Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.5
USERS' SCORE
Good
Based on 3 Reviews
8.3
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Zinc (as Zinc bisglycinate)
30 mg
273%
Top Medical Research Studies
9
This study was designed as a randomized double-blind, placebo-controlled trial to examine how zinc gluconate supplementation might alleviate migraine symptoms in adult women. We followed 60 women, averaging about 35 years old, who either received 15 mg of zinc per day or a placebo for a duration of 12 weeks.
Over the trial, we observed significant improvements in those taking zinc. The frequency of migraine attacks, as well as the duration and severity of the headaches, drastically decreased for participants receiving zinc. We used various assessments, such as a numerical rating scale and the Migraine Disability Assessment test, to evaluate these changes.
Additionally, zinc supplementation showed a notable reduction in levels of low-density lipoprotein (LDL) cholesterol and high-sensitivity C-reactive protein (hs-CRP), both of which are associated with inflammation. However, no significant changes in triglycerides or high-density lipoprotein (HDL) levels were seen. After taking initial values into account, the changes in lipid levels and hs-CRP weren’t significant.
Overall, we found that zinc supplementation can beneficially impact migraine symptoms, reducing their severity and frequency among women. This offers a promising direction for migraine management without the side effects often associated with traditional medications.
Over the trial, we observed significant improvements in those taking zinc. The frequency of migraine attacks, as well as the duration and severity of the headaches, drastically decreased for participants receiving zinc. We used various assessments, such as a numerical rating scale and the Migraine Disability Assessment test, to evaluate these changes.
Additionally, zinc supplementation showed a notable reduction in levels of low-density lipoprotein (LDL) cholesterol and high-sensitivity C-reactive protein (hs-CRP), both of which are associated with inflammation. However, no significant changes in triglycerides or high-density lipoprotein (HDL) levels were seen. After taking initial values into account, the changes in lipid levels and hs-CRP weren’t significant.
Overall, we found that zinc supplementation can beneficially impact migraine symptoms, reducing their severity and frequency among women. This offers a promising direction for migraine management without the side effects often associated with traditional medications.
Read More
7
We aimed to understand how zinc supplementation influences the frequency of migraine attacks. In this structured clinical trial, 80 patients suffering from migraines participated, receiving either zinc sulfate or a placebo over eight weeks.
Our results revealed that those who took zinc experienced a notable decrease in the frequency of their migraine attacks and, to some extent, in headache severity. Specifically, participants on zinc reported 2.55 fewer migraine attacks on average compared to only 0.42 fewer for those on the placebo. However, when we adjusted for certain factors, the reduction in headache severity lost its statistical significance.
It's essential to note that while zinc supplementation appeared to help with attack frequency, other aspects of migraines, such as their duration and daily headache impact, remained unchanged. This suggests that zinc might specifically influence how often migraines occur rather than their intensity or lasting effects. Further research is encouraged to explore varying dosages and longer intervention periods for a more profound understanding of zinc's potential benefits.
Our results revealed that those who took zinc experienced a notable decrease in the frequency of their migraine attacks and, to some extent, in headache severity. Specifically, participants on zinc reported 2.55 fewer migraine attacks on average compared to only 0.42 fewer for those on the placebo. However, when we adjusted for certain factors, the reduction in headache severity lost its statistical significance.
It's essential to note that while zinc supplementation appeared to help with attack frequency, other aspects of migraines, such as their duration and daily headache impact, remained unchanged. This suggests that zinc might specifically influence how often migraines occur rather than their intensity or lasting effects. Further research is encouraged to explore varying dosages and longer intervention periods for a more profound understanding of zinc's potential benefits.
Read More
8
We investigated the connection between dietary zinc intake and the occurrence of migraines among adults, utilizing data from the National Health and Nutrition Examination Survey (NHANES) collected between 1999 and 2004.
Our findings indicated that higher zinc intake was linked to a lower prevalence of migraines. Participants who consumed more zinc, particularly those in the middle to higher intake groups, experienced fewer migraine episodes compared to those who consumed the least zinc.
Interestingly, we found that age plays a role in this relationship. Specifically, adults aged between 20 and 50 displayed a non-linear association between zinc intake and migraine occurrence, suggesting that age modifies the impact of zinc on migraines. Overall, these results point to the potential benefits of including sufficient zinc in our diets as a preventative measure against migraines.
Our findings indicated that higher zinc intake was linked to a lower prevalence of migraines. Participants who consumed more zinc, particularly those in the middle to higher intake groups, experienced fewer migraine episodes compared to those who consumed the least zinc.
Interestingly, we found that age plays a role in this relationship. Specifically, adults aged between 20 and 50 displayed a non-linear association between zinc intake and migraine occurrence, suggesting that age modifies the impact of zinc on migraines. Overall, these results point to the potential benefits of including sufficient zinc in our diets as a preventative measure against migraines.
Read More
Most Useful Reviews
10
Migraine-free product
No more migraines—this product is wonderful!
Read More
7.5
Improved migraine control
The delivery was prompt, and the packaging remained intact. Taking a 30 mg capsule daily significantly reduces my migraine and boosts my immunity. I hope to continue this and that my migraine will not return.
Read More
6
Mild relief experienced
Although my original migraine persists, it has become a bit milder since I started using this product. I now take zinc in the morning and magnesium in the evening for self-care.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.5
- All Researches
9.5
We embarked on an investigation into the potential of zinc as a treatment for migraines. The study involved 30 migraine sufferers who were given 75 mg of zinc sulfate daily for six weeks, along with vitamin B-complex and vitamin A or E during the first ten days.
Remarkably, this combination led to a significant improvement in most participants, suggesting that zinc could play a vital role in alleviating migraine symptoms. Zinc's effectiveness may stem from its essential functions in various biological processes, such as supporting the nervous system and regulating mineral balance in the body.
However, it’s important to note that the research combined zinc with other supplements, which makes it challenging to ascertain zinc's isolated effect on migraines. Future studies may benefit from a more controlled approach—perhaps comparing zinc against a placebo or examining its impact in larger groups.
Overall, this exploration opens new avenues for understanding how zinc and other nutrients can contribute to migraine relief, but further research is needed to fully validate these findings.
Remarkably, this combination led to a significant improvement in most participants, suggesting that zinc could play a vital role in alleviating migraine symptoms. Zinc's effectiveness may stem from its essential functions in various biological processes, such as supporting the nervous system and regulating mineral balance in the body.
However, it’s important to note that the research combined zinc with other supplements, which makes it challenging to ascertain zinc's isolated effect on migraines. Future studies may benefit from a more controlled approach—perhaps comparing zinc against a placebo or examining its impact in larger groups.
Overall, this exploration opens new avenues for understanding how zinc and other nutrients can contribute to migraine relief, but further research is needed to fully validate these findings.
Read More
9
This study was designed as a randomized double-blind, placebo-controlled trial to examine how zinc gluconate supplementation might alleviate migraine symptoms in adult women. We followed 60 women, averaging about 35 years old, who either received 15 mg of zinc per day or a placebo for a duration of 12 weeks.
Over the trial, we observed significant improvements in those taking zinc. The frequency of migraine attacks, as well as the duration and severity of the headaches, drastically decreased for participants receiving zinc. We used various assessments, such as a numerical rating scale and the Migraine Disability Assessment test, to evaluate these changes.
Additionally, zinc supplementation showed a notable reduction in levels of low-density lipoprotein (LDL) cholesterol and high-sensitivity C-reactive protein (hs-CRP), both of which are associated with inflammation. However, no significant changes in triglycerides or high-density lipoprotein (HDL) levels were seen. After taking initial values into account, the changes in lipid levels and hs-CRP weren’t significant.
Overall, we found that zinc supplementation can beneficially impact migraine symptoms, reducing their severity and frequency among women. This offers a promising direction for migraine management without the side effects often associated with traditional medications.
Over the trial, we observed significant improvements in those taking zinc. The frequency of migraine attacks, as well as the duration and severity of the headaches, drastically decreased for participants receiving zinc. We used various assessments, such as a numerical rating scale and the Migraine Disability Assessment test, to evaluate these changes.
Additionally, zinc supplementation showed a notable reduction in levels of low-density lipoprotein (LDL) cholesterol and high-sensitivity C-reactive protein (hs-CRP), both of which are associated with inflammation. However, no significant changes in triglycerides or high-density lipoprotein (HDL) levels were seen. After taking initial values into account, the changes in lipid levels and hs-CRP weren’t significant.
Overall, we found that zinc supplementation can beneficially impact migraine symptoms, reducing their severity and frequency among women. This offers a promising direction for migraine management without the side effects often associated with traditional medications.
Read More
8
We investigated the connection between dietary zinc intake and the occurrence of migraines among adults, utilizing data from the National Health and Nutrition Examination Survey (NHANES) collected between 1999 and 2004.
Our findings indicated that higher zinc intake was linked to a lower prevalence of migraines. Participants who consumed more zinc, particularly those in the middle to higher intake groups, experienced fewer migraine episodes compared to those who consumed the least zinc.
Interestingly, we found that age plays a role in this relationship. Specifically, adults aged between 20 and 50 displayed a non-linear association between zinc intake and migraine occurrence, suggesting that age modifies the impact of zinc on migraines. Overall, these results point to the potential benefits of including sufficient zinc in our diets as a preventative measure against migraines.
Our findings indicated that higher zinc intake was linked to a lower prevalence of migraines. Participants who consumed more zinc, particularly those in the middle to higher intake groups, experienced fewer migraine episodes compared to those who consumed the least zinc.
Interestingly, we found that age plays a role in this relationship. Specifically, adults aged between 20 and 50 displayed a non-linear association between zinc intake and migraine occurrence, suggesting that age modifies the impact of zinc on migraines. Overall, these results point to the potential benefits of including sufficient zinc in our diets as a preventative measure against migraines.
Read More
8
We explored the relationship between dietary zinc intake and migraine by analyzing data from the National Health and Nutrition Examination Survey conducted between 1999 and 2004. This cross-sectional study involved over 11,000 participants, with 20.2% reporting migraine attacks.
Our findings revealed an interesting trend: individuals who consumed higher amounts of zinc appeared to have a lower likelihood of experiencing migraines. Specifically, people in the highest zinc intake category were significantly less likely to report migraines compared to those with the lowest intake. These results suggest that increasing zinc consumption might be beneficial for migraine prevention.
However, it's important to note that while the study indicates an association between zinc intake and reduced migraine incidence, it doesn't definitively establish that zinc directly affects migraine pathophysiology. Thus, further research would be necessary to clarify the role of zinc in migraine management.
Overall, we've shed some light on how dietary zinc might play a role in migraines, suggesting that paying attention to zinc intake could be worthwhile for those affected by this condition.
Our findings revealed an interesting trend: individuals who consumed higher amounts of zinc appeared to have a lower likelihood of experiencing migraines. Specifically, people in the highest zinc intake category were significantly less likely to report migraines compared to those with the lowest intake. These results suggest that increasing zinc consumption might be beneficial for migraine prevention.
However, it's important to note that while the study indicates an association between zinc intake and reduced migraine incidence, it doesn't definitively establish that zinc directly affects migraine pathophysiology. Thus, further research would be necessary to clarify the role of zinc in migraine management.
Overall, we've shed some light on how dietary zinc might play a role in migraines, suggesting that paying attention to zinc intake could be worthwhile for those affected by this condition.
Read More
7
We explored the potential of zinc supplementation in individuals who experience migraines that don’t respond to traditional prophylactic therapies. Our focus was on four patients whose migraine symptoms had proven stubbornly resistant to standard treatments.
After adding zinc to their regimen, these patients reported a notable reduction in both the frequency and the severity of their headache episodes. These findings suggest that zinc may offer a new hope for those struggling with chronic migraines, particularly when existing medications fail to provide relief.
Although this small case series is encouraging, we recognize that further research is necessary to fully understand zinc's efficacy in treating migraines. Larger studies will help us determine how zinc can be integrated into migraine management strategies more broadly.
After adding zinc to their regimen, these patients reported a notable reduction in both the frequency and the severity of their headache episodes. These findings suggest that zinc may offer a new hope for those struggling with chronic migraines, particularly when existing medications fail to provide relief.
Although this small case series is encouraging, we recognize that further research is necessary to fully understand zinc's efficacy in treating migraines. Larger studies will help us determine how zinc can be integrated into migraine management strategies more broadly.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
10
Migraine-free product
No more migraines—this product is wonderful!
Read More
7.5
Improved migraine control
The delivery was prompt, and the packaging remained intact. Taking a 30 mg capsule daily significantly reduces my migraine and boosts my immunity. I hope to continue this and that my migraine will not return.
Read More
6
Mild relief experienced
Although my original migraine persists, it has become a bit milder since I started using this product. I now take zinc in the morning and magnesium in the evening for self-care.
Read More
Frequently Asked Questions
10
Migraine-free product
No more migraines—this product is wonderful!
7.5
Improved migraine control
The delivery was prompt, and the packaging remained intact. Taking a 30 mg capsule daily significantly reduces my migraine and boosts my immunity. I hope to continue this and that my migraine will not return.
6
Mild relief experienced
Although my original migraine persists, it has become a bit milder since I started using this product. I now take zinc in the morning and magnesium in the evening for self-care.
4
We explored the potential role of zinc in migraine management through a systematic review of existing studies. Our aim was to gather evidence from scientific databases to see if zinc could be an effective treatment choice, especially considering its known anti-inflammatory and antioxidant properties. We reviewed information from three major databases and identified 35 studies, eventually narrowing our focus to five studies that met our criteria—two clinical trials and three observational studies.
The results of our review suggest that zinc may have a positive impact on managing migraines, though the available evidence is still somewhat limited. The clinical trials we examined showed a low risk of bias, indicating that their results are reliable. However, we also acknowledge that more robust and larger clinical trials are needed to strengthen the evidence around zinc’s effectiveness in treating migraines.
Overall, while the findings are promising, we should approach them with caution until further studies can confirm the benefits of zinc in this context. As of now, the use of zinc for migraine treatment is an area that warrants further exploration.
The results of our review suggest that zinc may have a positive impact on managing migraines, though the available evidence is still somewhat limited. The clinical trials we examined showed a low risk of bias, indicating that their results are reliable. However, we also acknowledge that more robust and larger clinical trials are needed to strengthen the evidence around zinc’s effectiveness in treating migraines.
Overall, while the findings are promising, we should approach them with caution until further studies can confirm the benefits of zinc in this context. As of now, the use of zinc for migraine treatment is an area that warrants further exploration.
7
We explored the potential of zinc supplementation in individuals who experience migraines that don’t respond to traditional prophylactic therapies. Our focus was on four patients whose migraine symptoms had proven stubbornly resistant to standard treatments.
After adding zinc to their regimen, these patients reported a notable reduction in both the frequency and the severity of their headache episodes. These findings suggest that zinc may offer a new hope for those struggling with chronic migraines, particularly when existing medications fail to provide relief.
Although this small case series is encouraging, we recognize that further research is necessary to fully understand zinc's efficacy in treating migraines. Larger studies will help us determine how zinc can be integrated into migraine management strategies more broadly.
After adding zinc to their regimen, these patients reported a notable reduction in both the frequency and the severity of their headache episodes. These findings suggest that zinc may offer a new hope for those struggling with chronic migraines, particularly when existing medications fail to provide relief.
Although this small case series is encouraging, we recognize that further research is necessary to fully understand zinc's efficacy in treating migraines. Larger studies will help us determine how zinc can be integrated into migraine management strategies more broadly.
8
We investigated the connection between dietary zinc intake and the occurrence of migraines among adults, utilizing data from the National Health and Nutrition Examination Survey (NHANES) collected between 1999 and 2004.
Our findings indicated that higher zinc intake was linked to a lower prevalence of migraines. Participants who consumed more zinc, particularly those in the middle to higher intake groups, experienced fewer migraine episodes compared to those who consumed the least zinc.
Interestingly, we found that age plays a role in this relationship. Specifically, adults aged between 20 and 50 displayed a non-linear association between zinc intake and migraine occurrence, suggesting that age modifies the impact of zinc on migraines. Overall, these results point to the potential benefits of including sufficient zinc in our diets as a preventative measure against migraines.
Our findings indicated that higher zinc intake was linked to a lower prevalence of migraines. Participants who consumed more zinc, particularly those in the middle to higher intake groups, experienced fewer migraine episodes compared to those who consumed the least zinc.
Interestingly, we found that age plays a role in this relationship. Specifically, adults aged between 20 and 50 displayed a non-linear association between zinc intake and migraine occurrence, suggesting that age modifies the impact of zinc on migraines. Overall, these results point to the potential benefits of including sufficient zinc in our diets as a preventative measure against migraines.
9
This study was designed as a randomized double-blind, placebo-controlled trial to examine how zinc gluconate supplementation might alleviate migraine symptoms in adult women. We followed 60 women, averaging about 35 years old, who either received 15 mg of zinc per day or a placebo for a duration of 12 weeks.
Over the trial, we observed significant improvements in those taking zinc. The frequency of migraine attacks, as well as the duration and severity of the headaches, drastically decreased for participants receiving zinc. We used various assessments, such as a numerical rating scale and the Migraine Disability Assessment test, to evaluate these changes.
Additionally, zinc supplementation showed a notable reduction in levels of low-density lipoprotein (LDL) cholesterol and high-sensitivity C-reactive protein (hs-CRP), both of which are associated with inflammation. However, no significant changes in triglycerides or high-density lipoprotein (HDL) levels were seen. After taking initial values into account, the changes in lipid levels and hs-CRP weren’t significant.
Overall, we found that zinc supplementation can beneficially impact migraine symptoms, reducing their severity and frequency among women. This offers a promising direction for migraine management without the side effects often associated with traditional medications.
Over the trial, we observed significant improvements in those taking zinc. The frequency of migraine attacks, as well as the duration and severity of the headaches, drastically decreased for participants receiving zinc. We used various assessments, such as a numerical rating scale and the Migraine Disability Assessment test, to evaluate these changes.
Additionally, zinc supplementation showed a notable reduction in levels of low-density lipoprotein (LDL) cholesterol and high-sensitivity C-reactive protein (hs-CRP), both of which are associated with inflammation. However, no significant changes in triglycerides or high-density lipoprotein (HDL) levels were seen. After taking initial values into account, the changes in lipid levels and hs-CRP weren’t significant.
Overall, we found that zinc supplementation can beneficially impact migraine symptoms, reducing their severity and frequency among women. This offers a promising direction for migraine management without the side effects often associated with traditional medications.
9.5
We embarked on an investigation into the potential of zinc as a treatment for migraines. The study involved 30 migraine sufferers who were given 75 mg of zinc sulfate daily for six weeks, along with vitamin B-complex and vitamin A or E during the first ten days.
Remarkably, this combination led to a significant improvement in most participants, suggesting that zinc could play a vital role in alleviating migraine symptoms. Zinc's effectiveness may stem from its essential functions in various biological processes, such as supporting the nervous system and regulating mineral balance in the body.
However, it’s important to note that the research combined zinc with other supplements, which makes it challenging to ascertain zinc's isolated effect on migraines. Future studies may benefit from a more controlled approach—perhaps comparing zinc against a placebo or examining its impact in larger groups.
Overall, this exploration opens new avenues for understanding how zinc and other nutrients can contribute to migraine relief, but further research is needed to fully validate these findings.
Remarkably, this combination led to a significant improvement in most participants, suggesting that zinc could play a vital role in alleviating migraine symptoms. Zinc's effectiveness may stem from its essential functions in various biological processes, such as supporting the nervous system and regulating mineral balance in the body.
However, it’s important to note that the research combined zinc with other supplements, which makes it challenging to ascertain zinc's isolated effect on migraines. Future studies may benefit from a more controlled approach—perhaps comparing zinc against a placebo or examining its impact in larger groups.
Overall, this exploration opens new avenues for understanding how zinc and other nutrients can contribute to migraine relief, but further research is needed to fully validate these findings.
References
- Singhal S, Dutta SB, Bansal S, Dutta S, Shah RB. Zinc as An Emerging Therapy in the Management of Migraine: A Systematic Review. Neurol India. 2024;72:934. doi:10.4103/neurol-india.Neurol-India-D-23-00337
- Fukazawa R, Ishii R, Higashimoto Y, Hanya M, Shimizu Y, et al. Zinc Administration Favorably Affects Prophylactic Therapy-refractory Migraine Attacks: A Case Series. Intern Med. 2024;63:1631. doi:10.2169/internalmedicine.2111-23
- Zheng H, Tian S, Wu L, Zhong X, Liu M, et al. Dietary zinc intake in relation to migraine among adults: a cross sectional study of NHANES 1999-2004. Nutr Neurosci. 2024;27:667. doi:10.1080/1028415X.2023.2243678
- Liu H, Wang Q, Dong Z, Yu S. Dietary zinc intake and migraine in adults: a cross-sectional analysis of the National Health and Nutrition Examination Survey 1999-2004. Headache. 2023;63:127. doi:10.1111/head.14431
- Mazaheri M, Aghdam AM, Heidari M, Zarrin R. Assessing the Effect of Zinc Supplementation on the Frequency of Migraine Attack, Duration, Severity, Lipid Profile and hs-CRP in Adult Women. Clin Nutr Res. 2021;10:127. doi:10.7762/cnr.2021.10.2.127
- Ahmadi H, Mazloumi-Kiapey SS, Sadeghi O, Nasiri M, Khorvash F, et al. Zinc supplementation affects favorably the frequency of migraine attacks: a double-blind randomized placebo-controlled clinical trial. Nutr J. 2020;19:101. doi:10.1186/s12937-020-00618-9
- Dhillon KS, Singh J, Lyall JS. A new horizon into the pathobiology, etiology and treatment of migraine. Med Hypotheses. 2011;77:147. doi:10.1016/j.mehy.2011.03.050
