Infographics 
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 40 Researches
7.5
USERS' SCORE
Moderately Good
Based on 17 Reviews
7.2
Supplement Facts
Serving Size: 3 Caplets
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
15 mcg (600 IU)
75%
Calcium (as Calcium Carbonate and Calcium Gluconate)
1,000 mg
77%
Magnesium (as Magnesium Oxide and Magnesium Gluconate)
400 mg
95%
Zinc (as Zinc Gluconate and Zinc Citrate)
25 mg
227%
Sodium
10 mg
<1%
Top Medical Research Studies
8
We examined how vitamin D levels relate to acne and the potential connection with acne severity. By analyzing data from various studies, we found that 1,362 individuals with acne were compared against 1,081 healthy controls.
Our findings revealed that those with acne had significantly lower vitamin D levels compared to the healthy participants. Additionally, vitamin D deficiency was more prevalent among acne sufferers. Interestingly, we also observed a negative correlation between vitamin D levels and acne severity, suggesting that lower levels of this vitamin might be associated with more severe acne.
This evidence points to the possibility that vitamin D plays a role in acne development. However, while our results are compelling, they encourage further investigation into how vitamin D might influence acne severity and whether its supplementation could be beneficial for those affected by this condition.
Our findings revealed that those with acne had significantly lower vitamin D levels compared to the healthy participants. Additionally, vitamin D deficiency was more prevalent among acne sufferers. Interestingly, we also observed a negative correlation between vitamin D levels and acne severity, suggesting that lower levels of this vitamin might be associated with more severe acne.
This evidence points to the possibility that vitamin D plays a role in acne development. However, while our results are compelling, they encourage further investigation into how vitamin D might influence acne severity and whether its supplementation could be beneficial for those affected by this condition.
Read More
8
We sought to understand the connection between vitamin D levels and acne, along with how vitamin D supplementation might help those suffering from this common skin condition. Our investigation included various studies from a range of databases, focusing on the serum levels of a specific form of vitamin D—25(OH)D—and the effectiveness of vitamin D supplements for acne patients.
In our findings, we discovered that individuals with acne generally had lower serum levels of vitamin D. Specifically, the data revealed a significant difference, with acne patients showing a standardized mean difference of -7.66 ng/ml in vitamin D levels compared to those without the condition. Importantly, the articles we reviewed also pointed out the potential for vitamin D supplements to serve as a therapeutic option for improving acne.
Overall, this research contributes valuable insights into how vitamin D may play a role in managing acne, suggesting that addressing vitamin D deficiency in patients could have positive outcomes for their skin health.
In our findings, we discovered that individuals with acne generally had lower serum levels of vitamin D. Specifically, the data revealed a significant difference, with acne patients showing a standardized mean difference of -7.66 ng/ml in vitamin D levels compared to those without the condition. Importantly, the articles we reviewed also pointed out the potential for vitamin D supplements to serve as a therapeutic option for improving acne.
Overall, this research contributes valuable insights into how vitamin D may play a role in managing acne, suggesting that addressing vitamin D deficiency in patients could have positive outcomes for their skin health.
Read More
8
We explored how zinc affects acne through a systematic review and meta-analysis that looked at two main questions. First, we wanted to know if there are differences in zinc levels between people with acne and those without. Second, we examined how effective zinc treatments are for managing acne.
Our findings showed that individuals with acne had noticeably lower serum zinc levels compared to those in the control group. Furthermore, when we looked at treatments, those who received zinc showed a significant reduction in their inflammatory papule count—a common symptom of acne. Importantly, we noted that side effects from zinc supplementation were similar to those seen in other treatments, suggesting that zinc is safe to use.
Overall, acne patients appear to benefit from improved zinc levels, especially when zinc is used either on its own or alongside other acne treatments. This gives hope for those looking for effective ways to tackle acne issues!
Our findings showed that individuals with acne had noticeably lower serum zinc levels compared to those in the control group. Furthermore, when we looked at treatments, those who received zinc showed a significant reduction in their inflammatory papule count—a common symptom of acne. Importantly, we noted that side effects from zinc supplementation were similar to those seen in other treatments, suggesting that zinc is safe to use.
Overall, acne patients appear to benefit from improved zinc levels, especially when zinc is used either on its own or alongside other acne treatments. This gives hope for those looking for effective ways to tackle acne issues!
Read More
Most Useful Reviews
9
Effective acne solution
Affordable but effective, I bought this since many friends mentioned a magnesium or zinc deficiency may cause my acne. This supplement has definitely helped me with my acne.
Read More
9
Fewer acne spots
I really like these vitamins; my skin has improved, with fewer acne spots.
Read More
7.5
Convenient results
Excellent complex with noticeable results! It's convenient to take, just once daily with a meal. I've observed that my hair falls out less, my nails have improved, and acne on my face is less painful if it does occur. I've also felt calmer overall. This complex dietary supplement is quite effective.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 40 Researches
7.5
- All Researches
9.5
We examined how dietary supplementation with magnesium, among other nutrients, could help treat acne vulgaris. In a six-month study, one group received this natural supplement while another was given isotretinoin.
Notably, all participants in the magnesium group reported complete regression of their symptoms, contrasting with 68% in the isotretinoin group. This significant difference suggests that magnesium can be highly effective for acne treatment, offering a promising alternative with fewer side effects.
Notably, all participants in the magnesium group reported complete regression of their symptoms, contrasting with 68% in the isotretinoin group. This significant difference suggests that magnesium can be highly effective for acne treatment, offering a promising alternative with fewer side effects.
Read More
9.5
We investigated the effectiveness of a novel microneedle patch designed for acne treatment, which incorporates zinc-based nanoparticles. This patch combines sodium hyaluronate with zinc porphyrin-based metal-organic frameworks and zinc oxide. By using ultrasound to release activated oxygen, we observed a remarkable antibacterial efficiency, achieving a 99.73% reduction in acne-causing bacteria within just 15 minutes.
Zinc plays a crucial role in this innovative approach. Not only does it help eliminate harmful bacteria, but it also appears to enhance skin health. The presence of zinc ions promotes the up-regulation of genes associated with DNA replication, which supports the growth of fibroblasts. This is a vital process for skin repair and rejuvenation, showing that zinc can potentially contribute to both the treatment and recovery of acne-affected skin.
Overall, our findings suggest that this microneedle patch, which utilizes zinc and ultrasound-responsive technology, represents a promising strategy for effectively managing acne without relying on traditional antibiotics.
Zinc plays a crucial role in this innovative approach. Not only does it help eliminate harmful bacteria, but it also appears to enhance skin health. The presence of zinc ions promotes the up-regulation of genes associated with DNA replication, which supports the growth of fibroblasts. This is a vital process for skin repair and rejuvenation, showing that zinc can potentially contribute to both the treatment and recovery of acne-affected skin.
Overall, our findings suggest that this microneedle patch, which utilizes zinc and ultrasound-responsive technology, represents a promising strategy for effectively managing acne without relying on traditional antibiotics.
Read More
9
We explored the effectiveness of combining microfocused ultrasound with a calcium hydroxylapatite dermal filler for treating acne scars. This approach was evaluated in a group of healthy adults aged 35-55, who had moderate to severe facial scars from acne.
During the treatment, ultrasound was applied in a cross-hatch pattern to stimulate the skin, followed by injections of a diluted calcium hydroxylapatite filler mixed with lidocaine for comfort. The results were assessed 90 days later, focusing on changes in scar severity and overall satisfaction of the subjects.
The findings revealed significant improvement in acne scars, particularly in those with severe scarring. The majority of participants reported being satisfied with their results, and no adverse side effects were noted. While calcium hydroxylapatite alone was not isolated in this study, its combination with ultrasound showed promising results for reducing scar visibility.
During the treatment, ultrasound was applied in a cross-hatch pattern to stimulate the skin, followed by injections of a diluted calcium hydroxylapatite filler mixed with lidocaine for comfort. The results were assessed 90 days later, focusing on changes in scar severity and overall satisfaction of the subjects.
The findings revealed significant improvement in acne scars, particularly in those with severe scarring. The majority of participants reported being satisfied with their results, and no adverse side effects were noted. While calcium hydroxylapatite alone was not isolated in this study, its combination with ultrasound showed promising results for reducing scar visibility.
Read More
9
We investigated how zinc treatment affects acne, particularly focusing on its potential benefits for those suffering from acne rosacea. The study observed that zinc sulfate solution at a concentration of 5% played a notable role in reducing the severity of acne rosacea symptoms.
Findings indicated that around 40% to 60% of patients experienced a moderate to good response after using zinc. This suggests that zinc could be helpful for individuals looking for alternatives or supplements in their acne treatment regimen.
However, it's important to acknowledge that while zinc showed positive results, the isolated effect of zinc alone cannot be fully determined. It might have worked in conjunction with other treatment factors, which complicates our understanding of its effectiveness.
Therefore, we emphasize the need for further studies to clarify exactly how zinc contributes to acne treatment outcomes and to evaluate its role alongside other therapies.
Findings indicated that around 40% to 60% of patients experienced a moderate to good response after using zinc. This suggests that zinc could be helpful for individuals looking for alternatives or supplements in their acne treatment regimen.
However, it's important to acknowledge that while zinc showed positive results, the isolated effect of zinc alone cannot be fully determined. It might have worked in conjunction with other treatment factors, which complicates our understanding of its effectiveness.
Therefore, we emphasize the need for further studies to clarify exactly how zinc contributes to acne treatment outcomes and to evaluate its role alongside other therapies.
Read More
9
We assessed the potential of zinc oxide nanoparticles in combating acne. Using biogenically synthesized zinc oxide, we mixed it with a polymer to create a topical nanogel aimed at treating acne. Through rigorous testing against acne-causing bacteria, we observed that these biogenic nanoparticles showed a promising antibacterial effect, particularly against Gram-positive bacteria.
Notably, the particle size of our biogenic zinc oxide nanoparticles measured around 20 nm, indicating a high degree of purity. When pitted against chemogenic counterparts, the biogenic version proved to be more effective. This suggests that zinc oxide, especially when produced biogenically, could be a valuable addition to skincare products targeting acne.
Moreover, the study highlights the environment-friendly aspect of using biogenic zinc oxide in skincare formulations, making it a preferable choice for those concerned about sustainability. Our findings suggest that these hybrid nanogels could serve as an effective solution against skin infections associated with acne, adding to their appeal in modern skincare.
Notably, the particle size of our biogenic zinc oxide nanoparticles measured around 20 nm, indicating a high degree of purity. When pitted against chemogenic counterparts, the biogenic version proved to be more effective. This suggests that zinc oxide, especially when produced biogenically, could be a valuable addition to skincare products targeting acne.
Moreover, the study highlights the environment-friendly aspect of using biogenic zinc oxide in skincare formulations, making it a preferable choice for those concerned about sustainability. Our findings suggest that these hybrid nanogels could serve as an effective solution against skin infections associated with acne, adding to their appeal in modern skincare.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 17 Reviews
7.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective acne solution
Affordable but effective, I bought this since many friends mentioned a magnesium or zinc deficiency may cause my acne. This supplement has definitely helped me with my acne.
Read More
9
Fewer acne spots
I really like these vitamins; my skin has improved, with fewer acne spots.
Read More
7.5
Convenient results
Excellent complex with noticeable results! It's convenient to take, just once daily with a meal. I've observed that my hair falls out less, my nails have improved, and acne on my face is less painful if it does occur. I've also felt calmer overall. This complex dietary supplement is quite effective.
Read More
7.5
Supports acne treatment
I consistently order this product due to my acne-prone skin and the need for zinc. It also contains calcium and vitamin D for bone health, which I enjoy taking.
Read More
6
Sleep improvement
97 people found this helpful
The doctor advised me to take this at night due to a stressful period. Since starting, I have been sleeping better, and the cramps in my legs have disappeared. It helps reduce acne, but the effects take about 10 days to notice. The composition is excellent and the quality is good; I noticed results after two weeks.
Read More
Frequently Asked Questions
6
Sleep improvement
97 people found this helpful
The doctor advised me to take this at night due to a stressful period. Since starting, I have been sleeping better, and the cramps in my legs have disappeared. It helps reduce acne, but the effects take about 10 days to notice. The composition is excellent and the quality is good; I noticed results after two weeks.
6
Less painful acne
I find taking these vitamins quite convenient—just one capsule daily with meals, which doesn't require much time. After a month of use, I noticed that my hair is shedding less, my nails have improved, and if acne appears on my face, it is no longer as painful. I also feel a bit calmer concerning my nervous system. Overall, I appreciate the vitamins.
9
Fewer acne spots
I really like these vitamins; my skin has improved, with fewer acne spots.
9
Significant acne reduction
An outstanding complex that my family uses. Following Covid, my mother's hair condition improved after a month of use. My niece struggled with acne, but now her skin is much clearer and inflammation has subsided. We are very pleased with the results!
7.5
Convenient results
Excellent complex with noticeable results! It's convenient to take, just once daily with a meal. I've observed that my hair falls out less, my nails have improved, and acne on my face is less painful if it does occur. I've also felt calmer overall. This complex dietary supplement is quite effective.
7.5
Visible acne improvement
My husband and I regularly take magnesium and zinc supplements. My husband suffers from severe leg cramps, while I have acne on my t-zone due to hormonal imbalance. I decided to combine these elements into one supplement. Pros include three microelements, a large quantity, visible results, excellent quality, and good pricing, making it accessible.
6
Stabilises skin conditions
Under stress at work, I began taking magnesium combined with calcium, vitamin D, and zinc. It calms my mood, and I find that it helps combat occasional acne on my chin triggered by hormonal imbalance.
0
Not beneficial
Unfortunately, I had a negative experience and it caused acne. My hair fell out while taking it, and I found the composition to be poor. I am not happy with it.
7.5
Improved skin condition
The complex is excellent, providing everything necessary to support immunity. I appreciate the quality; calcium and magnesium complement each other for better absorption, while zinc bolsters the immune system and enhances skin condition, particularly in relation to acne. I certainly noticed an improvement. The delivery is my favourite, and the taste is acceptable. Additionally, I experienced increased invigoration, energy, and endurance, and vitamin D3 contributed to my activity.
7.5
Clear skin achieved
I repurchased this for my son, a teenager with knee joint issues. It is vital for him to take calcium regularly. I appreciate that it includes magnesium, zinc, and vitamin D, essential for a growing child and effective in combating acne, promoting clearer skin.
8
We examined how calcium treatment influences sebum production, particularly in relation to acne. Sebocytes, the cells in our skin that produce oil, were treated with calcium, and we confirmed increased lipid production using well-established techniques. This response is important because excessive sebum is a key factor in acne development.
Our findings showed that calcium not only increased the overall sebum output but also stepped up the levels of several key regulators involved in the lipogenesis process. Notably, we observed that calcium treatment boosted the expression of proteins like SREBP1, which plays a crucial role in managing lipid levels in skin cells.
We also discovered that the transcription factor KLF4 was elevated with calcium treatment. This raised a fascinating question: could KLF4 be enhancing lipid production? To test this, we overexpressed KLF4 in sebocytes, and indeed found that it further stimulated the expression of lipid-producing proteins and increased overall lipid production.
In conclusion, our study sheds light on the significant role of calcium in sebum production and highlights KLF4 as a promising new regulator in this process. These insights may open doors for developing more effective acne treatments by targeting sebum production pathways.
Our findings showed that calcium not only increased the overall sebum output but also stepped up the levels of several key regulators involved in the lipogenesis process. Notably, we observed that calcium treatment boosted the expression of proteins like SREBP1, which plays a crucial role in managing lipid levels in skin cells.
We also discovered that the transcription factor KLF4 was elevated with calcium treatment. This raised a fascinating question: could KLF4 be enhancing lipid production? To test this, we overexpressed KLF4 in sebocytes, and indeed found that it further stimulated the expression of lipid-producing proteins and increased overall lipid production.
In conclusion, our study sheds light on the significant role of calcium in sebum production and highlights KLF4 as a promising new regulator in this process. These insights may open doors for developing more effective acne treatments by targeting sebum production pathways.
8
We explored how calcium may impact skin health, particularly in relation to acne. The study utilized an innovative screening method to identify effective exfoliating agents, focusing on amino acids like carnitine and serine. While the results highlighted these agents as effective in enhancing skin exfoliation, the study also noted the role of calcium.
However, it’s important to clarify that while calcium was mentioned, the study did not specifically isolate its effects on acne treatment. The agents tested showed effective results in improving the skin's turnover rate, hinting at potential benefits for various skin issues, including dullness and minor acne.
Ultimately, while the research signifies the promise of calcium in skincare, it stops short of stating it as a proven treatment for acne. For now, the focus remains on agents like carnitine and serine, which could support healthier skin through enhanced exfoliation.
However, it’s important to clarify that while calcium was mentioned, the study did not specifically isolate its effects on acne treatment. The agents tested showed effective results in improving the skin's turnover rate, hinting at potential benefits for various skin issues, including dullness and minor acne.
Ultimately, while the research signifies the promise of calcium in skincare, it stops short of stating it as a proven treatment for acne. For now, the focus remains on agents like carnitine and serine, which could support healthier skin through enhanced exfoliation.
8
We explored the effectiveness of calcium hydroxylapatite as a treatment for moderate to severe atrophic acne scars. In a carefully structured study, twenty women with noticeable acne scars were treated with calcium hydroxylapatite alone and also in combination with high-intensity microfocused ultrasound (HIFU).
Our assessments showed promising results. After just one month, those who received the calcium treatment noted an improvement in their skin texture and wrinkles when compared to those who received a placebo. By three and six months, every participant in the study reported an improvement in their acne scars.
However, it's important to highlight that while the calcium treatment was indeed effective, adding HIFU did not provide any additional benefits beyond the results seen from calcium alone. This suggests that while calcium hydroxylapatite stands out as a solid option for tackling acne scars, pairing it with HIFU doesn’t necessarily enhance its effectiveness.
Our assessments showed promising results. After just one month, those who received the calcium treatment noted an improvement in their skin texture and wrinkles when compared to those who received a placebo. By three and six months, every participant in the study reported an improvement in their acne scars.
However, it's important to highlight that while the calcium treatment was indeed effective, adding HIFU did not provide any additional benefits beyond the results seen from calcium alone. This suggests that while calcium hydroxylapatite stands out as a solid option for tackling acne scars, pairing it with HIFU doesn’t necessarily enhance its effectiveness.
References
- Li X, Zeng X, Kim D, Jiang J, Wei F, et al. Krüppel-like factor 4 (KLF4) facilitates lipid production in immortalized human sebocytes via regulating the expression of SREBP1. Biochem Biophys Res Commun. 2023;667:146. 10.1016/j.bbrc.2023.05.043
- Antonino A, Francesco A. Prospective and randomized comparative study of calcium hydroxylapatite vs calcium hydroxylapatite plus HIFU in treatment of moderate-to-severe acne scars. J Cosmet Dermatol. 2021;20:53. 10.1111/jocd.13472
- Ahn B, Lee SH, Kim JH, Goh A, Park SG, et al. Identification and validation of amino acid-based mild exfoliating agents through a de novo screening method. J Cosmet Dermatol. 2019;18:1404. 10.1111/jocd.12871
- Casabona G. Combined use of microfocused ultrasound and a calcium hydroxylapatite dermal filler for treating atrophic acne scars: A pilot study. J Cosmet Laser Ther. 2018;20:301. 10.1080/14764172.2017.1406606
- Zouboulis CC, Seltmann H, Abdel-Naser MB, Hossini AM, Menon GK, et al. Effects of Extracellular Calcium and 1,25 dihydroxyvitamin D3 on Sebaceous Gland Cells In vitro and In vivo. Acta Derm Venereol. 2017;97:313. 10.2340/00015555-2525
- Dahlan NH, Sitohang IBS, Indriatmi W, Wibowo H, Enggy LE. Correlation Between Reduced IL-1β Levels in Acne Lesions and the Decrease in Acne Inflammatory Lesions Following Topical Vitamin D Administration: A Double-Blind Randomized Controlled Trial. Clin Cosmet Investig Dermatol. 2024;17:2183. 10.2147/CCID.S475068
- Talida V, Tudor SS, Mihaela I, Daniela-Rodica M, Gabriela A F, et al. The Impact of Vitamin D Receptor Gene Polymorphisms () in Correlation with Oxidative Stress and Hormonal and Dermatologic Manifestations in Polycystic Ovary Syndrome. Medicina (Kaunas). 2024;60. 10.3390/medicina60091501
- Ruikchuchit T, Juntongjin P. Role of vitamin D supplement adjunct to topical benzoyl peroxide in acne: a randomized double-blinded controlled study. Int J Womens Dermatol. 2024;10:e163. 10.1097/JW9.0000000000000163
- Hussein RS, Dayel SB, Abahussein O. Prospective study of the effects of isotretinoin and vitamin D levels on severe acne vulgaris. Turk J Med Sci. 2023;53:1732. 10.55730/1300-0144.5742
- Mahran A, Ghazally A, Ali AS, Bakr RM. Efficacy and safety of calcipotriol as a potential topical treatment of acne vulgaris: a randomized, controlled, triple blinded, split-face clinical trial. Clin Exp Dermatol. 2024;49:348. 10.1093/ced/llad371
- Iqbal T, Asim SA, Bhatti S, Sajid M, Mirza R, et al. Association of Vitamin D with Moderate to Severe Acne Vulgaris. J Coll Physicians Surg Pak. 2023;33:527. 10.29271/jcpsp.2023.05.527
- Abdel-Wahab HM, Ali AK, Ragaie MH. Calcipotriol: A novel tool in treatment of acne vulgaris. Dermatol Ther. 2022;35:e15690. 10.1111/dth.15690
- Rasti SD, Dewinta NR, Kamal RH, Adissadah AF, Madanny AE, et al. Correlation between Serum 25-Hydroxy Vitamin D Levels and the Severity of Acne Vulgaris: A Systematic Review. Indian J Dermatol. 2022;67:31. 10.4103/ijd.ijd_871_21
- Shrestha S, Agrawal S, Lamsal M. Vitamin D level in patients with moderate-to-severe acne: A case-control study combined with prospective study following oral isotretinoin treatment. J Cosmet Dermatol. 2022;21:5127. 10.1111/jocd.14996
- Singh A, Khurana A, Sardana K, Dixit N, Chitkara A. Correlation of Serum 25-Hydroxy Vitamin D and Interleukin-17 Levels with Disease Severity in Acne Vulgaris. Indian J Dermatol. 2021;66:291. 10.4103/ijd.IJD_551_19
- Hasamoh Y, Thadanipon K, Juntongjin P. Association between Vitamin D Level and Acne, and Correlation with Disease Severity: A Meta-Analysis. Dermatology. 2022;238:404. 10.1159/000517514
- Wang M, Zhou Y, Yan Y. Vitamin D status and efficacy of vitamin D supplementation in acne patients: A systematic review and meta-analysis. J Cosmet Dermatol. 2021;20:3802. 10.1111/jocd.14057
- Singh A, Dorjay K, Sinha S, Chitkara A. The interplay of vitamin D and body mass index in acne patients vs. controls. J Cosmet Dermatol. 2021;20:3689. 10.1111/jocd.14034
- Kemeriz F, Tuncer SÇ, Acar EM, Tuğrul B. Evaluation of 25-hydroxy vitamin D levels and disease severity in patients with acne vulgaris. Dermatol Ther. 2020;33:e13393. 10.1111/dth.13393
- Welch K, Latifzada MA, Frykstrand S, Strømme M. Investigation of the Antibacterial Effect of Mesoporous Magnesium Carbonate. ACS Omega. 2016;1:907. 10.1021/acsomega.6b00124
- Li M, Tang Y, Lin C, Huang Q, Lei D, et al. Serum Macroelement and Microelement Concentrations in Patients with Polycystic Ovary Syndrome: a Cross-Sectional Study. Biol Trace Elem Res. 2017;176:73. 10.1007/s12011-016-0782-4
- Lee WJ, Kim SL, Choe YS, Jang YH, Lee SJ, et al. Magnesium Ascorbyl Phosphate Regulates the Expression of Inflammatory Biomarkers in Cultured Sebocytes. Ann Dermatol. 2015;27:376. 10.5021/ad.2015.27.4.376
- Pezza M, Carlomagno V, Sammarco E, Trischitta A, Ceddia C, et al. Association of Myo-Inositol and Microlipodispersed Magnesium in Androgen-Dependent Dermatological Diseases: A Retrospective Study. Pharmaceuticals (Basel). 2025;18. 10.3390/ph18020251
- de Souza Pereira R. Treatment of Resistant Acne Vulgaris in Adolescents Using Dietary Supplementation with Magnesium, Phosphate and Fatty Acids (Omega 6 and 7): Comparison with 13-Cis-Retinoic Acid. J Diet Suppl. 2023;20:706. 10.1080/19390211.2022.2100550
- Li L, Hajam I, McGee JS, Tang Z, Zhang Y, et al. Comparative transcriptome analysis of acne vulgaris, rosacea, and hidradenitis suppurativa supports high-dose dietary zinc as a therapeutic agent. Exp Dermatol. 2024;33:e15145. 10.1111/exd.15145
- Algarin YA, Pulumati A, Jaalouk D, Tan J, Nouri K. The role of vitamins and nutrients in rosacea. Arch Dermatol Res. 2024;316:142. 10.1007/s00403-024-02895-4
- Akman TC, Yazici M, Atila A, Mertoglu C. Analysis of Isotretinoin-Induced Alterations in the Levels of Plasma Trace Elements: Investigation of the Relationship Between Magnesium, Phosphorus, Potassium, Zinc, and Treatment-Related Side Effects. Biol Trace Elem Res. 2024;202:4858. 10.1007/s12011-023-04053-9
- Li L, Hajam I, McGee JS, Tang Z, Zhang Y, et al. Comparative Transcriptome Analysis of Acne vulgaris, Rosacea, and Hidradenitis Suppurativa Supports High Dose Dietary Zinc as a Therapeutic Agent. medRxiv. 2023. 10.1101/2023.11.28.23299152
- Shields A, Ly S, Wafae B, Chang YF, Manjaly P, et al. Safety and Effectiveness of Oral Nutraceuticals for Treating Acne: A Systematic Review. JAMA Dermatol. 2023;159:1373. 10.1001/jamadermatol.2023.3949
- Tan YY, Wong LS, Nyam KL, Wittayanarakul K, Zawawi NA, et al. Development and Evaluation of Topical Zinc Oxide Nanogels Formulation Using and Its Effect on Acne Vulgaris. Molecules. 2023;28. 10.3390/molecules28196749
- Xiang Y, Lu J, Mao C, Zhu Y, Wang C, et al. Ultrasound-triggered interfacial engineering-based microneedle for bacterial infection acne treatment. Sci Adv. 2023;9:eadf0854. 10.1126/sciadv.adf0854
- Towersey L, Correia P, Fajgenbaum Feiges M, Euzébio Gonçalves Junior J, Sant'Anna B, et al. Assessment of the Benefit of a Deep Cleansing Gel Containing Salicylic Acid 2%, Zinc Gluconate 0.2% and Lipohydroxy Acids 0.05% in Patients with Mild to Moderate Truncal Acne: Results from an Exploratory Study. Clin Cosmet Investig Dermatol. 2023;16:119. 10.2147/CCID.S394123
- Salah E. Oral Zinc as a Novel Adjuvant and Sparing Therapy for Systemic Isotretinoin in Acne Vulgaris: A Preliminary Comparative Study. J Clin Aesthet Dermatol. 2022;15:58.
- Naji HH, Al-Azawi RSA, Ibrahim NJ, Kzar HH. Investigation of the Role of Zn/Cu Index and its Correlation with Physiological Activity of SOD 1 and GRx in Males with Acne Vulgaris. Arch Razi Inst. 2022;77:623. 10.22092/ARI.2021.356857.1928
- Searle T, Ali FR, Al-Niaimi F. Zinc in dermatology. J Dermatolog Treat. 2022;33:2455. 10.1080/09546634.2022.2062282
- Poizeau F, Plantier F, Bell H, Moyal-Barracco M. Vulvar Fordyce adenitis: A cohort of 45 women. Ann Dermatol Venereol. 2021;148:221. 10.1016/j.annder.2021.04.001
- Tolino E, Skroza N, Mambrin A, Proietti I, Bernardini N, et al. An Open-label Study Comparing Oral Zinc to Lymecycline in the Treatment of Acne Vulgaris. J Clin Aesthet Dermatol. 2021;14:56.
- Maillard A, Pastor D, Merat R. Anti-PD-1-Induced Hidradenitis Suppurativa. Dermatopathology (Basel). 2021;8:37. 10.3390/dermatopathology8010007
- Abendrot M, Płuciennik E, Felczak A, Zawadzka K, Piątczak E, et al. Zinc(II) Complexes of Amino Acids as New Active Ingredients for Anti-Acne Dermatological Preparations. Int J Mol Sci. 2021;22. 10.3390/ijms22041641
- Yee BE, Richards P, Sui JY, Marsch AF. Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta-analysis. Dermatol Ther. 2020;33:e14252. 10.1111/dth.14252
