Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.3
USERS' SCORE
Moderately Good
Based on 46 Reviews
7.9
Supplement Facts
Serving Size:  3 Caplets
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
15 mcg (600 IU)
75%
Calcium  (as Calcium Carbonate and Calcium Gluconate)
1,000 mg
77%
Magnesium  (as Magnesium Oxide and Magnesium Gluconate)
400 mg
95%
Zinc (as Zinc Gluconate and Zinc Citrate)
25 mg
227%
Sodium
10 mg
<1%

Top Medical Research Studies

We observed a fascinating case involving a male in his 40s who experienced persistent inflammatory back pain for three months. Despite having a negative test for HLA-B27, a marker often associated with axial spondyloarthritis, clinical assessments suggested possible underlying issues.

The clinical investigation led to an MRI, which confirmed bilateral symmetrical sacroiliitis. Interestingly, further tests showed he had very low vitamin D levels along with elevated parathyroid hormone—indicating a possible deficiency impacting his condition.

After starting treatment with vitamin D alongside nonsteroidal anti-inflammatory drugs (NSAIDs), he experienced notable relief from his symptoms. His condition improved significantly, and follow-up tests indicated that his vitamin D levels had normalized.

This case demonstrates the potential benefits of vitamin D in managing back pain, especially when classical markers are inconclusive. It highlights how a thorough diagnosis can reveal interconnected health issues and improve treatment outcomes.
Read More
We explored the effectiveness of magnesium sulfate (MS) in relieving low back pain (LBP) for patients who underwent iliac venous stenting. This study involved 97 patients, divided into two groups: one received MS infusion during their surgery, while the other did not.

Patients who received MS experienced significantly lower pain levels at all follow-up intervals. We found that, at 24 hours after surgery, those in the magnesium group consumed much less tramadol—a common pain medication—compared to the control group. Additionally, the need for extra pain relief was lower among those who received magnesium.

Importantly, the side effects like nausea and vomiting were similar in both groups, indicating that magnesium can be a safe option for pain management after this type of surgery. Overall, the findings suggest that magnesium sulfate not only alleviates pain but also reduces reliance on opioids, making it a valuable treatment for postoperative care.
Read More
8
Vitamin D alleviates back pain
We conducted a randomized controlled trial to investigate how vitamin D supplementation might alleviate lower back pain in patients suffering from lumbar spinal stenosis. This study involved patients with severely low vitamin D levels, specifically under 10 ng/mL. Participants were divided into two groups: one received vitamin D supplements, while the other did not.

Over a period of several weeks, we measured pain levels and functional recovery using simple questionnaires and health surveys. Notably, we observed that those who received vitamin D injections reported significant improvements in their back pain and overall quality of life compared to those who didn’t.

Our findings suggest that addressing vitamin D deficiency might play a crucial role in managing back pain for individuals with spinal stenosis who are not candidates for surgical intervention. The results demonstrate a promising correlation between high-dose vitamin D supplementation and enhanced functional outcomes in these patients.
Read More

Most Useful Reviews

9
Pain relief achieved
151 people found this helpful
A wonderful complex of minerals! I'm shocked by the effect! I am 39, and for the last two years, I've suffered from severe leg pain, particularly after long walks. After a month of taking these minerals, the pain completely disappeared! I continue with a month on and a month off. I hope my honest feedback helps others.
Read More
9
Knee pain relief
9 people found this helpful
It really relieved my friend’s knee pain! Although it was meant for back pain, she found great relief. After taking it, she returned home in high spirits. I suggested she stock up during a special offer.
Read More
9
Back and joint issues
7 people found this helpful
For this price, my husband and I have taken it intermittently for our third time. I've noticed less hair loss (I also take biotin), while my husband’s back pain has stopped and his knees no longer crack. My previously unhealthy nails are now growing well, despite being infected.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.3
  • All Researches
We observed a fascinating case involving a male in his 40s who experienced persistent inflammatory back pain for three months. Despite having a negative test for HLA-B27, a marker often associated with axial spondyloarthritis, clinical assessments suggested possible underlying issues.

The clinical investigation led to an MRI, which confirmed bilateral symmetrical sacroiliitis. Interestingly, further tests showed he had very low vitamin D levels along with elevated parathyroid hormone—indicating a possible deficiency impacting his condition.

After starting treatment with vitamin D alongside nonsteroidal anti-inflammatory drugs (NSAIDs), he experienced notable relief from his symptoms. His condition improved significantly, and follow-up tests indicated that his vitamin D levels had normalized.

This case demonstrates the potential benefits of vitamin D in managing back pain, especially when classical markers are inconclusive. It highlights how a thorough diagnosis can reveal interconnected health issues and improve treatment outcomes.
Read More
We explored the effectiveness of magnesium sulfate (MS) in relieving low back pain (LBP) for patients who underwent iliac venous stenting. This study involved 97 patients, divided into two groups: one received MS infusion during their surgery, while the other did not.

Patients who received MS experienced significantly lower pain levels at all follow-up intervals. We found that, at 24 hours after surgery, those in the magnesium group consumed much less tramadol—a common pain medication—compared to the control group. Additionally, the need for extra pain relief was lower among those who received magnesium.

Importantly, the side effects like nausea and vomiting were similar in both groups, indicating that magnesium can be a safe option for pain management after this type of surgery. Overall, the findings suggest that magnesium sulfate not only alleviates pain but also reduces reliance on opioids, making it a valuable treatment for postoperative care.
Read More
We explored the impact of calcium and vitamin D supplementation combined with sling core stabilization training on back pain in a 70-year-old female patient suffering from osteoporosis. The patient engaged in this form of exercise three times a week, focusing on strengthening the deep muscles of her spine.

After a year of dedicated training, not only did her back pain significantly improve, but a follow-up examination also indicated an increase in her bone mineral density. This suggests that the combined approach of exercise and supplementation might promote better bone health and potentially reduce pain.

However, it’s important to note that while we saw positive changes in this case, the specific contributions of calcium alone cannot be clearly identified due to the concurrent treatments involved. Therefore, we recognize that further studies are needed to isolate calcium's effects to conclusively determine its role in managing back pain effectively.
Read More
9
Vitamin D aids back pain relief
We conducted a retrospective review to uncover how vitamin D treatment impacts back pain in individuals diagnosed with adult-onset hypophosphatemic osteomalacia. In our exploration, we found that eight patients, primarily experiencing widespread musculoskeletal pain, were assessed over a span from January 2011 to December 2019.

Each patient presented with low phosphorus levels, elevated alkaline phosphatase, and indicative imaging results. Notably, back pain was reported as the most common complaint, along with muscle weakness in over half of the cases. Our findings highlighted the effectiveness of vitamin D in tandem with phosphorus supplementation, as all patients reported significant improvements in pain, muscle strength, and gait after receiving treatment.

Importantly, we noted that the specific diagnosis of each patient varied. In six cases, treatment was prompted by adefovir-induced Fanconi syndrome, while the remaining two patients had tumor-induced osteomalacia and light-chain nephropathy. This variation indicates the diverse etiologies of hypophosphatemic osteomalacia, further emphasizing the importance of targeted treatment based on individual needs.

In conclusion, our study suggests that vitamin D, especially when combined with phosphorus, plays a crucial role in alleviating back pain associated with this condition. By enhancing the understanding of the relationship between vitamin D treatment and back pain, we aim to shed light on effective management strategies for those suffering from similar symptoms.
Read More
9
Magnesium therapy aids back pain
We conducted a double-blind study to evaluate the effectiveness of magnesium therapy for chronic low back pain that has a neuropathic component. Our research involved 80 patients, all of whom were already engaged in physical therapy and taking medications like anticonvulsants and antidepressants.

Among the participants, we divided them into two groups: one group received a placebo for six weeks, while the other group was treated with a two-week intravenous magnesium infusion followed by four weeks of oral magnesium supplements.

The results were promising for those in the magnesium group. By the end of the study, their pain intensity decreased significantly, with scores dropping from an average of 7.5 to 4.7 over six months. Additionally, we observed notable improvements in their lumbar spine mobility, suggesting that magnesium therapy could be beneficial for those suffering from this type of chronic pain.

Overall, our findings indicate that sequential intravenous and oral magnesium treatment can effectively ease pain and enhance mobility in individuals with refractory low back pain featuring a neuropathic aspect.
Read More

User Reviews

USERS' SCORE
Moderately Good
Based on 46 Reviews
7.9
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Pain relief achieved
151 people found this helpful
A wonderful complex of minerals! I'm shocked by the effect! I am 39, and for the last two years, I've suffered from severe leg pain, particularly after long walks. After a month of taking these minerals, the pain completely disappeared! I continue with a month on and a month off. I hope my honest feedback helps others.
Read More
9
Knee pain relief
9 people found this helpful
It really relieved my friend’s knee pain! Although it was meant for back pain, she found great relief. After taking it, she returned home in high spirits. I suggested she stock up during a special offer.
Read More
9
Back and joint issues
7 people found this helpful
For this price, my husband and I have taken it intermittently for our third time. I've noticed less hair loss (I also take biotin), while my husband’s back pain has stopped and his knees no longer crack. My previously unhealthy nails are now growing well, despite being infected.
Read More
9
Knee pain gone
4 people found this helpful
Very good! In the short time I started taking this, I felt an incredible difference. My knee pain just disappeared—praise God.
Read More
9
No more pain
3 people found this helpful
I experienced back pain for six months. Visiting the osteopath helped temporarily. I took this supplement nightly, and recently realised that my back no longer bothers me. I did not alter my lifestyle or see an osteopath, so this dietary supplement must have helped.
Read More

Frequently Asked Questions

9
Inflammation reduction
2 people found this helpful
I've used these vitamins for about three weeks, and they've significantly reduced my back pain caused by Osteoarthritis. The magnesium helps with inflammation, allowing me to work longer hours without discomfort.
9
No more pain
3 people found this helpful
I experienced back pain for six months. Visiting the osteopath helped temporarily. I took this supplement nightly, and recently realised that my back no longer bothers me. I did not alter my lifestyle or see an osteopath, so this dietary supplement must have helped.
9
Reduced knee pain
1 people found this helpful
My father has been taking these supplements for two months. We found it on iHerb after he liked the effectiveness he experienced, as his back pain has diminished over time.
9
Pain relief achieved
151 people found this helpful
A wonderful complex of minerals! I'm shocked by the effect! I am 39, and for the last two years, I've suffered from severe leg pain, particularly after long walks. After a month of taking these minerals, the pain completely disappeared! I continue with a month on and a month off. I hope my honest feedback helps others.
9
Knee pain gone
4 people found this helpful
Very good! In the short time I started taking this, I felt an incredible difference. My knee pain just disappeared—praise God.
9
Back and joint issues
7 people found this helpful
For this price, my husband and I have taken it intermittently for our third time. I've noticed less hair loss (I also take biotin), while my husband’s back pain has stopped and his knees no longer crack. My previously unhealthy nails are now growing well, despite being infected.
9
Improved back pain
1 people found this helpful
I was pleasantly surprised that this supplement effectively aided my back pain and knee issues. I have used glucosamine with chondroitin for years, but needed something stronger. The combination of glucosamine, chondroitin, collagen, ascorbic acid, and a mineral complex has not only protected my spine and knees but also improved my skin, which is crucial due to my work with chemicals.
6
Knee pain improvement
3 people found this helpful
My knees hurt after exercising, so I began taking calcium, hoping to alleviate the pain. Initially, I experienced abdominal discomfort at night, so I shifted to taking it in the morning. Although my knee pain has improved, I'm uncertain if it's due to the supplement or just healing over time. The calcium supplementation seems to have addressed my issue!
7.5
Pain relief achieved
2 people found this helpful
My husband no longer suffers from back pain or knee discomfort. He has to squat for his job, which can be uncomfortable, but since taking three pills daily, he feels less pain in his knees and back.
9
Pain-free workouts
2 people found this helpful
Be careful not to overdose; I suggest taking two pills, one in the morning and one at lunch. I twisted my knee years ago and occasionally felt pain during workouts, but this supplement has made me forget the pain.
7.5
Pain relief during pregnancy
3 people found this helpful
I highly recommend this calcium supplement, which I started during pregnancy and continue during lactation. Previously, my back and legs ached terribly from week 30, but after a week of taking three tablets at night, the pain vanished. My skin, hair, and nails are now perfect. I’ve also ordered for my mother and mother-in-law.
9
Relieved lower back
1 people found this helpful
I've been taking this for a month and am thrilled with the results! My lower back discomfort has significantly reduced, and I feel much better when lifting loads.
8
Vitamin D alleviates back pain
We conducted a randomized controlled trial to investigate how vitamin D supplementation might alleviate lower back pain in patients suffering from lumbar spinal stenosis. This study involved patients with severely low vitamin D levels, specifically under 10 ng/mL. Participants were divided into two groups: one received vitamin D supplements, while the other did not.

Over a period of several weeks, we measured pain levels and functional recovery using simple questionnaires and health surveys. Notably, we observed that those who received vitamin D injections reported significant improvements in their back pain and overall quality of life compared to those who didn’t.

Our findings suggest that addressing vitamin D deficiency might play a crucial role in managing back pain for individuals with spinal stenosis who are not candidates for surgical intervention. The results demonstrate a promising correlation between high-dose vitamin D supplementation and enhanced functional outcomes in these patients.
We observed a fascinating case involving a male in his 40s who experienced persistent inflammatory back pain for three months. Despite having a negative test for HLA-B27, a marker often associated with axial spondyloarthritis, clinical assessments suggested possible underlying issues.

The clinical investigation led to an MRI, which confirmed bilateral symmetrical sacroiliitis. Interestingly, further tests showed he had very low vitamin D levels along with elevated parathyroid hormone—indicating a possible deficiency impacting his condition.

After starting treatment with vitamin D alongside nonsteroidal anti-inflammatory drugs (NSAIDs), he experienced notable relief from his symptoms. His condition improved significantly, and follow-up tests indicated that his vitamin D levels had normalized.

This case demonstrates the potential benefits of vitamin D in managing back pain, especially when classical markers are inconclusive. It highlights how a thorough diagnosis can reveal interconnected health issues and improve treatment outcomes.
2
Vitamin D ineffective for back pain
We examined the effectiveness of vitamin D supplementation for people dealing with chronic low back pain (CLBP). Through a systematic review of randomized controlled trials, we focused on understanding whether vitamin D could bring any relief to those suffering from this persistent discomfort.

Our analysis of ten trials found that vitamin D supplementation did not lead to significant reductions in pain levels compared to control groups. This held true regardless of participants' initial vitamin D levels, and even long-term use did not show considerable improvements in pain outcomes. Interestingly, using active forms of vitamin D also failed to provide the hoped-for relief.

Despite these findings, it’s important to note that vitamin D might still play a role in a broader treatment plan for CLBP. However, as of now, there isn’t enough evidence to suggest that it can independently alleviate the pain. Further investigation is necessary to understand the potential long-term effects and the reasons behind the lack of benefit observed in our study.
We explored the impact of calcium and vitamin D supplementation combined with sling core stabilization training on back pain in a 70-year-old female patient suffering from osteoporosis. The patient engaged in this form of exercise three times a week, focusing on strengthening the deep muscles of her spine.

After a year of dedicated training, not only did her back pain significantly improve, but a follow-up examination also indicated an increase in her bone mineral density. This suggests that the combined approach of exercise and supplementation might promote better bone health and potentially reduce pain.

However, it’s important to note that while we saw positive changes in this case, the specific contributions of calcium alone cannot be clearly identified due to the concurrent treatments involved. Therefore, we recognize that further studies are needed to isolate calcium's effects to conclusively determine its role in managing back pain effectively.

References

  1. Liu J, Xu D, Liu L, Huang C, Guo Z, et al. Regular sling core stabilization training improves bone density based on calcium and vitamin D supplementation. BMC Musculoskelet Disord. 2023;24:815. doi:10.1186/s12891-023-06896-8
  2. Lee TJ, Tsai RY, Ho CC, Chen CM, Li CP. Updated Meta-analysis Reveals Limited Efficacy of Vitamin D Supplementation in Chronic Low Back Pain. In Vivo. 2024;38:2955. doi:10.21873/invivo.13778
  3. Bose S, Mohanasundaram K, Rajalakshmi KV, Perumal Kumaresan A, Simon J. An Unusual Mimic of Axial Spondyloarthritis: A Case Report. Cureus. 2024;16:e61441. doi:10.7759/cureus.61441
  4. V N, Nair GG, Jose BC, Abraham A. Study on Vitamin D Levels in 30 to 40-Year-Old Females With Low Back Pain. Cureus. 2024;16:e54238. doi:10.7759/cureus.54238
  5. Scaturro D, Vitagliani F, Tomasello S, Sconza C, Respizzi S, et al. Combined Rehabilitation with Alpha Lipoic Acid, Acetyl-L-Carnitine, Resveratrol, and Cholecalciferolin Discogenic Sciatica in Young People: A Randomized Clinical Trial. Medicina (Kaunas). 2023;59. doi:10.3390/medicina59122197
  6. Kim S, Kim SW, Lee BC, Kim DH, Sung DH. Adult-onset hypophosphatemic osteomalacia as a cause of widespread musculoskeletal pain: A retrospective case series of single center experience. World J Clin Cases. 2023;11:7785. doi:10.12998/wjcc.v11.i32.7785
  7. Ko S, Kim HC, Kwon J. The effectiveness of vitamin D3 supplementation in improving functional outcome of non-surgically treated symptomatic lumbar spinal stenosis: Randomized controlled clinical trial - Pilot study. Medicine (Baltimore). 2023;102:e32672. doi:10.1097/MD.0000000000032672
  8. Evangelatos G, Kouna K, Iliopoulos A, Fragoulis GE. Musculoskeletal Complications of Celiac Disease: A Case-Based Review. Mediterr J Rheumatol. 2023;34:86. doi:10.31138/mjr.34.1.86
  9. Dechsupa S, Yingsakmongkol W, Limthongkul W, Singhatanadgige W, Jitjumnong M, et al. Vitamin D Inadequacy Affects Skeletal Muscle Index and Physical Performance in Lumbar Disc Degeneration. Int J Mol Sci. 2023;24. doi:10.3390/ijms24043152
  10. Dadkhah P, Hashemi M, Taheri M, Alizadeh Ojoor A, Jaffari M, et al. A Comparison of Analgesic Efficacy of Triamcinolone vs Magnesium Sulfate as Adjuvants in Caudal Block in Patients with Low Back Pain: A Double-Blind Randomized Controlled Trial. Anesth Pain Med. 2024;14:e145718. doi:10.5812/aapm-145718
  11. Zhang T, Wang Y, Li R, Xin J, Zheng Z, et al. ROS-responsive magnesium-containing microspheres for antioxidative treatment of intervertebral disc degeneration. Acta Biomater. 2023;158:475. doi:10.1016/j.actbio.2023.01.020
  12. Celenlioglu AE, Sir E, Ors-Yildirim N, Yildirim AK, Ince ME, et al. Effect of perioperative intravenous magnesium sulfate on postoperative pain after iliac venous stenting. J Vasc Surg Venous Lymphat Disord. 2023;11:517. doi:10.1016/j.jvsv.2022.09.008
  13. Marchesi N, Govoni S, Allegri M. Non-drug pain relievers active on non-opioid pain mechanisms. Pain Pract. 2022;22:255. doi:10.1111/papr.13073
  14. Huber D, Grafetstätter C, Proßegger J, Pichler C, Wöll E, et al. Green exercise and mg-ca-SO thermal balneotherapy for the treatment of non-specific chronic low back pain: a randomized controlled clinical trial. BMC Musculoskelet Disord. 2019;20:221. doi:10.1186/s12891-019-2582-4
  15. Yousef AA, Al-deeb AE. A double-blinded randomised controlled study of the value of sequential intravenous and oral magnesium therapy in patients with chronic low back pain with a neuropathic component. Anaesthesia. 2013;68:260. doi:10.1111/anae.12107
  16. Vormann J, Worlitschek M, Goedecke T, Silver B. Supplementation with alkaline minerals reduces symptoms in patients with chronic low back pain. J Trace Elem Med Biol. 2001;15:179.
  17. Bhardwaj A, Swe KMM, Sinha NK. Treatment for osteoporosis in people with beta-thalassaemia. Cochrane Database Syst Rev. 2023;5:CD010429. doi:10.1002/14651858.CD010429.pub3
  18. Bhardwaj A, Swe KM, Sinha NK, Osunkwo I. Treatment for osteoporosis in people with ß-thalassaemia. Cochrane Database Syst Rev. 2016;3:CD010429. doi:10.1002/14651858.CD010429.pub2
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