and blood vessel disorders. This can include conditions such as coronary artery disease, which leads to heart attacks; cerebrovascular disease that results in strokes; and peripheral artery disease affecting blood flow to the limbs. The key risk factors for CVD often include high blood pressure, high cholesterol, obesity, smoking, a sedentary lifestyle, and diabetes. By identifying and managing these risk factors, individuals can significantly reduce their likelihood of developing cardiovascular problems.
Prevention and treatment strategies often involve lifestyle modifications such as adopting a heart-healthy diet rich in fruits, vegetables, whole grains, and lean proteins, alongside engaging in regular physical activity. In some cases, medications might be necessary to control blood pressure or cholesterol levels. Regular check-ups with a healthcare provider are essential for monitoring heart health, especially for individuals with a family history of CVD. Understanding the signs and symptoms of cardiovascular issues—like chest pain, shortness of breath, or fatigue—can help in seeking timely medical attention, ultimately leading to better outcomes.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Magnesium is an essential mineral that plays a significant role in various bodily functions, including heart health. Research has shown that adequate magnesium intake can help regulate blood pressure, maintain normal heart rhythms, and support overall cardiovascular function. Some studies suggest that higher magnesium levels may be associated with a lower risk of cardiovascular disease, as magnesium helps to keep blood vessels dilated and can prevent harmful calcium buildup in arterial walls.
However, it’s important to note that while magnesium supplementation can be beneficial, it should not be seen as a standalone treatment for cardiovascular disease. A well-rounded approach that includes a balanced diet rich in magnesium (found in foods like leafy greens, nuts, seeds, and whole grains), regular physical activity, and maintaining a healthy weight is essential for optimal heart health. As always, it is best to consult with a healthcare provider before making any substantial changes to your diet or supplement routine, especially if you have existing heart conditions or other health concerns.
Based on user reviews, the timeframe to see noticeable results from taking magnesium supplements for cardiovascular health varies. Some users have reported improvements in their cardiovascular system, such as better sleep and reduced stress levels, as quickly as within a week of starting supplementation Read Review. Additionally, other users noted significant easing of nervousness and improved overall well-being shortly after incorporating magnesium into their routine Read Review.
However, individual experiences may differ based on personal health conditions and lifestyle factors. While many users appreciate the quick benefits, others might take longer to observe substantial changes in their cardiovascular health. It’s worth noting that consistent use is key to achieving the optimal results and managing conditions such as hypertension or anxiety Read Review.
Emerging scientific research suggests that magnesium may play an important role in cardiovascular health. Several studies have found associations between magnesium levels and risks related to various cardiovascular diseases, highlighting its potential benefits. For example, one study showed that higher serum magnesium concentrations in patients with chronic kidney disease were correlated with lower cardiovascular mortality risks, indicating that maintaining adequate magnesium levels could be crucial for heart health in this population [2]. Furthermore, research has pointed out that insufficient magnesium levels can lead to increased inflammation and oxidative stress, both of which are linked to heart complications [6].
Moreover, recent findings indicate that magnesium supplementation may improve outcomes in patients with heart failure, specifically showing significant reductions in early mortality rates and improved long-term outcomes [5]. It also appears to positively influence blood sugar management, which is particularly relevant for individuals with diabetes, who face a higher risk of cardiovascular events [4]. Overall, while more randomized controlled trials are necessary to substantiate these findings, the current body of research suggests that magnesium supplementation and dietary intake could be beneficial for cardiovascular health.[9].
Based on user reviews, many individuals have reported notable improvements in a variety of symptoms after incorporating magnesium supplements into their routines. Users have experienced reduced feelings of nervousness and improved sleep quality, with some individuals noting these changes within just a week of starting their supplementation . Overall, these testimonials suggest that magnesium can alleviate anxiety, enhance emotional well-being, and contribute positively to cardiovascular health by normalizing blood pressure and preventing vascular complications Read Review.
Furthermore, several users emphasize the role magnesium plays in reducing chronic fatigue and irritability, particularly for those with demanding lifestyles, such as athletes and office workers Read Review. Overall, while experiences may vary, consistent use seems key to achieving these health benefits, and many find that magnesium serves as an effective tool for enhancing their general quality of life Read Review.
Users have reported positive experiences when combining magnesium supplements with other nutraceuticals for managing cardiovascular health. Many individuals have acknowledged that magnesium plays a crucial role in maintaining overall cardiovascular function, particularly by regulating blood pressure, alleviating muscle spasms, and improving myocardial nutrition to help prevent heart attacks Read Review. This mineral not only aids in the prevention of ischaemic heart disease and arterial hypertension but also works synergistically with other supplements to enhance heart and vascular health, as evidenced by improvements in sleep and reduced stress levels after users integrated it into their routine Read Review.
Moreover, users have noted that magnesium can mitigate symptoms associated with chronic stress and fatigue, particularly beneficial for those with demanding lifestyles or those engaged in athletic activities Read Review. This supplement is seen as a complementary resource for those dealing with heart issues, enhancing the efficacy of other dietary or herbal supplements directed towards cardiovascular care. Collectively, these user experiences highlight the potential of magnesium as an effective ally in a broader supplement regimen aimed at supporting cardiovascular health and alleviating related discomforts Read Review.
Based on user reviews, there appears to be a general consensus on the benefits of magnesium for cardiovascular health. Users report that increasing magnesium intake can help reduce the risk of ischemic heart disease and arterial hypertension, while normalizing blood pressure and alleviating stress (see review Read Review). It also helps maintain the balance of potassium and sodium, which is essential for preventing edema and hypertensive crises. The calming effects of magnesium on the nervous system during periods of anxiety and depression indicate its broader positive impact on well-being and cardiovascular function (Read Review, Read Review).
Regarding the right dose, while specific amounts are not detailed in the reviews, many users have reported significant improvements in stress levels, sleep quality, and overall cardiovascular function after supplementation. For instance, one user experienced better sleep and reduced stress within a week of using glycinate, noted for its better bioavailability (see review Read Review). Overall, magnesium supplements, particularly forms such as glycinate and chelated magnesium, are highly recommended for individuals looking to enhance their cardiovascular health.
7.5
Effective for stress
2 people found this helpful
I had a great experience sourcing magnesium from this site, although all previous chelated options were out of stock. This time, I chose glycinate, known for its bioavailability and assimilation, particularly beneficial for those with anaemia by addressing deficiencies in vitamin B, vitamin C, and magnesium. Unlike citrate, it does not stimulate bowel movements and effectively calms the nervous system, combating stress and anxiety. It serves as a supplementary treatment for heart disease, diabetes, insomnia, and inflammation. The capsules are large, but my 10-year-old can swallow them easily; for my 5-year-old, I mix it with water. After taking it, my family felt significant improvements in sleep and stress levels within a week.
7.5
Eased nervousness
Frankly, I have noticed a significant easing of my nervousness after use.
9
Improved heart health
7 people found this helpful
Chelated magnesium is a vital supplement that can significantly enhance your quality of life, alleviating irritability and chronic fatigue. It is essential for athletes who lose magnesium during training and for office workers who experience active brain activity. This trace element is crucial for those with heart and vascular issues; it helps maintain potassium and sodium balance, preventing oedema and hypertensive crises. Magnesium is also beneficial in angina pectoris, as it relaxes the coronary vessels, easing seizures and improving myocardial nutrition to help avoid heart attacks. Additionally, it's recommended for vegetative-vascular dystonia, increasing stress resilience, and is safe for pregnant women, especially in the first trimester when the baby’s nervous system develops.
9
Reduced heart disease risk
3 people found this helpful
Magnesium is an essential trace element that we obtain solely through food, capable of reducing the risk of ischaemic heart disease and arterial hypertension, as well as preventing strokes. It normalises blood pressure, alleviates muscle spasms, and prevents blood vessel constriction, while also serving as a natural anti-stress agent. Magnesium has a calming effect on the nervous system during periods of anxiety and depression, protecting it from stress. By increasing magnesium intake, one can reduce the frequency and intensity of migraines, enhancing overall cardiovascular health.
7.5
Better cardiovascular function
After taking this supplement, I observed improved sleep, reduced stress, and better functioning of my cardiovascular system. I highly recommend it to anyone experiencing magnesium deficiency.
8
Magnesium linked to cardiovascular health
Upper normal serum magnesium is associated with a reduction in incident death from fatal heart failure, coronary heart disease and stroke in non-dialysis patients with CKD stages 4 and 5.
We examined how magnesium levels in the blood could influence the risk of death from cardiovascular issues in patients with advanced chronic kidney disease (CKD). Our study tracked 1,271 individuals with CKD stages 4 and 5 over a decade, focusing on those who had not previously experienced major heart-related events.
We discovered that higher serum magnesium concentrations were linked to lower risks of dying from conditions like heart failure, coronary heart disease, and stroke. By stratifying patients based on their magnesium levels, we found that those in the highest group experienced significantly better outcomes.
This suggests that maintaining adequate magnesium levels might be important for protecting cardiovascular health in these patients. While it’s just one piece of the puzzle, our findings highlight the potential benefits of magnesium as a factor worth considering in the management of cardiovascular risks.
8
Magnesium's impact on heart health
The Role of Dietary Magnesium in Cardiovascular Disease.
We examined the connection between dietary magnesium and cardiovascular disease, focusing on how magnesium intake or serum levels relate to heart health. Over the last couple of decades, numerous studies have shown that low magnesium levels are associated with several heart-related issues, including high blood pressure, heart attacks, and even heart failure.
Our insights reveal that even mild or moderate magnesium deficiencies can trigger physiological and metabolic changes that may heighten cardiovascular risks. When magnesium levels are insufficient, we see a rise in inflammation, oxidative stress, and issues with how fats are processed in the body, which can lead to serious heart problems.
Furthermore, we noted that many individuals often consume less magnesium than what is recommended, particularly those who do not regularly eat whole grains, legumes, or green vegetables. This widespread lack of magnesium is concerning, as it could be a significant factor influencing heart disease in the general population.
8
Magnesium's impact on HFpEF mortality
Propensity score matched cohort study on magnesium supplementation and mortality in critically ill patients with HFpEF.
We explored how magnesium supplementation affects mortality rates in patients with heart failure with preserved ejection fraction (HFpEF), a subset of heart failure where treatment options are limited. The study analyzed data from the MIMIC-IV database, focusing on patients from 2008 to 2019. Using a technique called propensity score matching, we aimed to create a balanced comparison between those who received magnesium supplements and those who did not.
Our primary focus was on the 28-day all-cause mortality rate, along with secondary analyses of ICU stays, one-year mortality, and overall hospitalization duration. In total, we evaluated 1,970 patients, splitting them evenly between the magnesium and non-magnesium groups. The outcomes were striking: magnesium intake was associated with a significant reduction in mortality within the first 28 days, particularly benefiting older adults, women, and individuals with hypertension.
While magnesium supplementation showed promise in reducing mortality and also improved longer-term outcomes, we noted that it was linked to longer stays in both ICU and hospital settings. Interestingly, we found that blood urea nitrogen levels may play a role in mediating the relationship between magnesium intake and mortality, suggesting a more complex interaction at play.
This research highlights the potential of magnesium as a valuable treatment for those grappling with HFpEF, especially certain at-risk groups. As we consider these findings, further research is needed to explore magnesium's effects more thoroughly and understand its full implications for patient care.
8
Magnesium impacts blood sugar control
Serum magnesium, not calcium, is inversely associated with abnormal HbA1c concentrations in adults with coronary artery disease.
We explored the connections between magnesium (Mg), calcium (Ca), and abnormal levels of HbA1c—a key marker for blood sugar management—in adults with coronary artery disease (CAD). Our research involved a substantial group of 11,934 patients, allowing us to gain valuable insights into how these minerals impact cardiovascular health.
Our findings reveal a noteworthy association: higher serum magnesium levels appear to be linked to lower HbA1c concentrations. Specifically, patients with higher magnesium levels showed a significant decrease in the likelihood of having abnormal HbA1c readings. In contrast, calcium levels did not demonstrate a similar beneficial effect; they were not associated with abnormal HbA1c levels at all.
Interestingly, we also noted that while magnesium correlates with better fasting blood glucose outcomes, higher calcium levels were actually associated with worse results. Additionally, our analysis indicated that inflammation, as gauged by a specific blood marker, didn't mediate the relationship between magnesium and HbA1c. This suggests that magnesium might play a direct role in blood sugar regulation, separate from inflammation's influence.
Overall, our study highlights magnesium's potential importance in managing blood sugar levels among individuals with heart disease, pointing to a promising area for future research and potential dietary considerations.
7
Magnesium may lower heart failure risk
Nonprescription Magnesium Supplement Use and Risk of Heart Failure in Patients With Diabetes: A Target Trial Emulation.
We investigated the effects of nonprescription magnesium supplements on heart failure risk in diabetic veterans. By reviewing health records of over 94,000 individuals, we compared those who took magnesium with those who did not.
Our findings showed that magnesium users had a lower incidence of heart failure and major cardiac events, such as strokes and heart attacks. Despite this promising association, further randomized controlled trials are needed to confirm these results.
References
Yu H, Zhou C, Yang S, Yu J, Zhang X, et al. Mitigation of arteriosclerosis through transcriptional regulation of ferroptosis and lipid metabolism by magnesium. Biomaterials. 2025;319:123135. 10.1016/j.biomaterials.2025.123135
Moyano-Peregrin C, Rodelo-Haad C, Martín-Malo A, Muñoz-Castañeda JR, Ojeda R, et al. Upper normal serum magnesium is associated with a reduction in incident death from fatal heart failure, coronary heart disease and stroke in non-dialysis patients with CKD stages 4 and 5. Clin Kidney J. 2025;18:sfae390. 10.1093/ckj/sfae390
Wang F, Mao Y, Sun J, Yang J, Xiao L, et al. Models based on dietary nutrients predicting all-cause and cardiovascular mortality in people with diabetes. Sci Rep. 2025;15:4600. 10.1038/s41598-025-88480-9
Dong H, Lu N, Wang J, Hu P. Serum magnesium, not calcium, is inversely associated with abnormal HbA1c concentrations in adults with coronary artery disease. Asia Pac J Clin Nutr. 2025;34:104. 10.6133/apjcn.202502_34(1).0010
Song L, Ying J, Li M, Ying L, Zhao C. Propensity score matched cohort study on magnesium supplementation and mortality in critically ill patients with HFpEF. Sci Rep. 2025;15:1944. 10.1038/s41598-025-85931-1
Nielsen FH. The Role of Dietary Magnesium in Cardiovascular Disease. Nutrients. 2024;16. 10.3390/nu16234223
Sun L, Du J. Magnesium status, serum vitamin D concentration and mortality among congestive heart failure patients: a cohort study from NHANES 2007-2018. Magnes Res. 2024;37:61. 10.1684/mrh.2024.0528
Urbanowicz T, Hanć A, Frąckowiak J, Piecek J, Spasenenko I, et al. The Hypothesis of Trace Elements Involvement in the Coronary Arteries Atherosclerotic Plaques' Location. J Clin Med. 2024;13. 10.3390/jcm13226933
Cheng Y, Zullo AR, Yin Y, Shao Y, Liu S, et al. Nonprescription Magnesium Supplement Use and Risk of Heart Failure in Patients With Diabetes: A Target Trial Emulation. J Am Heart Assoc. 2025;14:e038870. 10.1161/JAHA.124.038870
Shahsavani Z, Masoumi SJ, Barati-Boldaji R, Shamshirgardi E, Kafipour R, et al. Dietary Calcium to Magnesium Ratio and Risk of Cardiovascular Diseases. Biol Trace Elem Res. 2025. 10.1007/s12011-025-04587-0
Pariona-Vargas F, Mun KT, Lo EH, Starkman S, Sanossian N, et al. Is there diurnal variation in neuroprotective and thrombolytic therapy effect upon acute cerebral ischemia outcome?. J Stroke Cerebrovasc Dis. 2025;34:108278. 10.1016/j.jstrokecerebrovasdis.2025.108278
Amer SA, Abo-Elnour DE, Abbas A, Abdelrahman AS, Hamdy HM, et al. Calcium, magnesium, and vitamin D supplementations as complementary therapy for hypertensive patients: a systematic review and meta-analysis. BMC Complement Med Ther. 2025;25:89. 10.1186/s12906-025-04809-x