Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.5
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Magnesium(from 513 mg Buffered Magnesium Glycinate Chelate Complex [Magnesium Oxide and Magnesium Bisglycinate])
200 mg
48%
Magnesium-Rich Plants BlendOrganic Spinach LeafOrganic Chard LeafOrganic Okra FruitOrganic Quinoa Grain (Chenopodium quinoa)Organic Black Bean (Phaseolus vulgaris)Organic Pumpkin SeedOrganic Sunflower SeedOrganic Flaxseed
30 mg
**
Top Medical Research Studies
9
We explored the impact of a new treatment, Marial®, on patients suffering from gastroesophageal reflux disease (GERD). In a large survey involving 56 gastroenterological offices across Italy, patients were treated with either proton pump inhibitors (PPIs), a combination of PPIs and an additional remedy, or the Marial® formulation containing magnesium alginate. The results showed that both Marial® and the combination therapy significantly reduced heartburn symptoms, with Marial® proving to be more effective than the combination. Overall, patients reported a marked improvement in their GERD-related symptoms.
Read More
8
GutGard® shows promise for heartburn
In a well-designed phase III trial, we explored how GutGard®, a licorice extract, helps relieve heartburn related to gastroesophageal reflux. Over 28 days, participants were randomly assigned to receive either GutGard® or a placebo without knowing which one they had.
Remarkably, those taking GutGard® reported quicker relief from their GER symptoms, particularly heartburn, compared to those on the placebo. This suggests that GutGard® may offer an effective, safe option for managing heartburn symptoms.
Remarkably, those taking GutGard® reported quicker relief from their GER symptoms, particularly heartburn, compared to those on the placebo. This suggests that GutGard® may offer an effective, safe option for managing heartburn symptoms.
Read More
7
Rapid relief, similar effectiveness observed
We conducted a study to see how well a fixed-dose combination of esomeprazole and magnesium hydroxide works for heartburn compared to enteric-coated esomeprazole. By using a crossover design, forty-nine healthy subjects received each treatment, allowing us to closely observe the effects.
Our findings showed that the combination drug reached maximum concentration faster and achieved gastric pH levels that suggest quicker acid suppression. Despite these advantages, the overall effectiveness in reducing gastric acidity was similar for both treatments. This indicates that while magnesium may enhance the speed of relief, it doesn't significantly outperform traditional esomeprazole.
Our findings showed that the combination drug reached maximum concentration faster and achieved gastric pH levels that suggest quicker acid suppression. Despite these advantages, the overall effectiveness in reducing gastric acidity was similar for both treatments. This indicates that while magnesium may enhance the speed of relief, it doesn't significantly outperform traditional esomeprazole.
Read More
Most Useful Reviews
9
Very effective
I absolutely love this magnesium! It’s easy to take, and I’m pleased it doesn’t cause any discomfort or heartburn, making it my top choice.
Read More
9
Good sleep quality
NATURELO is renowned for its quality. Although it’s slightly pricier, it caused no heartburn, and I slept well due to the chelate magnesium and vegetable ingredients. I’m keen to try other products from them, as the ones I received as gifts were delightful!
Read More
7.5
No negative effects
I appreciated the composition of this particular magnesium, as it has no adverse effects on my gastric mucosa; other brands have triggered heartburn immediately after use.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.5
- All Researches
9
We explored the impact of a new treatment, Marial®, on patients suffering from gastroesophageal reflux disease (GERD). In a large survey involving 56 gastroenterological offices across Italy, patients were treated with either proton pump inhibitors (PPIs), a combination of PPIs and an additional remedy, or the Marial® formulation containing magnesium alginate. The results showed that both Marial® and the combination therapy significantly reduced heartburn symptoms, with Marial® proving to be more effective than the combination. Overall, patients reported a marked improvement in their GERD-related symptoms.
Read More
8
GutGard® shows promise for heartburn
In a well-designed phase III trial, we explored how GutGard®, a licorice extract, helps relieve heartburn related to gastroesophageal reflux. Over 28 days, participants were randomly assigned to receive either GutGard® or a placebo without knowing which one they had.
Remarkably, those taking GutGard® reported quicker relief from their GER symptoms, particularly heartburn, compared to those on the placebo. This suggests that GutGard® may offer an effective, safe option for managing heartburn symptoms.
Remarkably, those taking GutGard® reported quicker relief from their GER symptoms, particularly heartburn, compared to those on the placebo. This suggests that GutGard® may offer an effective, safe option for managing heartburn symptoms.
Read More
7
Rapid relief, similar effectiveness observed
We conducted a study to see how well a fixed-dose combination of esomeprazole and magnesium hydroxide works for heartburn compared to enteric-coated esomeprazole. By using a crossover design, forty-nine healthy subjects received each treatment, allowing us to closely observe the effects.
Our findings showed that the combination drug reached maximum concentration faster and achieved gastric pH levels that suggest quicker acid suppression. Despite these advantages, the overall effectiveness in reducing gastric acidity was similar for both treatments. This indicates that while magnesium may enhance the speed of relief, it doesn't significantly outperform traditional esomeprazole.
Our findings showed that the combination drug reached maximum concentration faster and achieved gastric pH levels that suggest quicker acid suppression. Despite these advantages, the overall effectiveness in reducing gastric acidity was similar for both treatments. This indicates that while magnesium may enhance the speed of relief, it doesn't significantly outperform traditional esomeprazole.
Read More
7
We investigated how different types of mineral waters might assist in treating patients with gastroesophageal reflux disease (GERD). Ninety patients were split into three groups: a control group receiving standard treatment, one group drinking boric sodium bicarbonate water, and another consuming highly mineralized sodium-magnesium water.
While basic treatment showed little effectiveness, the boric water alleviated some symptoms, and the magnesium water notably improved dyspepsia and liver function. Overall, our findings support the use of mineral waters as part of a comprehensive GERD treatment plan.
While basic treatment showed little effectiveness, the boric water alleviated some symptoms, and the magnesium water notably improved dyspepsia and liver function. Overall, our findings support the use of mineral waters as part of a comprehensive GERD treatment plan.
Read More
7
We investigated the effectiveness of dietary changes and natural remedies in treating gastrointestinal symptoms in a 73-year-old woman with newly diagnosed Parkinson's disease. The patient faced constipation and acid reflux after starting medication. By increasing her vegetable intake, fiber, protein, and hydration while reducing sugars, she saw improvements in her symptoms. Notably, integrating apple cider vinegar, deglycyrrhizinated licorice, probiotics, and magnesium citrate helped alleviate her acid reflux significantly—50% improvement within just five days. Ultimately, she achieved complete symptom resolution in one month, highlighting the promise of diet and natural treatments.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Very effective
I absolutely love this magnesium! It’s easy to take, and I’m pleased it doesn’t cause any discomfort or heartburn, making it my top choice.
Read More
9
Good sleep quality
NATURELO is renowned for its quality. Although it’s slightly pricier, it caused no heartburn, and I slept well due to the chelate magnesium and vegetable ingredients. I’m keen to try other products from them, as the ones I received as gifts were delightful!
Read More
7.5
No negative effects
I appreciated the composition of this particular magnesium, as it has no adverse effects on my gastric mucosa; other brands have triggered heartburn immediately after use.
Read More
Frequently Asked Questions
9
Very effective
I absolutely love this magnesium! It’s easy to take, and I’m pleased it doesn’t cause any discomfort or heartburn, making it my top choice.
7.5
No negative effects
I appreciated the composition of this particular magnesium, as it has no adverse effects on my gastric mucosa; other brands have triggered heartburn immediately after use.
9
Good sleep quality
NATURELO is renowned for its quality. Although it’s slightly pricier, it caused no heartburn, and I slept well due to the chelate magnesium and vegetable ingredients. I’m keen to try other products from them, as the ones I received as gifts were delightful!
8
GutGard® shows promise for heartburn
In a well-designed phase III trial, we explored how GutGard®, a licorice extract, helps relieve heartburn related to gastroesophageal reflux. Over 28 days, participants were randomly assigned to receive either GutGard® or a placebo without knowing which one they had.
Remarkably, those taking GutGard® reported quicker relief from their GER symptoms, particularly heartburn, compared to those on the placebo. This suggests that GutGard® may offer an effective, safe option for managing heartburn symptoms.
Remarkably, those taking GutGard® reported quicker relief from their GER symptoms, particularly heartburn, compared to those on the placebo. This suggests that GutGard® may offer an effective, safe option for managing heartburn symptoms.
7
We investigated the effectiveness of dietary changes and natural remedies in treating gastrointestinal symptoms in a 73-year-old woman with newly diagnosed Parkinson's disease. The patient faced constipation and acid reflux after starting medication. By increasing her vegetable intake, fiber, protein, and hydration while reducing sugars, she saw improvements in her symptoms. Notably, integrating apple cider vinegar, deglycyrrhizinated licorice, probiotics, and magnesium citrate helped alleviate her acid reflux significantly—50% improvement within just five days. Ultimately, she achieved complete symptom resolution in one month, highlighting the promise of diet and natural treatments.
References
- Raj JP, Saxena U, Belhekar MN, Mamde A, Darak H, et al. Efficacy and Safety of GutGard® in Managing Gastroesophageal Reflux-Related Symptoms: A Phase III, Single-Centre, Double-Blind, Randomized Placebo-Controlled Trial. Complement Med Res. 2025;32:26. doi:10.1159/000543367
- Kim Y, Bae S, Jeon I, Kwon J, Hong SH, et al. Pharmacokinetics and Pharmacodynamics of a Fixed-Dose Combination of Esomeprazole and Magnesium Hydroxide Compared to the Enteric-Coated Esomeprazole. Clin Ther. 2024;46:870. doi:10.1016/j.clinthera.2024.08.006
- Dragomiretska NV, Babov KD, Gushcha SG, Zabolotna IB, Plakida AL, et al. Application of mineral waters in the complex treatment of patients with gastroesophageal reflux disease. Minerva Gastroenterol Dietol. 2020;66:225. doi:10.23736/S1121-421X.20.02601-X
- Neiworth-Petshow EM, Baldwin-Sayre C. Naturopathic Treatment of Gastrointestinal Dysfunction in the Setting of Parkinson's Disease. Integr Med (Encinitas). 2018;17:44.
- Bianchetti M, Peralta S, Nicita R, Aragona SE, Ciprandi G. Emerging from gastroesophageal reflux (EMERGE): An Italian survey - II the viewpoint of the patient. J Biol Regul Homeost Agents. 2018;32:983.
- Aragona SE, Mereghetti G, Bianchetti M, Mangiavillano B, Zurlo T, et al. Regenerative medicine in the treatment of gastro-esophageal reflux disease and laryngo-pharyngeal reflux. From research to cure. J Biol Regul Homeost Agents. 2017;31:207.
