Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.4
USERS' SCORE
Good
Based on 25 Reviews
8.8
Supplement Facts
Serving Size: 3 Caplets
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
15 mcg (600 IU)
75%
Calcium (as Calcium Carbonate and Calcium Gluconate)
1,000 mg
77%
Magnesium (as Magnesium Oxide and Magnesium Gluconate)
400 mg
95%
Zinc (as Zinc Gluconate and Zinc Citrate)
25 mg
227%
Sodium
10 mg
<1%
Top Medical Research Studies
8
We explored the potential benefits of vitamin D supplementation for reducing the risk of influenza infections. Through a comprehensive analysis of multiple Randomized Controlled Trials (RCTs), we aimed to clarify whether taking vitamin D can help prevent the flu.
Our investigation identified 10 relevant trials that included a total of 4,859 participants. These studies varied in their dosages and duration of vitamin D use, allowing us to assess overall effectiveness across different populations.
The findings were encouraging: our analysis demonstrated that vitamin D supplementation appears to significantly reduce the risk of getting influenza, suggesting that those who increase their vitamin D intake might be better protected during flu season.
Importantly, we did not find significant differences between the studies that could affect our result, and there was no hint of publication bias. Consequently, we can confidently suggest that including vitamin D in our health strategies could enhance our defenses against the flu.
Our investigation identified 10 relevant trials that included a total of 4,859 participants. These studies varied in their dosages and duration of vitamin D use, allowing us to assess overall effectiveness across different populations.
The findings were encouraging: our analysis demonstrated that vitamin D supplementation appears to significantly reduce the risk of getting influenza, suggesting that those who increase their vitamin D intake might be better protected during flu season.
Importantly, we did not find significant differences between the studies that could affect our result, and there was no hint of publication bias. Consequently, we can confidently suggest that including vitamin D in our health strategies could enhance our defenses against the flu.
Read More
8
We conducted a practical study to investigate how daily vitamin D3 supplementation at 5000 IU might help reduce flu-like illnesses in healthcare workers. This was especially important during the COVID-19 pandemic, where preventing viral infections is crucial for those on the front lines.
Our study involved 255 healthcare workers who received the vitamin D3 supplement for at least two months and compared them to a control group of 2827 workers who did not receive the supplement. We asked participants to monitor themselves for any flu-like symptoms and report for COVID-19 testing accordingly.
The results were promising; those supplementing with vitamin D experienced a significant reduction in the incidence of flu-like illnesses. The numbers showed a noteworthy drop in non-COVID-19 flu-like illness rates among those taking the supplement. However, when it came to COVID-19 related flu-like illnesses, the difference was not statistically significant.
Overall, our exploration of vitamin D3's effects suggests that it may be a beneficial addition to the health routines of healthcare workers to stave off flu-like illnesses, although its influence on COVID-19 specifically requires further investigation.
Our study involved 255 healthcare workers who received the vitamin D3 supplement for at least two months and compared them to a control group of 2827 workers who did not receive the supplement. We asked participants to monitor themselves for any flu-like symptoms and report for COVID-19 testing accordingly.
The results were promising; those supplementing with vitamin D experienced a significant reduction in the incidence of flu-like illnesses. The numbers showed a noteworthy drop in non-COVID-19 flu-like illness rates among those taking the supplement. However, when it came to COVID-19 related flu-like illnesses, the difference was not statistically significant.
Overall, our exploration of vitamin D3's effects suggests that it may be a beneficial addition to the health routines of healthcare workers to stave off flu-like illnesses, although its influence on COVID-19 specifically requires further investigation.
Read More
8
We investigated the intriguing link between sunlight exposure, vitamin D production, and flu incidence. The study revealed that higher levels of sunlight are associated with a noticeable decrease in flu cases, particularly during the severe H1N1 epidemic in the fall of 2009.
Our findings indicate that a 10% increase in relative sunlight can lower the flu index during September and October by about 1.1 points on a 10-point scale. This layer of sunlight acts like a shield, helping protect individuals from catching the flu, thanks in part to its role in vitamin D production in our bodies.
A complementary study in New York State backed up these observations, reinforcing the message that adequate sunlight might be key in reducing flu incidence.
Our findings indicate that a 10% increase in relative sunlight can lower the flu index during September and October by about 1.1 points on a 10-point scale. This layer of sunlight acts like a shield, helping protect individuals from catching the flu, thanks in part to its role in vitamin D production in our bodies.
A complementary study in New York State backed up these observations, reinforcing the message that adequate sunlight might be key in reducing flu incidence.
Read More
Most Useful Reviews
9.5
Migraines ceased
¡Excelente! For years I suffered from migraines, believed to be due to low zinc during ovulation and menstruation. I took calcium, magnesium, and zinc at 100%. My migraines stopped. If I felt a migraine brewing, I took two. My doctor thought I was crazy, but he later acknowledged it could be hormonal. For 10 years, I took this until menopause. Now, I use it to keep my bones healthy and strengthen my body against colds and flu. After mistakenly buying a lower strength, my migraines returned, confirming its effectiveness.
Read More
10
Never sick again
I never get sick anymore after consuming this vitamin—no flu or cough. Thanks!
Read More
10
Immune support
A very good complex of Mg, Zn, and D3! I’ve repurchased it for my mum, and she really liked it, finding it effective for strengthening her immune system. During the Covid quarantine, my mum continued to work and thankfully avoided catching the virus, flu, or cold. I highly recommend this product.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.4
- All Researches
9
We recently examined how vitamin D impacts our body's response to influenza H1N1, an important viral infection. Utilizing 142 clinical cases from the Department of Otolaryngology at Sun Yat-sen University, we dug into the effects of vitamin D deficiency on chronic rhinosinusitis (CRS), a condition that frequently involves damage to the airway's lining. By studying airway organoids treated with vitamin D, we were able to simulate how this treatment might bolster our defenses against flu viruses and bacteria like Staphylococcus aureus.
Our observations showed that many patients with CRS suffered from vitamin D deficiency. Notably, those who received vitamin D treatment exhibited faster cell growth in the nasal epithelium. When exposed to the H1N1 virus, these treated organoids demonstrated a remarkable ability to fend off the infection better than those without vitamin D. This protection stemmed from enhancements in host defenses, including improved production of antimicrobial proteins, reduced inflammation, and better epithelial integrity—crucial factors in fighting off infections.
We also uncovered some fascinating insights about the biological mechanisms at work. Vitamin D seemed to actively influence how epithelial cells develop and repair themselves while managing immune responses against infections. These findings underscore the significance of addressing vitamin D deficiency, especially for those vulnerable to respiratory illnesses.
Our observations showed that many patients with CRS suffered from vitamin D deficiency. Notably, those who received vitamin D treatment exhibited faster cell growth in the nasal epithelium. When exposed to the H1N1 virus, these treated organoids demonstrated a remarkable ability to fend off the infection better than those without vitamin D. This protection stemmed from enhancements in host defenses, including improved production of antimicrobial proteins, reduced inflammation, and better epithelial integrity—crucial factors in fighting off infections.
We also uncovered some fascinating insights about the biological mechanisms at work. Vitamin D seemed to actively influence how epithelial cells develop and repair themselves while managing immune responses against infections. These findings underscore the significance of addressing vitamin D deficiency, especially for those vulnerable to respiratory illnesses.
Read More
9
We investigated the potential of zinc in combination with herbal polyphenols and copper to reduce the infectivity of respiratory RNA viruses, including the flu. This study is particularly timely due to the ongoing challenges posed by viruses like SARS-CoV-2, highlighting the need for effective therapeutic solutions.
Zinc ions are known to play a role in modulating viral RNA replication, which makes them an appealing option for decreasing viral loads and infectivity. However, a significant challenge is that the natural concentration of zinc in our cells is often too low for effective results. To tackle this, we combined zinc picolinate, a form of zinc that’s easier for the body to absorb, with a range of flavonoids—natural compounds renowned for their antioxidant properties and existing antiviral effects.
We ensured that these combinations were safe by assessing their impact on cultured cells, confirming that they didn’t harm cell viability. When tested further, our results revealed an impressive 50-95% reduction in viral genome replication levels across a variety of respiratory RNA viruses, including the flu virus, which suggests that this combination therapy could be promising in the fight against such illnesses.
Overall, our findings highlight an innovative approach to treating viral infections that is non-toxic, derived from nature, and may remain effective against emerging viral strains.
Zinc ions are known to play a role in modulating viral RNA replication, which makes them an appealing option for decreasing viral loads and infectivity. However, a significant challenge is that the natural concentration of zinc in our cells is often too low for effective results. To tackle this, we combined zinc picolinate, a form of zinc that’s easier for the body to absorb, with a range of flavonoids—natural compounds renowned for their antioxidant properties and existing antiviral effects.
We ensured that these combinations were safe by assessing their impact on cultured cells, confirming that they didn’t harm cell viability. When tested further, our results revealed an impressive 50-95% reduction in viral genome replication levels across a variety of respiratory RNA viruses, including the flu virus, which suggests that this combination therapy could be promising in the fight against such illnesses.
Overall, our findings highlight an innovative approach to treating viral infections that is non-toxic, derived from nature, and may remain effective against emerging viral strains.
Read More
8
We explored how vitamin D supplementation might help reduce the risk of respiratory infections, particularly the flu, in care homes. Our systematic review of several randomized controlled trials focused on interventions to reduce the transmission of acute respiratory infections, looking beyond just vaccines.
Our findings highlighted that high-dose vitamin D supplementation led to a significant decrease in the incidence of acute respiratory infections, reducing the likelihood of getting sick. Specifically, one trial indicated a 40% reduction in these infections among participants receiving vitamin D compared to those who did not.
However, not all studies we reviewed showed compelling results for related supplements like vitamins, minerals, probiotics, and herbal aids, which did not significantly impact infection rates. This means that while vitamin D supplementation shows promise, more research is needed to fully understand its effects and confirm its benefits in combating flu and other respiratory illnesses.
Our findings highlighted that high-dose vitamin D supplementation led to a significant decrease in the incidence of acute respiratory infections, reducing the likelihood of getting sick. Specifically, one trial indicated a 40% reduction in these infections among participants receiving vitamin D compared to those who did not.
However, not all studies we reviewed showed compelling results for related supplements like vitamins, minerals, probiotics, and herbal aids, which did not significantly impact infection rates. This means that while vitamin D supplementation shows promise, more research is needed to fully understand its effects and confirm its benefits in combating flu and other respiratory illnesses.
Read More
8
We conducted a practical study to investigate how daily vitamin D3 supplementation at 5000 IU might help reduce flu-like illnesses in healthcare workers. This was especially important during the COVID-19 pandemic, where preventing viral infections is crucial for those on the front lines.
Our study involved 255 healthcare workers who received the vitamin D3 supplement for at least two months and compared them to a control group of 2827 workers who did not receive the supplement. We asked participants to monitor themselves for any flu-like symptoms and report for COVID-19 testing accordingly.
The results were promising; those supplementing with vitamin D experienced a significant reduction in the incidence of flu-like illnesses. The numbers showed a noteworthy drop in non-COVID-19 flu-like illness rates among those taking the supplement. However, when it came to COVID-19 related flu-like illnesses, the difference was not statistically significant.
Overall, our exploration of vitamin D3's effects suggests that it may be a beneficial addition to the health routines of healthcare workers to stave off flu-like illnesses, although its influence on COVID-19 specifically requires further investigation.
Our study involved 255 healthcare workers who received the vitamin D3 supplement for at least two months and compared them to a control group of 2827 workers who did not receive the supplement. We asked participants to monitor themselves for any flu-like symptoms and report for COVID-19 testing accordingly.
The results were promising; those supplementing with vitamin D experienced a significant reduction in the incidence of flu-like illnesses. The numbers showed a noteworthy drop in non-COVID-19 flu-like illness rates among those taking the supplement. However, when it came to COVID-19 related flu-like illnesses, the difference was not statistically significant.
Overall, our exploration of vitamin D3's effects suggests that it may be a beneficial addition to the health routines of healthcare workers to stave off flu-like illnesses, although its influence on COVID-19 specifically requires further investigation.
Read More
8
We explored the potential benefits of vitamin D supplementation for reducing the risk of influenza infections. Through a comprehensive analysis of multiple Randomized Controlled Trials (RCTs), we aimed to clarify whether taking vitamin D can help prevent the flu.
Our investigation identified 10 relevant trials that included a total of 4,859 participants. These studies varied in their dosages and duration of vitamin D use, allowing us to assess overall effectiveness across different populations.
The findings were encouraging: our analysis demonstrated that vitamin D supplementation appears to significantly reduce the risk of getting influenza, suggesting that those who increase their vitamin D intake might be better protected during flu season.
Importantly, we did not find significant differences between the studies that could affect our result, and there was no hint of publication bias. Consequently, we can confidently suggest that including vitamin D in our health strategies could enhance our defenses against the flu.
Our investigation identified 10 relevant trials that included a total of 4,859 participants. These studies varied in their dosages and duration of vitamin D use, allowing us to assess overall effectiveness across different populations.
The findings were encouraging: our analysis demonstrated that vitamin D supplementation appears to significantly reduce the risk of getting influenza, suggesting that those who increase their vitamin D intake might be better protected during flu season.
Importantly, we did not find significant differences between the studies that could affect our result, and there was no hint of publication bias. Consequently, we can confidently suggest that including vitamin D in our health strategies could enhance our defenses against the flu.
Read More
User Reviews
USERS' SCORE
Good
Based on 25 Reviews
8.8
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Migraines ceased
¡Excelente! For years I suffered from migraines, believed to be due to low zinc during ovulation and menstruation. I took calcium, magnesium, and zinc at 100%. My migraines stopped. If I felt a migraine brewing, I took two. My doctor thought I was crazy, but he later acknowledged it could be hormonal. For 10 years, I took this until menopause. Now, I use it to keep my bones healthy and strengthen my body against colds and flu. After mistakenly buying a lower strength, my migraines returned, confirming its effectiveness.
Read More
10
Never sick again
I never get sick anymore after consuming this vitamin—no flu or cough. Thanks!
Read More
10
Immune support
A very good complex of Mg, Zn, and D3! I’ve repurchased it for my mum, and she really liked it, finding it effective for strengthening her immune system. During the Covid quarantine, my mum continued to work and thankfully avoided catching the virus, flu, or cold. I highly recommend this product.
Read More
9.5
Migraine relief
Just MAGIC! For years, I suffered from severe migraines until my doctor prescribed Ca Mg Zn. I started taking it daily, and my migraines vanished. If I sensed a migraine coming, I would take two and avoid the discomfort. After 10 years, my migraines finally went away. Now, I use it to maintain healthy bones and strengthen my body against colds and flu, ensuring my blood levels stay normal. I know it helped with my migraines because I once bought a lower strength and they returned. When I got the right strength, they disappeared again. Highly recommended!
Read More
9.5
Effective protection
A fantastic immune booster! My family and I have used this product for two years, and it has greatly helped us stay protected from colds, flu, and even Covid-19! There are no side effects, and it genuinely boosts our immune health!
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Willcox ML, Lavu D, Yousaf U, Dalton S, Roberts N, et al. The effectiveness of interventions to reduce the transmission of acute respiratory infections in care homes: a systematic review. J Public Health (Oxf). 2024;46:551. doi:10.1093/pubmed/fdae178
- Liao S, Huang Y, Zhang J, Xiong Q, Chi M, et al. Vitamin D promotes epithelial tissue repair and host defense responses against influenza H1N1 virus and Staphylococcus aureus infections. Respir Res. 2023;24:175. doi:10.1186/s12931-023-02477-4
- van Helmond N, Brobyn TL, LaRiccia PJ, Cafaro T, Hunter K, et al. Vitamin D3 Supplementation at 5000 IU Daily for the Prevention of Influenza-like Illness in Healthcare Workers: A Pragmatic Randomized Clinical Trial. Nutrients. 2022;15. doi:10.3390/nu15010180
- Arora J, Patel DR, Nicol MJ, Field CJ, Restori KH, et al. Vitamin D and the Ability to Produce 1,25(OH)D Are Critical for Protection from Viral Infection of the Lungs. Nutrients. 2022;14. doi:10.3390/nu14153061
- Huang YN, Chi H, Chiu NC, Huang CY, Li ST, et al. A randomized trial of vitamin D supplementation to prevent seasonal influenza and enterovirus infection in children. J Microbiol Immunol Infect. 2022;55:803. doi:10.1016/j.jmii.2022.01.003
- Zhu Z, Zhu X, Gu L, Zhan Y, Chen L, et al. Association Between Vitamin D and Influenza: Meta-Analysis and Systematic Review of Randomized Controlled Trials. Front Nutr. 2021;8:799709. doi:10.3389/fnut.2021.799709
- Godan Hauptman A, Lukić-Grlić A, Vraneš J, Milošević M, Gagro A. The effect of standard-dose wintertime vitamin D supplementation on influenza infection in immunized nursing home elderly residents. Croat Med J. 2021;62:495.
- Abioye AI, Bromage S, Fawzi W. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis. BMJ Glob Health. 2021;6. doi:10.1136/bmjgh-2020-003176
- Slusky DJG, Zeckhauser RJ. Sunlight and Protection Against Influenza. Econ Hum Biol. 2021;40:100942. doi:10.1016/j.ehb.2020.100942
- Kanellopoulou C, George AB, Masutani E, Cannons JL, Ravell JC, et al. Mg regulation of kinase signaling and immune function. J Exp Med. 2019;216:1828. doi:10.1084/jem.20181970
- Muniz FWMG, Casarin M, Pola NM, Rösing CK, Silveira TMD, et al. Efficacy of regular gargling with a cetylpyridinium chloride plus zinc containing mouthwash can reduce upper respiratory symptoms. PLoS One. 2025;20:e0316807. doi:10.1371/journal.pone.0316807
- Nishi K, Yoshimoto S, Nishi S, Nishi T, Nishi R, et al. Epipharyngeal Abrasive Therapy Down-regulates the Expression of Cav1.2: A Key Molecule in Influenza Virus Entry. In Vivo. 2022;36:2357. doi:10.21873/invivo.12967
- Kreiser T, Zaguri D, Sachdeva S, Zamostiano R, Mograbi J, et al. Inhibition of Respiratory RNA Viruses by a Composition of Ionophoric Polyphenols with Metal Ions. Pharmaceuticals (Basel). 2022;15. doi:10.3390/ph15030377
- Nakashima A, Horio Y, Suzuki K, Isegawa Y. Antiviral Activity and Underlying Action Mechanism of Euglena Extract against Influenza Virus. Nutrients. 2021;13. doi:10.3390/nu13113911
- Sadeghsoltani F, Mohammadzadeh I, Safari MM, Hassanpour P, Izadpanah M, et al. Zinc and Respiratory Viral Infections: Important Trace Element in Anti-viral Response and Immune Regulation. Biol Trace Elem Res. 2022;200:2556. doi:10.1007/s12011-021-02859-z
