5/12/2025
Last update
5/12/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
USERS' SCORE
Good
Based on 3 Reviews
8.4
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Magnesium (as Magnesium Oxide)
500 mg
119%
Top Medical Research Studies
9
We explored the connection between dietary magnesium intake and hypertension along with other health issues in US adults. In our study, we analyzed data from over 24,000 people, taking into account various lifestyle factors.
We found that those with higher magnesium intake had significantly lower rates of hypertension, diabetes, and hyperlipidemia compared to those with the least intake. Notably, participants in the highest quintile of magnesium consumption were less likely to suffer from these conditions.
These results suggest that increasing magnesium-rich foods in our diets could help prevent these prevalent health concerns.
We found that those with higher magnesium intake had significantly lower rates of hypertension, diabetes, and hyperlipidemia compared to those with the least intake. Notably, participants in the highest quintile of magnesium consumption were less likely to suffer from these conditions.
These results suggest that increasing magnesium-rich foods in our diets could help prevent these prevalent health concerns.
Read More
8
Magnesium effectively lowers blood pressure
We explored how magnesium supplementation can affect systolic blood pressure (SBP) in the general population. Through careful analysis of placebo-controlled, randomized clinical trials, we focused on understanding the optimal dosages and treatment durations necessary to achieve significant reductions in SBP. Past findings revealed that magnesium could reduce SBP by an average of 2.79 mm Hg, and our goal was to dive deeper into these results.
Our meta-analysis showed promising outcomes. Specifically, we noticed that magnesium taken at lower doses, particularly ≤360 mg per day, led to a notable decrease in SBP of about 3.03 mm Hg, especially when the treatment duration exceeded three months. This suggests that for those looking to manage their blood pressure, longer-term use of magnesium at these dosages may be beneficial.
While we found encouraging evidence pointing to the effectiveness of magnesium in lowering SBP, we acknowledge the importance of further studies. These future investigations should focus on varied dosages and longer follow-up periods to strengthen our understanding and provide tailored recommendations for individuals seeking to utilize magnesium in their hypertension management strategies.
Our meta-analysis showed promising outcomes. Specifically, we noticed that magnesium taken at lower doses, particularly ≤360 mg per day, led to a notable decrease in SBP of about 3.03 mm Hg, especially when the treatment duration exceeded three months. This suggests that for those looking to manage their blood pressure, longer-term use of magnesium at these dosages may be beneficial.
While we found encouraging evidence pointing to the effectiveness of magnesium in lowering SBP, we acknowledge the importance of further studies. These future investigations should focus on varied dosages and longer follow-up periods to strengthen our understanding and provide tailored recommendations for individuals seeking to utilize magnesium in their hypertension management strategies.
Read More
8
We examined how the magnesium depletion score (MDS) affects mortality risks in individuals with hypertension. By analyzing data from over 12,000 participants in a national health survey, we discovered that those with higher MDS levels significantly faced increased risks of both all-cause and cardiovascular deaths.
Our findings highlighted that individuals grouped in the higher MDS category had an elevated mortality risk compared to those in the lower and middle categories, underscoring the potential of MDS as a simple tool for identifying at-risk patients.
In essence, maintaining adequate magnesium levels could play a critical role in improving health outcomes for those suffering from hypertension.
Our findings highlighted that individuals grouped in the higher MDS category had an elevated mortality risk compared to those in the lower and middle categories, underscoring the potential of MDS as a simple tool for identifying at-risk patients.
In essence, maintaining adequate magnesium levels could play a critical role in improving health outcomes for those suffering from hypertension.
Read More
Most Useful Reviews
9
Heart and vessel support
I am 45 years old and take magnesium for hypertension as prescribed by my doctor. He recommended this product from iHerb. Magnesium positively influences heart and blood vessel function.
Read More
8
Stress and spasm relief
I bought this magnesium for my mother, who takes it regularly. She finds the tablets large and chews them because swallowing is difficult. It improves her heart function (arrhythmia) and alleviates hypertension. It’s beneficial for her nervous system, enabling her to handle stress better and relieving leg cramps that used to occur without magnesium.
Read More
7.5
Effective blood pressure reduction
This magnesium offers great value. I’ve taken it for some time—one tablet nightly. The dosage is perfect, avoiding laxative effects as it’s in oxide form, and it slightly lowers blood pressure, which is vital for my hypertension. It helps with arrhythmias and provides a calming effect. Don’t worry about the dosage; not all is absorbed. It’s beneficial for men with high glucose levels and enhances testosterone and physical performance. This option is significantly cheaper than what's available in pharmacies.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
- All Researches
9
We conducted a retrospective study to investigate how magnesium sulfate paired with labetalol affects vascular health and pregnancy outcomes in women with preeclampsia—a serious condition that can occur during pregnancy characterized by high blood pressure.
Our analysis focused on clinical data from 262 women treated for preeclampsia. The patients were divided into two groups: one group received magnesium sulfate alone, while the other group was treated with both magnesium sulfate and labetalol. By measuring key indicators such as nitric oxide and endothelin-1 levels, along with blood pressure readings, we aimed to determine the effectiveness of these treatments.
The results showed that the combination of magnesium sulfate and labetalol notably improved vascular function and pregnancy outcomes for these women. Not only did this treatment help in better controlling high blood pressure during pregnancy, but it also reduced the chances of adverse outcomes for both mothers and babies. Importantly, the study found this combined treatment to be as safe as using magnesium sulfate alone.
This reinforces the idea that magnesium can play a significant role in treating hypertension during pregnancy, especially when paired with other medications like labetalol.
Our analysis focused on clinical data from 262 women treated for preeclampsia. The patients were divided into two groups: one group received magnesium sulfate alone, while the other group was treated with both magnesium sulfate and labetalol. By measuring key indicators such as nitric oxide and endothelin-1 levels, along with blood pressure readings, we aimed to determine the effectiveness of these treatments.
The results showed that the combination of magnesium sulfate and labetalol notably improved vascular function and pregnancy outcomes for these women. Not only did this treatment help in better controlling high blood pressure during pregnancy, but it also reduced the chances of adverse outcomes for both mothers and babies. Importantly, the study found this combined treatment to be as safe as using magnesium sulfate alone.
This reinforces the idea that magnesium can play a significant role in treating hypertension during pregnancy, especially when paired with other medications like labetalol.
Read More
9
We examined an experimental model of pulmonary arterial hypertension (PAH) induced by monocrotaline in rats. Our research focused on the combined effects of Magnesium sulfate along with Rosuvastatin and Sildenafil, which were administered two weeks after the initial MCT injection.
Using measures like the Fulton Index and various cardiac dimensions, we observed improvements in right ventricular function and markers of oxidative stress. Notably, Magnesium sulfate appeared to work well with Rosuvastatin, which is known for its anti-inflammatory properties, enhancing the overall treatment effectiveness on pulmonary hypertension.
However, since Magnesium was administered in combination with these other treatments, we could not determine its isolated benefits on hypertension specifically. The study did highlight the importance of multi-pronged approaches in tackling such complex conditions, suggesting that further research might clarify Magnesium's unique contributions to managing hypertension.
Using measures like the Fulton Index and various cardiac dimensions, we observed improvements in right ventricular function and markers of oxidative stress. Notably, Magnesium sulfate appeared to work well with Rosuvastatin, which is known for its anti-inflammatory properties, enhancing the overall treatment effectiveness on pulmonary hypertension.
However, since Magnesium was administered in combination with these other treatments, we could not determine its isolated benefits on hypertension specifically. The study did highlight the importance of multi-pronged approaches in tackling such complex conditions, suggesting that further research might clarify Magnesium's unique contributions to managing hypertension.
Read More
9
We examined a cohort of neonates born at or above 36 weeks gestation to assess the impact of antenatal magnesium sulfate on hypoxic-ischemic encephalopathy linked to hypertensive disorders of pregnancy.
Our analysis revealed that these disorders significantly increase the risk of moderate to severe brain injury. Importantly, we observed that receiving magnesium sulfate reduced the odds of developing hypoxic-ischemic encephalopathy in affected infants.
However, it’s crucial to understand that while our study shows an association, it does not establish a cause-and-effect relationship.
Our analysis revealed that these disorders significantly increase the risk of moderate to severe brain injury. Importantly, we observed that receiving magnesium sulfate reduced the odds of developing hypoxic-ischemic encephalopathy in affected infants.
However, it’s crucial to understand that while our study shows an association, it does not establish a cause-and-effect relationship.
Read More
9
We explored the connection between dietary magnesium intake and hypertension along with other health issues in US adults. In our study, we analyzed data from over 24,000 people, taking into account various lifestyle factors.
We found that those with higher magnesium intake had significantly lower rates of hypertension, diabetes, and hyperlipidemia compared to those with the least intake. Notably, participants in the highest quintile of magnesium consumption were less likely to suffer from these conditions.
These results suggest that increasing magnesium-rich foods in our diets could help prevent these prevalent health concerns.
We found that those with higher magnesium intake had significantly lower rates of hypertension, diabetes, and hyperlipidemia compared to those with the least intake. Notably, participants in the highest quintile of magnesium consumption were less likely to suffer from these conditions.
These results suggest that increasing magnesium-rich foods in our diets could help prevent these prevalent health concerns.
Read More
8
Magnesium effectively lowers blood pressure
We explored how magnesium supplementation can affect systolic blood pressure (SBP) in the general population. Through careful analysis of placebo-controlled, randomized clinical trials, we focused on understanding the optimal dosages and treatment durations necessary to achieve significant reductions in SBP. Past findings revealed that magnesium could reduce SBP by an average of 2.79 mm Hg, and our goal was to dive deeper into these results.
Our meta-analysis showed promising outcomes. Specifically, we noticed that magnesium taken at lower doses, particularly ≤360 mg per day, led to a notable decrease in SBP of about 3.03 mm Hg, especially when the treatment duration exceeded three months. This suggests that for those looking to manage their blood pressure, longer-term use of magnesium at these dosages may be beneficial.
While we found encouraging evidence pointing to the effectiveness of magnesium in lowering SBP, we acknowledge the importance of further studies. These future investigations should focus on varied dosages and longer follow-up periods to strengthen our understanding and provide tailored recommendations for individuals seeking to utilize magnesium in their hypertension management strategies.
Our meta-analysis showed promising outcomes. Specifically, we noticed that magnesium taken at lower doses, particularly ≤360 mg per day, led to a notable decrease in SBP of about 3.03 mm Hg, especially when the treatment duration exceeded three months. This suggests that for those looking to manage their blood pressure, longer-term use of magnesium at these dosages may be beneficial.
While we found encouraging evidence pointing to the effectiveness of magnesium in lowering SBP, we acknowledge the importance of further studies. These future investigations should focus on varied dosages and longer follow-up periods to strengthen our understanding and provide tailored recommendations for individuals seeking to utilize magnesium in their hypertension management strategies.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Heart and vessel support
I am 45 years old and take magnesium for hypertension as prescribed by my doctor. He recommended this product from iHerb. Magnesium positively influences heart and blood vessel function.
Read More
8
Stress and spasm relief
I bought this magnesium for my mother, who takes it regularly. She finds the tablets large and chews them because swallowing is difficult. It improves her heart function (arrhythmia) and alleviates hypertension. It’s beneficial for her nervous system, enabling her to handle stress better and relieving leg cramps that used to occur without magnesium.
Read More
7.5
Effective blood pressure reduction
This magnesium offers great value. I’ve taken it for some time—one tablet nightly. The dosage is perfect, avoiding laxative effects as it’s in oxide form, and it slightly lowers blood pressure, which is vital for my hypertension. It helps with arrhythmias and provides a calming effect. Don’t worry about the dosage; not all is absorbed. It’s beneficial for men with high glucose levels and enhances testosterone and physical performance. This option is significantly cheaper than what's available in pharmacies.
Read More
Frequently Asked Questions
7.5
Effective blood pressure reduction
This magnesium offers great value. I’ve taken it for some time—one tablet nightly. The dosage is perfect, avoiding laxative effects as it’s in oxide form, and it slightly lowers blood pressure, which is vital for my hypertension. It helps with arrhythmias and provides a calming effect. Don’t worry about the dosage; not all is absorbed. It’s beneficial for men with high glucose levels and enhances testosterone and physical performance. This option is significantly cheaper than what's available in pharmacies.
8
Stress and spasm relief
I bought this magnesium for my mother, who takes it regularly. She finds the tablets large and chews them because swallowing is difficult. It improves her heart function (arrhythmia) and alleviates hypertension. It’s beneficial for her nervous system, enabling her to handle stress better and relieving leg cramps that used to occur without magnesium.
9
Heart and vessel support
I am 45 years old and take magnesium for hypertension as prescribed by my doctor. He recommended this product from iHerb. Magnesium positively influences heart and blood vessel function.
8
Magnesium effectively lowers blood pressure
We explored how magnesium supplementation can affect systolic blood pressure (SBP) in the general population. Through careful analysis of placebo-controlled, randomized clinical trials, we focused on understanding the optimal dosages and treatment durations necessary to achieve significant reductions in SBP. Past findings revealed that magnesium could reduce SBP by an average of 2.79 mm Hg, and our goal was to dive deeper into these results.
Our meta-analysis showed promising outcomes. Specifically, we noticed that magnesium taken at lower doses, particularly ≤360 mg per day, led to a notable decrease in SBP of about 3.03 mm Hg, especially when the treatment duration exceeded three months. This suggests that for those looking to manage their blood pressure, longer-term use of magnesium at these dosages may be beneficial.
While we found encouraging evidence pointing to the effectiveness of magnesium in lowering SBP, we acknowledge the importance of further studies. These future investigations should focus on varied dosages and longer follow-up periods to strengthen our understanding and provide tailored recommendations for individuals seeking to utilize magnesium in their hypertension management strategies.
Our meta-analysis showed promising outcomes. Specifically, we noticed that magnesium taken at lower doses, particularly ≤360 mg per day, led to a notable decrease in SBP of about 3.03 mm Hg, especially when the treatment duration exceeded three months. This suggests that for those looking to manage their blood pressure, longer-term use of magnesium at these dosages may be beneficial.
While we found encouraging evidence pointing to the effectiveness of magnesium in lowering SBP, we acknowledge the importance of further studies. These future investigations should focus on varied dosages and longer follow-up periods to strengthen our understanding and provide tailored recommendations for individuals seeking to utilize magnesium in their hypertension management strategies.
9
We explored the connection between dietary magnesium intake and hypertension along with other health issues in US adults. In our study, we analyzed data from over 24,000 people, taking into account various lifestyle factors.
We found that those with higher magnesium intake had significantly lower rates of hypertension, diabetes, and hyperlipidemia compared to those with the least intake. Notably, participants in the highest quintile of magnesium consumption were less likely to suffer from these conditions.
These results suggest that increasing magnesium-rich foods in our diets could help prevent these prevalent health concerns.
We found that those with higher magnesium intake had significantly lower rates of hypertension, diabetes, and hyperlipidemia compared to those with the least intake. Notably, participants in the highest quintile of magnesium consumption were less likely to suffer from these conditions.
These results suggest that increasing magnesium-rich foods in our diets could help prevent these prevalent health concerns.
9
We conducted a retrospective study to investigate how magnesium sulfate paired with labetalol affects vascular health and pregnancy outcomes in women with preeclampsia—a serious condition that can occur during pregnancy characterized by high blood pressure.
Our analysis focused on clinical data from 262 women treated for preeclampsia. The patients were divided into two groups: one group received magnesium sulfate alone, while the other group was treated with both magnesium sulfate and labetalol. By measuring key indicators such as nitric oxide and endothelin-1 levels, along with blood pressure readings, we aimed to determine the effectiveness of these treatments.
The results showed that the combination of magnesium sulfate and labetalol notably improved vascular function and pregnancy outcomes for these women. Not only did this treatment help in better controlling high blood pressure during pregnancy, but it also reduced the chances of adverse outcomes for both mothers and babies. Importantly, the study found this combined treatment to be as safe as using magnesium sulfate alone.
This reinforces the idea that magnesium can play a significant role in treating hypertension during pregnancy, especially when paired with other medications like labetalol.
Our analysis focused on clinical data from 262 women treated for preeclampsia. The patients were divided into two groups: one group received magnesium sulfate alone, while the other group was treated with both magnesium sulfate and labetalol. By measuring key indicators such as nitric oxide and endothelin-1 levels, along with blood pressure readings, we aimed to determine the effectiveness of these treatments.
The results showed that the combination of magnesium sulfate and labetalol notably improved vascular function and pregnancy outcomes for these women. Not only did this treatment help in better controlling high blood pressure during pregnancy, but it also reduced the chances of adverse outcomes for both mothers and babies. Importantly, the study found this combined treatment to be as safe as using magnesium sulfate alone.
This reinforces the idea that magnesium can play a significant role in treating hypertension during pregnancy, especially when paired with other medications like labetalol.
7
We conducted a randomized clinical trial to explore the effects of magnesium from deep ocean sources on adults dealing with hypertension, diabetes, or high cholesterol. Patients participated by consuming either magnesium-enriched water or a placebo over a four-week period.
Throughout the trial, we focused on key health indicators, including body mass index (BMI) and levels of insulin and triglycerides, among others. Our findings indicated that, despite some participants consuming less magnesium than the recommended daily allowance, those who drank magnesium-enriched water showed meaningful improvements in various metabolic markers.
Notably, we found that this water not only supported better metabolic outcomes but also positively influenced gut microbiome diversity. The magnesium-enriched water helped maintain a balanced abundance of beneficial gut bacteria, which is crucial for overall health. This indicates that boosting our magnesium intake, through sources like deep ocean water, might play a valuable role in controlling hypertension and possibly preventing related conditions without any significant adverse effects.
Throughout the trial, we focused on key health indicators, including body mass index (BMI) and levels of insulin and triglycerides, among others. Our findings indicated that, despite some participants consuming less magnesium than the recommended daily allowance, those who drank magnesium-enriched water showed meaningful improvements in various metabolic markers.
Notably, we found that this water not only supported better metabolic outcomes but also positively influenced gut microbiome diversity. The magnesium-enriched water helped maintain a balanced abundance of beneficial gut bacteria, which is crucial for overall health. This indicates that boosting our magnesium intake, through sources like deep ocean water, might play a valuable role in controlling hypertension and possibly preventing related conditions without any significant adverse effects.
8
We examined how the magnesium depletion score (MDS) affects mortality risks in individuals with hypertension. By analyzing data from over 12,000 participants in a national health survey, we discovered that those with higher MDS levels significantly faced increased risks of both all-cause and cardiovascular deaths.
Our findings highlighted that individuals grouped in the higher MDS category had an elevated mortality risk compared to those in the lower and middle categories, underscoring the potential of MDS as a simple tool for identifying at-risk patients.
In essence, maintaining adequate magnesium levels could play a critical role in improving health outcomes for those suffering from hypertension.
Our findings highlighted that individuals grouped in the higher MDS category had an elevated mortality risk compared to those in the lower and middle categories, underscoring the potential of MDS as a simple tool for identifying at-risk patients.
In essence, maintaining adequate magnesium levels could play a critical role in improving health outcomes for those suffering from hypertension.
References
- Kang H, Lee UJ, Park BY, Kim M, Yang M. Effects of deep ocean-derived magnesium-enhanced water on metabolic diseases with microbiome changes. Diabetes Metab Syndr. 2025;19:103203. 10.1016/j.dsx.2025.103203
- Liu Y, Li W, Sun Y, Wang Z. Effects of magnesium sulfate combined with labetalol on vascular endothelial function and pregnancy outcomes in pregnant women with preeclampsia. Am J Transl Res. 2024;16:7096. 10.62347/COZZ1407
- Behers BJ, Behers BM, Stephenson-Moe CA, Vargas IA, Meng Z, et al. Magnesium and Potassium Supplementation for Systolic Blood Pressure Reduction in the General Normotensive Population: A Systematic Review and Subgroup Meta-Analysis for Optimal Dosage and Treatment Length. Nutrients. 2024;16. 10.3390/nu16213617
- Hojda SE, Chis IC, Mîrza TV, Clichici S. Monocrotaline-induced pulmonary arterial hypertension: the benefic effects of magnesium sulfate, Rosuvastatin and Sildenafil. Med Pharm Rep. 2024;97:528. 10.15386/mpr-2804
- Gong Y, Zhou C, Wan Y, Yin H. Association of magnesium deficiency, tobacco smoke exposure and hypertension in children and adolescents: evidence from the NHANES 2007-2018. BMC Pediatr. 2024;24:647. 10.1186/s12887-024-05097-z
- Amer SA, Abo-Elnour DE, Abbas A, Abdelrahman AS, Hamdy HM, et al. Calcium, magnesium, and vitamin D supplementations as complementary therapy for hypertensive patients: a systematic review and meta-analysis. BMC Complement Med Ther. 2025;25:89. 10.1186/s12906-025-04809-x
- Dariy V, Serikov K, Kmyta O, Rybalko T, Kolesnyk O. PERSONIFICATION OF ANTIHYPERTENSIVE THERAPY IN ISCHEMIC CEREBRAL STROKE. Georgian Med News. 2024.
- Song J, Zhang Y, Lin Z, Tang J, Yang X, et al. Higher Magnesium Depletion Score Increases the Risk of All-cause and Cardiovascular Mortality in Hypertension Participants. Biol Trace Elem Res. 2025;203:1287. 10.1007/s12011-024-04254-w
- Minor KC, Liu J, Druzin ML, El-Sayed YY, Hintz SR, et al. Magnesium sulfate and risk of hypoxic-ischemic encephalopathy in a high-risk cohort. Am J Obstet Gynecol. 2024;231:647.e1. 10.1016/j.ajog.2024.04.001
- Wang Q, Si K, Xing X, Ye X, Liu Z, et al. Association between dietary magnesium intake and muscle mass among hypertensive population: evidence from the National Health and Nutrition Examination Survey. Nutr J. 2024;23:37. 10.1186/s12937-024-00940-6
- Yerubandi S, Devi Kallur S, Gala A, Chandra Ravula P, Surapaneni T, et al. Eclampsia reduction with maternal early warning trigger tool. Pregnancy Hypertens. 2024;35:6. 10.1016/j.preghy.2023.11.007
- Peng Z, Zhang J, Xiao Y, Dong W. Comparison of outcomes following intravenous magnesium compared with intravenous labetalol and oral nifedipine in 355 pregnant Han Chinese women with preeclampsia. Medicine (Baltimore). 2023;102:e35334. 10.1097/MD.0000000000035334
- Su HC, Lin CP, Ho WJ, Chou SH, Wu CT, et al. Factors affecting the intensity of chronic musculoskeletal pain in patients with cardiovascular disease and evaluation of the efficacy of magnesium emulsion cream for muscle cramps. Medicine (Baltimore). 2023;102:e35532. 10.1097/MD.0000000000035532
- Vongpatanasin W, Giacona JM, Pittman D, Murillo A, Khan G, et al. Potassium Magnesium Citrate Is Superior to Potassium Chloride in Reversing Metabolic Side Effects of Chlorthalidone. Hypertension. 2023;80:2611. 10.1161/HYPERTENSIONAHA.123.21932
- Behers BJ, Melchor J, Behers BM, Meng Z, Swanson PJ, et al. Vitamins and Minerals for Blood Pressure Reduction in the General, Normotensive Population: A Systematic Review and Meta-Analysis of Six Supplements. Nutrients. 2023;15. 10.3390/nu15194223
- Han M, Zhang Y, Fang J, Sun M, Liu Q, et al. Associations between dietary magnesium intake and hypertension, diabetes, and hyperlipidemia. Hypertens Res. 2024;47:331. 10.1038/s41440-023-01439-z
