We aimed to uncover the connection between dietary zinc deficiency and symptoms associated with major depressive disorder (MDD). In our study, we used rats fed either a zinc-adequate diet or one deficient in zinc for four weeks.
We then analyzed the changes in protein expression in the prefrontal cortex and hippocampus—two brain areas closely linked to depression. This approach allowed us to see how zinc deficiency impacts the brain at a molecular level.
Our findings revealed that significant alterations occurred in proteins related to zinc transport and mitochondrial function due to the deficiency. In particular, we saw a notable decline in the activity of complex I of the mitochondrial energy production pathway in the prefrontal cortex.
These results suggest that low zinc levels can disrupt vital brain functions, potentially contributing to the development of depressive symptoms. This highlights the importance of maintaining adequate zinc levels for mental health.
Read More
9
Zinc complex offers depression relief
Exploring Zn(II)-Acetyl l-carnitine complex for simultaneous management of depression, chronic pain, and neuroprotection.
We investigated the potential benefits of a novel zinc complex, specifically Zn(ALC)Cl(HO), for its effectiveness in treating depression. This innovative compound combines zinc with acetyl-l-carnitine, which is known for its role in energy metabolism and protecting brain cells.
Our findings revealed that this zinc complex displays a remarkable 54% improvement in antidepressant activity compared to standard acetyl-l-carnitine. We also observed its ability to reduce pain in tests involving chronic conditions, showing promise in enhancing overall mental and physical health.
Additionally, this compound demonstrated capability to cross the blood-brain barrier, protecting against cell damage from excessive glutamate. We think these results indicate that Zn(ALC)Cl(HO) could be a significant step forward in managing not just depression but also neurodegenerative challenges.
Read More
8
Zinc may improve depressive symptoms
Drugs with glutamate-based mechanisms of action in psychiatry.
We explored the potential impact of zinc on depression, focusing on how this important mineral might help improve mood. Various studies suggest that zinc could play a role in combating depressive symptoms, offering a promising avenue for those who find themselves struggling with mental health issues.
While the research is still developing, there’s an encouraging indication that zinc may enhance the effectiveness of other treatments for depression. However, details about specific studies or methodologies are limited in our findings, which makes it tricky to fully gauge just how beneficial zinc is on its own.
We remain open to the need for more extensive research to truly understand zinc's place in depression treatment. The results so far are positive, yet more comprehensive studies could shed light on the best ways to incorporate zinc into therapeutic strategies for mental health.
Read More
Most Useful Reviews
9
Reduces depression effectively
Definitely a necessary addition! I've used this supplement for a long time, three times a year for 30 days with great results. It boosts mood and memory, alleviates depression and anxiety, reduces the formation of fatty plaques, strengthens the immune system, and regulates glucose metabolism. It's an antioxidant that protects cells and aids growth and development during puberty. For men, it governs testosterone formation, improves sperm motility, and supports prostate health, while in women, it is vital for ovulation, menstrual regularity, and breastfeeding.
Read More
7.5
Zinc alleviates symptoms
5 people found this helpful
Zinc has helped significantly! It should be taken an hour before or two hours after meals, as certain foods disrupt zinc absorption. Zinc deficiency leads to fatigue, depression, loss of appetite, and reduced concentration. High doses of zinc can hinder calcium and magnesium absorption, while calcium-rich diets can impede zinc uptake. It's crucial to maintain a two-hour gap between zinc intake and foods that are rich in phytates or phosphates. Zinc crosses the placental barrier and is present in breast milk, so during pregnancy, its use must prioritize the mother's benefits against potential risks to the fetus. A beneficial combination includes zinc with selenium alongside vitamins A, E, and Omega-3.
Read More
7.5
Boosts overall health
3 people found this helpful
Excellent! Zinc is vital to the normal function of many systems, including the immune and nervous systems. It's crucial for skin restoration, brain function, toxin defence, and regulating insulin. Symptoms of deficiency include acne, reduced immunity, sleep disturbances, fatigue, depression, and hair loss. Various forms of zinc are available, but picolinate and chelate are best absorbed. Avoid taking it with coffee or dairy; wait an hour and a half to ensure proper absorption.
We investigated the potential benefits of a novel zinc complex, specifically Zn(ALC)Cl(HO), for its effectiveness in treating depression. This innovative compound combines zinc with acetyl-l-carnitine, which is known for its role in energy metabolism and protecting brain cells.
Our findings revealed that this zinc complex displays a remarkable 54% improvement in antidepressant activity compared to standard acetyl-l-carnitine. We also observed its ability to reduce pain in tests involving chronic conditions, showing promise in enhancing overall mental and physical health.
Additionally, this compound demonstrated capability to cross the blood-brain barrier, protecting against cell damage from excessive glutamate. We think these results indicate that Zn(ALC)Cl(HO) could be a significant step forward in managing not just depression but also neurodegenerative challenges.
Read More
8
Zinc's potential role in depression
Dissociative Identity Disorder Cotreated With Zinc and L-carnosine: A Case Report.
We examined a case involving a 30-year-old woman diagnosed with dissociative identity disorder (DID) and bipolar I disorder. This patient was found to have zinc deficiency, which may have contributed to her mental health challenges, including emotional instability and dissociation.
While she initially did not respond to medications like aripiprazole and clonazepam, her symptoms started to improve with zinc supplementation at a dosage of 50 mg daily over five months. The real breakthrough came when we combined this with L-carnosine, a dipeptide known for its neuroprotective effects. Gradually increasing the L-carnosine dose from 0.5 g daily to 2 g daily led to marked improvements in her mental health conditions, including reduced dissociation and mood instability.
After five months of this combined treatment, her distinct alter identities diminished significantly, and within two years, they had disappeared completely. Notably, when the treatment was discontinued during a three-year follow-up, the identities resurfaced. The improvements were accompanied by a resolution of her zinc deficiency symptoms and reductions in her depression and dissociation severity scores.
Overall, this case suggests that zinc and L-carnosine may play a role in alleviating some depressive symptoms associated with dissociative identity disorder, but further investigation is warranted to understand the extent of zinc's contribution to these effects.
Read More
8
Zinc may improve depressive symptoms
Drugs with glutamate-based mechanisms of action in psychiatry.
We explored the potential impact of zinc on depression, focusing on how this important mineral might help improve mood. Various studies suggest that zinc could play a role in combating depressive symptoms, offering a promising avenue for those who find themselves struggling with mental health issues.
While the research is still developing, there’s an encouraging indication that zinc may enhance the effectiveness of other treatments for depression. However, details about specific studies or methodologies are limited in our findings, which makes it tricky to fully gauge just how beneficial zinc is on its own.
We remain open to the need for more extensive research to truly understand zinc's place in depression treatment. The results so far are positive, yet more comprehensive studies could shed light on the best ways to incorporate zinc into therapeutic strategies for mental health.
Read More
8
Zinc's role in obesity-depression cycle
The WFS1-ZnT3-Zn Axis Regulates the Vicious Cycle of Obesity and Depression.
We explored the intriguing relationship between zinc, obesity, and depression in a recent study. By examining mice with a specific deficiency in the WFS1 gene, we uncovered how this gene plays a significant role in both conditions. We fed these mice a high-fat diet and observed that their lack of WFS1 exacerbated symptoms of both obesity and depression.
In our investigation using human stem cells, we found that WFS1 is essential for regulating zinc levels within neural progenitor cells. This regulation influences cell health, especially in scenarios where lipid metabolism is disrupted. A key player in this process is the zinc transporter ZnT3, which WFS1 inhibits. Essentially, when WFS1 isn't functioning properly, it leads to imbalances in zinc that can promote cell death, a concern we found tied to obesity-related lipid issues.
Additionally, we tested riluzole, a therapeutic agent known for its nervous system benefits. This treatment showed promise in regulating ZnT3 and maintaining zinc balance, helping to protect neural progenitor cells from detrimental effects caused by excess fat. Riluzole administration in mice not only helped mitigate obesity but also eased related depressive symptoms.
However, while zinc is a significant factor within the framework of brain health, our findings suggest that the dynamics of how it interacts with obesity and depression are complex. Thus, while we noted zinc's importance through its linked pathways, we didn't isolate its effects separately, leaving some questions unanswered about zinc treatment's effectiveness on depression alone.
Read More
8
Zinc's potential in depression treatment
BEHAVIORAL AND NEUROCHEMICAL CHANGES DURING INTRANASAL ADMINISTRATION OF ALPHA-GLUTAMYL-TRYPTOPHAN AND CHELATE COMPLEX OF ZINC ARGINYL-GLYCINATE ON MONOAMINE SYSTEMS DYSFUNCTIONS KNOCK-OUT MODELS.
We investigated how intranasal administration of a chelate complex of zinc arginyl-glycinate combined with alpha-glutamyl-tryptophan affects behaviors typically linked to depression. The study involved a variety of rodent models, namely Wistar and DAT-KO rats, as well as C57Bl6 and TAAR1-KO mice, allowing us to explore different genetic backgrounds in relation to depressive behaviors.
Our findings revealed that this specific method of zinc treatment along with the dipeptide showed potential in reducing anxiety and depressive-like behavior, especially after acute administration in C57Bl6 mice. Interestingly, chronic intranasal use also influenced anxiety levels in tested rodents but more consistent improvements in depressive behaviors were noted with acute treatments.
We suggest that intranasal delivery of this zinc and dipeptide combination could be a promising avenue to explore further as a possible new approach for addressing anxiety and depression. It also highlights the need for pre-clinical studies to confirm these benefits before any clinical applications can be considered.
Definitely a necessary addition! I've used this supplement for a long time, three times a year for 30 days with great results. It boosts mood and memory, alleviates depression and anxiety, reduces the formation of fatty plaques, strengthens the immune system, and regulates glucose metabolism. It's an antioxidant that protects cells and aids growth and development during puberty. For men, it governs testosterone formation, improves sperm motility, and supports prostate health, while in women, it is vital for ovulation, menstrual regularity, and breastfeeding.
Read More
7.5
Zinc alleviates symptoms
5 people found this helpful
Zinc has helped significantly! It should be taken an hour before or two hours after meals, as certain foods disrupt zinc absorption. Zinc deficiency leads to fatigue, depression, loss of appetite, and reduced concentration. High doses of zinc can hinder calcium and magnesium absorption, while calcium-rich diets can impede zinc uptake. It's crucial to maintain a two-hour gap between zinc intake and foods that are rich in phytates or phosphates. Zinc crosses the placental barrier and is present in breast milk, so during pregnancy, its use must prioritize the mother's benefits against potential risks to the fetus. A beneficial combination includes zinc with selenium alongside vitamins A, E, and Omega-3.
Read More
7.5
Boosts overall health
3 people found this helpful
Excellent! Zinc is vital to the normal function of many systems, including the immune and nervous systems. It's crucial for skin restoration, brain function, toxin defence, and regulating insulin. Symptoms of deficiency include acne, reduced immunity, sleep disturbances, fatigue, depression, and hair loss. Various forms of zinc are available, but picolinate and chelate are best absorbed. Avoid taking it with coffee or dairy; wait an hour and a half to ensure proper absorption.
Read More
7.5
Essential dietary supplement
2 people found this helpful
I regularly stock up on this supplement at home! Zinc is critical for many systems in the body, including the immune and nervous systems. It aids skin restoration, brain function, and toxin filtration, and helps normalise insulin synthesis. Symptoms of deficiency consist of acne, chicken blindness, sleep disturbances, fatigue, depression, and diminished immunity. The best-absorbed forms are picolinate and chelate. It's best not to take it with coffee and dairy, allowing an hour and a half before consuming zinc.
Read More
Frequently Asked Questions
Depression is a common and serious mental health condition characterized by persistent feelings of sadness, hopelessness, and a lack of interest or pleasure in activities that were once enjoyable. It can affect anyone, regardless of age, gender, or background, and it goes beyond just feeling down; it can interfere significantly with daily life, impacting relationships, work performance, and overall well-being. Symptoms of depression may include changes in appetite or weight, sleep disturbances, fatigue, difficulty concentrating, and thoughts of worthlessness or suicide.
The causes of depression are complex and may involve a combination of genetic, biological, environmental, and psychological factors. While it's a serious condition that can be debilitating, the good news is that it is treatable. Various treatment options are available, including therapy, medication, lifestyle changes, and support groups. If you or someone you know is struggling with depression, seeking help from a healthcare professional is a crucial step toward recovery.
Zinc is a versatile metal known for its various applications in industry and health. It is a bluish-white metallic element represented by the symbol Zn and atomic number 30 on the periodic table. Zinc is primarily used for galvanizing steel to prevent rusting, in the manufacturing of alloys, and as a component in batteries. Additionally, zinc plays a crucial role in biological processes, making it an essential trace element in the human diet. It is involved in immune function, protein synthesis, wound healing, and DNA synthesis, highlighting its importance in maintaining overall health and well-being.
Zinc has been studied for its potential role in mental health, including depression. Research indicates that zinc deficiency is linked to higher levels of depression and anxiety. Supplementing with zinc may help improve mood and alleviate some symptoms associated with depression, particularly in individuals with low baseline levels of this essential mineral. A few studies have suggested that zinc supplementation can have a positive effect on mood and may enhance the efficacy of traditional antidepressant medications.
However, it's important to approach zinc supplementation cautiously. While it can be beneficial for some, excessive zinc intake may lead to adverse effects, including nausea, headaches, and a potential imbalance with other essential minerals. If you're considering zinc for depression, it’s best to consult with a healthcare professional for personalized advice and to evaluate your specific nutritional needs. Ultimately, zinc should not be seen as a standalone treatment for depression, but rather as part of a broader, holistic approach that may include therapy and proper medical intervention.
Based on user reviews, the timeline for seeing results from zinc supplementation for depression varies. Some users report significant improvements after just a few weeks of consistent use, particularly when taken correctly as it can alleviate fatigue and enhance mood (Read Review). Others mention that they have experienced great results after long-term use, indicating that ongoing supplementation can be beneficial in improving depressive symptoms (Read Review).
It's important to note that individual responses may differ, and factors such as dosage, diet, and personal health conditions can influence how quickly you may notice a change. Users emphasize the significance of proper absorption, suggesting that how and when you take zinc can affect its efficacy in combating depression (Read Review). Many recommend combining zinc with other nutrients for optimal benefits, which may also contribute to quicker results in mood enhancement.
Recent scientific research suggests that zinc may play a beneficial role in treating depression, with several studies highlighting its impact on mood and mental health. One study demonstrated that a zinc-acetyl L-carnitine complex provided a 54% improvement in antidepressant activity compared to traditional acetyl-l-carnitine, showcasing zinc’s potential as a novel therapeutic option for depression [1]. Additionally, research has indicated that zinc deficiency can lead to significant alterations in protein expression in brain regions related to depression, underscoring the need for adequate zinc levels to maintain mental well-being [4].
Moreover, findings regarding the effects of intranasal zinc combined with dipeptides are promising, revealing potential in reducing depressive behaviors in rodent models, although further investigation is needed to establish clinical applications [7]. Collectively, while the research points to zinc's importance in managing depressive symptoms, it also calls for more comprehensive studies to fully understand how zinc can effectively be integrated into depression treatment strategies [5]. Overall, these findings highlight that zinc supplementation could be a valuable adjunct to existing depression therapies, warranting further exploration.
Users have reported a range of improvements in symptoms related to mood and overall health through zinc supplementation. One user noted a significant boost in mood and memory, alongside a reduction in depression and anxiety, highlighting the broad benefits of zinc for both mental and physical health (Read Review). Additionally, another user emphasized that zinc can help mitigate symptoms of depression and fatigue, especially when taken at optimal times to ensure proper absorption (Read Review).
Moreover, many users underscored the importance of zinc for maintaining the normal function of various bodily systems, including the nervous and immune systems. Reports indicate that correcting zinc deficiency might lead to improvements in sleep disturbances, hair loss, and a general uplift in energy levels and concentration, reinforcing the notion that zinc is a critical nutrient for both physical and mental wellness (Read Review). However, it's essential to remember that individual results can vary based on specific health conditions and dietary habits.
Users report positive experiences when combining zinc with other supplements to help manage depression. Several reviewers highlight that taking zinc in conjunction with selenium and vitamins A, E, and Omega-3 can be particularly beneficial. One user notes that this combination enhances zinc's efficacy, suggesting it helps alleviate depressive symptoms more effectively than zinc alone (Read Review). Moreover, many users emphasize the vital role of zinc in supporting overall health, including the immune and nervous systems, which can contribute to mood stability (Read Review).
Additionally, users caution about proper timing and absorption when taking zinc with other supplements. They recommend maintaining a two-hour gap between zinc supplementation and foods rich in phytates or phosphates, as these can interfere with zinc absorption, thus potentially reducing its effectiveness in combating depression (Read Review). The consensus is clear: while zinc can be effective in managing depressive symptoms on its own, combining it thoughtfully with other nutrients can bolster its benefits and enhance the overall mood-regulating effects.
Based on user reviews, those using Zinc for treating depression have reported positive effects on mood, memory, and overall emotional well-being. One user observed significant improvements after taking Zinc three times a year for 30 days, stating it alleviated symptoms of depression and anxiety (Read Review). Another user emphasized the importance of dosage and absorption timing, indicating a proper intake schedule to maximize efficacy, suggesting Zinc be taken an hour before or two hours after meals to prevent food interference with absorption (Read Review).
Users also noted the necessity of avoiding high doses of Zinc, as they can hinder the absorption of essential minerals such as calcium and magnesium, which are also vital for mental health (Read Review). Zinc is recognized for its critical role in supporting the immune and nervous systems, contributing to skin health and mood regulation. Hence, maintaining the right dose and absorption techniques appears vital for those looking to Zinc as a supplement for depression relief (Read Review). Overall, users convey that while Zinc can be beneficial, proper dosing and intake protocol are essential for optimal results.
7.5
Zinc alleviates symptoms
5 people found this helpful
Zinc has helped significantly! It should be taken an hour before or two hours after meals, as certain foods disrupt zinc absorption. Zinc deficiency leads to fatigue, depression, loss of appetite, and reduced concentration. High doses of zinc can hinder calcium and magnesium absorption, while calcium-rich diets can impede zinc uptake. It's crucial to maintain a two-hour gap between zinc intake and foods that are rich in phytates or phosphates. Zinc crosses the placental barrier and is present in breast milk, so during pregnancy, its use must prioritize the mother's benefits against potential risks to the fetus. A beneficial combination includes zinc with selenium alongside vitamins A, E, and Omega-3.
9
Reduces depression effectively
Definitely a necessary addition! I've used this supplement for a long time, three times a year for 30 days with great results. It boosts mood and memory, alleviates depression and anxiety, reduces the formation of fatty plaques, strengthens the immune system, and regulates glucose metabolism. It's an antioxidant that protects cells and aids growth and development during puberty. For men, it governs testosterone formation, improves sperm motility, and supports prostate health, while in women, it is vital for ovulation, menstrual regularity, and breastfeeding.
7.5
Boosts overall health
3 people found this helpful
Excellent! Zinc is vital to the normal function of many systems, including the immune and nervous systems. It's crucial for skin restoration, brain function, toxin defence, and regulating insulin. Symptoms of deficiency include acne, reduced immunity, sleep disturbances, fatigue, depression, and hair loss. Various forms of zinc are available, but picolinate and chelate are best absorbed. Avoid taking it with coffee or dairy; wait an hour and a half to ensure proper absorption.
9
Zinc complex offers depression relief
Exploring Zn(II)-Acetyl l-carnitine complex for simultaneous management of depression, chronic pain, and neuroprotection.
We investigated the potential benefits of a novel zinc complex, specifically Zn(ALC)Cl(HO), for its effectiveness in treating depression. This innovative compound combines zinc with acetyl-l-carnitine, which is known for its role in energy metabolism and protecting brain cells.
Our findings revealed that this zinc complex displays a remarkable 54% improvement in antidepressant activity compared to standard acetyl-l-carnitine. We also observed its ability to reduce pain in tests involving chronic conditions, showing promise in enhancing overall mental and physical health.
Additionally, this compound demonstrated capability to cross the blood-brain barrier, protecting against cell damage from excessive glutamate. We think these results indicate that Zn(ALC)Cl(HO) could be a significant step forward in managing not just depression but also neurodegenerative challenges.
7
Zinc deficiency impacts brain function
Proteomics analysis in rats reveals convergent mechanisms between major depressive disorder and dietary zinc deficiency.
We aimed to uncover the connection between dietary zinc deficiency and symptoms associated with major depressive disorder (MDD). In our study, we used rats fed either a zinc-adequate diet or one deficient in zinc for four weeks.
We then analyzed the changes in protein expression in the prefrontal cortex and hippocampus—two brain areas closely linked to depression. This approach allowed us to see how zinc deficiency impacts the brain at a molecular level.
Our findings revealed that significant alterations occurred in proteins related to zinc transport and mitochondrial function due to the deficiency. In particular, we saw a notable decline in the activity of complex I of the mitochondrial energy production pathway in the prefrontal cortex.
These results suggest that low zinc levels can disrupt vital brain functions, potentially contributing to the development of depressive symptoms. This highlights the importance of maintaining adequate zinc levels for mental health.
8
Zinc's potential in depression treatment
BEHAVIORAL AND NEUROCHEMICAL CHANGES DURING INTRANASAL ADMINISTRATION OF ALPHA-GLUTAMYL-TRYPTOPHAN AND CHELATE COMPLEX OF ZINC ARGINYL-GLYCINATE ON MONOAMINE SYSTEMS DYSFUNCTIONS KNOCK-OUT MODELS.
We investigated how intranasal administration of a chelate complex of zinc arginyl-glycinate combined with alpha-glutamyl-tryptophan affects behaviors typically linked to depression. The study involved a variety of rodent models, namely Wistar and DAT-KO rats, as well as C57Bl6 and TAAR1-KO mice, allowing us to explore different genetic backgrounds in relation to depressive behaviors.
Our findings revealed that this specific method of zinc treatment along with the dipeptide showed potential in reducing anxiety and depressive-like behavior, especially after acute administration in C57Bl6 mice. Interestingly, chronic intranasal use also influenced anxiety levels in tested rodents but more consistent improvements in depressive behaviors were noted with acute treatments.
We suggest that intranasal delivery of this zinc and dipeptide combination could be a promising avenue to explore further as a possible new approach for addressing anxiety and depression. It also highlights the need for pre-clinical studies to confirm these benefits before any clinical applications can be considered.
8
Zinc may improve depressive symptoms
Drugs with glutamate-based mechanisms of action in psychiatry.
We explored the potential impact of zinc on depression, focusing on how this important mineral might help improve mood. Various studies suggest that zinc could play a role in combating depressive symptoms, offering a promising avenue for those who find themselves struggling with mental health issues.
While the research is still developing, there’s an encouraging indication that zinc may enhance the effectiveness of other treatments for depression. However, details about specific studies or methodologies are limited in our findings, which makes it tricky to fully gauge just how beneficial zinc is on its own.
We remain open to the need for more extensive research to truly understand zinc's place in depression treatment. The results so far are positive, yet more comprehensive studies could shed light on the best ways to incorporate zinc into therapeutic strategies for mental health.
References
Caro-Ramírez JY, Bazán LO, Piro OE, Echeverría GA, Jori K, et al. Exploring Zn(II)-Acetyl l-carnitine complex for simultaneous management of depression, chronic pain, and neuroprotection. J Inorg Biochem. 2025;267:112857. doi:10.1016/j.jinorgbio.2025.112857
Siodłak D, Doboszewska U, Nowak G, Wlaź P, Mlyniec K. Investigating the role of GPR39 in treatment of stress-induced depression and anxiety. Psychopharmacology (Berl). 2025. doi:10.1007/s00213-024-06736-0
Sakae K, Suka M, Yanagisawa H. Dissociative Identity Disorder Cotreated With Zinc and L-carnosine: A Case Report. Cureus. 2024;16:e74794. doi:10.7759/cureus.74794
Gąsior Ł, Pochwat B, Zaręba-Kozioł M, Włodarczyk J, Grabrucker AM, et al. Proteomics analysis in rats reveals convergent mechanisms between major depressive disorder and dietary zinc deficiency. Pharmacol Rep. 2025;77:145. doi:10.1007/s43440-024-00681-7
Chrobak AA, Siwek M. Drugs with glutamate-based mechanisms of action in psychiatry. Pharmacol Rep. 2024;76:1256. doi:10.1007/s43440-024-00656-8
Gong M, Fang Y, Yang K, Yuan F, Hu R, et al. The WFS1-ZnT3-Zn Axis Regulates the Vicious Cycle of Obesity and Depression. Adv Sci (Weinh). 2024;11:e2403405. doi:10.1002/advs.202403405
Apryatin S, Lopachev A, Zhukov I, Efimova E, Apryatina V. BEHAVIORAL AND NEUROCHEMICAL CHANGES DURING INTRANASAL ADMINISTRATION OF ALPHA-GLUTAMYL-TRYPTOPHAN AND CHELATE COMPLEX OF ZINC ARGINYL-GLYCINATE ON MONOAMINE SYSTEMS DYSFUNCTIONS KNOCK-OUT MODELS. Georgian Med News. 2024.