Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 40 Researches
7.5
USERS' SCORE
Moderately Good
Based on 17 Reviews
7.8
Supplement Facts
Serving Size:  3 Caplets
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
15 mcg (600 IU)
75%
Calcium  (as Calcium Carbonate and Calcium Gluconate)
1,000 mg
77%
Magnesium  (as Magnesium Oxide and Magnesium Gluconate)
400 mg
95%
Zinc (as Zinc Gluconate and Zinc Citrate)
25 mg
227%
Sodium
10 mg
<1%

Top Medical Research Studies

8
Vitamin D's effect on acne
We examined how vitamin D levels relate to acne and the potential connection with acne severity. By analyzing data from various studies, we found that 1,362 individuals with acne were compared against 1,081 healthy controls.

Our findings revealed that those with acne had significantly lower vitamin D levels compared to the healthy participants. Additionally, vitamin D deficiency was more prevalent among acne sufferers. Interestingly, we also observed a negative correlation between vitamin D levels and acne severity, suggesting that lower levels of this vitamin might be associated with more severe acne.

This evidence points to the possibility that vitamin D plays a role in acne development. However, while our results are compelling, they encourage further investigation into how vitamin D might influence acne severity and whether its supplementation could be beneficial for those affected by this condition.
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8
Vitamin D and acne relationship examined
We sought to understand the connection between vitamin D levels and acne, along with how vitamin D supplementation might help those suffering from this common skin condition. Our investigation included various studies from a range of databases, focusing on the serum levels of a specific form of vitamin D—25(OH)D—and the effectiveness of vitamin D supplements for acne patients.

In our findings, we discovered that individuals with acne generally had lower serum levels of vitamin D. Specifically, the data revealed a significant difference, with acne patients showing a standardized mean difference of -7.66 ng/ml in vitamin D levels compared to those without the condition. Importantly, the articles we reviewed also pointed out the potential for vitamin D supplements to serve as a therapeutic option for improving acne.

Overall, this research contributes valuable insights into how vitamin D may play a role in managing acne, suggesting that addressing vitamin D deficiency in patients could have positive outcomes for their skin health.
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8
Zinc effective for acne treatment
We explored how zinc affects acne through a systematic review and meta-analysis that looked at two main questions. First, we wanted to know if there are differences in zinc levels between people with acne and those without. Second, we examined how effective zinc treatments are for managing acne.

Our findings showed that individuals with acne had noticeably lower serum zinc levels compared to those in the control group. Furthermore, when we looked at treatments, those who received zinc showed a significant reduction in their inflammatory papule count—a common symptom of acne. Importantly, we noted that side effects from zinc supplementation were similar to those seen in other treatments, suggesting that zinc is safe to use.

Overall, acne patients appear to benefit from improved zinc levels, especially when zinc is used either on its own or alongside other acne treatments. This gives hope for those looking for effective ways to tackle acne issues!
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Most Useful Reviews

9.5
Fewer acne spots
I really like these vitamins; my skin has improved, with fewer acne spots.
Read More
8.8
Convenient results
Excellent complex with noticeable results! It's convenient to take, just once daily with a meal. I've observed that my hair falls out less, my nails have improved, and acne on my face is less painful if it does occur. I've also felt calmer overall. This complex dietary supplement is quite effective.
Read More
8.8
Supports acne treatment
I consistently order this product due to my acne-prone skin and the need for zinc. It also contains calcium and vitamin D for bone health, which I enjoy taking.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 40 Researches
7.5
  • All Researches
9.5
Magnesium supplementation shows promise
We examined how dietary supplementation with magnesium, among other nutrients, could help treat acne vulgaris. In a six-month study, one group received this natural supplement while another was given isotretinoin.

Notably, all participants in the magnesium group reported complete regression of their symptoms, contrasting with 68% in the isotretinoin group. This significant difference suggests that magnesium can be highly effective for acne treatment, offering a promising alternative with fewer side effects.
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9.5
Zinc's role in acne treatment
We investigated the effectiveness of a novel microneedle patch designed for acne treatment, which incorporates zinc-based nanoparticles. This patch combines sodium hyaluronate with zinc porphyrin-based metal-organic frameworks and zinc oxide. By using ultrasound to release activated oxygen, we observed a remarkable antibacterial efficiency, achieving a 99.73% reduction in acne-causing bacteria within just 15 minutes.

Zinc plays a crucial role in this innovative approach. Not only does it help eliminate harmful bacteria, but it also appears to enhance skin health. The presence of zinc ions promotes the up-regulation of genes associated with DNA replication, which supports the growth of fibroblasts. This is a vital process for skin repair and rejuvenation, showing that zinc can potentially contribute to both the treatment and recovery of acne-affected skin.

Overall, our findings suggest that this microneedle patch, which utilizes zinc and ultrasound-responsive technology, represents a promising strategy for effectively managing acne without relying on traditional antibiotics.
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9
Calcium filler shows promise for scars
We explored the effectiveness of combining microfocused ultrasound with a calcium hydroxylapatite dermal filler for treating acne scars. This approach was evaluated in a group of healthy adults aged 35-55, who had moderate to severe facial scars from acne.

During the treatment, ultrasound was applied in a cross-hatch pattern to stimulate the skin, followed by injections of a diluted calcium hydroxylapatite filler mixed with lidocaine for comfort. The results were assessed 90 days later, focusing on changes in scar severity and overall satisfaction of the subjects.

The findings revealed significant improvement in acne scars, particularly in those with severe scarring. The majority of participants reported being satisfied with their results, and no adverse side effects were noted. While calcium hydroxylapatite alone was not isolated in this study, its combination with ultrasound showed promising results for reducing scar visibility.
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We investigated how zinc treatment affects acne, particularly focusing on its potential benefits for those suffering from acne rosacea. The study observed that zinc sulfate solution at a concentration of 5% played a notable role in reducing the severity of acne rosacea symptoms.

Findings indicated that around 40% to 60% of patients experienced a moderate to good response after using zinc. This suggests that zinc could be helpful for individuals looking for alternatives or supplements in their acne treatment regimen.

However, it's important to acknowledge that while zinc showed positive results, the isolated effect of zinc alone cannot be fully determined. It might have worked in conjunction with other treatment factors, which complicates our understanding of its effectiveness.

Therefore, we emphasize the need for further studies to clarify exactly how zinc contributes to acne treatment outcomes and to evaluate its role alongside other therapies.
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9
We assessed the potential of zinc oxide nanoparticles in combating acne. Using biogenically synthesized zinc oxide, we mixed it with a polymer to create a topical nanogel aimed at treating acne. Through rigorous testing against acne-causing bacteria, we observed that these biogenic nanoparticles showed a promising antibacterial effect, particularly against Gram-positive bacteria.

Notably, the particle size of our biogenic zinc oxide nanoparticles measured around 20 nm, indicating a high degree of purity. When pitted against chemogenic counterparts, the biogenic version proved to be more effective. This suggests that zinc oxide, especially when produced biogenically, could be a valuable addition to skincare products targeting acne.

Moreover, the study highlights the environment-friendly aspect of using biogenic zinc oxide in skincare formulations, making it a preferable choice for those concerned about sustainability. Our findings suggest that these hybrid nanogels could serve as an effective solution against skin infections associated with acne, adding to their appeal in modern skincare.
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User Reviews

USERS' SCORE
Moderately Good
Based on 17 Reviews
7.8
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9.5
Fewer acne spots
I really like these vitamins; my skin has improved, with fewer acne spots.
Read More
8.8
Convenient results
Excellent complex with noticeable results! It's convenient to take, just once daily with a meal. I've observed that my hair falls out less, my nails have improved, and acne on my face is less painful if it does occur. I've also felt calmer overall. This complex dietary supplement is quite effective.
Read More
8.8
Supports acne treatment
I consistently order this product due to my acne-prone skin and the need for zinc. It also contains calcium and vitamin D for bone health, which I enjoy taking.
Read More
8.3
Effective acne solution
Affordable but effective, I bought this since many friends mentioned a magnesium or zinc deficiency may cause my acne. This supplement has definitely helped me with my acne.
Read More
6.8
Sleep improvement
The doctor advised me to take this at night due to a stressful period. Since starting, I have been sleeping better, and the cramps in my legs have disappeared. It helps reduce acne, but the effects take about 10 days to notice. The composition is excellent and the quality is good; I noticed results after two weeks.
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Frequently Asked Questions

No FAQs are available for this product and symptom.

References

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  2. Antonino A, Francesco A. Prospective and randomized comparative study of calcium hydroxylapatite vs calcium hydroxylapatite plus HIFU in treatment of moderate-to-severe acne scars. J Cosmet Dermatol. 2021;20:53. doi:10.1111/jocd.13472
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  5. Zouboulis CC, Seltmann H, Abdel-Naser MB, Hossini AM, Menon GK, et al. Effects of Extracellular Calcium and 1,25 dihydroxyvitamin D3 on Sebaceous Gland Cells In vitro and In vivo. Acta Derm Venereol. 2017;97:313. doi:10.2340/00015555-2525
  6. Dahlan NH, Sitohang IBS, Indriatmi W, Wibowo H, Enggy LE. Correlation Between Reduced IL-1β Levels in Acne Lesions and the Decrease in Acne Inflammatory Lesions Following Topical Vitamin D Administration: A Double-Blind Randomized Controlled Trial. Clin Cosmet Investig Dermatol. 2024;17:2183. doi:10.2147/CCID.S475068
  7. Talida V, Tudor SS, Mihaela I, Daniela-Rodica M, Gabriela A F, et al. The Impact of Vitamin D Receptor Gene Polymorphisms () in Correlation with Oxidative Stress and Hormonal and Dermatologic Manifestations in Polycystic Ovary Syndrome. Medicina (Kaunas). 2024;60. doi:10.3390/medicina60091501
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  14. Shrestha S, Agrawal S, Lamsal M. Vitamin D level in patients with moderate-to-severe acne: A case-control study combined with prospective study following oral isotretinoin treatment. J Cosmet Dermatol. 2022;21:5127. doi:10.1111/jocd.14996
  15. Singh A, Khurana A, Sardana K, Dixit N, Chitkara A. Correlation of Serum 25-Hydroxy Vitamin D and Interleukin-17 Levels with Disease Severity in Acne Vulgaris. Indian J Dermatol. 2021;66:291. doi:10.4103/ijd.IJD_551_19
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  21. Li M, Tang Y, Lin C, Huang Q, Lei D, et al. Serum Macroelement and Microelement Concentrations in Patients with Polycystic Ovary Syndrome: a Cross-Sectional Study. Biol Trace Elem Res. 2017;176:73. doi:10.1007/s12011-016-0782-4
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  27. Akman TC, Yazici M, Atila A, Mertoglu C. Analysis of Isotretinoin-Induced Alterations in the Levels of Plasma Trace Elements: Investigation of the Relationship Between Magnesium, Phosphorus, Potassium, Zinc, and Treatment-Related Side Effects. Biol Trace Elem Res. 2024;202:4858. doi:10.1007/s12011-023-04053-9
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