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However, by giving them oral vitamin C at doses of 125 and 250 mg/kg, we observed a significant reduction in these severe outcomes. Vitamin C seemed to modulate the expression of certain genes related to the immune response, such as MAVS and IRF3, and increased the expression of NF-κB, which plays a key role in the body's antiviral defense.
Our research suggested that vitamin C's protective effects might stem from its ability to inhibit excess cortisol production in the adrenal gland, which is often elevated due to stress. By lowering cortisol levels, vitamin C may help reduce susceptibility to influenza infections, making it a potential ally during the flu season, especially for those experiencing stress.
Through these findings, we highlighted a new mechanism for how vitamin C can be beneficial during influenza infections, particularly for those who are feeling overwhelmed.
Among all the compounds we evaluated, one stood out: the 2,3-O,O-dibenzyl-6-deoxy-L-ascorbic acid-betulinic acid conjugate. It displayed significant anti-influenza activity with an effective concentration (EC50) of just 8.7 μM and was not toxic to the cells used in our testing. This suggests that combining vitamin C with these triterpenes might enhance their ability to fight the flu virus, marking an exciting avenue for further research.
We also discovered that this particular compound acts early in the influenza lifecycle, interfering with the virus's ability to attach to cells. We confirmed this by observing that it inhibited the hemagglutination—a crucial step that allows the virus to spread. Our findings indicate that L-ascorbic acid-conjugated triterpenes hold promise as potential anti-influenza agents, specifically targeting viral entry and enhancing the effectiveness of treatment strategies.
In this study, we focused on five different compounds that are structurally distinct from sialic acid, which is the natural substrate of neuraminidase. Among those tested, vitamin C was one of the compounds alongside others like acetyl phenylalanylmethionine and propanoic acid derivatives. We found that these compounds inhibited NA activity, but the degree of inhibition varied.
Notably, the inhibition we observed was in the millimolar range, which suggests that while there is some effect, the affinity of vitamin C to inhibit neuraminidase is moderate compared to the reference drug zanamivir. The IC values for the compounds ranged from 6.4 to 73 mM, indicating that they are not as potent as zanamivir.
Overall, our study presents vitamin C and other small organic molecules as potential lead compounds for developing new neuraminidase inhibitors, even if vitamin C’s impact on flu remains to be clarified as part of a broader analysis of multiple compounds.
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Our findings were quite promising. We observed that both red ginseng and vitamin C elevated the activation levels of immune cells, particularly T-cells and natural killer (NK) cells, known for their vital role in combating viruses. This combination not only helped boost immune cell activity but also reduced lung inflammation caused by the influenza virus, which is crucial for better survival rates during infections.
In cases where vitamin C levels were low in a specific mouse model, we noted that the added nutrients significantly improved their condition. They experienced reduced viral load and inflammation in their lungs after receiving red ginseng and vitamin C, compared to those without this supplementation. These insights suggest that while red ginseng and vitamin C collectively support immune health, the interplay of these substances can be crucial in managing flu infections effectively.
Among all the compounds we evaluated, one stood out: the 2,3-O,O-dibenzyl-6-deoxy-L-ascorbic acid-betulinic acid conjugate. It displayed significant anti-influenza activity with an effective concentration (EC50) of just 8.7 μM and was not toxic to the cells used in our testing. This suggests that combining vitamin C with these triterpenes might enhance their ability to fight the flu virus, marking an exciting avenue for further research.
We also discovered that this particular compound acts early in the influenza lifecycle, interfering with the virus's ability to attach to cells. We confirmed this by observing that it inhibited the hemagglutination—a crucial step that allows the virus to spread. Our findings indicate that L-ascorbic acid-conjugated triterpenes hold promise as potential anti-influenza agents, specifically targeting viral entry and enhancing the effectiveness of treatment strategies.
However, by giving them oral vitamin C at doses of 125 and 250 mg/kg, we observed a significant reduction in these severe outcomes. Vitamin C seemed to modulate the expression of certain genes related to the immune response, such as MAVS and IRF3, and increased the expression of NF-κB, which plays a key role in the body's antiviral defense.
Our research suggested that vitamin C's protective effects might stem from its ability to inhibit excess cortisol production in the adrenal gland, which is often elevated due to stress. By lowering cortisol levels, vitamin C may help reduce susceptibility to influenza infections, making it a potential ally during the flu season, especially for those experiencing stress.
Through these findings, we highlighted a new mechanism for how vitamin C can be beneficial during influenza infections, particularly for those who are feeling overwhelmed.
Additionally, we observed that vitamin C also helps shorten the duration of flu symptoms by around 9%. This effect seemed to be more pronounced in men and people from middle-income countries, highlighting the complexity of health factors influenced by gender and socio-economic status.
Overall, while the findings suggest vitamin C can be a modicum of hope in managing flu symptoms, it isn't a standalone solution. Our results advocate for more research to fully understand the impact of vitamin C, especially in the context of the ongoing challenges posed by various respiratory viruses, including influenza.
In this study, we focused on five different compounds that are structurally distinct from sialic acid, which is the natural substrate of neuraminidase. Among those tested, vitamin C was one of the compounds alongside others like acetyl phenylalanylmethionine and propanoic acid derivatives. We found that these compounds inhibited NA activity, but the degree of inhibition varied.
Notably, the inhibition we observed was in the millimolar range, which suggests that while there is some effect, the affinity of vitamin C to inhibit neuraminidase is moderate compared to the reference drug zanamivir. The IC values for the compounds ranged from 6.4 to 73 mM, indicating that they are not as potent as zanamivir.
Overall, our study presents vitamin C and other small organic molecules as potential lead compounds for developing new neuraminidase inhibitors, even if vitamin C’s impact on flu remains to be clarified as part of a broader analysis of multiple compounds.
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Frequently Asked Questions
The flu, short for influenza, is a contagious respiratory illness caused by influenza viruses. It affects the nose, throat, and sometimes the lungs, leading to a range of symptoms that can vary in severity. Common symptoms include fever, chills, muscle aches, cough, congestion, runny nose, headaches, and fatigue. The flu can lead to serious complications, particularly in vulnerable populations such as young children, the elderly, pregnant women, and those with underlying health conditions.
The flu virus spreads primarily through respiratory droplets when an infected person coughs, sneezes, or talks. It can also be transmitted by touching surfaces contaminated with the virus and then touching one's face. Vaccination is the most effective way to prevent the flu, and the vaccine is typically updated annually to provide protection against the most common circulating strains. In addition to vaccination, practicing good hygiene, such as frequent handwashing and respiratory etiquette, can help minimize the risk of infection.
Ascorbic acid, commonly known as vitamin C, is a water-soluble vitamin that is essential for various bodily functions, including the synthesis of collagen, the absorption of iron, and the maintenance of a healthy immune system. Found naturally in a variety of fruits and vegetables, especially citrus fruits, strawberries, kiwi, and bell peppers, it serves as a potent antioxidant, helping to protect cells from damage by free radicals. Given that the human body cannot synthesize ascorbic acid on its own, it must be obtained through diet or supplementation.
In addition to its fundamental role in supporting overall health, ascorbic acid has garnered interest for its potential benefits in skincare and wound healing. Topical applications of vitamin C can help reduce the appearance of fine lines and improve skin texture, making it a popular ingredient in various cosmetic formulations. Additionally, it plays a crucial role in the body's ability to repair tissues and produce important neurotransmitters. For those looking to boost their vitamin C intake, incorporating a variety of vitamin C-rich foods into your diet or considering a supplement can be effective strategies.
Ascorbic acid, commonly known as vitamin C, is often touted for its immune-boosting properties. While some studies suggest that high doses of vitamin C can reduce the duration and severity of cold symptoms, the evidence regarding its effectiveness for the flu specifically is less concrete. The flu is caused by the influenza virus, and ascorbic acid may not directly combat the virus itself. However, maintaining adequate levels of vitamin C is crucial for overall immune function, which could potentially help your body respond better to illnesses, including the flu.
If you're considering using ascorbic acid as a supplement for flu prevention or treatment, it's important to consult with a healthcare professional. They can provide guidance based on your individual health needs and advise on proper dosages. In general, while incorporating vitamin C-rich foods, like oranges, strawberries, and bell peppers, into your diet can be beneficial for your immune health, relying solely on ascorbic acid to combat the flu is not a substitute for vaccines, antiviral medications, or other proven preventive measures.
Based on user reviews, the time it takes to see results from the supplement varies among individuals. Some users report quick relief, stating the supplement is excellent for combating flu symptoms and supports overall immunity ((Read Review); (Read Review)). Others suggest that while they appreciate its effects for preventing illness, they have not noticed a significant impact while already experiencing a cold or flu ((Read Review)).
In general, users recommend consistent daily use for perceived benefits, with some mentioning that taking an increased dose during illness may help ease symptoms more effectively ((Read Review); (Read Review)). The varying experiences suggest that results may come quickly for some, while for others, it may be less effective during an active illness.
Vitamin C has shown promising potential in supporting immune health and alleviating flu symptoms, according to various studies. One research piece demonstrated that vitamin C supplementation not only reduced the risk of acute respiratory infections, including the flu, but also shortened symptom duration by around 9% [1]. Another study revealed that vitamin C, alongside red ginseng, significantly boosted immune cell activity and reduced lung inflammation during flu infections [3]. This indicates that vitamin C could play a synergistic role in enhancing the body's response to the flu virus.
Additionally, research has explored the inhibitory effects of vitamin C on the neuraminidase activity of influenza viruses. While vitamin C showed some potential in this area, its effectiveness was found to be moderate compared to established antiviral medications [2]. Furthermore, in animal studies, vitamin C has been noted to protect against severe pneumonia symptoms caused by the H1N1 strain, particularly when the subjects were under stress [5]. Overall, while vitamin C could be a beneficial addition to flu management strategies, further research is warranted to fully understand its efficacy and mechanisms.
Based on user reviews, many have reported noticeable improvements in their immunity and a reduction in cold and flu symptoms when taking this supplement. For instance, one user stated it provides "excellent support for immunity," helping to combat both cold and flu symptoms effectively ((Read Review)). Others echoed these sentiments, highlighting its efficacy in making flu less contagious and easing symptoms during illness, particularly with increased dosages ((Read Review); (Read Review)).
That said, experiences can vary significantly; not all users felt the same level of relief. For example, one individual who had previously avoided illness was disappointed when this supplement did not prevent them from catching a cold and flu, despite regular usage ((Read Review)). Overall, while many users have praised its effectiveness for improving immunity and alleviating symptoms, individual results may vary, highlighting the importance of personal experience and consistent usage.
Based on user reviews, many individuals have found that combining this supplement with other supplements can enhance their overall efforts in managing flu symptoms. A user mentioned using it alongside dietary changes and supplements, resulting in better immunity and quicker recovery from flu ((Read Review)). Another family reported that increasing their dosage during illness made their flu experience more bearable, suggesting that taking two tablets a day while sick eased their symptoms significantly ((Read Review)).
However, not all reviews conveyed favorable outcomes in combination with other products. One user expressed disappointment that this supplement did not prevent their cold or flu, despite previously enjoying wellness benefits from a different vitamin regimen ((Read Review)). Overall, while many users endorse the supplement's effectiveness for flu management and its supportive role in their health regimens, results appear to be mixed when paired with other treatments.
While specific optimal doses for Ascorbic Acid in treating flu can vary, research indicates that doses around 125 to 250 mg/kg may show significant benefits in reducing severe symptoms related to influenza, particularly in stressed subjects (e.g., mice) faced with an H1N1 infection [5]. Another study suggests that vitamin C might mitigate flu symptoms and enhance immune cell activation when combined with other compounds, which highlights its supportive role in flu management rather than being a standalone remedy [3].
Importantly, while there is promise in using vitamin C for alleviating flu symptoms—evident in its observed ability to reduce symptom duration by about 9%—more extensive human studies are needed to refine these dose recommendations and further investigate its efficacy [1]. Given the moderate inhibition of viral activity observed in various studies, it’s crucial to consider vitamin C as part of a broader approach to flu treatment, possibly alongside other therapeutic strategies [2]. Ultimately, consulting a healthcare professional is advisable for personalized dosage recommendations.
Additionally, we observed that vitamin C also helps shorten the duration of flu symptoms by around 9%. This effect seemed to be more pronounced in men and people from middle-income countries, highlighting the complexity of health factors influenced by gender and socio-economic status.
Overall, while the findings suggest vitamin C can be a modicum of hope in managing flu symptoms, it isn't a standalone solution. Our results advocate for more research to fully understand the impact of vitamin C, especially in the context of the ongoing challenges posed by various respiratory viruses, including influenza.
Our findings were quite promising. We observed that both red ginseng and vitamin C elevated the activation levels of immune cells, particularly T-cells and natural killer (NK) cells, known for their vital role in combating viruses. This combination not only helped boost immune cell activity but also reduced lung inflammation caused by the influenza virus, which is crucial for better survival rates during infections.
In cases where vitamin C levels were low in a specific mouse model, we noted that the added nutrients significantly improved their condition. They experienced reduced viral load and inflammation in their lungs after receiving red ginseng and vitamin C, compared to those without this supplementation. These insights suggest that while red ginseng and vitamin C collectively support immune health, the interplay of these substances can be crucial in managing flu infections effectively.
In this study, we focused on five different compounds that are structurally distinct from sialic acid, which is the natural substrate of neuraminidase. Among those tested, vitamin C was one of the compounds alongside others like acetyl phenylalanylmethionine and propanoic acid derivatives. We found that these compounds inhibited NA activity, but the degree of inhibition varied.
Notably, the inhibition we observed was in the millimolar range, which suggests that while there is some effect, the affinity of vitamin C to inhibit neuraminidase is moderate compared to the reference drug zanamivir. The IC values for the compounds ranged from 6.4 to 73 mM, indicating that they are not as potent as zanamivir.
Overall, our study presents vitamin C and other small organic molecules as potential lead compounds for developing new neuraminidase inhibitors, even if vitamin C’s impact on flu remains to be clarified as part of a broader analysis of multiple compounds.
However, by giving them oral vitamin C at doses of 125 and 250 mg/kg, we observed a significant reduction in these severe outcomes. Vitamin C seemed to modulate the expression of certain genes related to the immune response, such as MAVS and IRF3, and increased the expression of NF-κB, which plays a key role in the body's antiviral defense.
Our research suggested that vitamin C's protective effects might stem from its ability to inhibit excess cortisol production in the adrenal gland, which is often elevated due to stress. By lowering cortisol levels, vitamin C may help reduce susceptibility to influenza infections, making it a potential ally during the flu season, especially for those experiencing stress.
Through these findings, we highlighted a new mechanism for how vitamin C can be beneficial during influenza infections, particularly for those who are feeling overwhelmed.
References
- Abioye AI, Bromage S, Fawzi W. Effect of micronutrient supplements on influenza and other respiratory tract infections among adults: a systematic review and meta-analysis. BMJ Glob Health. 2021;6. doi:10.1136/bmjgh-2020-003176
- Márquez-Domínguez L, Reyes-Leyva J, Herrera-Camacho I, Santos-López G, Scior T. Five Novel Non-Sialic Acid-Like Scaffolds Inhibit In Vitro H1N1 and H5N2 Neuraminidase Activity of Influenza a Virus. Molecules. 2020;25. doi:10.3390/molecules25184248
- Kim H, Jang M, Kim Y, Choi J, Jeon J, et al. Red ginseng and vitamin C increase immune cell activity and decrease lung inflammation induced by influenza A virus/H1N1 infection. J Pharm Pharmacol. 2016;68:406. doi:10.1111/jphp.12529
- Wang H, Xu R, Shi Y, Si L, Jiao P, et al. Design, synthesis and biological evaluation of novel L-ascorbic acid-conjugated pentacyclic triterpene derivatives as potential influenza virus entry inhibitors. Eur J Med Chem. 2016;110:376. doi:10.1016/j.ejmech.2016.01.005
- Cai Y, Li YF, Tang LP, Tsoi B, Chen M, et al. A new mechanism of vitamin C effects on A/FM/1/47(H1N1) virus-induced pneumonia in restraint-stressed mice. Biomed Res Int. 2015;2015:675149. doi:10.1155/2015/675149
