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SCIENTIFIC SCORE
Questionable
Based on 5 Researches
6.8
USERS' SCORE
Good
Based on 1 Reviews
8.5
Supplement Facts
Serving Size: 3 Capsules
Amount Per Serving
%DV
Organic Echinacea purpurea (stem, leaf, flower)
1.2 g
**
Top Medical Research Studies
8
Echinacea shows potential for anxiety
The anxiolytic potential and psychotropic side effects of an echinacea preparation in laboratory animals and healthy volunteers.
Directly addresses anxiety treatment
We investigated the potential of Echinacea angustifolia to reduce anxiety through various tests in both laboratory animals and healthy volunteers. The study design included tests like the elevated plus-maze and the conditioned fear test on rats, which helped us observe the anxiolytic effects of the echinacea extract.
We found that the extract noticeably decreased anxiety levels in the elevated plus-maze and improved responses to contextual fear conditioning without causing any harmful side effects at high dosages. Furthermore, the extract showed no impact on memory, movement, or reward-seeking behavior in rats.
On the human side, we administered a pharmacological formulation containing the echinacea extract to volunteers who had elevated anxiety levels as measured by the State-Trait Anxiety Inventory. After a week of taking high doses, participants reported a significant decrease in anxiety, which persisted for two more weeks after stopping treatment. However, the lower dose of echinacea did not yield significant changes in anxiety levels.
Overall, this study suggests that Echinacea angustifolia could be a promising option for helping manage anxiety, at least in higher quantities.
We found that the extract noticeably decreased anxiety levels in the elevated plus-maze and improved responses to contextual fear conditioning without causing any harmful side effects at high dosages. Furthermore, the extract showed no impact on memory, movement, or reward-seeking behavior in rats.
On the human side, we administered a pharmacological formulation containing the echinacea extract to volunteers who had elevated anxiety levels as measured by the State-Trait Anxiety Inventory. After a week of taking high doses, participants reported a significant decrease in anxiety, which persisted for two more weeks after stopping treatment. However, the lower dose of echinacea did not yield significant changes in anxiety levels.
Overall, this study suggests that Echinacea angustifolia could be a promising option for helping manage anxiety, at least in higher quantities.
Read More
8
Echinacea shows promise for anxiety relief
The effect of Echinacea preparations in three laboratory tests of anxiety: comparison with chlordiazepoxide.
Direct evidence of efficacy
We set out to explore the effects of Echinacea preparations on anxiety, motivated by the recent discovery of active components within Echinacea that might influence behavior. We examined five different Echinacea extracts in an effort to determine their anxiolytic potential in laboratory settings.
Our findings revealed that three of these extracts were effective at reducing anxiety levels, while two showed only a narrow dosing range for effectiveness. One particular extract stood out, demonstrating significant anxiety reduction over a broader dose range of 3-8 mg/kg. We consistently observed these anxiolytic effects in various tests, including the elevated plus-maze and social interaction tests.
Importantly, we didn't find any suppressive effects on locomotion at any of the doses used—a common concern with conventional anxiety medications like chlordiazepoxide, which effectively reduced anxiety but also caused lethargy at higher doses. This study offers valuable insight into Echinacea as a potential alternative treatment for anxiety, highlighting its strong safety profile and the need for further research to pinpoint which specific preparations yield the best results.
Our findings revealed that three of these extracts were effective at reducing anxiety levels, while two showed only a narrow dosing range for effectiveness. One particular extract stood out, demonstrating significant anxiety reduction over a broader dose range of 3-8 mg/kg. We consistently observed these anxiolytic effects in various tests, including the elevated plus-maze and social interaction tests.
Importantly, we didn't find any suppressive effects on locomotion at any of the doses used—a common concern with conventional anxiety medications like chlordiazepoxide, which effectively reduced anxiety but also caused lethargy at higher doses. This study offers valuable insight into Echinacea as a potential alternative treatment for anxiety, highlighting its strong safety profile and the need for further research to pinpoint which specific preparations yield the best results.
Read More
7
Echinacea influences anxiety-related neurons
The effects of an Echinacea preparation on synaptic transmission and the firing properties of CA1 pyramidal cells in the hippocampus.
Study directly explores anxiety effects
We set out to understand the effects of an Echinacea extract on the brain's inner workings, particularly in an area known for its role in anxiety – the hippocampus. Using sophisticated in vitro techniques, we found that Echinacea significantly dampened excitatory synaptic transmission in hippocampal slices. This means that the communication between certain neurons was reduced when exposed to Echinacea, which could explain its potential anxiolytic effects.
In our experiments, we also noted that at lower doses, Echinacea decreased the spiking activity of CA1 pyramidal cells, which are crucial for the processing of information. Interestingly, when we applied higher concentrations of the extract, this spiking activity increased. This dual nature of Echinacea suggests that its effects depend heavily on the dosage used.
While we observed these changes in excitatory synaptic transmission and neuronal firing, the extract did not seem to affect the inhibitory transmission or the passive properties of the pyramidal cells. Overall, our findings support the notion that Echinacea affects the brain in ways that may help to alleviate anxiety, specifically through its action on excitatory synapses without changing inhibitory signals.
In our experiments, we also noted that at lower doses, Echinacea decreased the spiking activity of CA1 pyramidal cells, which are crucial for the processing of information. Interestingly, when we applied higher concentrations of the extract, this spiking activity increased. This dual nature of Echinacea suggests that its effects depend heavily on the dosage used.
While we observed these changes in excitatory synaptic transmission and neuronal firing, the extract did not seem to affect the inhibitory transmission or the passive properties of the pyramidal cells. Overall, our findings support the notion that Echinacea affects the brain in ways that may help to alleviate anxiety, specifically through its action on excitatory synapses without changing inhibitory signals.
Read More
Most Useful Reviews
8.3
Helps with anxiety
When echinacea and elderberry are not available, I feel anxious. I take echinacea from this manufacturer and can confidently recommend it.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 5 Researches
6.8
8
Echinacea shows potential for anxiety
The anxiolytic potential and psychotropic side effects of an echinacea preparation in laboratory animals and healthy volunteers.
Directly addresses anxiety treatment
We investigated the potential of Echinacea angustifolia to reduce anxiety through various tests in both laboratory animals and healthy volunteers. The study design included tests like the elevated plus-maze and the conditioned fear test on rats, which helped us observe the anxiolytic effects of the echinacea extract.
We found that the extract noticeably decreased anxiety levels in the elevated plus-maze and improved responses to contextual fear conditioning without causing any harmful side effects at high dosages. Furthermore, the extract showed no impact on memory, movement, or reward-seeking behavior in rats.
On the human side, we administered a pharmacological formulation containing the echinacea extract to volunteers who had elevated anxiety levels as measured by the State-Trait Anxiety Inventory. After a week of taking high doses, participants reported a significant decrease in anxiety, which persisted for two more weeks after stopping treatment. However, the lower dose of echinacea did not yield significant changes in anxiety levels.
Overall, this study suggests that Echinacea angustifolia could be a promising option for helping manage anxiety, at least in higher quantities.
We found that the extract noticeably decreased anxiety levels in the elevated plus-maze and improved responses to contextual fear conditioning without causing any harmful side effects at high dosages. Furthermore, the extract showed no impact on memory, movement, or reward-seeking behavior in rats.
On the human side, we administered a pharmacological formulation containing the echinacea extract to volunteers who had elevated anxiety levels as measured by the State-Trait Anxiety Inventory. After a week of taking high doses, participants reported a significant decrease in anxiety, which persisted for two more weeks after stopping treatment. However, the lower dose of echinacea did not yield significant changes in anxiety levels.
Overall, this study suggests that Echinacea angustifolia could be a promising option for helping manage anxiety, at least in higher quantities.
Read More
8
Echinacea shows promise for anxiety relief
The effect of Echinacea preparations in three laboratory tests of anxiety: comparison with chlordiazepoxide.
Direct evidence of efficacy
We set out to explore the effects of Echinacea preparations on anxiety, motivated by the recent discovery of active components within Echinacea that might influence behavior. We examined five different Echinacea extracts in an effort to determine their anxiolytic potential in laboratory settings.
Our findings revealed that three of these extracts were effective at reducing anxiety levels, while two showed only a narrow dosing range for effectiveness. One particular extract stood out, demonstrating significant anxiety reduction over a broader dose range of 3-8 mg/kg. We consistently observed these anxiolytic effects in various tests, including the elevated plus-maze and social interaction tests.
Importantly, we didn't find any suppressive effects on locomotion at any of the doses used—a common concern with conventional anxiety medications like chlordiazepoxide, which effectively reduced anxiety but also caused lethargy at higher doses. This study offers valuable insight into Echinacea as a potential alternative treatment for anxiety, highlighting its strong safety profile and the need for further research to pinpoint which specific preparations yield the best results.
Our findings revealed that three of these extracts were effective at reducing anxiety levels, while two showed only a narrow dosing range for effectiveness. One particular extract stood out, demonstrating significant anxiety reduction over a broader dose range of 3-8 mg/kg. We consistently observed these anxiolytic effects in various tests, including the elevated plus-maze and social interaction tests.
Importantly, we didn't find any suppressive effects on locomotion at any of the doses used—a common concern with conventional anxiety medications like chlordiazepoxide, which effectively reduced anxiety but also caused lethargy at higher doses. This study offers valuable insight into Echinacea as a potential alternative treatment for anxiety, highlighting its strong safety profile and the need for further research to pinpoint which specific preparations yield the best results.
Read More
7
Echinacea does not effectively reduce anxiety
Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence.
Minimal relevance to treatment efficacy.
We explored the potential effects of echinacea on anxiety through a thorough review of existing studies. The research aimed to investigate whether echinacea could effectively alleviate symptoms associated with various anxiety disorders.
Our findings revealed that, while many herbal remedies were examined for their anxiolytic properties, current evidence does not support the use of echinacea as a reliable treatment for any anxiety disorder. Although studies included echinacea among other herbal treatments, there was no definitive proof of its effectiveness in improving anxiety outcomes.
It's important to note that the conclusions drawn about echinacea are based on the overall analysis of the reviewed studies, which assessed a range of plants. Participants in the included studies did not benefit significantly from echinacea treatment compared to other options. Therefore, we should approach the use of echinacea for anxiety with caution and acknowledge that more research is needed to thoroughly assess its potential in this area.
Our findings revealed that, while many herbal remedies were examined for their anxiolytic properties, current evidence does not support the use of echinacea as a reliable treatment for any anxiety disorder. Although studies included echinacea among other herbal treatments, there was no definitive proof of its effectiveness in improving anxiety outcomes.
It's important to note that the conclusions drawn about echinacea are based on the overall analysis of the reviewed studies, which assessed a range of plants. Participants in the included studies did not benefit significantly from echinacea treatment compared to other options. Therefore, we should approach the use of echinacea for anxiety with caution and acknowledge that more research is needed to thoroughly assess its potential in this area.
Read More
7
Echinacea influences anxiety-related neurons
The effects of an Echinacea preparation on synaptic transmission and the firing properties of CA1 pyramidal cells in the hippocampus.
Study directly explores anxiety effects
We set out to understand the effects of an Echinacea extract on the brain's inner workings, particularly in an area known for its role in anxiety – the hippocampus. Using sophisticated in vitro techniques, we found that Echinacea significantly dampened excitatory synaptic transmission in hippocampal slices. This means that the communication between certain neurons was reduced when exposed to Echinacea, which could explain its potential anxiolytic effects.
In our experiments, we also noted that at lower doses, Echinacea decreased the spiking activity of CA1 pyramidal cells, which are crucial for the processing of information. Interestingly, when we applied higher concentrations of the extract, this spiking activity increased. This dual nature of Echinacea suggests that its effects depend heavily on the dosage used.
While we observed these changes in excitatory synaptic transmission and neuronal firing, the extract did not seem to affect the inhibitory transmission or the passive properties of the pyramidal cells. Overall, our findings support the notion that Echinacea affects the brain in ways that may help to alleviate anxiety, specifically through its action on excitatory synapses without changing inhibitory signals.
In our experiments, we also noted that at lower doses, Echinacea decreased the spiking activity of CA1 pyramidal cells, which are crucial for the processing of information. Interestingly, when we applied higher concentrations of the extract, this spiking activity increased. This dual nature of Echinacea suggests that its effects depend heavily on the dosage used.
While we observed these changes in excitatory synaptic transmission and neuronal firing, the extract did not seem to affect the inhibitory transmission or the passive properties of the pyramidal cells. Overall, our findings support the notion that Echinacea affects the brain in ways that may help to alleviate anxiety, specifically through its action on excitatory synapses without changing inhibitory signals.
Read More
4
Echinacea shows mood effects
An investigation into the anxiety-relieving and mood-enhancing effects of Echinacea angustifolia (EP107™): A randomised, double-blind, placebo-controlled study.
Direct insight into echinacea
In a comprehensive study focused on the effects of echinacea angustifolia, we conducted a randomized, double-blind, placebo-controlled trial over six weeks with 108 adults experiencing mild to moderate anxiety. Participants were assigned to receive either a placebo, 20 mg, or 40 mg of echinacea extract twice daily.
While the results did not show significant improvements in anxiety levels compared to the placebo group, we did observe notable enhancements in mood, particularly in positive and negative affects, as well as emotional wellbeing. These findings suggest that echinacea may have some antidepressant effects, even if its ability to specifically reduce anxiety was not clearly established.
The positive changes in mood were identified primarily through secondary measures and warrant further investigation. Future research utilizing more defined populations and validated tools could help clarify the relationship between echinacea and anxiety treatment more definitively.
While the results did not show significant improvements in anxiety levels compared to the placebo group, we did observe notable enhancements in mood, particularly in positive and negative affects, as well as emotional wellbeing. These findings suggest that echinacea may have some antidepressant effects, even if its ability to specifically reduce anxiety was not clearly established.
The positive changes in mood were identified primarily through secondary measures and warrant further investigation. Future research utilizing more defined populations and validated tools could help clarify the relationship between echinacea and anxiety treatment more definitively.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Reviews
8.5
8.3
Helps with anxiety
When echinacea and elderberry are not available, I feel anxious. I take echinacea from this manufacturer and can confidently recommend it.
