The supplement Silybum marianum, commonly known as milk thistle, shows promise in supporting acne treatment based on several scientific studies. For instance, a large-scale international study involving over 4,200 young participants indicated that a dermocosmetic product containing Silybum marianum helped reduce reliance on traditional anti-acne medications while managing acne effectively when applied for 8 to 12 weeks [1].
Furthermore, another long-term study over the course of a year reported significant improvements in skin health, with participants experiencing a 45.6% reduction in acne lesions after six months, and 59.6% after twelve months, showcasing the extract's potential as a supplementary treatment [2]. Moreover, Silybum marianum has been highlighted for its preventive effects against future breakouts, with research showing a significant decrease in microcomedones, the precursors to acne lesions, when using a topical formulation containing the extract [3]. Overall, while further research is needed to solidify these findings, Silybum marianum appears to have a supportive role in managing and preventing acne.