Last update
4/1/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 1 Review
8.3
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B-6 (as Pyridoxine Hydrochloride)
100 mg
5,882%
Top Medical Research Studies
7
Vitamin B6 effects on psoriasis inflammation
We explored the intriguing connection between vitamin B6 and psoriasis, a skin condition affecting about 3% of people worldwide. This research centers on how vitamin B6 impacts skin inflammation, focusing on its metabolites and their effects on inflammatory markers in psoriasis patients.
Through thorough analysis and functional studies, we observed that vitamin B6 compounds could decrease the infiltration of neutrophils, reduce oxidative stress, and lower Nfkb activity in zebrafish models mimicking skin inflammation. Impressively, when we inhibited specific enzymes regulated by vitamin B6, namely glycogen phosphorylase L (Pygl) and glucose-6-phosphate dehydrogenase (G6pd), we found a significant reduction in oxidative-stress-induced inflammation.
These findings suggest that while G6pd typically plays a vital role in fighting oxidative stress, it also seems to work with glycogen stores to fuel inflammation through the action of NADPH oxidase. This brings to light potential new treatment targets for psoriasis and similar inflammatory skin disorders, emphasizing the need for continuous exploration in this area.
Through thorough analysis and functional studies, we observed that vitamin B6 compounds could decrease the infiltration of neutrophils, reduce oxidative stress, and lower Nfkb activity in zebrafish models mimicking skin inflammation. Impressively, when we inhibited specific enzymes regulated by vitamin B6, namely glycogen phosphorylase L (Pygl) and glucose-6-phosphate dehydrogenase (G6pd), we found a significant reduction in oxidative-stress-induced inflammation.
These findings suggest that while G6pd typically plays a vital role in fighting oxidative stress, it also seems to work with glycogen stores to fuel inflammation through the action of NADPH oxidase. This brings to light potential new treatment targets for psoriasis and similar inflammatory skin disorders, emphasizing the need for continuous exploration in this area.
Read More
Most Useful Reviews
6
Temporary psoriasis relief
7 people found this helpful
When I take B6, I've noticed it helps clear my psoriasis and dry, flaky patches of skin. While it’s a temporary fix, B6 is the only thing that assists with my persistent dry lips. It didn’t alleviate my internal neurological pain or chronic fatigue but has shown positive effects on my skin.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
- All Researches
7
Vitamin B6 effects on psoriasis inflammation
We explored the intriguing connection between vitamin B6 and psoriasis, a skin condition affecting about 3% of people worldwide. This research centers on how vitamin B6 impacts skin inflammation, focusing on its metabolites and their effects on inflammatory markers in psoriasis patients.
Through thorough analysis and functional studies, we observed that vitamin B6 compounds could decrease the infiltration of neutrophils, reduce oxidative stress, and lower Nfkb activity in zebrafish models mimicking skin inflammation. Impressively, when we inhibited specific enzymes regulated by vitamin B6, namely glycogen phosphorylase L (Pygl) and glucose-6-phosphate dehydrogenase (G6pd), we found a significant reduction in oxidative-stress-induced inflammation.
These findings suggest that while G6pd typically plays a vital role in fighting oxidative stress, it also seems to work with glycogen stores to fuel inflammation through the action of NADPH oxidase. This brings to light potential new treatment targets for psoriasis and similar inflammatory skin disorders, emphasizing the need for continuous exploration in this area.
Through thorough analysis and functional studies, we observed that vitamin B6 compounds could decrease the infiltration of neutrophils, reduce oxidative stress, and lower Nfkb activity in zebrafish models mimicking skin inflammation. Impressively, when we inhibited specific enzymes regulated by vitamin B6, namely glycogen phosphorylase L (Pygl) and glucose-6-phosphate dehydrogenase (G6pd), we found a significant reduction in oxidative-stress-induced inflammation.
These findings suggest that while G6pd typically plays a vital role in fighting oxidative stress, it also seems to work with glycogen stores to fuel inflammation through the action of NADPH oxidase. This brings to light potential new treatment targets for psoriasis and similar inflammatory skin disorders, emphasizing the need for continuous exploration in this area.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
6
Temporary psoriasis relief
7 people found this helpful
When I take B6, I've noticed it helps clear my psoriasis and dry, flaky patches of skin. While it’s a temporary fix, B6 is the only thing that assists with my persistent dry lips. It didn’t alleviate my internal neurological pain or chronic fatigue but has shown positive effects on my skin.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- MartĂnez-Navarro FJ, MartĂnez-Morcillo FJ, LĂłpez-Muñoz A, Pardo-Sánchez I, MartĂnez-MenchĂłn T, et al. The vitamin B6-regulated enzymes PYGL and G6PD fuel NADPH oxidases to promote skin inflammation. Dev Comp Immunol. 2020;108:103666. 10.1016/j.dci.2020.103666
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