Overview
SCIENTIFIC SCORE
Questionable
Based on 21 Researches
6.5
USERS' SCORE
Likely Ineffective
Based on 36 Reviews
3.1
Supplement Facts
Serving Size: 2 Gummies
Amount Per Serving
%DV
Calories
15
Total Carbohydrate
3 g
1%**
Total Sugars
2 g
***
Includes 2 g Added Sugars
4%**
Vitamin C (as Ascorbic Acid)
15 mg
17%
Vitamin E (as dl-Alpha Tocopheryl Acetate)
6.7 mg
45%
Biotin (as d-Biotin)
2,500 mcg
8,333%
Sodium
10 mg
<1%
Top Medical Research Studies
1
We explored the effectiveness of vitamin E alongside isotretinoin, a common treatment for severe acne. In an investigator-blinded, randomized study involving 82 patients, participants were divided into two groups. One group received isotretinoin alone, while the other combined it with 800 IU of vitamin E, over a period of 16 weeks.
Our main goal was to determine whether vitamin E could reduce the side-effects associated with isotretinoin, which are often bothersome for patients. Throughout the study, we assessed various mucocutaneous side effects, such as facial dryness and redness, as well as changes in serum lipid and liver enzyme levels.
Ultimately, we found no significant difference in the incidence or severity of side effects between the two treatment groups. This indicates that vitamin E did not provide any noticeable benefit when added to isotretinoin therapy for acne vulgaris.
While vitamin E is often suggested as a remedy to lighten the side effects of medications, our findings suggest that its use alongside isotretinoin may not be helpful.
Our main goal was to determine whether vitamin E could reduce the side-effects associated with isotretinoin, which are often bothersome for patients. Throughout the study, we assessed various mucocutaneous side effects, such as facial dryness and redness, as well as changes in serum lipid and liver enzyme levels.
Ultimately, we found no significant difference in the incidence or severity of side effects between the two treatment groups. This indicates that vitamin E did not provide any noticeable benefit when added to isotretinoin therapy for acne vulgaris.
While vitamin E is often suggested as a remedy to lighten the side effects of medications, our findings suggest that its use alongside isotretinoin may not be helpful.
Read More
2
We conducted a study to assess whether vitamin E could help reduce the side effects associated with isotretinoin, a common treatment for severe acne. In this double-blind, randomized trial, we assigned 140 participants to receive either isotretinoin paired with a daily dose of 800 IU of vitamin E or a placebo over 20 weeks.
We closely monitored the participants for any side effects such as dry eyes and dry lips. Despite our hopes, the addition of vitamin E did not show any significant improvement in the side effects experienced by those taking isotretinoin. In essence, we found that vitamin E had little to no effect in alleviating the discomfort associated with isotretinoin treatment for acne.
This study thoroughly evaluated the potential benefits of combining vitamin E with isotretinoin but ultimately concluded that the vitamin does not mitigate the adverse side effects of the medication. It’s clear that vitamin E alone might not be the miracle solution for easing isotretinoin side effects as some had hoped.
We closely monitored the participants for any side effects such as dry eyes and dry lips. Despite our hopes, the addition of vitamin E did not show any significant improvement in the side effects experienced by those taking isotretinoin. In essence, we found that vitamin E had little to no effect in alleviating the discomfort associated with isotretinoin treatment for acne.
This study thoroughly evaluated the potential benefits of combining vitamin E with isotretinoin but ultimately concluded that the vitamin does not mitigate the adverse side effects of the medication. It’s clear that vitamin E alone might not be the miracle solution for easing isotretinoin side effects as some had hoped.
Read More
9
We explored the effects of vitamin E on acne by conducting an open-label study with 17 patients who had mild to moderate acne vulgaris. Over eight weeks, these patients followed a standard regimen involving salicylic acid and benzoyl peroxide, with the addition of topical vitamin E in sunflower seed oil.
Throughout the study, we observed that all participants experienced clinical improvements, including a reduction in the number of acne lesions. Interestingly, significant improvements were noted as early as Week 2, indicating that vitamin E may play a beneficial role in managing acne symptoms. Furthermore, patients reported positive feedback regarding the ease of application and tolerability of the treatment.
Although we cannot definitively say vitamin E is a cure for acne, our findings suggest that it may help alleviate some symptoms when used alongside established treatments. This research sheds light on the potential of topical antioxidants like vitamin E in the ongoing battle against acne, inviting further exploration into their effectiveness and role in skincare.
Throughout the study, we observed that all participants experienced clinical improvements, including a reduction in the number of acne lesions. Interestingly, significant improvements were noted as early as Week 2, indicating that vitamin E may play a beneficial role in managing acne symptoms. Furthermore, patients reported positive feedback regarding the ease of application and tolerability of the treatment.
Although we cannot definitively say vitamin E is a cure for acne, our findings suggest that it may help alleviate some symptoms when used alongside established treatments. This research sheds light on the potential of topical antioxidants like vitamin E in the ongoing battle against acne, inviting further exploration into their effectiveness and role in skincare.
Read More
Most Useful Reviews
0
Caused acne
25 people found this helpful
The vitamins tasted pleasant, yet they caused acne for me. I can't recommend them for those with problematic skin. If you're prone to acne, regular vitamins are better. Used for four days.
Read More
0
Severe acne outbreak
4 people found this helpful
I've never cried so much over my skin! It worsened, with more acne than ever. Even strangers commented on my face. I can't recommend this product to anyone!
Read More
0
Acne explosion
3 people found this helpful
While I liked the taste and texture, I experienced a sudden explosion of acne despite following the recommended dosage. Biotin can lead to acne for some, so do consider it before purchasing!
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 21 Researches
6.5
- All Researches
9
Lactoferrin and zinc reduce acne
We observed how a combination of lactoferrin, vitamin E, and zinc might affect mild to moderate acne. In a rigorously designed study, 168 participants aged 13 to 40 were randomly assigned to receive either a treatment capsule containing these ingredients or a placebo twice a day over the course of three months.
The results showcased that those taking the lactoferrin combination saw a notable reduction in acne lesions—an early 14.5% improvement after just two weeks, reaching a maximum of 28.5% reduction by week ten. While vitamin E was part of the treatment, it’s essential to understand that it was combined with lactoferrin and zinc. This means we can't pinpoint vitamin E's specific role in the improvements observed.
Throughout the trial, no adverse effects were reported, reinforcing the safety of the treatment. Overall, this study presents promising findings for those struggling with mild to moderate acne, particularly with the effective dosing of lactoferrin alongside vitamin E and zinc.
The results showcased that those taking the lactoferrin combination saw a notable reduction in acne lesions—an early 14.5% improvement after just two weeks, reaching a maximum of 28.5% reduction by week ten. While vitamin E was part of the treatment, it’s essential to understand that it was combined with lactoferrin and zinc. This means we can't pinpoint vitamin E's specific role in the improvements observed.
Throughout the trial, no adverse effects were reported, reinforcing the safety of the treatment. Overall, this study presents promising findings for those struggling with mild to moderate acne, particularly with the effective dosing of lactoferrin alongside vitamin E and zinc.
Read More
9
We explored the effects of vitamin E on acne by conducting an open-label study with 17 patients who had mild to moderate acne vulgaris. Over eight weeks, these patients followed a standard regimen involving salicylic acid and benzoyl peroxide, with the addition of topical vitamin E in sunflower seed oil.
Throughout the study, we observed that all participants experienced clinical improvements, including a reduction in the number of acne lesions. Interestingly, significant improvements were noted as early as Week 2, indicating that vitamin E may play a beneficial role in managing acne symptoms. Furthermore, patients reported positive feedback regarding the ease of application and tolerability of the treatment.
Although we cannot definitively say vitamin E is a cure for acne, our findings suggest that it may help alleviate some symptoms when used alongside established treatments. This research sheds light on the potential of topical antioxidants like vitamin E in the ongoing battle against acne, inviting further exploration into their effectiveness and role in skincare.
Throughout the study, we observed that all participants experienced clinical improvements, including a reduction in the number of acne lesions. Interestingly, significant improvements were noted as early as Week 2, indicating that vitamin E may play a beneficial role in managing acne symptoms. Furthermore, patients reported positive feedback regarding the ease of application and tolerability of the treatment.
Although we cannot definitively say vitamin E is a cure for acne, our findings suggest that it may help alleviate some symptoms when used alongside established treatments. This research sheds light on the potential of topical antioxidants like vitamin E in the ongoing battle against acne, inviting further exploration into their effectiveness and role in skincare.
Read More
9
We looked into how a combination of RetinSphere® and vitamin E affects mild comedonal acne (MCA). In our study, we measured important factors like sebum oxidation and inflammatory markers before and after treatment in 18 patients with MCA and 10 healthy controls.
Our findings showed that while the amount of sebum and squalene was similar before treatment between the groups, patients with MCA had higher levels of lipid peroxidation and oxidized squalene. These elevated markers contribute to inflammation and acne formation.
After 4 weeks, there was a notable decrease in oxidized lipids and inflammation markers in the lesions, bringing them in line with unaffected areas. These changes were accompanied by visible clinical improvement in the patients by the 8-week mark.
Yet, it’s important to recognize that while vitamin E was part of the treatment mix, this study did not isolate its specific effects. Thus, while we observed positive results, we cannot definitively attribute all improvements directly to vitamin E alone.
Our findings showed that while the amount of sebum and squalene was similar before treatment between the groups, patients with MCA had higher levels of lipid peroxidation and oxidized squalene. These elevated markers contribute to inflammation and acne formation.
After 4 weeks, there was a notable decrease in oxidized lipids and inflammation markers in the lesions, bringing them in line with unaffected areas. These changes were accompanied by visible clinical improvement in the patients by the 8-week mark.
Yet, it’s important to recognize that while vitamin E was part of the treatment mix, this study did not isolate its specific effects. Thus, while we observed positive results, we cannot definitively attribute all improvements directly to vitamin E alone.
Read More
8
We investigated the potential of a dietary supplement containing vitamin E and other ingredients to alleviate side effects from oral isotretinoin therapy in acne patients. The study involved forty-eight participants with nodular acne, divided into two groups. One group received isotretinoin combined with the supplement, while the other only received isotretinoin for six months.
Our findings revealed that the group taking the dietary supplement reported fewer side effects, experiencing less dryness and redness of the skin, as well as improved hydration levels. Participants also showed increased adherence to their treatment regimen when supplemented, which is encouraging for those battling the challenges of acne and its treatment.
The supplement's formulation, enriched with vitamin E and other antioxidants, seems to support skin health during isotretinoin therapy, helping to mitigate common discomforts like dry skin and erythema. This suggests that vitamin E plays a beneficial role when included in a combination supplement, enhancing overall treatment experience for patients undergoing isotretinoin therapy.
Our findings revealed that the group taking the dietary supplement reported fewer side effects, experiencing less dryness and redness of the skin, as well as improved hydration levels. Participants also showed increased adherence to their treatment regimen when supplemented, which is encouraging for those battling the challenges of acne and its treatment.
The supplement's formulation, enriched with vitamin E and other antioxidants, seems to support skin health during isotretinoin therapy, helping to mitigate common discomforts like dry skin and erythema. This suggests that vitamin E plays a beneficial role when included in a combination supplement, enhancing overall treatment experience for patients undergoing isotretinoin therapy.
Read More
8
We aimed to understand how plasma levels of vitamins A and E relate to acne conditions. To do this, we compared vitamin concentrations in 100 newly diagnosed acne patients with 100 healthy individuals of similar age. We utilized high-performance liquid chromatography to ensure accurate measurements, and acne severity was evaluated using the Global Acne Grading System.
Our findings revealed that acne patients had noticeably lower levels of both vitamin A and vitamin E compared to the controls. Specifically, vitamin A levels were 336.5 µg/L for patients versus 418.1 µg/L for healthy individuals, while vitamin E levels were 5.4 mg/L in patients against 5.9 mg/L in controls.
Additionally, we observed a clear link: as the severity of acne increased, the plasma levels of vitamins A and E tended to decrease. This suggests that these vitamins may play a role in the condition's progression, highlighting their potential importance in acne management.
However, it's essential to consider that while the correlation between low vitamin levels and acne severity is significant, the study does not confirm that vitamin E supplementation alone can effectively treat acne.
Our findings revealed that acne patients had noticeably lower levels of both vitamin A and vitamin E compared to the controls. Specifically, vitamin A levels were 336.5 µg/L for patients versus 418.1 µg/L for healthy individuals, while vitamin E levels were 5.4 mg/L in patients against 5.9 mg/L in controls.
Additionally, we observed a clear link: as the severity of acne increased, the plasma levels of vitamins A and E tended to decrease. This suggests that these vitamins may play a role in the condition's progression, highlighting their potential importance in acne management.
However, it's essential to consider that while the correlation between low vitamin levels and acne severity is significant, the study does not confirm that vitamin E supplementation alone can effectively treat acne.
Read More
User Reviews
USERS' SCORE
Likely Ineffective
Based on 36 Reviews
3.1
- All Reviews
- Positive Reviews
- Negative Reviews
0
Caused acne
25 people found this helpful
The vitamins tasted pleasant, yet they caused acne for me. I can't recommend them for those with problematic skin. If you're prone to acne, regular vitamins are better. Used for four days.
Read More
0
Severe acne outbreak
4 people found this helpful
I've never cried so much over my skin! It worsened, with more acne than ever. Even strangers commented on my face. I can't recommend this product to anyone!
Read More
0
Acne explosion
3 people found this helpful
While I liked the taste and texture, I experienced a sudden explosion of acne despite following the recommended dosage. Biotin can lead to acne for some, so do consider it before purchasing!
Read More
0
Not suitable
2 people found this helpful
Unfortunately, they didn’t suit me. I developed acne, both small and large, so I stopped taking them. My skin improved once I stopped taking the vitamins.
Read More
0
Unexpected acne
2 people found this helpful
Be cautious with these vitamins! I expected clear skin, but ended up with teenage-like acne on my forehead and even noticed more hair loss.
Read More
Frequently Asked Questions
0
Caused acne
25 people found this helpful
The vitamins tasted pleasant, yet they caused acne for me. I can't recommend them for those with problematic skin. If you're prone to acne, regular vitamins are better. Used for four days.
0
Pimples appeared
1 people found this helpful
The gummy has a good flavour, but after taking just one, I noticed some pimples that resembled acne on my face.
9
Improved acne condition
1 people found this helpful
Pleasant-tasting jelly vitamins improved my skin condition after two weeks, clearing up previously untreated acne. I have noticed no negative effects and will be ordering more.
0
No effect
Without Effect. I drank the jar, but acne persisted. I do not recommend it.
0
Acne explosion
3 people found this helpful
While I liked the taste and texture, I experienced a sudden explosion of acne despite following the recommended dosage. Biotin can lead to acne for some, so do consider it before purchasing!
0
Internal acne
1 people found this helpful
Unfortunately, these vitamins didn't work for me. I developed painful internal acne, which vanished once I stopped taking them. I noticed the same pattern upon resuming them.
0
Severe acne outbreak
4 people found this helpful
I've never cried so much over my skin! It worsened, with more acne than ever. Even strangers commented on my face. I can't recommend this product to anyone!
9
Skin is clear
These delicious vitamins had an immediate positive effect on my skin, leaving it clear of acne, with shiny hair and strengthened nails.
0
Acne risk
Good, but it could work too well. If I take a gummi every day, I get acne spots, so I only take one occasionally. However, it works effectively!
0
Acne risk
Just a reminder that biotin can induce acne in some individuals. I am one of those people.
7
We examined the relationship between serum vitamin E levels and acne as part of a broader investigation into chronic inflammatory skin diseases. Our analysis included a number of studies that focused on vitamin E in patients, comparing their serum levels with those of healthy individuals.
The findings revealed that patients with acne had significantly lower levels of serum vitamin E compared to controls. This supports the idea that vitamin E might play a role in skin health, although we must note that the study did not delve into how vitamin E treatment specifically improves acne.
In short, while the lower vitamin E levels in acne patients are noteworthy, the study leaves us without conclusive evidence of vitamin E’s direct impact on treating acne. We highlight the importance of evaluating vitamin E status as part of managing skin health across various conditions, including acne.
The findings revealed that patients with acne had significantly lower levels of serum vitamin E compared to controls. This supports the idea that vitamin E might play a role in skin health, although we must note that the study did not delve into how vitamin E treatment specifically improves acne.
In short, while the lower vitamin E levels in acne patients are noteworthy, the study leaves us without conclusive evidence of vitamin E’s direct impact on treating acne. We highlight the importance of evaluating vitamin E status as part of managing skin health across various conditions, including acne.
9
We explored the effects of vitamin E on acne by conducting an open-label study with 17 patients who had mild to moderate acne vulgaris. Over eight weeks, these patients followed a standard regimen involving salicylic acid and benzoyl peroxide, with the addition of topical vitamin E in sunflower seed oil.
Throughout the study, we observed that all participants experienced clinical improvements, including a reduction in the number of acne lesions. Interestingly, significant improvements were noted as early as Week 2, indicating that vitamin E may play a beneficial role in managing acne symptoms. Furthermore, patients reported positive feedback regarding the ease of application and tolerability of the treatment.
Although we cannot definitively say vitamin E is a cure for acne, our findings suggest that it may help alleviate some symptoms when used alongside established treatments. This research sheds light on the potential of topical antioxidants like vitamin E in the ongoing battle against acne, inviting further exploration into their effectiveness and role in skincare.
Throughout the study, we observed that all participants experienced clinical improvements, including a reduction in the number of acne lesions. Interestingly, significant improvements were noted as early as Week 2, indicating that vitamin E may play a beneficial role in managing acne symptoms. Furthermore, patients reported positive feedback regarding the ease of application and tolerability of the treatment.
Although we cannot definitively say vitamin E is a cure for acne, our findings suggest that it may help alleviate some symptoms when used alongside established treatments. This research sheds light on the potential of topical antioxidants like vitamin E in the ongoing battle against acne, inviting further exploration into their effectiveness and role in skincare.
9
Lactoferrin and zinc reduce acne
We observed how a combination of lactoferrin, vitamin E, and zinc might affect mild to moderate acne. In a rigorously designed study, 168 participants aged 13 to 40 were randomly assigned to receive either a treatment capsule containing these ingredients or a placebo twice a day over the course of three months.
The results showcased that those taking the lactoferrin combination saw a notable reduction in acne lesions—an early 14.5% improvement after just two weeks, reaching a maximum of 28.5% reduction by week ten. While vitamin E was part of the treatment, it’s essential to understand that it was combined with lactoferrin and zinc. This means we can't pinpoint vitamin E's specific role in the improvements observed.
Throughout the trial, no adverse effects were reported, reinforcing the safety of the treatment. Overall, this study presents promising findings for those struggling with mild to moderate acne, particularly with the effective dosing of lactoferrin alongside vitamin E and zinc.
The results showcased that those taking the lactoferrin combination saw a notable reduction in acne lesions—an early 14.5% improvement after just two weeks, reaching a maximum of 28.5% reduction by week ten. While vitamin E was part of the treatment, it’s essential to understand that it was combined with lactoferrin and zinc. This means we can't pinpoint vitamin E's specific role in the improvements observed.
Throughout the trial, no adverse effects were reported, reinforcing the safety of the treatment. Overall, this study presents promising findings for those struggling with mild to moderate acne, particularly with the effective dosing of lactoferrin alongside vitamin E and zinc.
7
Isotretinoin effective; vitamin E limited
We designed a study to assess whether adding vitamin E could enhance the effectiveness of isotretinoin, a common treatment for severe acne. The study involved 60 participants who received isotretinoin at a dose of 0.5 mg/kg/day for six months. We divided the participants into two groups: one received 800 IU of vitamin E daily, while the other was given cod liver oil capsules with the same dosage.
During the study, we monitored the participants for side effects at various intervals—specifically at one, four, and six weeks into the treatment. The results indicated that cheilitis, or chapped lips, was the most frequently reported side effect, affecting 69% of the patients. Additionally, both groups experienced epistaxis (nosebleeds) in about 22% of the cases. We also noted other side effects like dry skin, itching, stomach discomfort, and brittle nails.
Importantly, we observed that while isotretinoin remains a highly effective option for treating severe and stubborn acne, the addition of vitamin E did not show a significant benefit. The frequency and severity of complications were generally lower at four and six weeks, suggesting that the body might adapt to the treatment over time.
In summary, while isotretinoin is effective, vitamin E might not offer additional advantages in managing acne treatment.
During the study, we monitored the participants for side effects at various intervals—specifically at one, four, and six weeks into the treatment. The results indicated that cheilitis, or chapped lips, was the most frequently reported side effect, affecting 69% of the patients. Additionally, both groups experienced epistaxis (nosebleeds) in about 22% of the cases. We also noted other side effects like dry skin, itching, stomach discomfort, and brittle nails.
Importantly, we observed that while isotretinoin remains a highly effective option for treating severe and stubborn acne, the addition of vitamin E did not show a significant benefit. The frequency and severity of complications were generally lower at four and six weeks, suggesting that the body might adapt to the treatment over time.
In summary, while isotretinoin is effective, vitamin E might not offer additional advantages in managing acne treatment.
1
We explored the effectiveness of vitamin E alongside isotretinoin, a common treatment for severe acne. In an investigator-blinded, randomized study involving 82 patients, participants were divided into two groups. One group received isotretinoin alone, while the other combined it with 800 IU of vitamin E, over a period of 16 weeks.
Our main goal was to determine whether vitamin E could reduce the side-effects associated with isotretinoin, which are often bothersome for patients. Throughout the study, we assessed various mucocutaneous side effects, such as facial dryness and redness, as well as changes in serum lipid and liver enzyme levels.
Ultimately, we found no significant difference in the incidence or severity of side effects between the two treatment groups. This indicates that vitamin E did not provide any noticeable benefit when added to isotretinoin therapy for acne vulgaris.
While vitamin E is often suggested as a remedy to lighten the side effects of medications, our findings suggest that its use alongside isotretinoin may not be helpful.
Our main goal was to determine whether vitamin E could reduce the side-effects associated with isotretinoin, which are often bothersome for patients. Throughout the study, we assessed various mucocutaneous side effects, such as facial dryness and redness, as well as changes in serum lipid and liver enzyme levels.
Ultimately, we found no significant difference in the incidence or severity of side effects between the two treatment groups. This indicates that vitamin E did not provide any noticeable benefit when added to isotretinoin therapy for acne vulgaris.
While vitamin E is often suggested as a remedy to lighten the side effects of medications, our findings suggest that its use alongside isotretinoin may not be helpful.
4
We explored how vitamin E, specifically alpha-tocopherol, impacts skin cells when exposed to benzoyl peroxide, a common acne treatment. During our investigation, we found that when skin cells, known as keratinocytes, were placed on a layer of alpha-tocopherol, they showed a protective response against the harmful effects of benzoyl peroxide. This suggests that vitamin E may help shield the skin from irritations associated with acne treatment.
However, we also discovered that when alpha-tocopherol was mixed with ethanol and added directly, it had the opposite effect, actually increasing the toxicity of benzoyl peroxide. This points to the importance of how vitamin E is applied; it needs to be done correctly for any potential benefits to shine through. Furthermore, incorporating another antioxidant, N-acetylcysteine, not only reduced cell damage but when paired with alpha-tocopherol, they worked together to provide even greater protection.
While we found that vitamin E can be beneficial, it’s important to note that this protection hinges on the method of application. Thus, understanding how to use vitamin E alongside other treatments could play a vital role in optimizing acne therapies in the future.
However, we also discovered that when alpha-tocopherol was mixed with ethanol and added directly, it had the opposite effect, actually increasing the toxicity of benzoyl peroxide. This points to the importance of how vitamin E is applied; it needs to be done correctly for any potential benefits to shine through. Furthermore, incorporating another antioxidant, N-acetylcysteine, not only reduced cell damage but when paired with alpha-tocopherol, they worked together to provide even greater protection.
While we found that vitamin E can be beneficial, it’s important to note that this protection hinges on the method of application. Thus, understanding how to use vitamin E alongside other treatments could play a vital role in optimizing acne therapies in the future.
References
- Liu X, Yang G, Luo M, Lan Q, Shi X, et al. Serum vitamin E levels and chronic inflammatory skin diseases: A systematic review and meta-analysis. PLoS One. 2021;16:e0261259. doi:10.1371/journal.pone.0261259
- Chan H, Chan G, Santos J, Dee K, Co JK. A randomized, double-blind, placebo-controlled trial to determine the efficacy and safety of lactoferrin with vitamin E and zinc as an oral therapy for mild to moderate acne vulgaris. Int J Dermatol. 2017;56:686. doi:10.1111/ijd.13607
- Mills OH, Criscito MC, Schlesinger TE, Verdicchio R, Szoke E. Addressing Free Radical Oxidation in Acne Vulgaris. J Clin Aesthet Dermatol. 2016;9:25.
- Fabbrocini G, Cameli N, Lorenzi S, De Padova MP, Marasca C, et al. A dietary supplement to reduce side effects of oral isotretinoin therapy in acne patients. G Ital Dermatol Venereol. 2014;149:441.
- Capitanio B, Lora V, Ludovici M, Sinagra JL, Ottaviani M, et al. Modulation of sebum oxidation and interleukin-1α levels associates with clinical improvement of mild comedonal acne. J Eur Acad Dermatol Venereol. 2014;28:1792. doi:10.1111/jdv.12431
- Goforoushan F, Azimi H, Goldust M. Efficacy of vitamin E to prevent dermal complications of isotretinoin. Pak J Biol Sci. 2013;16:548.
- Ozuguz P, Dogruk Kacar S, Ekiz O, Takci Z, Balta I, et al. Evaluation of serum vitamins A and E and zinc levels according to the severity of acne vulgaris. Cutan Ocul Toxicol. 2014;33:99. doi:10.3109/15569527.2013.808656
- Aktürk AŞ, Güzel S, Bulca S, Demirsoy EO, Bayramgürler D, et al. Effects of isotretinoin on serum vitamin E levels in patients with acne. Int J Dermatol. 2013;52:363. doi:10.1111/j.1365-4632.2012.05676.x
- Erturan İ, Naziroğlu M, Akkaya VB. Isotretinoin treatment induces oxidative toxicity in blood of patients with acne vulgaris: a clinical pilot study. Cell Biochem Funct. 2012;30:552. doi:10.1002/cbf.2830
- El-Akawi Z, Abdel-Latif N, Abdul-Razzak K. Does the plasma level of vitamins A and E affect acne condition?. Clin Exp Dermatol. 2006;31:430.
- Strumia R. Dermatologic signs in patients with eating disorders. Am J Clin Dermatol. 2005;6:165.
- Kus S, Gün D, Demirçay Z, Sur H. Vitamin E does not reduce the side-effects of isotretinoin in the treatment of acne vulgaris. Int J Dermatol. 2005;44:248.
- Bellei E, Rota C, Bergamini S, Manfredini P, Albertazzi A, et al. Effect of alpha-tocopherol and N-acetylcysteine on benzoyl peroxide toxicity in human keratinocytes. J Biochem Mol Toxicol. 2004;18:107.
- Weber SU, Thiele JJ, Han N, Luu C, Valacchi G, et al. Topical alpha-tocotrienol supplementation inhibits lipid peroxidation but fails to mitigate increased transepidermal water loss after benzoyl peroxide treatment of human skin. Free Radic Biol Med. 2003;34:170.
- Strauss JS, Gottlieb AB, Jones T, Koo JY, Leyden JJ, et al. Concomitant administration of vitamin E does not change the side effects of isotretinoin as used in acne vulgaris: a randomized trial. J Am Acad Dermatol. 2000;43:777.
- Michaëlsson G, Edqvist LE. Erythrocyte glutathione peroxidase activity in acne vulgaris and the effect of selenium and vitamin E treatment. Acta Derm Venereol. 1984;64:9.
- Marasca C, Ruggiero A, Cacciapuoti S, Fabbrocini G, Annunziata MC. Probiotic supplement combined with topical therapy in the treatment of mild to moderate acne: results from an Italian single centre interventional study. Ital J Dermatol Venerol. 2022;157:510. doi:10.23736/S2784-8671.22.07361-3
- Aksac SE, Bilgili SG, Yavuz GO, Yavuz IH, Aksac M, et al. Evaluation of biophysical skin parameters and hair changes in patients with acne vulgaris treated with isotretinoin, and the effect of biotin use on these parameters. Int J Dermatol. 2021;60:980. doi:10.1111/ijd.15485
- Piraccini BM, Berardesca E, Fabbrocini G, Micali G, Tosti A. Biotin: overview of the treatment of diseases of cutaneous appendages and of hyperseborrhea. G Ital Dermatol Venereol. 2019;154:557. doi:10.23736/S0392-0488.19.06434-4
- Advani K, Batra M, Tajpuriya S, Gupta R, Saraswat A, et al. Efficacy of combination therapy of inositols, antioxidants and vitamins in obese and non-obese women with polycystic ovary syndrome: an observational study. J Obstet Gynaecol. 2020;40:96. doi:10.1080/01443615.2019.1604644
- Tolino E, Skroza N, Mambrin A, Bernardini N, Zuber S, et al. Novel combination for the treatment of acne differentiated based on gender: a new step towards personalized treatment. G Ital Dermatol Venereol. 2018;153:866. doi:10.23736/S0392-0488.18.05710-3
