Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 44 Researches
7.8
USERS' SCORE
Moderately Good
Based on 62 Reviews
7.7
Supplement Facts
Serving Size: 3 Caplets
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
15 mcg (600 IU)
75%
Calcium (as Calcium Carbonate and Calcium Gluconate)
1,000 mg
77%
Magnesium (as Magnesium Oxide and Magnesium Gluconate)
400 mg
95%
Zinc (as Zinc Gluconate and Zinc Citrate)
25 mg
227%
Sodium
10 mg
<1%
Top Medical Research Studies
9
We explored the effects of a special material called magnesium-based zeolitic imidazolate frameworks, or Mg-ZIF, on osteoporosis. This study aimed to find a way to tackle osteoporosis by reducing reactive oxygen species (ROS)—harmful molecules that affect our bone health.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
Our findings revealed that Mg-ZIF is effective at scavenging ROS, which helps boost the bone-forming ability of bone mesenchymal stem cells (BMSCs). By promoting osteogenic differentiation, Mg-ZIF supports the formation of new bone while simultaneously discouraging the development of fat cells from BMSCs, a process known as lipogenic differentiation.
In our in vivo experiments, we confirmed that administering Mg-ZIF could successfully lower ROS levels and mitigate the effects of osteoporosis. On a deeper level, the mechanism behind this involves Mg-ZIF enhancing BMSC differentiation into bone-forming cells by upregulating specific lipid metabolic pathways.
Overall, we believe that Mg-ZIF holds promise as a therapeutic approach for osteoporosis. By addressing the oxidative stress in the bone marrow environment, it opens a new door for potential treatments targeting this common bone disease.
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9
In our exploration of osteoporosis treatment, we focused on the effects of magnesium, particularly when combined with phosphorylated collagen peptide-magnesium chelates. Our study utilized osteoblast MC3T3-E1 cells and incorporated ovariectomized mice to simulate postmenopausal osteoporosis, which allowed us to see how magnesium might help in strengthening bones.
We observed that magnesium plays a vital role in bone health, especially in the context of osteoporosis. The results indicated that the combination treatment could enhance bone formation and improve overall bone density in our models. This suggests that magnesium, alongside other compounds, may offer a promising approach to managing osteoporosis.
However, it's important to note that while we found positive effects, the detailed mechanisms of how magnesium works in this specific treatment remain complex and may involve interactions with other components. Further research is needed to fully understand its efficacy and the best ways to integrate magnesium into osteoporosis treatment strategies.
We observed that magnesium plays a vital role in bone health, especially in the context of osteoporosis. The results indicated that the combination treatment could enhance bone formation and improve overall bone density in our models. This suggests that magnesium, alongside other compounds, may offer a promising approach to managing osteoporosis.
However, it's important to note that while we found positive effects, the detailed mechanisms of how magnesium works in this specific treatment remain complex and may involve interactions with other components. Further research is needed to fully understand its efficacy and the best ways to integrate magnesium into osteoporosis treatment strategies.
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9
Nanopowder eggshells improve bone health
We examined how nanopowder eggshells (NPES) could influence bone health in both healthy and ovariectomy-induced osteoporosis rats.
In our research, we found that NPES treatment significantly enhanced indicators of bone formation, like calcium and osteocalcin, particularly in healthy rats.
Additionally, in the ovariectomized group, NPES treatment helped improve levels of vital nutrients and reduced bone resorption.
Overall, our findings suggest that NPES may play a beneficial role in bettering bone health in osteoporosis models.
In our research, we found that NPES treatment significantly enhanced indicators of bone formation, like calcium and osteocalcin, particularly in healthy rats.
Additionally, in the ovariectomized group, NPES treatment helped improve levels of vital nutrients and reduced bone resorption.
Overall, our findings suggest that NPES may play a beneficial role in bettering bone health in osteoporosis models.
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Most Useful Reviews
9
Supports osteoporosis treatment
19 people found this helpful
Calcium is vital for human health. A deficiency can lead to osteoporosis. Magnesium calms the nervous system, while zinc strengthens immunity. This 3-in-1 combo, featuring D3 to enhance calcium absorption, is an excellent supplement for its price and quality.
Read More
9
Improved sleep
11 people found this helpful
I took this supplement containing calcium, magnesium, zinc, and vitamin D3 to improve my sleep quality and bone health during menopause. I've noticed better sleep since starting the fourth course, though the large tablets are hard to swallow.
Read More
9
Enhances osteoporosis prevention
8 people found this helpful
This supplement’s composition is outstanding! Calcium, magnesium, zinc, and vitamin D-3 are vital for maintaining health and preventing colds, while also decreasing osteoporosis risk. The long tablets are easy to swallow; I recommend taking them daily, especially for older adults like me.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 44 Researches
7.8
- All Researches
9
Our research explored the effects of a new calcium-loaded complex, made from Antarctic krill protein and enriched with pectin, on calcium absorption and bone health in mice with calcium deficiency. We created a model that simulated calcium deficiency, which is a significant concern as it can contribute to osteoporosis.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
Read More
9
We explored how salmon calcitonin (sCT) works in tandem with calcium antagonists—specifically verapamil, nifedipine, and diltiazem—to influence blood calcium and phosphorus levels in female rats with osteoporosis post-ovarian removal.
The study involved a systematic approach where we administered these combinations to different groups of osteoporotic rats and measured their blood levels. Our findings revealed that combining sCT with nifedipine had a particularly strong effect in lowering both calcium and phosphorus in the blood, outperforming the use of sCT alone.
Our analysis indicated that while sCT with nifedipine was most effective, the combinations with verapamil and diltiazem also showed beneficial effects, albeit to a lesser extent. These insights provide valuable information on how combination therapies might be targeted for treating postmenopausal osteoporosis, potentially paving the way for more effective treatment options in human patients.
The study involved a systematic approach where we administered these combinations to different groups of osteoporotic rats and measured their blood levels. Our findings revealed that combining sCT with nifedipine had a particularly strong effect in lowering both calcium and phosphorus in the blood, outperforming the use of sCT alone.
Our analysis indicated that while sCT with nifedipine was most effective, the combinations with verapamil and diltiazem also showed beneficial effects, albeit to a lesser extent. These insights provide valuable information on how combination therapies might be targeted for treating postmenopausal osteoporosis, potentially paving the way for more effective treatment options in human patients.
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9
We explored how a specific probiotic strain, FSHHK13M1, affects vitamin D metabolism and osteoporosis in mice. Previous research pointed out that the gut microbiota plays a crucial role in vitamin D metabolism, which is especially relevant for older adults who tend to suffer from osteoporosis due to declining organ functions.
Our study demonstrated that treating the mice with FSHHK13M1 led to a significant increase in their serum levels of active vitamin D metabolites, particularly 1,25-dihydroxy vitamin D. This increase was linked to activation of important bone health pathways, helping to fortify bone structure and function.
Not only did we observe improvements in vitamin D levels, but the intervention also restored balance in the gut microbiota, which showed signs of imbalance in mice suffering from osteoporosis. The findings suggest that FSHHK13M1 could be a promising direction for improving bone health and reducing fracture risks in the elderly by enhancing vitamin D levels naturally.
Overall, this research highlights the potential of combining probiotics with vitamin D strategies for better management of osteoporosis, especially in older populations who often face challenges absorbing conventional treatments.
Our study demonstrated that treating the mice with FSHHK13M1 led to a significant increase in their serum levels of active vitamin D metabolites, particularly 1,25-dihydroxy vitamin D. This increase was linked to activation of important bone health pathways, helping to fortify bone structure and function.
Not only did we observe improvements in vitamin D levels, but the intervention also restored balance in the gut microbiota, which showed signs of imbalance in mice suffering from osteoporosis. The findings suggest that FSHHK13M1 could be a promising direction for improving bone health and reducing fracture risks in the elderly by enhancing vitamin D levels naturally.
Overall, this research highlights the potential of combining probiotics with vitamin D strategies for better management of osteoporosis, especially in older populations who often face challenges absorbing conventional treatments.
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9
We examined how dietary intake of magnesium, along with potassium and sodium, influences bone health, specifically focusing on osteoporosis and bone mineral density (BMD) in adults across the U.S. Our analysis was based on data from the National Health and Nutrition Examination Surveys, which spanned from 2005 to 2018, involving over 10,000 participants.
The findings revealed a positive association between higher dietary intake of potassium, magnesium, and sodium and improved BMD of the femur. This means that those who consumed more of these nutrients tended to have stronger bones. Additionally, we observed that a higher intake of these minerals was linked to a lower occurrence of osteopenia and osteoporosis.
Our study highlights how magnesium, when part of a broader nutrient intake that includes potassium and sodium, could play a significant role in maintaining bone health. While our research points to a beneficial relationship, more targeted studies are needed to definitively isolate the effects of magnesium alone on osteoporosis. Overall, this reinforces the importance of a balanced diet for bone health.
The findings revealed a positive association between higher dietary intake of potassium, magnesium, and sodium and improved BMD of the femur. This means that those who consumed more of these nutrients tended to have stronger bones. Additionally, we observed that a higher intake of these minerals was linked to a lower occurrence of osteopenia and osteoporosis.
Our study highlights how magnesium, when part of a broader nutrient intake that includes potassium and sodium, could play a significant role in maintaining bone health. While our research points to a beneficial relationship, more targeted studies are needed to definitively isolate the effects of magnesium alone on osteoporosis. Overall, this reinforces the importance of a balanced diet for bone health.
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9
We delved into the use of a unique injectable hydrogel loaded with magnesium to address the challenges of repairing osteoporotic bone defects. The study aimed to understand how this magnesium-infused hydrogel could combat the excessive reactive oxygen species (ROS) that hinder bone repair. With impressive qualities such as excellent injectability and adaptability, the hydrogel can be introduced into irregular bone areas without the need for major surgery.
Once injected, the hydrogel not only transforms into a supportive scaffold but also begins to release hydrogen and magnesium ions. This release is key in reducing harmful intracellular ROS and guiding the immune response favorably by promoting macrophage polarization. We observed that this gel suppressed the formation of osteoclasts, the cells responsible for bone resorption, while simultaneously encouraging the growth of new bone cells.
Animal experiments further illuminated the effectiveness of the magnesium-loaded hydrogel, showing a remarkable ability to enhance the repair of bone defects by controlling inflammation and supporting bone formation. Overall, our findings shine a light on the potential of magnesium-based hydrogels as promising solutions for those dealing with osteoporosis-related bone damage.
Once injected, the hydrogel not only transforms into a supportive scaffold but also begins to release hydrogen and magnesium ions. This release is key in reducing harmful intracellular ROS and guiding the immune response favorably by promoting macrophage polarization. We observed that this gel suppressed the formation of osteoclasts, the cells responsible for bone resorption, while simultaneously encouraging the growth of new bone cells.
Animal experiments further illuminated the effectiveness of the magnesium-loaded hydrogel, showing a remarkable ability to enhance the repair of bone defects by controlling inflammation and supporting bone formation. Overall, our findings shine a light on the potential of magnesium-based hydrogels as promising solutions for those dealing with osteoporosis-related bone damage.
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User Reviews
USERS' SCORE
Moderately Good
Based on 62 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Supports osteoporosis treatment
19 people found this helpful
Calcium is vital for human health. A deficiency can lead to osteoporosis. Magnesium calms the nervous system, while zinc strengthens immunity. This 3-in-1 combo, featuring D3 to enhance calcium absorption, is an excellent supplement for its price and quality.
Read More
9
Improved sleep
11 people found this helpful
I took this supplement containing calcium, magnesium, zinc, and vitamin D3 to improve my sleep quality and bone health during menopause. I've noticed better sleep since starting the fourth course, though the large tablets are hard to swallow.
Read More
9
Enhances osteoporosis prevention
8 people found this helpful
This supplement’s composition is outstanding! Calcium, magnesium, zinc, and vitamin D-3 are vital for maintaining health and preventing colds, while also decreasing osteoporosis risk. The long tablets are easy to swallow; I recommend taking them daily, especially for older adults like me.
Read More
9
Supports bone health
5 people found this helpful
This supplement helps reduce osteoporosis risk. With 1000 mg of calcium, 400 mg of magnesium, 25 mg of zinc, and 600 IU of vitamin D3, it effectively supports bone health. The smooth, easy-to-swallow capsules are taken daily with meals, without any harmful additives.
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9
Normal levels achieved
3 people found this helpful
To increase bone density, my doctor recommended calcium tablets and vitamin D3 due to my osteoporosis. After regular use, my levels normalised. It's also said to help against the new coronavirus, so I’ll continue to use it.
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Frequently Asked Questions
9
Reduced shoulder pain
3 people found this helpful
My shoulder was hurting, and after an X-ray, the doctor diagnosed it as osteoporosis. A blood test showed normal calcium levels, yet the doctor suggested I take calcium and vitamin D supplements for better absorption. I took 2 tablets daily in the evening. After two months, my shoulder pain diminished significantly, allowing me to sleep comfortably on my right side. I've been advised to take calcium supplements twice a year for a few months. Wishing everyone great health! I hope my review helps.
9
Improved sleep
11 people found this helpful
I took this supplement containing calcium, magnesium, zinc, and vitamin D3 to improve my sleep quality and bone health during menopause. I've noticed better sleep since starting the fourth course, though the large tablets are hard to swallow.
9
Normal levels achieved
3 people found this helpful
To increase bone density, my doctor recommended calcium tablets and vitamin D3 due to my osteoporosis. After regular use, my levels normalised. It's also said to help against the new coronavirus, so I’ll continue to use it.
9
Positive trend noted
2 people found this helpful
This product has completely met my expectations and aids in treating osteoporosis. Recent studies show a positive trend in my condition.
7.5
Alleviates vitamin deficiency
4 people found this helpful
This top-quality supplement contains minerals like calcium and vitamin D, which combat osteoporosis and enhance health. It's sealed for freshness, reasonably priced, and has no unpleasant taste.
7.5
Boosted health
12 people found this helpful
I used these throughout winter alongside vitamin D3, magnesium, and omega fatty acids, noting improved skin, shiny hair, and stronger nails. I’ve not caught a cold all winter! Good vitamins for osteoporosis prevention, although the capsules are somewhat difficult to swallow.
9
Improves osteoporosis symptoms
2 people found this helpful
These calcium tablets are high quality, including magnesium and vitamin D3 for better calcium absorption. They significantly improved my osteoporosis symptoms. They are reasonably priced, and I’ve purchased them three times as they are worth it.
9
Supports bone health
5 people found this helpful
This supplement helps reduce osteoporosis risk. With 1000 mg of calcium, 400 mg of magnesium, 25 mg of zinc, and 600 IU of vitamin D3, it effectively supports bone health. The smooth, easy-to-swallow capsules are taken daily with meals, without any harmful additives.
7.5
Osteoporosis reduction
147 people found this helpful
Nature's Bounty offers fantastic products. The serving size is three tablets, which include 15 mcg of vitamin D, 1000 mg of calcium, 400 mg of magnesium, and 25 mg of zinc. This combination may lower the risk of osteoporosis. The quality is great, and I appreciate the packaging!
9
Vital minerals
26 people found this helpful
Calcium, magnesium, and zinc are key to our health. They support bones, teeth, and immune function. I started taking two capsules daily, and I believe my health has improved. At my age, I need to manage my joints, and this supplement feels beneficial. I plan to continue using it!
4
We conducted a thorough review of various treatments for osteoporosis in people living with HIV, particularly focusing on the role of calcium. Our analysis included randomized controlled trials that compared different treatment strategies, such as calcium combined with medications like zoledronate or alendronate.
While zoledronate showed promising results in improving bone mineral density, calcium was often used alongside these treatments. Unfortunately, this combination makes it difficult to isolate the specific effects of calcium on osteoporosis. We found that alendronate, although it helped reduce certain bone turnover markers, did not significantly improve bone density.
Overall, the study indicates that while calcium plays a role in treatment combinations, its isolated impact on osteoporosis remains unclear. We emphasized the need for more focused research to determine calcium's true effectiveness in enhancing bone health for those affected by HIV.
While zoledronate showed promising results in improving bone mineral density, calcium was often used alongside these treatments. Unfortunately, this combination makes it difficult to isolate the specific effects of calcium on osteoporosis. We found that alendronate, although it helped reduce certain bone turnover markers, did not significantly improve bone density.
Overall, the study indicates that while calcium plays a role in treatment combinations, its isolated impact on osteoporosis remains unclear. We emphasized the need for more focused research to determine calcium's true effectiveness in enhancing bone health for those affected by HIV.
9
Our research explored the effects of a new calcium-loaded complex, made from Antarctic krill protein and enriched with pectin, on calcium absorption and bone health in mice with calcium deficiency. We created a model that simulated calcium deficiency, which is a significant concern as it can contribute to osteoporosis.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
We observed that chronic calcium deprivation led to decreased calcium absorption and deterioration of bone structure. However, the P + Ca + HMP complex significantly improved calcium retention and increased the strength of the femur, indicating a positive impact on bone health.
Additionally, this complex improved the structure of the trabecular network, which is essential for maintaining strong bones. The presence of beneficial bacteria in the gut also rose after the intervention, and these were linked to better calcium absorption and bone synthesis. Overall, these findings point to the potential of the P + Ca + HMP complex as an effective calcium supplement that could help prevent calcium deficiency and thus support bone health.
8
We examined the relationship between vitamin D levels and the risk of new vertebral fractures after patients underwent a specific spine procedure called percutaneous vertebral augmentation. Our focus was on postmenopausal women aged 50 and above, who often face an increased risk of fractures due to osteoporosis.
In this retrospective study, we categorized patients into groups based on whether they experienced new osteoporotic vertebral fractures or not. Our analysis revealed that low levels of serum 25-hydroxyvitamin D are an independent risk factor for these new fractures.
This suggests that maintaining adequate vitamin D levels could be crucial for individuals recovering from this type of spinal surgery. By ensuring active vitamin D supplementation after the procedure, patients may significantly lower their chances of future osteoporotic vertebral fractures, promoting better recovery and overall health.
In this retrospective study, we categorized patients into groups based on whether they experienced new osteoporotic vertebral fractures or not. Our analysis revealed that low levels of serum 25-hydroxyvitamin D are an independent risk factor for these new fractures.
This suggests that maintaining adequate vitamin D levels could be crucial for individuals recovering from this type of spinal surgery. By ensuring active vitamin D supplementation after the procedure, patients may significantly lower their chances of future osteoporotic vertebral fractures, promoting better recovery and overall health.
7
We explored how calcium treatment influences bone mineralization, particularly in the context of osteoporosis. Our study involved human mesenchymal stem cells (hMSCs) that were cultured in two different environments: one with calcium and another with dexamethasone, a medication often used to treat inflammation and other conditions.
Interestingly, while both treatments increased mineralization of hMSCs, we noted that levels of a specific microRNA, miR-125b, decreased with exposure to either calcium or dexamethasone. When we introduced a miR-125b mimic in the dexamethasone-treated cells, mineralization increased; however, it did the opposite in the calcium-treated cells. This suggests that calcium's effect can vary significantly depending on the context in which it is applied.
We also identified key targets of miR-125b that play roles in bone development, highlighting the complexity behind how calcium treatments might work in conjunction with other factors like dexamethasone. Overall, our findings contribute to a deeper understanding of bone metabolism and suggest that while calcium is important, its effectiveness might not be straightforward and may require further exploration.
Interestingly, while both treatments increased mineralization of hMSCs, we noted that levels of a specific microRNA, miR-125b, decreased with exposure to either calcium or dexamethasone. When we introduced a miR-125b mimic in the dexamethasone-treated cells, mineralization increased; however, it did the opposite in the calcium-treated cells. This suggests that calcium's effect can vary significantly depending on the context in which it is applied.
We also identified key targets of miR-125b that play roles in bone development, highlighting the complexity behind how calcium treatments might work in conjunction with other factors like dexamethasone. Overall, our findings contribute to a deeper understanding of bone metabolism and suggest that while calcium is important, its effectiveness might not be straightforward and may require further exploration.
References
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- Dai Q, Wang Z, Liu C, Chen X, Cao X. High performance injectable Mg doped bioactive glass bone cement for the regulation of osteogenic immune microenvironment. Biomater Adv. 2024;160:213864. doi:10.1016/j.bioadv.2024.213864
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- Qin L, Liu Q, Zhang T, Tang X, Mo X, et al. Association Between Combined Polymetallic Exposure and Osteoporosis. Biol Trace Elem Res. 2024;202:3945. doi:10.1007/s12011-023-04002-6
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- Al-Garawi ZS, Al-Qaisi AHI, Al-Shamari KA, Öztürkkan FE, Necefoğlu H. The utility of Hibiscus sabdariffa L. to prepare metal oxides NPs for clinical application on osteoporosis supported by theoretical study. Bioprocess Biosyst Eng. 2024;47:753. doi:10.1007/s00449-024-03012-5
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- Zhu Y, Jia G, Yang Y, Weng J, Liu S, et al. Biomimetic Porous Magnesium Alloy Scaffolds Promote the Repair of Osteoporotic Bone Defects in Rats through Activating the Wnt/β-Catenin Signaling Pathway. ACS Biomater Sci Eng. 2023;9:3435. doi:10.1021/acsbiomaterials.2c01097
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