Effectiveness of eight-week zinc supplementation on vitamin D status and leptin levels in a population of postmenopausal women: a double-blind randomized trial.
We set out to understand how zinc supplementation could affect vitamin D status and leptin levels in postmenopausal women. The study involved 51 healthy postmenopausal women aged between 44 and 76 from Granada, Spain. They were divided into two groups: one receiving a zinc supplement of 50 mg daily for eight weeks and the other receiving a placebo.
Our findings revealed that zinc supplementation significantly improved vitamin D status in these women. Particularly, those who had reached menopause at a younger age saw a notable increase in their vitamin D levels after taking zinc.
Additionally, we discovered a connection between zinc and leptin levels, a hormone that regulates energy balance. Both dietary zinc intake and its plasma levels were found to be inversely related to serum leptin levels—meaning as zinc levels increased, leptin levels tended to decrease.
Overall, these results suggest that zinc supplementation may play a beneficial role during menopause by enhancing vitamin D levels and influencing leptin balance among postmenopausal women.
Read More
9
Zinc gel improves menopausal symptoms
Zinc-containing Vaginal Moisturizer Gel Improves Postmenopausal Vulvovaginal Symptoms: A Pilot Study.
We evaluated the impact of a zinc-containing vaginal moisturizer gel on postmenopausal women experiencing genitourinary symptoms of menopause (GSM). Some women hesitate to use hormonal treatments like vaginal estrogen, which can be highly effective. To explore an alternative, we asked 37 participants to apply the gel daily for two weeks while tracking their symptoms.
Throughout the study, we used various methods to assess improvement. The Vaginal Health Index, which measures vaginal health, showed significant improvement after treatment. We also noted that participants reported reduced levels of vaginal pain and dryness on a visual analog scale, with the most notable benefit occurring for vaginal dryness. Additionally, the vulvovaginal symptom questionnaire indicated a substantial decrease in overall symptoms. Notably, side effects were minor and infrequent, which is encouraging for those considering this option.
In summary, our findings suggest that a novel zinc-containing vaginal moisturizer gel can effectively alleviate postmenopausal vulvovaginal symptoms without serious side effects, providing a viable solution for women who prefer non-hormonal treatments.
Read More
8
Zinc enhances antioxidant protection
Erythrocyte Zn concentration and antioxidant response after supplementation with Zn in a postmenopausal population. A double-blind randomized trial.
We assessed how zinc (Zn) supplementation can impact the health of postmenopausal women, particularly regarding their antioxidant status. In this study, fifty-one women participating were split into two groups: one receiving a placebo treatment and the other receiving zinc supplements. This double-blind randomized trial lasted for eight weeks and focused on measuring changes in mineral status along with different antioxidant markers in the blood.
Before the intervention, we noticed that many participants had low zinc levels, which can lead to weakened antioxidant defenses—especially critical for postmenopausal women due to hormonal changes. After eight weeks of zinc supplementation, we saw a marked improvement in zinc levels among the women receiving the supplements. There were also significant positive correlations between zinc levels and overall antioxidant capacity, as well as specific antioxidant enzymes like glutathione peroxidase.
From our findings, it seems clear that zinc supplementation is a promising way to address deficiencies and bolster antioxidant defenses in postmenopausal women. This could not only support their nutritional health but might also contribute positively to their overall well-being during this transitional life stage.
Read More
Most Useful Reviews
9
Family wellness
During the pandemic, doctors recommended zinc for its benefits, including supporting skin health and aiding in menopause. It's effective for acne and hair loss, and essential for overall family well-being.
Read More
7.5
Menopause support
263 people found this helpful
Zinc positively affects women's reproductive health and can also help with menopause symptoms like hair loss and skin issues. This supplement is well-absorbed and free from artificial additives. I've noticed less hair fall and improved skin, and it helps strengthen immunity during illness.
Read More
7.5
Reproductive Health
1 people found this helpful
Zinc is crucial for both men and women. In women, it supports reproductive system development and can alleviate menopause symptoms such as hair loss and weight gain. This zinc is high quality and highly effective; I recommend it for overall health.
Effectiveness of eight-week zinc supplementation on vitamin D status and leptin levels in a population of postmenopausal women: a double-blind randomized trial.
We set out to understand how zinc supplementation could affect vitamin D status and leptin levels in postmenopausal women. The study involved 51 healthy postmenopausal women aged between 44 and 76 from Granada, Spain. They were divided into two groups: one receiving a zinc supplement of 50 mg daily for eight weeks and the other receiving a placebo.
Our findings revealed that zinc supplementation significantly improved vitamin D status in these women. Particularly, those who had reached menopause at a younger age saw a notable increase in their vitamin D levels after taking zinc.
Additionally, we discovered a connection between zinc and leptin levels, a hormone that regulates energy balance. Both dietary zinc intake and its plasma levels were found to be inversely related to serum leptin levels—meaning as zinc levels increased, leptin levels tended to decrease.
Overall, these results suggest that zinc supplementation may play a beneficial role during menopause by enhancing vitamin D levels and influencing leptin balance among postmenopausal women.
Read More
9
Zinc gel improves menopausal symptoms
Zinc-containing Vaginal Moisturizer Gel Improves Postmenopausal Vulvovaginal Symptoms: A Pilot Study.
We evaluated the impact of a zinc-containing vaginal moisturizer gel on postmenopausal women experiencing genitourinary symptoms of menopause (GSM). Some women hesitate to use hormonal treatments like vaginal estrogen, which can be highly effective. To explore an alternative, we asked 37 participants to apply the gel daily for two weeks while tracking their symptoms.
Throughout the study, we used various methods to assess improvement. The Vaginal Health Index, which measures vaginal health, showed significant improvement after treatment. We also noted that participants reported reduced levels of vaginal pain and dryness on a visual analog scale, with the most notable benefit occurring for vaginal dryness. Additionally, the vulvovaginal symptom questionnaire indicated a substantial decrease in overall symptoms. Notably, side effects were minor and infrequent, which is encouraging for those considering this option.
In summary, our findings suggest that a novel zinc-containing vaginal moisturizer gel can effectively alleviate postmenopausal vulvovaginal symptoms without serious side effects, providing a viable solution for women who prefer non-hormonal treatments.
Read More
8
Zinc enhances antioxidant protection
Erythrocyte Zn concentration and antioxidant response after supplementation with Zn in a postmenopausal population. A double-blind randomized trial.
We assessed how zinc (Zn) supplementation can impact the health of postmenopausal women, particularly regarding their antioxidant status. In this study, fifty-one women participating were split into two groups: one receiving a placebo treatment and the other receiving zinc supplements. This double-blind randomized trial lasted for eight weeks and focused on measuring changes in mineral status along with different antioxidant markers in the blood.
Before the intervention, we noticed that many participants had low zinc levels, which can lead to weakened antioxidant defenses—especially critical for postmenopausal women due to hormonal changes. After eight weeks of zinc supplementation, we saw a marked improvement in zinc levels among the women receiving the supplements. There were also significant positive correlations between zinc levels and overall antioxidant capacity, as well as specific antioxidant enzymes like glutathione peroxidase.
From our findings, it seems clear that zinc supplementation is a promising way to address deficiencies and bolster antioxidant defenses in postmenopausal women. This could not only support their nutritional health but might also contribute positively to their overall well-being during this transitional life stage.
Read More
8
Zinc improves nutritional markers post-menopause
Effect of zinc supplementation on circulating concentrations of homocysteine, vitamin B, and folate in a postmenopausal population.
In our study, we examined how zinc supplementation could affect menopausal women, particularly focusing on markers like homocysteine, vitamin B, and folate levels. We worked with 51 postmenopausal women aged between 44 and 76 years, dividing them into two groups: one received a placebo, while the other was given 50 mg of zinc daily for eight weeks.
After analyzing the results, we found that those who took zinc showed significantly higher folate levels compared to their baseline measurements. Additionally, we observed a noteworthy decrease in homocysteine levels when comparing the two groups after the intervention. Interestingly, we also noted a strong correlation between higher folate and vitamin B levels with lower homocysteine levels in the zinc group.
These findings suggest that zinc supplementation can have positive effects on certain nutritional markers in menopausal women. However, we emphasize the need for further research with larger sample sizes and refined dosing to validate and expand upon our results.
Read More
7
Zinc impacts postmenopausal obesity
Excess dietary zinc drives a Cushing's-like syndrome in ovariectomized mice - Implications for postmenopausal obesity.
We investigated the effects of dietary zinc on obesity related to menopause, particularly in female mice that underwent ovariectomy (Ovx). Our findings revealed that excess zinc led to significant weight gain and symptoms resembling Cushing's syndrome, even though these mice did not consume more food.
The accumulation of zinc in the adrenal glands played a crucial role by interfering with steroid production. This is particularly important since, in Ovx mice, adrenal steroids are the only source of estrogen. The lack of estrogen triggered adrenal hyperplasia and an increase in glucocorticoids, which contributed to the development of Cushing's-like symptoms.
Interestingly, our results showed that supplementing with adrenal steroids could counteract the negative impacts of excess zinc. We also found a positive correlation between plasma zinc levels and cortisol while noting a negative correlation with adrenal steroids and estrogen levels in overweight postmenopausal women.
These insights suggest that it may be beneficial for postmenopausal women to avoid high dietary zinc and consider adrenal steroid supplementation to help manage obesity effectively.
During the pandemic, doctors recommended zinc for its benefits, including supporting skin health and aiding in menopause. It's effective for acne and hair loss, and essential for overall family well-being.
Read More
7.5
Menopause support
263 people found this helpful
Zinc positively affects women's reproductive health and can also help with menopause symptoms like hair loss and skin issues. This supplement is well-absorbed and free from artificial additives. I've noticed less hair fall and improved skin, and it helps strengthen immunity during illness.
Read More
7.5
Reproductive Health
1 people found this helpful
Zinc is crucial for both men and women. In women, it supports reproductive system development and can alleviate menopause symptoms such as hair loss and weight gain. This zinc is high quality and highly effective; I recommend it for overall health.
Read More
7.5
Menopause relief
Zinc is essential for both men's and women's health and significantly eases menopause symptoms. It’s beneficial for skin and overall well-being.
Read More
7.5
Essential nutrient
I take zinc regularly to combat deficiency signs, including menopausal symptoms. It's essential for hormonal balance and supports health in so many areas.
Menopause is a natural biological process that marks the end of a woman's reproductive years, characterized by the cessation of menstruation and a decline in hormonal levels, particularly estrogen and progesterone. Typically occurring between the ages of 45 and 55, menopause can bring a variety of physical and emotional changes. Common symptoms may include hot flashes, night sweats, mood swings, and changes in sleep patterns. It is important to note that menopause is a gradual process and often begins with perimenopause, where women may experience irregular periods and increased symptoms for several years before periods stop completely.
While menopause is a natural phase of life, it can have significant impacts on a woman's health and well-being. This transition can increase the risk of certain health issues, such as osteoporosis and cardiovascular disease, due in part to lowered hormone levels. Therefore, it is advisable for women to consult with healthcare providers to discuss potential management strategies and lifestyle adjustments during this time. These may include hormone replacement therapy, dietary changes, regular physical activity, and alternative therapies, all aimed at alleviating symptoms and promoting overall health during and after menopause.
Zinc is a versatile metal known for its various applications in industry and health. It is a bluish-white metallic element represented by the symbol Zn and atomic number 30 on the periodic table. Zinc is primarily used for galvanizing steel to prevent rusting, in the manufacturing of alloys, and as a component in batteries. Additionally, zinc plays a crucial role in biological processes, making it an essential trace element in the human diet. It is involved in immune function, protein synthesis, wound healing, and DNA synthesis, highlighting its importance in maintaining overall health and well-being.
Zinc may play a supportive role during menopause, as it is known for its importance in numerous bodily functions, including immune response and hormone regulation. Some studies suggest that adequate zinc levels might help alleviate certain menopausal symptoms, such as mood swings, sleep disturbances, and fatigue. Additionally, zinc contributes to bone health, which is particularly important during menopause, as the decline in estrogen levels can lead to increased bone density loss.
However, it's worth noting that while zinc can contribute to overall health, it should not be viewed as a primary treatment for menopause-related symptoms. Women experiencing significant discomfort or health changes during menopause should consult a healthcare provider for personalized advice and treatment options. Supplementation of zinc should be approached with caution, as excessive intake can lead to adverse health effects. In summary, while zinc may offer some benefits during menopause, more research is needed to fully understand its impact and effectiveness.
Zinc can play a supportive role in managing some menopause symptoms, particularly when it comes to mood and cognitive function. However, the time it takes to see results can vary significantly from person to person. Many users report experiencing benefits within a few weeks of consistent use, while others may take longer to notice any changes. Factors influencing this timeline might include the severity of symptoms, dosage, overall health, and any other supplements or medications you may be taking.
It's essential to maintain patience and give your body the time it needs to adjust to the zinc supplements. To help monitor your progress, consider keeping a journal of symptoms and any other changes in your well-being as you incorporate zinc into your routine. If after a few months you do not notice any improvement, it may be worthwhile to consult a healthcare provider to assess your supplementation strategy or explore alternative options tailored to your individual needs.
Scientific research supports the use of zinc supplementation for managing certain aspects of menopause in women. A study involving postmenopausal women showed that zinc supplementation positively impacted antioxidant levels, with significant improvements in antioxidant capacity and specific enzyme activity after eight weeks of daily zinc intake [2]. Moreover, another trial indicated that zinc may also enhance vitamin D levels and influence leptin balance, factors that are crucial for maintaining overall health during menopause [4].
Additionally, a zinc-containing vaginal moisturizer gel has been demonstrated to effectively alleviate genitourinary symptoms in postmenopausal women, showing significant reductions in vaginal pain and dryness without serious side effects [7]. However, some research highlights the complexities surrounding zinc levels, revealing that excess zinc may exacerbate obesity-related issues and suggesting a balanced approach to zinc intake [1]. Overall, while zinc supplementation appears to provide notable benefits for some menopausal symptoms, further research is deemed necessary for optimal dosage and to explore the broader implications of zinc on menopausal health.
Users have reported noticeable improvements in various symptoms attributed to zinc supplementation, particularly among women experiencing menopause. Many have highlighted enhancements in skin health and a reduction in hair loss. For instance, one reviewer noted a decrease in hair fall and enhanced skin condition after starting zinc Read Review. Others echoed these sentiments, emphasizing zinc's effectiveness in easing menopause-related issues like hair loss and skin problems, which reinforces its value for overall well-being Read ReviewRead Review.
In addition to dermatological and hair-related benefits, users have also observed positive effects on reproductive health and immune support, particularly during illness Read Review. Reviewers noted that regular consumption of zinc supplements helped with hormonal balance and overall health maintenance, making it a desirable option for those facing both menopausal symptoms and general wellness concerns Read Review. While individual results can vary, the collective feedback suggests a strong alignment on zinc's beneficial effects across multiple health facets.
Users report that combining zinc with other supplements can enhance its effectiveness in managing menopause symptoms. Many reviewers emphasize that zinc not only helps with hair loss and skin issues but also supports overall reproductive health Read Review. When used alongside other supplements aimed at hormonal balance or overall well-being, zinc appears to offer compounded benefits. For instance, one user mentioned that regular intake of zinc has positively affected their menopause symptoms and improved their health across multiple areas Read Review.
Additionally, there’s a consensus among users that zinc's role in immune support further complements its menopausal benefits. Reviewers indicated that while zinc effectively addresses hair loss and skin health, its combination with other elements may boost overall vitality during this transition period Read Review. Overall, the feedback suggests that users experience a synergistic effect when using zinc in conjunction with other supplements tailored to menopause management.
Based on current research, the optimal dose of zinc for treating menopausal symptoms appears to be around 50 mg per day. In a study that included 51 postmenopausal women, participants received 50 mg of zinc daily for eight weeks, which led to significant improvements in folate levels and reductions in homocysteine levels, markers that are important for menopausal health [3]. Another study confirmed that a similar dosage not only enhanced vitamin D status but also improved leptin levels among the same demographic [4].
It is important to note that while zinc supplementation shows promise in improving certain health markers during menopause, excessive zinc intake may lead to adverse effects, such as obesity risks in some cases [1]. Therefore, it's essential for individuals to consult with a healthcare provider before starting any supplementation to tailor the dosage to their specific health needs.
7.5
Menopause support
263 people found this helpful
Zinc positively affects women's reproductive health and can also help with menopause symptoms like hair loss and skin issues. This supplement is well-absorbed and free from artificial additives. I've noticed less hair fall and improved skin, and it helps strengthen immunity during illness.
9
Family wellness
During the pandemic, doctors recommended zinc for its benefits, including supporting skin health and aiding in menopause. It's effective for acne and hair loss, and essential for overall family well-being.
7.5
Menopause relief
Zinc is essential for both men's and women's health and significantly eases menopause symptoms. It’s beneficial for skin and overall well-being.
7.5
Essential nutrient
I take zinc regularly to combat deficiency signs, including menopausal symptoms. It's essential for hormonal balance and supports health in so many areas.
7.5
Hormonal stability
Zinc is gaining attention due to its role in combating viral infections and maintaining overall health. It's particularly important for women experiencing menopause, alleviating various symptoms and supporting well-being.
8
Zinc enhances antioxidant protection
Erythrocyte Zn concentration and antioxidant response after supplementation with Zn in a postmenopausal population. A double-blind randomized trial.
We assessed how zinc (Zn) supplementation can impact the health of postmenopausal women, particularly regarding their antioxidant status. In this study, fifty-one women participating were split into two groups: one receiving a placebo treatment and the other receiving zinc supplements. This double-blind randomized trial lasted for eight weeks and focused on measuring changes in mineral status along with different antioxidant markers in the blood.
Before the intervention, we noticed that many participants had low zinc levels, which can lead to weakened antioxidant defenses—especially critical for postmenopausal women due to hormonal changes. After eight weeks of zinc supplementation, we saw a marked improvement in zinc levels among the women receiving the supplements. There were also significant positive correlations between zinc levels and overall antioxidant capacity, as well as specific antioxidant enzymes like glutathione peroxidase.
From our findings, it seems clear that zinc supplementation is a promising way to address deficiencies and bolster antioxidant defenses in postmenopausal women. This could not only support their nutritional health but might also contribute positively to their overall well-being during this transitional life stage.
9
Zinc enhances vitamin D in menopause
Effectiveness of eight-week zinc supplementation on vitamin D status and leptin levels in a population of postmenopausal women: a double-blind randomized trial.
We set out to understand how zinc supplementation could affect vitamin D status and leptin levels in postmenopausal women. The study involved 51 healthy postmenopausal women aged between 44 and 76 from Granada, Spain. They were divided into two groups: one receiving a zinc supplement of 50 mg daily for eight weeks and the other receiving a placebo.
Our findings revealed that zinc supplementation significantly improved vitamin D status in these women. Particularly, those who had reached menopause at a younger age saw a notable increase in their vitamin D levels after taking zinc.
Additionally, we discovered a connection between zinc and leptin levels, a hormone that regulates energy balance. Both dietary zinc intake and its plasma levels were found to be inversely related to serum leptin levels—meaning as zinc levels increased, leptin levels tended to decrease.
Overall, these results suggest that zinc supplementation may play a beneficial role during menopause by enhancing vitamin D levels and influencing leptin balance among postmenopausal women.
9
Zinc gel improves menopausal symptoms
Zinc-containing Vaginal Moisturizer Gel Improves Postmenopausal Vulvovaginal Symptoms: A Pilot Study.
We evaluated the impact of a zinc-containing vaginal moisturizer gel on postmenopausal women experiencing genitourinary symptoms of menopause (GSM). Some women hesitate to use hormonal treatments like vaginal estrogen, which can be highly effective. To explore an alternative, we asked 37 participants to apply the gel daily for two weeks while tracking their symptoms.
Throughout the study, we used various methods to assess improvement. The Vaginal Health Index, which measures vaginal health, showed significant improvement after treatment. We also noted that participants reported reduced levels of vaginal pain and dryness on a visual analog scale, with the most notable benefit occurring for vaginal dryness. Additionally, the vulvovaginal symptom questionnaire indicated a substantial decrease in overall symptoms. Notably, side effects were minor and infrequent, which is encouraging for those considering this option.
In summary, our findings suggest that a novel zinc-containing vaginal moisturizer gel can effectively alleviate postmenopausal vulvovaginal symptoms without serious side effects, providing a viable solution for women who prefer non-hormonal treatments.
7
Zinc impacts postmenopausal obesity
Excess dietary zinc drives a Cushing's-like syndrome in ovariectomized mice - Implications for postmenopausal obesity.
We investigated the effects of dietary zinc on obesity related to menopause, particularly in female mice that underwent ovariectomy (Ovx). Our findings revealed that excess zinc led to significant weight gain and symptoms resembling Cushing's syndrome, even though these mice did not consume more food.
The accumulation of zinc in the adrenal glands played a crucial role by interfering with steroid production. This is particularly important since, in Ovx mice, adrenal steroids are the only source of estrogen. The lack of estrogen triggered adrenal hyperplasia and an increase in glucocorticoids, which contributed to the development of Cushing's-like symptoms.
Interestingly, our results showed that supplementing with adrenal steroids could counteract the negative impacts of excess zinc. We also found a positive correlation between plasma zinc levels and cortisol while noting a negative correlation with adrenal steroids and estrogen levels in overweight postmenopausal women.
These insights suggest that it may be beneficial for postmenopausal women to avoid high dietary zinc and consider adrenal steroid supplementation to help manage obesity effectively.
8
Zinc improves nutritional markers post-menopause
Effect of zinc supplementation on circulating concentrations of homocysteine, vitamin B, and folate in a postmenopausal population.
In our study, we examined how zinc supplementation could affect menopausal women, particularly focusing on markers like homocysteine, vitamin B, and folate levels. We worked with 51 postmenopausal women aged between 44 and 76 years, dividing them into two groups: one received a placebo, while the other was given 50 mg of zinc daily for eight weeks.
After analyzing the results, we found that those who took zinc showed significantly higher folate levels compared to their baseline measurements. Additionally, we observed a noteworthy decrease in homocysteine levels when comparing the two groups after the intervention. Interestingly, we also noted a strong correlation between higher folate and vitamin B levels with lower homocysteine levels in the zinc group.
These findings suggest that zinc supplementation can have positive effects on certain nutritional markers in menopausal women. However, we emphasize the need for further research with larger sample sizes and refined dosing to validate and expand upon our results.
References
Zhao Y, Wang Y, Hu L, Chen H, Xiao X, et al. Excess dietary zinc drives a Cushing's-like syndrome in ovariectomized mice - Implications for postmenopausal obesity. Biochem Biophys Res Commun. 2022;630:101. doi:10.1016/j.bbrc.2022.09.042
Vázquez-Lorente H, Molina-López J, Herrera-Quintana L, Gamarra-Morales Y, Quintero-Osso B, et al. Erythrocyte Zn concentration and antioxidant response after supplementation with Zn in a postmenopausal population. A double-blind randomized trial. Exp Gerontol. 2022;162:111766. doi:10.1016/j.exger.2022.111766
Vázquez-Lorente H, Herrera-Quintana L, Molina-López J, Gamarra Y, Planells E. Effect of zinc supplementation on circulating concentrations of homocysteine, vitamin B, and folate in a postmenopausal population. J Trace Elem Med Biol. 2022;71:126942. doi:10.1016/j.jtemb.2022.126942
Vázquez-Lorente H, Molina-López J, Herrera-Quintana L, Gamarra-Morales Y, López-González B, et al. Effectiveness of eight-week zinc supplementation on vitamin D status and leptin levels in a population of postmenopausal women: a double-blind randomized trial. J Trace Elem Med Biol. 2021;65:126730. doi:10.1016/j.jtemb.2021.126730
Csikós A, Kozma B, Pór Á, Kovács I, Lampé R, et al. Zinc Transporter 9 (SLC30A9) Expression Is Decreased in the Vaginal Tissues of Menopausal Women. Biol Trace Elem Res. 2021;199:4011. doi:10.1007/s12011-020-02525-w
Damjanovich P, Sipos AG, Larson K, Cunningham TD, Takacs P, et al. Cervicovaginal lavage fluid zinc level as a marker of vaginal atrophy. Menopause. 2020;27:776. doi:10.1097/GME.0000000000001536
Takacs P, Kozma B, Erdodi B, Jakab A, Larson K, et al. Zinc-containing Vaginal Moisturizer Gel Improves Postmenopausal Vulvovaginal Symptoms: A Pilot Study. J Menopausal Med. 2019;25:63. doi:10.6118/jmm.2019.25.1.63