5/14/2025
Last update
5/14/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 19 Researches
8.2
USERS' SCORE
Good
Based on 5 Reviews
8.6
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Magnesium(from 513 mg Buffered Magnesium Glycinate Chelate Complex [Magnesium Oxide and Magnesium Bisglycinate])
200 mg
48%
Magnesium-Rich Plants BlendOrganic Spinach LeafOrganic Chard LeafOrganic Okra FruitOrganic Quinoa Grain (Chenopodium quinoa)Organic Black Bean (Phaseolus vulgaris)Organic Pumpkin SeedOrganic Sunflower SeedOrganic Flaxseed
30 mg
**
Top Medical Research Studies
9
We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
Read More
9
In our exploration of osteoporosis treatment, we focused on the effects of magnesium, particularly when combined with phosphorylated collagen peptide-magnesium chelates. Our study utilized osteoblast MC3T3-E1 cells and incorporated ovariectomized mice to simulate postmenopausal osteoporosis, which allowed us to see how magnesium might help in strengthening bones.
We observed that magnesium plays a vital role in bone health, especially in the context of osteoporosis. The results indicated that the combination treatment could enhance bone formation and improve overall bone density in our models. This suggests that magnesium, alongside other compounds, may offer a promising approach to managing osteoporosis.
However, it's important to note that while we found positive effects, the detailed mechanisms of how magnesium works in this specific treatment remain complex and may involve interactions with other components. Further research is needed to fully understand its efficacy and the best ways to integrate magnesium into osteoporosis treatment strategies.
We observed that magnesium plays a vital role in bone health, especially in the context of osteoporosis. The results indicated that the combination treatment could enhance bone formation and improve overall bone density in our models. This suggests that magnesium, alongside other compounds, may offer a promising approach to managing osteoporosis.
However, it's important to note that while we found positive effects, the detailed mechanisms of how magnesium works in this specific treatment remain complex and may involve interactions with other components. Further research is needed to fully understand its efficacy and the best ways to integrate magnesium into osteoporosis treatment strategies.
Read More
9
Nanopowder eggshells improve bone health
We examined how nanopowder eggshells (NPES) could influence bone health in both healthy and ovariectomy-induced osteoporosis rats.
In our research, we found that NPES treatment significantly enhanced indicators of bone formation, like calcium and osteocalcin, particularly in healthy rats.
Additionally, in the ovariectomized group, NPES treatment helped improve levels of vital nutrients and reduced bone resorption.
Overall, our findings suggest that NPES may play a beneficial role in bettering bone health in osteoporosis models.
In our research, we found that NPES treatment significantly enhanced indicators of bone formation, like calcium and osteocalcin, particularly in healthy rats.
Additionally, in the ovariectomized group, NPES treatment helped improve levels of vital nutrients and reduced bone resorption.
Overall, our findings suggest that NPES may play a beneficial role in bettering bone health in osteoporosis models.
Read More
Most Useful Reviews
9
Bone health benefits
89 people found this helpful
Magnesium is crucial for everyone! Most people lack it. This brand, derived from a food source, excels in benefits ranging from bone health and formation to absorbing calcium and preventing osteoporosis. Consistent intake is necessary!
Read More
9
Suitable for osteoporosis
I purchased this natural, safe product for my mother, who suffers from osteoporosis, and it suits her perfectly. It's excellent for her needs.
Read More
7.5
Recommended for osteoporosis
This magnesium supplement has excellent quality, supported by research. I took it alongside a group of vitamins for bone health, recommended by Dr. Karim Ali, who focuses on osteoporosis management.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 19 Researches
8.2
- All Researches
9
We examined how dietary intake of magnesium, along with potassium and sodium, influences bone health, specifically focusing on osteoporosis and bone mineral density (BMD) in adults across the U.S. Our analysis was based on data from the National Health and Nutrition Examination Surveys, which spanned from 2005 to 2018, involving over 10,000 participants.
The findings revealed a positive association between higher dietary intake of potassium, magnesium, and sodium and improved BMD of the femur. This means that those who consumed more of these nutrients tended to have stronger bones. Additionally, we observed that a higher intake of these minerals was linked to a lower occurrence of osteopenia and osteoporosis.
Our study highlights how magnesium, when part of a broader nutrient intake that includes potassium and sodium, could play a significant role in maintaining bone health. While our research points to a beneficial relationship, more targeted studies are needed to definitively isolate the effects of magnesium alone on osteoporosis. Overall, this reinforces the importance of a balanced diet for bone health.
The findings revealed a positive association between higher dietary intake of potassium, magnesium, and sodium and improved BMD of the femur. This means that those who consumed more of these nutrients tended to have stronger bones. Additionally, we observed that a higher intake of these minerals was linked to a lower occurrence of osteopenia and osteoporosis.
Our study highlights how magnesium, when part of a broader nutrient intake that includes potassium and sodium, could play a significant role in maintaining bone health. While our research points to a beneficial relationship, more targeted studies are needed to definitively isolate the effects of magnesium alone on osteoporosis. Overall, this reinforces the importance of a balanced diet for bone health.
Read More
9
We delved into the use of a unique injectable hydrogel loaded with magnesium to address the challenges of repairing osteoporotic bone defects. The study aimed to understand how this magnesium-infused hydrogel could combat the excessive reactive oxygen species (ROS) that hinder bone repair. With impressive qualities such as excellent injectability and adaptability, the hydrogel can be introduced into irregular bone areas without the need for major surgery.
Once injected, the hydrogel not only transforms into a supportive scaffold but also begins to release hydrogen and magnesium ions. This release is key in reducing harmful intracellular ROS and guiding the immune response favorably by promoting macrophage polarization. We observed that this gel suppressed the formation of osteoclasts, the cells responsible for bone resorption, while simultaneously encouraging the growth of new bone cells.
Animal experiments further illuminated the effectiveness of the magnesium-loaded hydrogel, showing a remarkable ability to enhance the repair of bone defects by controlling inflammation and supporting bone formation. Overall, our findings shine a light on the potential of magnesium-based hydrogels as promising solutions for those dealing with osteoporosis-related bone damage.
Once injected, the hydrogel not only transforms into a supportive scaffold but also begins to release hydrogen and magnesium ions. This release is key in reducing harmful intracellular ROS and guiding the immune response favorably by promoting macrophage polarization. We observed that this gel suppressed the formation of osteoclasts, the cells responsible for bone resorption, while simultaneously encouraging the growth of new bone cells.
Animal experiments further illuminated the effectiveness of the magnesium-loaded hydrogel, showing a remarkable ability to enhance the repair of bone defects by controlling inflammation and supporting bone formation. Overall, our findings shine a light on the potential of magnesium-based hydrogels as promising solutions for those dealing with osteoporosis-related bone damage.
Read More
9
We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
Read More
9
In our exploration of osteoporosis treatment, we focused on the effects of magnesium, particularly when combined with phosphorylated collagen peptide-magnesium chelates. Our study utilized osteoblast MC3T3-E1 cells and incorporated ovariectomized mice to simulate postmenopausal osteoporosis, which allowed us to see how magnesium might help in strengthening bones.
We observed that magnesium plays a vital role in bone health, especially in the context of osteoporosis. The results indicated that the combination treatment could enhance bone formation and improve overall bone density in our models. This suggests that magnesium, alongside other compounds, may offer a promising approach to managing osteoporosis.
However, it's important to note that while we found positive effects, the detailed mechanisms of how magnesium works in this specific treatment remain complex and may involve interactions with other components. Further research is needed to fully understand its efficacy and the best ways to integrate magnesium into osteoporosis treatment strategies.
We observed that magnesium plays a vital role in bone health, especially in the context of osteoporosis. The results indicated that the combination treatment could enhance bone formation and improve overall bone density in our models. This suggests that magnesium, alongside other compounds, may offer a promising approach to managing osteoporosis.
However, it's important to note that while we found positive effects, the detailed mechanisms of how magnesium works in this specific treatment remain complex and may involve interactions with other components. Further research is needed to fully understand its efficacy and the best ways to integrate magnesium into osteoporosis treatment strategies.
Read More
9
We explored a cutting-edge approach to tackle the challenges in repairing bones affected by osteoporosis. Drawing inspiration from the healing properties of hot springs, we created a unique calcium magnesium phosphate bone cement infused with manganese ions.
This innovative scaffold not only promotes the regeneration of neurovascular networks but also helps reduce harmful substances in the bone's environment. Our results indicate that this method significantly aids in bone healing, highlighting its potential for treating osteoporosis effectively.
This innovative scaffold not only promotes the regeneration of neurovascular networks but also helps reduce harmful substances in the bone's environment. Our results indicate that this method significantly aids in bone healing, highlighting its potential for treating osteoporosis effectively.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Bone health benefits
89 people found this helpful
Magnesium is crucial for everyone! Most people lack it. This brand, derived from a food source, excels in benefits ranging from bone health and formation to absorbing calcium and preventing osteoporosis. Consistent intake is necessary!
Read More
9
Suitable for osteoporosis
I purchased this natural, safe product for my mother, who suffers from osteoporosis, and it suits her perfectly. It's excellent for her needs.
Read More
7.5
Recommended for osteoporosis
This magnesium supplement has excellent quality, supported by research. I took it alongside a group of vitamins for bone health, recommended by Dr. Karim Ali, who focuses on osteoporosis management.
Read More
7.5
Healthy recovery
This supplement is a good choice due to its convenient form for absorption and dosage. It has helped my body recover following a coronavirus infection. I recommend it for preventing osteoporosis, cardiovascular diseases, and other issues like diabetes and migraines. It’s a practical and healthy supplement that I trust.
Read More
7.5
Supports overall health
Magnesium Glycinate is highly absorbable, bound to glycine, making it gentle on the stomach and effective for overall health. It improves sleep quality, reduces anxiety, supports the nervous system, and helps with mood regulation. It enhances calcium absorption, thus lowering the risk of osteoporosis while stabilising blood sugar levels, beneficial for diabetics. The recommended daily dose is 200-400 mg, depending on your needs.
Read More
Frequently Asked Questions
7.5
Healthy recovery
This supplement is a good choice due to its convenient form for absorption and dosage. It has helped my body recover following a coronavirus infection. I recommend it for preventing osteoporosis, cardiovascular diseases, and other issues like diabetes and migraines. It’s a practical and healthy supplement that I trust.
7.5
Supports overall health
Magnesium Glycinate is highly absorbable, bound to glycine, making it gentle on the stomach and effective for overall health. It improves sleep quality, reduces anxiety, supports the nervous system, and helps with mood regulation. It enhances calcium absorption, thus lowering the risk of osteoporosis while stabilising blood sugar levels, beneficial for diabetics. The recommended daily dose is 200-400 mg, depending on your needs.
9
Suitable for osteoporosis
I purchased this natural, safe product for my mother, who suffers from osteoporosis, and it suits her perfectly. It's excellent for her needs.
7.5
Recommended for osteoporosis
This magnesium supplement has excellent quality, supported by research. I took it alongside a group of vitamins for bone health, recommended by Dr. Karim Ali, who focuses on osteoporosis management.
9
We examined how dietary intake of magnesium, along with potassium and sodium, influences bone health, specifically focusing on osteoporosis and bone mineral density (BMD) in adults across the U.S. Our analysis was based on data from the National Health and Nutrition Examination Surveys, which spanned from 2005 to 2018, involving over 10,000 participants.
The findings revealed a positive association between higher dietary intake of potassium, magnesium, and sodium and improved BMD of the femur. This means that those who consumed more of these nutrients tended to have stronger bones. Additionally, we observed that a higher intake of these minerals was linked to a lower occurrence of osteopenia and osteoporosis.
Our study highlights how magnesium, when part of a broader nutrient intake that includes potassium and sodium, could play a significant role in maintaining bone health. While our research points to a beneficial relationship, more targeted studies are needed to definitively isolate the effects of magnesium alone on osteoporosis. Overall, this reinforces the importance of a balanced diet for bone health.
The findings revealed a positive association between higher dietary intake of potassium, magnesium, and sodium and improved BMD of the femur. This means that those who consumed more of these nutrients tended to have stronger bones. Additionally, we observed that a higher intake of these minerals was linked to a lower occurrence of osteopenia and osteoporosis.
Our study highlights how magnesium, when part of a broader nutrient intake that includes potassium and sodium, could play a significant role in maintaining bone health. While our research points to a beneficial relationship, more targeted studies are needed to definitively isolate the effects of magnesium alone on osteoporosis. Overall, this reinforces the importance of a balanced diet for bone health.
7
We explored the fascinating role of magnesium in osteoporosis, a condition that leads to weakened bones and increased fracture risk. Through our investigation, we observed that magnesium is vital for bone health and plays a significant part in bone formation and maintenance.
Magnesium deficiency can impact bone structure indirectly by interfering with calcium homeostasis. This interplay is orchestrated mainly through two key regulators: parathyroid hormone and vitamin D. Parathyroid hormone influences the production of essential proteins that regulate osteoclast formation, which is responsible for bone resorption.
We also learned that vitamin D works in tandem with magnesium to facilitate the balance between bone formation and resorption. When magnesium levels are low, this balance can tip in favor of bone loss, ultimately leading to osteoporosis. The RANK/RANKL/OPG signaling pathway is crucial in this context, as it governs the relationship between bone-building cells and those that break down bone.
Importantly, clinical studies indicate that magnesium supplementation may ease some symptoms of osteoporosis, although further research is needed to assess its effectiveness compared to other treatments. Overall, we understand that maintaining adequate magnesium levels is essential for bone health and may help prevent the progression of osteoporosis.
Magnesium deficiency can impact bone structure indirectly by interfering with calcium homeostasis. This interplay is orchestrated mainly through two key regulators: parathyroid hormone and vitamin D. Parathyroid hormone influences the production of essential proteins that regulate osteoclast formation, which is responsible for bone resorption.
We also learned that vitamin D works in tandem with magnesium to facilitate the balance between bone formation and resorption. When magnesium levels are low, this balance can tip in favor of bone loss, ultimately leading to osteoporosis. The RANK/RANKL/OPG signaling pathway is crucial in this context, as it governs the relationship between bone-building cells and those that break down bone.
Importantly, clinical studies indicate that magnesium supplementation may ease some symptoms of osteoporosis, although further research is needed to assess its effectiveness compared to other treatments. Overall, we understand that maintaining adequate magnesium levels is essential for bone health and may help prevent the progression of osteoporosis.
8
In our exploration of how magnesium can help treat osteoporosis, we focused on a unique combination of materials to improve bone healing. The study investigated the use of magnesium alloys, known for their biodegradability and suitable elasticity for bone repair. However, it also incorporated graphene oxide quantum dots and layered double hydroxides to enhance the overall effect.
The results showed promise, particularly with the construction of a honeycomb-like coated structure on magnesium alloys. This innovative design helps regulate the degradation rate of magnesium, providing a conducive environment for bone regeneration. By allowing osteoblasts, the cells responsible for bone formation, to survive better and function properly, we observed that magnesium combined with these materials may effectively promote bone healing in osteoporotic patients.
Specifically, the activation of mitophagy—where damaged mitochondria in osteoblasts are cleared—was identified as a key factor in supporting osteogenesis. The improvement in bone regeneration and integration was confirmed using a rat model with femoral defects. Our findings suggest that magnesium alloys' combination with advanced materials like graphene oxide and layered double hydroxides may represent a promising approach to addressing osteoporosis-related bone defects.
The results showed promise, particularly with the construction of a honeycomb-like coated structure on magnesium alloys. This innovative design helps regulate the degradation rate of magnesium, providing a conducive environment for bone regeneration. By allowing osteoblasts, the cells responsible for bone formation, to survive better and function properly, we observed that magnesium combined with these materials may effectively promote bone healing in osteoporotic patients.
Specifically, the activation of mitophagy—where damaged mitochondria in osteoblasts are cleared—was identified as a key factor in supporting osteogenesis. The improvement in bone regeneration and integration was confirmed using a rat model with femoral defects. Our findings suggest that magnesium alloys' combination with advanced materials like graphene oxide and layered double hydroxides may represent a promising approach to addressing osteoporosis-related bone defects.
9
We delved into the use of a unique injectable hydrogel loaded with magnesium to address the challenges of repairing osteoporotic bone defects. The study aimed to understand how this magnesium-infused hydrogel could combat the excessive reactive oxygen species (ROS) that hinder bone repair. With impressive qualities such as excellent injectability and adaptability, the hydrogel can be introduced into irregular bone areas without the need for major surgery.
Once injected, the hydrogel not only transforms into a supportive scaffold but also begins to release hydrogen and magnesium ions. This release is key in reducing harmful intracellular ROS and guiding the immune response favorably by promoting macrophage polarization. We observed that this gel suppressed the formation of osteoclasts, the cells responsible for bone resorption, while simultaneously encouraging the growth of new bone cells.
Animal experiments further illuminated the effectiveness of the magnesium-loaded hydrogel, showing a remarkable ability to enhance the repair of bone defects by controlling inflammation and supporting bone formation. Overall, our findings shine a light on the potential of magnesium-based hydrogels as promising solutions for those dealing with osteoporosis-related bone damage.
Once injected, the hydrogel not only transforms into a supportive scaffold but also begins to release hydrogen and magnesium ions. This release is key in reducing harmful intracellular ROS and guiding the immune response favorably by promoting macrophage polarization. We observed that this gel suppressed the formation of osteoclasts, the cells responsible for bone resorption, while simultaneously encouraging the growth of new bone cells.
Animal experiments further illuminated the effectiveness of the magnesium-loaded hydrogel, showing a remarkable ability to enhance the repair of bone defects by controlling inflammation and supporting bone formation. Overall, our findings shine a light on the potential of magnesium-based hydrogels as promising solutions for those dealing with osteoporosis-related bone damage.
8
Magnesium enhances osteoporosis treatment
We explored how magnesium, along with other components, could address the challenges posed by osteoporosis. In this study, researchers developed a novel bone cement that incorporates magnesium oxide nanoparticles, aiming to enhance bone regeneration.
This innovative cement, known as C/AM-PL/C, demonstrated impressive mechanical strength and the ability to remain effective during injection. By releasing magnesium and calcium, the cement not only supported the growth of new blood vessels but also encouraged the differentiation of bone-forming cells.
Furthermore, the study highlighted that the cement could help inhibit the formation of bone-resorbing cells, providing a dual action beneficial for osteoporosis treatment. Especially noteworthy was how this cement improved healing in animal models with osteoporosis-related bone defects, showing promise as a treatment option for those suffering from this condition.
Overall, it appears that magnesium, when combined with other components in this novel cement, plays a significant role in encouraging bone healing and combatting the effects of osteoporosis.
This innovative cement, known as C/AM-PL/C, demonstrated impressive mechanical strength and the ability to remain effective during injection. By releasing magnesium and calcium, the cement not only supported the growth of new blood vessels but also encouraged the differentiation of bone-forming cells.
Furthermore, the study highlighted that the cement could help inhibit the formation of bone-resorbing cells, providing a dual action beneficial for osteoporosis treatment. Especially noteworthy was how this cement improved healing in animal models with osteoporosis-related bone defects, showing promise as a treatment option for those suffering from this condition.
Overall, it appears that magnesium, when combined with other components in this novel cement, plays a significant role in encouraging bone healing and combatting the effects of osteoporosis.
8
Magnesium improves osteoporosis treatment
We explored the importance of magnesium in treating osteoporosis through a novel approach that combines magnesium and calcium in targeted delivery systems. This study focused on how these essential minerals can influence the bone formation process, particularly within the challenging inflammatory environment that often accompanies osteoporosis.
By designing a multifunctional nanoplatform, we aimed to effectively transport magnesium and calcium directly to the bones. Our platform, which features calcium-based nanoparticles combined with magnesium organic frameworks, successfully released these minerals in response to the acidic conditions typical in osteoporotic tissue. This targeted delivery not only helped to regulate inflammation but also promoted the growth of new bone.
We found that our magnesium and calcium combination could suppress inflammation and support new bone formation by inhibiting key signaling pathways involved in the inflammatory response. The results highlighted the potential for magnesium, alongside calcium, to play a significant role in improving bone health in individuals with osteoporosis.
Ultimately, our findings provide important insights into collaborative therapeutic strategies that target both the bone microenvironment and the osteogenic process. This research could pave the way for new magnesium-centric treatments that enhance bone health for those suffering from bone metabolic diseases.
By designing a multifunctional nanoplatform, we aimed to effectively transport magnesium and calcium directly to the bones. Our platform, which features calcium-based nanoparticles combined with magnesium organic frameworks, successfully released these minerals in response to the acidic conditions typical in osteoporotic tissue. This targeted delivery not only helped to regulate inflammation but also promoted the growth of new bone.
We found that our magnesium and calcium combination could suppress inflammation and support new bone formation by inhibiting key signaling pathways involved in the inflammatory response. The results highlighted the potential for magnesium, alongside calcium, to play a significant role in improving bone health in individuals with osteoporosis.
Ultimately, our findings provide important insights into collaborative therapeutic strategies that target both the bone microenvironment and the osteogenic process. This research could pave the way for new magnesium-centric treatments that enhance bone health for those suffering from bone metabolic diseases.
8
We explored the connection between magnesium and osteoporosis by examining data from 2,115 participants. A variety of methods, including LASSO regression and logistic regression, were employed to analyze plasma concentrations of 22 different metals and their relationship with osteoporosis.
From our analysis, we found that magnesium plays a notable role in the likelihood of developing osteoporosis. Specifically, it was consistently associated with a reduced risk of this condition. In our findings, magnesium showed a negative correlation with osteoporosis, meaning higher levels of this essential mineral were linked to a lower chance of osteoporosis.
However, we also noted that exposure to metals like aluminum and cadmium was positively associated with an increased risk of osteoporosis, indicating that a combination of various metal exposures could influence bone health adversely. While magnesium appears to offer protective benefits, the interplay of different metals complicates the overall picture.
From our analysis, we found that magnesium plays a notable role in the likelihood of developing osteoporosis. Specifically, it was consistently associated with a reduced risk of this condition. In our findings, magnesium showed a negative correlation with osteoporosis, meaning higher levels of this essential mineral were linked to a lower chance of osteoporosis.
However, we also noted that exposure to metals like aluminum and cadmium was positively associated with an increased risk of osteoporosis, indicating that a combination of various metal exposures could influence bone health adversely. While magnesium appears to offer protective benefits, the interplay of different metals complicates the overall picture.
References
- Hu W, Feng X, Wen C. Relationship between multi-nutrient intake and bone loss and osteoporosis in U.S. adults: Findings from NHANES. Medicine (Baltimore). 2024;103:e40768. 10.1097/MD.0000000000040768
- Li D, Dai D, Wang J, Zhang C. Honeycomb Bionic Graphene Oxide Quantum Dot/Layered Double Hydroxide Composite Nanocoating Promotes Osteoporotic Bone Regeneration via Activating Mitophagy. Small. 2024;20:e2403907. 10.1002/smll.202403907
- Zhou H, He Z, Cao Y, Chu L, Liang B, et al. An injectable magnesium-loaded hydrogel releases hydrogen to promote osteoporotic bone repair via ROS scavenging and immunomodulation. Theranostics. 2024;14:3739. 10.7150/thno.97412
- Liu L, Luo P, Wen P, Xu P. The role of magnesium in the pathogenesis of osteoporosis. Front Endocrinol (Lausanne). 2024;15:1406248. 10.3389/fendo.2024.1406248
- Huang L, Cai P, Bian M, Yu J, Xiao L, et al. Injectable and high-strength PLGA/CPC loaded ALN/MgO bone cement for bone regeneration by facilitating osteogenesis and inhibiting osteoclastogenesis in osteoporotic bone defects. Mater Today Bio. 2024;26:101092. 10.1016/j.mtbio.2024.101092
- Weng Z, Ye J, Cai C, Liu Z, Liu Y, et al. Inflammatory microenvironment regulation and osteogenesis promotion by bone-targeting calcium and magnesium repletion nanoplatform for osteoporosis therapy. J Nanobiotechnology. 2024;22:314. 10.1186/s12951-024-02581-7
- Dai Q, Wang Z, Liu C, Chen X, Cao X. High performance injectable Mg doped bioactive glass bone cement for the regulation of osteogenic immune microenvironment. Biomater Adv. 2024;160:213864. 10.1016/j.bioadv.2024.213864
- Li J, Chen Y, Zha D, Wu C, Li X, et al. Mg-ZIF nanozyme regulates the switch between osteogenic and lipogenic differentiation in BMSCs via lipid metabolism. Lipids Health Dis. 2024;23:88. 10.1186/s12944-024-02083-3
- Qin L, Liu Q, Zhang T, Tang X, Mo X, et al. Association Between Combined Polymetallic Exposure and Osteoporosis. Biol Trace Elem Res. 2024;202:3945. 10.1007/s12011-023-04002-6
- Ma T, Guan Y, Feng J, Yang Y, Chen J, et al. Osteogenic effect of magnesium oxychloride cement modified with phytic acid and loaded with strontium ranelate. Biomater Res. 2023;27:128. 10.1186/s40824-023-00474-8
- Zhang C, Du B, Deng G, Zhang S, Yu T, et al. Anti-osteoporosis properties of phosphorylated collagen peptide-magnesium chelates in osteoblast MC3T3-E1 cells and ovariectomized mice. Chin Med J (Engl). 2024;137:1762. 10.1097/CM9.0000000000002877
- Zhao Y, Liu J, Hu L, Yao X, Tu R, et al. Novel "hot spring"-mimetic scaffolds for sequential neurovascular network reconstruction and osteoporosis reversion. Biomaterials. 2025;320:123191. 10.1016/j.biomaterials.2025.123191
- Al-Garawi ZS, Al-Qaisi AHI, Al-Shamari KA, Öztürkkan FE, Necefoğlu H. The utility of Hibiscus sabdariffa L. to prepare metal oxides NPs for clinical application on osteoporosis supported by theoretical study. Bioprocess Biosyst Eng. 2024;47:753. 10.1007/s00449-024-03012-5
- Düğer H, Uçan B, Çalışkan M, Bostan H, Demirci T, et al. Hypomagnesemia may be associated with symptomatic disease in patients with primary hyperparathyroidism. Endocrine. 2024;83:466. 10.1007/s12020-023-03577-3
- Han H, Chen S, Wang X, Jin J, Li X, et al. Association of the composite dietary antioxidant index with bone mineral density in the United States general population: data from NHANES 2005-2010. J Bone Miner Metab. 2023;41:631. 10.1007/s00774-023-01438-7
- Zhu Y, Jia G, Yang Y, Weng J, Liu S, et al. Biomimetic Porous Magnesium Alloy Scaffolds Promote the Repair of Osteoporotic Bone Defects in Rats through Activating the Wnt/β-Catenin Signaling Pathway. ACS Biomater Sci Eng. 2023;9:3435. 10.1021/acsbiomaterials.2c01097
- Fouhy LE, Mangano KM, Zhang X, Hughes BD, Tucker KL, et al. Association between a Calcium-to-Magnesium Ratio and Osteoporosis among Puerto Rican Adults. J Nutr. 2023;153:2642. 10.1016/j.tjnut.2023.05.009
- Xie Y, Bao Z, Wang Z, Du D, Chen G, et al. Magnesium Ascorbyl Phosphate Promotes Bone Formation Via CaMKII Signaling. J Bone Miner Res. 2023;38:1015. 10.1002/jbmr.4820
- Salama RHM, Ali SS, Salama THM, Almged MA, Alsanory TA, et al. Dietary Effects of Nanopowder Eggshells on Mineral Contents, Bone Turnover Biomarkers, and Regulators of Bone Resorption in Healthy Rats and Ovariectomy-Induced Osteoporosis Rat Model. Appl Biochem Biotechnol. 2023;195:5034. 10.1007/s12010-022-04038-9
