Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 50 Researches
7.5
USERS' SCORE
Good
Based on 11 Reviews
8.1
Supplement Facts
Serving Size: 3 Caplets
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
15 mcg (600 IU)
75%
Calcium (as Calcium Carbonate and Calcium Gluconate)
1,000 mg
77%
Magnesium (as Magnesium Oxide and Magnesium Gluconate)
400 mg
95%
Zinc (as Zinc Gluconate and Zinc Citrate)
25 mg
227%
Sodium
10 mg
<1%
Top Medical Research Studies
9
We explored the potential benefits of vitamin D supplementation for treating migraines. Our analysis focused on several randomized controlled trials (RCTs) to examine how effective vitamin D could be in alleviating migraine symptoms.
Through our review, we included six RCTs involving 301 patients. The results were quite promising. Vitamin D supplementation significantly reduced the number of headache attacks per month and the number of headache days experienced by patients. Additionally, it improved the MIDAS score, which measures the impact of migraines on daily life.
However, it's important to note that vitamin D did not show a significant effect on how long migraine attacks lasted or the severity of the headaches. Overall, our findings suggest that while vitamin D might be beneficial for reducing certain migraine-related symptoms, it isn’t a miracle cure for everyone.
Through our review, we included six RCTs involving 301 patients. The results were quite promising. Vitamin D supplementation significantly reduced the number of headache attacks per month and the number of headache days experienced by patients. Additionally, it improved the MIDAS score, which measures the impact of migraines on daily life.
However, it's important to note that vitamin D did not show a significant effect on how long migraine attacks lasted or the severity of the headaches. Overall, our findings suggest that while vitamin D might be beneficial for reducing certain migraine-related symptoms, it isn’t a miracle cure for everyone.
Read More
9
We explored how vitamin D may impact migraines through a systematic review and meta-analysis of randomized controlled trials.
Analyzing data from five trials, we found that vitamin D significantly reduced the number of headache days, frequency of attacks, severity of headaches, and overall migraine-related disability compared to placebo.
This suggests that vitamin D treatment can effectively help alleviate migraine symptoms for many individuals.
Analyzing data from five trials, we found that vitamin D significantly reduced the number of headache days, frequency of attacks, severity of headaches, and overall migraine-related disability compared to placebo.
This suggests that vitamin D treatment can effectively help alleviate migraine symptoms for many individuals.
Read More
9
Magnesium reduces migraine symptoms
We explored how magnesium supplementation can help alleviate migraines, a condition that affects countless individuals and can be incredibly disabling. Research has shown a strong link between magnesium deficiency and various factors that contribute to migraines, such as neurological changes and inflammation.
Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.
We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.
Studies, including randomized controlled trials, indicate that magnesium can reduce the frequency and severity of migraine attacks, both in the short term and as a preventative measure. This effectiveness is thought to stem from magnesium's ability to influence nerve function and reduce stress responses in the body.
We've examined the accumulating evidence from case studies and clinical trials, and it clearly points to magnesium being a valuable option for those suffering from migraines. By addressing magnesium deficiency, we may offer a new avenue for relief and improved management of this challenging condition.
Read More
Most Useful Reviews
9
Effective supplement
I used this supplement to alleviate my migraines, and it has substantially reduced their frequency.
Read More
9
Enhanced sleep
I really liked this complex! It works particularly well during migraines and headaches. Taking it at night also improves sleep quality significantly. I recommend giving it a try.
Read More
9
Prevents migraine attacks
Calcium Magnesium Zinc with Vitamin D3 from Nature's Bounty is a comprehensive nutritional supplement that enhances the immune, nervous, cardiovascular, and musculoskeletal systems. It regulates blood coagulation, normal muscle contraction, and alleviates cramps, while also enhancing dental health and preventing migraine attacks. The supplement contains 100 tablets, and one to three should be taken daily with food. This product receives positive feedback and is recommended by myself and many others.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 50 Researches
7.5
- All Researches
9.5
We embarked on an investigation into the potential of zinc as a treatment for migraines. The study involved 30 migraine sufferers who were given 75 mg of zinc sulfate daily for six weeks, along with vitamin B-complex and vitamin A or E during the first ten days.
Remarkably, this combination led to a significant improvement in most participants, suggesting that zinc could play a vital role in alleviating migraine symptoms. Zinc's effectiveness may stem from its essential functions in various biological processes, such as supporting the nervous system and regulating mineral balance in the body.
However, it’s important to note that the research combined zinc with other supplements, which makes it challenging to ascertain zinc's isolated effect on migraines. Future studies may benefit from a more controlled approach—perhaps comparing zinc against a placebo or examining its impact in larger groups.
Overall, this exploration opens new avenues for understanding how zinc and other nutrients can contribute to migraine relief, but further research is needed to fully validate these findings.
Remarkably, this combination led to a significant improvement in most participants, suggesting that zinc could play a vital role in alleviating migraine symptoms. Zinc's effectiveness may stem from its essential functions in various biological processes, such as supporting the nervous system and regulating mineral balance in the body.
However, it’s important to note that the research combined zinc with other supplements, which makes it challenging to ascertain zinc's isolated effect on migraines. Future studies may benefit from a more controlled approach—perhaps comparing zinc against a placebo or examining its impact in larger groups.
Overall, this exploration opens new avenues for understanding how zinc and other nutrients can contribute to migraine relief, but further research is needed to fully validate these findings.
Read More
9
We aimed to understand how vitamin D impacts migraine headaches in children. Through a thorough review of existing literature, we explored the significant association between serum vitamin D levels and the frequency and duration of migraine episodes in the pediatric population.
Our findings suggest that children with migraines might benefit from vitamin D supplementation. By potentially reducing the number and intensity of migraine episodes, vitamin D could improve the overall quality of life for these young patients.
It's important to note that this connection primarily focuses on children, as most studies have looked at adults. With vitamin D deficiency being a growing public health concern, our research highlights how addressing this deficiency may serve as a helpful strategy in managing pediatric migraines.
Our findings suggest that children with migraines might benefit from vitamin D supplementation. By potentially reducing the number and intensity of migraine episodes, vitamin D could improve the overall quality of life for these young patients.
It's important to note that this connection primarily focuses on children, as most studies have looked at adults. With vitamin D deficiency being a growing public health concern, our research highlights how addressing this deficiency may serve as a helpful strategy in managing pediatric migraines.
Read More
9
We conducted a study to investigate whether adding vitamin D supplements to topiramate therapy would improve migraine outcomes in children aged 5 to 14. In our double-blinded clinical trial, we randomly assigned participants to receive either topiramate with a daily 5000-IU vitamin D supplement or topiramate with a placebo for four months. By evaluating changes in headache frequency, severity, disability, and overall response to treatment, we aimed to see if vitamin D could provide additional benefits.
Our findings were quite promising. The children receiving the vitamin D supplement had a significant reduction in the number of headaches they experienced each month compared to those on placebo. Additionally, the vitamin D group reported less disability due to migraines and a higher percentage of positive treatment responses. Specifically, about 76% of children in the vitamin D group showed a good response, compared to just over 53% in the placebo group.
Safety was assessed as well, with side effects occurring in 13.3% of the vitamin D group and 20% in the placebo group, indicating that vitamin D was well-tolerated. Overall, we believe that combining vitamin D with topiramate represents a safe and potentially effective approach to managing pediatric migraines.
Our findings were quite promising. The children receiving the vitamin D supplement had a significant reduction in the number of headaches they experienced each month compared to those on placebo. Additionally, the vitamin D group reported less disability due to migraines and a higher percentage of positive treatment responses. Specifically, about 76% of children in the vitamin D group showed a good response, compared to just over 53% in the placebo group.
Safety was assessed as well, with side effects occurring in 13.3% of the vitamin D group and 20% in the placebo group, indicating that vitamin D was well-tolerated. Overall, we believe that combining vitamin D with topiramate represents a safe and potentially effective approach to managing pediatric migraines.
Read More
9
We explored the potential benefits of vitamin D supplementation for treating migraines. Our analysis focused on several randomized controlled trials (RCTs) to examine how effective vitamin D could be in alleviating migraine symptoms.
Through our review, we included six RCTs involving 301 patients. The results were quite promising. Vitamin D supplementation significantly reduced the number of headache attacks per month and the number of headache days experienced by patients. Additionally, it improved the MIDAS score, which measures the impact of migraines on daily life.
However, it's important to note that vitamin D did not show a significant effect on how long migraine attacks lasted or the severity of the headaches. Overall, our findings suggest that while vitamin D might be beneficial for reducing certain migraine-related symptoms, it isn’t a miracle cure for everyone.
Through our review, we included six RCTs involving 301 patients. The results were quite promising. Vitamin D supplementation significantly reduced the number of headache attacks per month and the number of headache days experienced by patients. Additionally, it improved the MIDAS score, which measures the impact of migraines on daily life.
However, it's important to note that vitamin D did not show a significant effect on how long migraine attacks lasted or the severity of the headaches. Overall, our findings suggest that while vitamin D might be beneficial for reducing certain migraine-related symptoms, it isn’t a miracle cure for everyone.
Read More
9
We explored how vitamin D may impact migraines through a systematic review and meta-analysis of randomized controlled trials.
Analyzing data from five trials, we found that vitamin D significantly reduced the number of headache days, frequency of attacks, severity of headaches, and overall migraine-related disability compared to placebo.
This suggests that vitamin D treatment can effectively help alleviate migraine symptoms for many individuals.
Analyzing data from five trials, we found that vitamin D significantly reduced the number of headache days, frequency of attacks, severity of headaches, and overall migraine-related disability compared to placebo.
This suggests that vitamin D treatment can effectively help alleviate migraine symptoms for many individuals.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective supplement
I used this supplement to alleviate my migraines, and it has substantially reduced their frequency.
Read More
9
Enhanced sleep
I really liked this complex! It works particularly well during migraines and headaches. Taking it at night also improves sleep quality significantly. I recommend giving it a try.
Read More
9
Prevents migraine attacks
Calcium Magnesium Zinc with Vitamin D3 from Nature's Bounty is a comprehensive nutritional supplement that enhances the immune, nervous, cardiovascular, and musculoskeletal systems. It regulates blood coagulation, normal muscle contraction, and alleviates cramps, while also enhancing dental health and preventing migraine attacks. The supplement contains 100 tablets, and one to three should be taken daily with food. This product receives positive feedback and is recommended by myself and many others.
Read More
7.5
Quick relief
I have taken these vitamins for years and find them highly effective, impacting me positively within days. Specifically, magnesium is fantastic for my heightened physical activity and managing stress. It alleviates leg cramps swiftly and significantly relieves migraine pain, unlike expensive alternatives I’ve tried. The product is of excellent quality and has practical packaging.
Read More
7.5
Comprehensive benefits
6 people found this helpful
Calcium Magnesium Zinc With Vitamin D-3 from Nature's Bounty is a beneficial supplement aiding various bodily functions. It helps regulate blood clotting, muscle contraction, and can reduce migraine attacks. The product comes in a neatly designed jar of 100 tablets, and the manufacturer recommends taking up to three daily with meals. I advise this supplement as it has positively impacted both my health and that of my friends.
Read More
Frequently Asked Questions
7.5
Quick relief
I have taken these vitamins for years and find them highly effective, impacting me positively within days. Specifically, magnesium is fantastic for my heightened physical activity and managing stress. It alleviates leg cramps swiftly and significantly relieves migraine pain, unlike expensive alternatives I’ve tried. The product is of excellent quality and has practical packaging.
7.5
Headache prevention
I bought this to prevent migraines and have noticed a marked improvement after taking it for over a month, with no severe headaches since. I've also experienced less cramping in my calves upon waking, indicating improvement. If I continue to avoid headaches, I plan to keep purchasing this product.
7.5
Significant improvement
1 people found this helpful
Price and quality serve as an ally in combating migraines. I've been drinking magnesium for over six months to build its effects. I constantly order this complex with calcium and zinc, consuming one tablet daily and occasionally supplementing with multivitamins. I've noticed a considerable reduction in headaches and muscle tension, thanks to this alongside manual therapy and massage. The results are impressive, and I highly recommend it.
9
Effective supplement
I used this supplement to alleviate my migraines, and it has substantially reduced their frequency.
9
Enhanced sleep
I really liked this complex! It works particularly well during migraines and headaches. Taking it at night also improves sleep quality significantly. I recommend giving it a try.
7.5
Effective against migraines
The quality and combination of this supplement are excellent. Magnesium effectively combats migraines and headaches, while zinc improves hair, skin, and nails, and vitamin D3 addresses deficiencies in the nervous system and calcium absorption. After taking one capsule daily for two years, I’ve experienced good results. The packaging contains 90 tablets, and although I don't taste it as I consume it with water, I recommend it as it benefits my whole family, especially when combined with Omega.
7.5
Comprehensive benefits
6 people found this helpful
Calcium Magnesium Zinc With Vitamin D-3 from Nature's Bounty is a beneficial supplement aiding various bodily functions. It helps regulate blood clotting, muscle contraction, and can reduce migraine attacks. The product comes in a neatly designed jar of 100 tablets, and the manufacturer recommends taking up to three daily with meals. I advise this supplement as it has positively impacted both my health and that of my friends.
7
Our exploration into the connection between vitamin D levels and migraine prevalence drew on data from the National Health and Nutrition Examination Survey involving over 9,100 participants. The study specifically examined the concentration of vitamin D in the blood and how it relates to self-reported migraine experiences.
We observed that 20.53% of participants reported suffering from migraines, with a clear trend showing that those with lower levels of serum vitamin D tended to experience migraines more frequently. Interestingly, individuals in the highest vitamin D quartile reported a 16% lower incidence of migraines compared to those in the lowest quartile. This finding suggests that sufficient levels of vitamin D might play a role in reducing migraine frequency.
Overall, our analysis indicates a significant negative correlation between serum vitamin D levels and migraine prevalence among American adults. While the precise mechanisms behind this relationship warrant further investigation, our study provides valuable insights into how maintaining adequate vitamin D levels could potentially alleviate migraine symptoms for some individuals.
We observed that 20.53% of participants reported suffering from migraines, with a clear trend showing that those with lower levels of serum vitamin D tended to experience migraines more frequently. Interestingly, individuals in the highest vitamin D quartile reported a 16% lower incidence of migraines compared to those in the lowest quartile. This finding suggests that sufficient levels of vitamin D might play a role in reducing migraine frequency.
Overall, our analysis indicates a significant negative correlation between serum vitamin D levels and migraine prevalence among American adults. While the precise mechanisms behind this relationship warrant further investigation, our study provides valuable insights into how maintaining adequate vitamin D levels could potentially alleviate migraine symptoms for some individuals.
7
We examined how vitamin D affects migraines, drawing from a systematic review and meta-analysis of various dietary supplements. The study brought together evidence from twenty-two trials, focusing on significant outcomes like the frequency and severity of migraine attacks.
Specifically, vitamin D supplementation showed notable benefits. Participants who took vitamin D had a reduction in migraine frequency and the number of monthly migraine days compared to those who received a placebo. This indicates that vitamin D might play a role in alleviating migraines effectively.
Overall, the results suggest that while vitamin D treatment can be beneficial for migraine sufferers, there's still a call for further high-quality clinical trials to solidify our understanding and confirm these findings.
Specifically, vitamin D supplementation showed notable benefits. Participants who took vitamin D had a reduction in migraine frequency and the number of monthly migraine days compared to those who received a placebo. This indicates that vitamin D might play a role in alleviating migraines effectively.
Overall, the results suggest that while vitamin D treatment can be beneficial for migraine sufferers, there's still a call for further high-quality clinical trials to solidify our understanding and confirm these findings.
4
Vitamin D may affect migraine frequency
We explored the link between vitamin D levels and the frequency and severity of migraines in children. In this study, we reviewed data from 171 pediatric patients diagnosed with migraines between February and December 2022.
Our findings revealed that children experiencing fewer migraines (1-3 attacks per month) had a higher median vitamin D level of 15.6 μg/L compared to those with more frequent attacks (over 3 per month), whose levels dropped to 11.9 μg/L. This suggests that adequate vitamin D levels might be associated with a lower attack frequency.
Additionally, we observed a relationship between vitamin B levels and the duration of migraine attacks. Those with shorter attack durations (2-6 hours) had higher vitamin B levels than those suffering longer attacks (12-24 hours). Furthermore, we noted that patients not receiving prophylactic treatment had higher ferritin levels compared to those who were treated. This indicates that some micronutrient deficiency might be present in patients undergoing preventive therapies.
In conclusion, our research indicates that assessing micronutrient levels, particularly vitamin D, could be beneficial for children suffering from migraines.
Our findings revealed that children experiencing fewer migraines (1-3 attacks per month) had a higher median vitamin D level of 15.6 μg/L compared to those with more frequent attacks (over 3 per month), whose levels dropped to 11.9 μg/L. This suggests that adequate vitamin D levels might be associated with a lower attack frequency.
Additionally, we observed a relationship between vitamin B levels and the duration of migraine attacks. Those with shorter attack durations (2-6 hours) had higher vitamin B levels than those suffering longer attacks (12-24 hours). Furthermore, we noted that patients not receiving prophylactic treatment had higher ferritin levels compared to those who were treated. This indicates that some micronutrient deficiency might be present in patients undergoing preventive therapies.
In conclusion, our research indicates that assessing micronutrient levels, particularly vitamin D, could be beneficial for children suffering from migraines.
References
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- Ghorbani Z, Rafiee P, Fotouhi A, Haghighi S, Rasekh Magham R, et al. The effects of vitamin D supplementation on interictal serum levels of calcitonin gene-related peptide (CGRP) in episodic migraine patients: post hoc analysis of a randomized double-blind placebo-controlled trial. J Headache Pain. 2020;21:22. 10.1186/s10194-020-01090-w
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- Bhurat R, Premkumar S, Manokaran RK. Serum Magnesium Levels in Children With and Without Migraine: A Cross-Sectional Study. Indian Pediatr. 2022;59:623.
- Mazza GR, Solorio C, Stek AM, Kalayjian LA, Wilson ML, et al. Assessing the efficacy of magnesium oxide and riboflavin as preventative treatment of migraines in pregnancy. Arch Gynecol Obstet. 2023;308:1749. 10.1007/s00404-022-06872-y
- Guerrero-Toro C, Koroleva K, Ermakova E, Gafurov O, Abushik P, et al. Testing the Role of Glutamate NMDA Receptors in Peripheral Trigeminal Nociception Implicated in Migraine Pain. Int J Mol Sci. 2022;23. 10.3390/ijms23031529
- Matin H, Taghian F, Chitsaz A. Artificial intelligence analysis to explore synchronize exercise, cobalamin, and magnesium as new actors to therapeutic of migraine symptoms: a randomized, placebo-controlled trial. Neurol Sci. 2022;43:4413. 10.1007/s10072-021-05843-6
- Karim MR, Bhattacharjee M, Islam MS, Banerjee S, Hossain S, et al. Relation between Serum Magnesium Level and Migraine. Mymensingh Med J. 2021;30:301.
- Singhal S, Dutta SB, Bansal S, Dutta S, Shah RB. Zinc as An Emerging Therapy in the Management of Migraine: A Systematic Review. Neurol India. 2024;72:934. 10.4103/neurol-india.Neurol-India-D-23-00337
- Fukazawa R, Ishii R, Higashimoto Y, Hanya M, Shimizu Y, et al. Zinc Administration Favorably Affects Prophylactic Therapy-refractory Migraine Attacks: A Case Series. Intern Med. 2024;63:1631. 10.2169/internalmedicine.2111-23
- Zheng H, Tian S, Wu L, Zhong X, Liu M, et al. Dietary zinc intake in relation to migraine among adults: a cross sectional study of NHANES 1999-2004. Nutr Neurosci. 2024;27:667. 10.1080/1028415X.2023.2243678
- Liu H, Wang Q, Dong Z, Yu S. Dietary zinc intake and migraine in adults: a cross-sectional analysis of the National Health and Nutrition Examination Survey 1999-2004. Headache. 2023;63:127. 10.1111/head.14431
- Mazaheri M, Aghdam AM, Heidari M, Zarrin R. Assessing the Effect of Zinc Supplementation on the Frequency of Migraine Attack, Duration, Severity, Lipid Profile and hs-CRP in Adult Women. Clin Nutr Res. 2021;10:127. 10.7762/cnr.2021.10.2.127
- Ahmadi H, Mazloumi-Kiapey SS, Sadeghi O, Nasiri M, Khorvash F, et al. Zinc supplementation affects favorably the frequency of migraine attacks: a double-blind randomized placebo-controlled clinical trial. Nutr J. 2020;19:101. 10.1186/s12937-020-00618-9
- Dhillon KS, Singh J, Lyall JS. A new horizon into the pathobiology, etiology and treatment of migraine. Med Hypotheses. 2011;77:147. 10.1016/j.mehy.2011.03.050
