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SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.3
USERS' SCORE
Good
Based on 5 Reviews
8.6
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl and pyridoxal-5-phosphate)
50 mg
2,941%
Top Medical Research Studies
9
Vitamin B6 shows promise for migraines
Pyridoxine, folate and cobalamin for migraine: A systematic review.
Focus on vitamin B6 effects
We delved into the potential benefits of vitamin B6 (pyridoxine) in treating migraines, particularly in how it relates to other B vitamins like folate and B12. By examining various studies, we focused on the efficacy of B6 alone and in combination with these other vitamins.
The findings were intriguing! While the management of acute migraine attacks using these vitamins didn’t show promising results in one controlled trial, we noted significant benefits when B6 was used as a preventative measure. In several trials, B6 alone or combined with folate, or with both folate and B12, proved to be effective for adults suffering from migraine with aura—outperforming placebo treatments in most cases.
Interestingly, we also found that while folate as a standalone treatment didn’t yield better outcomes than placebo, the overall safety profile of these vitamins was quite good. Most participants reported only mild gastrointestinal side effects. However, we came across limited data regarding the effects of these vitamins on migraine without aura in both children and adults, making it difficult to draw broader conclusions.
In summary, our exploration of the role of vitamin B6 in migraine protection reveals its potential to aid adults with migraine with aura, though more thorough research is needed for other types, especially in younger populations.
The findings were intriguing! While the management of acute migraine attacks using these vitamins didn’t show promising results in one controlled trial, we noted significant benefits when B6 was used as a preventative measure. In several trials, B6 alone or combined with folate, or with both folate and B12, proved to be effective for adults suffering from migraine with aura—outperforming placebo treatments in most cases.
Interestingly, we also found that while folate as a standalone treatment didn’t yield better outcomes than placebo, the overall safety profile of these vitamins was quite good. Most participants reported only mild gastrointestinal side effects. However, we came across limited data regarding the effects of these vitamins on migraine without aura in both children and adults, making it difficult to draw broader conclusions.
In summary, our exploration of the role of vitamin B6 in migraine protection reveals its potential to aid adults with migraine with aura, though more thorough research is needed for other types, especially in younger populations.
Read More
9
Vitamin B6 reduces migraine severity
Genotypes of the MTHFR C677T and MTRR A66G genes act independently to reduce migraine disability in response to vitamin supplementation.
Relevant study on vitamin effects
We conducted a thorough investigation into how vitamin B6, along with other B vitamins, influences the occurrence and severity of migraines in women. The study was carefully designed as a six-month, randomized, double-blind, placebo-controlled trial involving 206 female patients diagnosed with migraine with aura.
By analyzing the effects of daily vitamin B supplementation—specifically vitamins B6, B9, and B12—we observed a significant reduction in homocysteine levels, a factor linked to migraine intensity. Moreover, the participants who received vitamin supplementation experienced decreased headache severity and lower migraine disability compared to those who received a placebo.
Furthermore, we found that the genetic makeup of the participants played a role in their response to the treatment. Carriers of certain gene variants showed an even greater improvement in their migraine symptoms, indicating that both MTHFR and MTRR gene variants independently contributed to the effectiveness of vitamin B6 supplementation.
Overall, we were encouraged to find that vitamin B6, combined with other B vitamins, can lead to meaningful relief for women suffering from migraines, depending on their genetic profile. This knowledge could lead to more personalized treatment approaches in managing migraine symptoms.
By analyzing the effects of daily vitamin B supplementation—specifically vitamins B6, B9, and B12—we observed a significant reduction in homocysteine levels, a factor linked to migraine intensity. Moreover, the participants who received vitamin supplementation experienced decreased headache severity and lower migraine disability compared to those who received a placebo.
Furthermore, we found that the genetic makeup of the participants played a role in their response to the treatment. Carriers of certain gene variants showed an even greater improvement in their migraine symptoms, indicating that both MTHFR and MTRR gene variants independently contributed to the effectiveness of vitamin B6 supplementation.
Overall, we were encouraged to find that vitamin B6, combined with other B vitamins, can lead to meaningful relief for women suffering from migraines, depending on their genetic profile. This knowledge could lead to more personalized treatment approaches in managing migraine symptoms.
Read More
8
Effectiveness of B vitamins evaluated
B vitamins and their combination could reduce migraine headaches: A randomized double-blind controlled trial.
Mixed results with Vitamin B6
We conducted a compelling study to find out how vitamin B6, along with other B vitamins, affects those who suffer from migraine headaches. Our research involved a structured, randomized, double-blind, placebo-controlled trial with 120 women experiencing episodic migraines. Participants were divided into groups that received either individual B vitamins like B1, B6, B12, and B9, a vitamin B complex, or a placebo for a duration of 12 weeks.
Throughout the study, we carefully monitored the frequency of headache attacks, the amount of abortive medication used, and the overall impact of migraines on daily life through questionnaires. The findings were quite promising—women taking vitamin B6, along with the other B vitamins, experienced a significant reduction in headache attacks compared to those on the placebo.
Furthermore, those receiving vitamins also reported improvements in migraine-related disability and a decrease in their reliance on abortive drugs. While our results highlight the potential benefit of B vitamins, including B6, in managing migraines, further research is essential to solidify these findings and determine the best treatment strategies.
Throughout the study, we carefully monitored the frequency of headache attacks, the amount of abortive medication used, and the overall impact of migraines on daily life through questionnaires. The findings were quite promising—women taking vitamin B6, along with the other B vitamins, experienced a significant reduction in headache attacks compared to those on the placebo.
Furthermore, those receiving vitamins also reported improvements in migraine-related disability and a decrease in their reliance on abortive drugs. While our results highlight the potential benefit of B vitamins, including B6, in managing migraines, further research is essential to solidify these findings and determine the best treatment strategies.
Read More
Most Useful Reviews
8.8
Helpful vitamins
Great and Important Vitamins! I buy these for my son as he suffers from migraines. They are very helpful and are part of his regimen, as recommended by his neurologist. I highly recommend them!
Read More
9.5
Managing migraine
I’m always pleased with this brand. Vitamin B6 aids me in managing migraine symptoms effectively.
Read More
8.3
Preventing migraine
I take Vitamin B6 to improve my memory and mood. I’ve noticed that with a course of Vitamin B6, my intercostal neuralgia is reduced and I rarely experience migraine attacks. Therefore, I highly recommend it.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.3
9.5
Vitamin B6's uncertain migraine benefit
A new horizon into the pathobiology, etiology and treatment of migraine.
Moderate relevance due to findings
In examining the role of vitamin B6 in migraine treatment, we delved into a unique regimen combining vitamin B complex with zinc sulfate. The study highlighted a group of 30 individuals suffering from migraines who were administered 75 mg of zinc sulfate daily for six weeks, alongside vitamin B-complex and vitamin A or E during the first ten days. This approach led to promising outcomes, with a significant number of participants showing relief from their migraine symptoms.
While vitamin B6 was part of the treatment protocol, it wasn't evaluated independently within the analysis. This lack of isolation makes it challenging to gauge the specific impact of vitamin B6 on migraine effectiveness.
Overall, the study suggests that there is potential for dietary interventions, particularly involving zinc and B vitamins, in alleviating migraine symptoms. However, more structured studies would be needed to determine the precise effectiveness of vitamin B6 on its own. Monitoring mineral levels may also enhance recovery strategies for individuals affected by migraines.
While vitamin B6 was part of the treatment protocol, it wasn't evaluated independently within the analysis. This lack of isolation makes it challenging to gauge the specific impact of vitamin B6 on migraine effectiveness.
Overall, the study suggests that there is potential for dietary interventions, particularly involving zinc and B vitamins, in alleviating migraine symptoms. However, more structured studies would be needed to determine the precise effectiveness of vitamin B6 on its own. Monitoring mineral levels may also enhance recovery strategies for individuals affected by migraines.
Read More
9
Vitamin B6 shows promise for migraines
Pyridoxine, folate and cobalamin for migraine: A systematic review.
Focus on vitamin B6 effects
We delved into the potential benefits of vitamin B6 (pyridoxine) in treating migraines, particularly in how it relates to other B vitamins like folate and B12. By examining various studies, we focused on the efficacy of B6 alone and in combination with these other vitamins.
The findings were intriguing! While the management of acute migraine attacks using these vitamins didn’t show promising results in one controlled trial, we noted significant benefits when B6 was used as a preventative measure. In several trials, B6 alone or combined with folate, or with both folate and B12, proved to be effective for adults suffering from migraine with aura—outperforming placebo treatments in most cases.
Interestingly, we also found that while folate as a standalone treatment didn’t yield better outcomes than placebo, the overall safety profile of these vitamins was quite good. Most participants reported only mild gastrointestinal side effects. However, we came across limited data regarding the effects of these vitamins on migraine without aura in both children and adults, making it difficult to draw broader conclusions.
In summary, our exploration of the role of vitamin B6 in migraine protection reveals its potential to aid adults with migraine with aura, though more thorough research is needed for other types, especially in younger populations.
The findings were intriguing! While the management of acute migraine attacks using these vitamins didn’t show promising results in one controlled trial, we noted significant benefits when B6 was used as a preventative measure. In several trials, B6 alone or combined with folate, or with both folate and B12, proved to be effective for adults suffering from migraine with aura—outperforming placebo treatments in most cases.
Interestingly, we also found that while folate as a standalone treatment didn’t yield better outcomes than placebo, the overall safety profile of these vitamins was quite good. Most participants reported only mild gastrointestinal side effects. However, we came across limited data regarding the effects of these vitamins on migraine without aura in both children and adults, making it difficult to draw broader conclusions.
In summary, our exploration of the role of vitamin B6 in migraine protection reveals its potential to aid adults with migraine with aura, though more thorough research is needed for other types, especially in younger populations.
Read More
9
Vitamin B6 reduces migraine severity
Genotypes of the MTHFR C677T and MTRR A66G genes act independently to reduce migraine disability in response to vitamin supplementation.
Relevant study on vitamin effects
We conducted a thorough investigation into how vitamin B6, along with other B vitamins, influences the occurrence and severity of migraines in women. The study was carefully designed as a six-month, randomized, double-blind, placebo-controlled trial involving 206 female patients diagnosed with migraine with aura.
By analyzing the effects of daily vitamin B supplementation—specifically vitamins B6, B9, and B12—we observed a significant reduction in homocysteine levels, a factor linked to migraine intensity. Moreover, the participants who received vitamin supplementation experienced decreased headache severity and lower migraine disability compared to those who received a placebo.
Furthermore, we found that the genetic makeup of the participants played a role in their response to the treatment. Carriers of certain gene variants showed an even greater improvement in their migraine symptoms, indicating that both MTHFR and MTRR gene variants independently contributed to the effectiveness of vitamin B6 supplementation.
Overall, we were encouraged to find that vitamin B6, combined with other B vitamins, can lead to meaningful relief for women suffering from migraines, depending on their genetic profile. This knowledge could lead to more personalized treatment approaches in managing migraine symptoms.
By analyzing the effects of daily vitamin B supplementation—specifically vitamins B6, B9, and B12—we observed a significant reduction in homocysteine levels, a factor linked to migraine intensity. Moreover, the participants who received vitamin supplementation experienced decreased headache severity and lower migraine disability compared to those who received a placebo.
Furthermore, we found that the genetic makeup of the participants played a role in their response to the treatment. Carriers of certain gene variants showed an even greater improvement in their migraine symptoms, indicating that both MTHFR and MTRR gene variants independently contributed to the effectiveness of vitamin B6 supplementation.
Overall, we were encouraged to find that vitamin B6, combined with other B vitamins, can lead to meaningful relief for women suffering from migraines, depending on their genetic profile. This knowledge could lead to more personalized treatment approaches in managing migraine symptoms.
Read More
8
Effectiveness of B vitamins evaluated
B vitamins and their combination could reduce migraine headaches: A randomized double-blind controlled trial.
Mixed results with Vitamin B6
We conducted a compelling study to find out how vitamin B6, along with other B vitamins, affects those who suffer from migraine headaches. Our research involved a structured, randomized, double-blind, placebo-controlled trial with 120 women experiencing episodic migraines. Participants were divided into groups that received either individual B vitamins like B1, B6, B12, and B9, a vitamin B complex, or a placebo for a duration of 12 weeks.
Throughout the study, we carefully monitored the frequency of headache attacks, the amount of abortive medication used, and the overall impact of migraines on daily life through questionnaires. The findings were quite promising—women taking vitamin B6, along with the other B vitamins, experienced a significant reduction in headache attacks compared to those on the placebo.
Furthermore, those receiving vitamins also reported improvements in migraine-related disability and a decrease in their reliance on abortive drugs. While our results highlight the potential benefit of B vitamins, including B6, in managing migraines, further research is essential to solidify these findings and determine the best treatment strategies.
Throughout the study, we carefully monitored the frequency of headache attacks, the amount of abortive medication used, and the overall impact of migraines on daily life through questionnaires. The findings were quite promising—women taking vitamin B6, along with the other B vitamins, experienced a significant reduction in headache attacks compared to those on the placebo.
Furthermore, those receiving vitamins also reported improvements in migraine-related disability and a decrease in their reliance on abortive drugs. While our results highlight the potential benefit of B vitamins, including B6, in managing migraines, further research is essential to solidify these findings and determine the best treatment strategies.
Read More
8
Vitamin B6 shows promise in migraine
The effects of folic acid and pyridoxine supplementation on characteristics of migraine attacks in migraine patients with aura: A double-blind, randomized placebo-controlled, clinical trial.
Limited isolated effect observed
We conducted a double-blind, randomized placebo-controlled trial to assess how vitamin B6, when combined with folic acid, influences migraine characteristics, specifically in those experiencing migraine with aura. In our study, 95 participants between 18 and 65 years old were evaluated in Isfahan, Iran, to observe the effects of these supplements on headache severity, frequency, and duration over three months.
Our findings showed that combining folic acid with vitamin B6 resulted in notable improvements for participants. There was a significant decrease in headache severity, attack frequency, and the overall impact on their lives as recorded in headache diaries. However, it's worth mentioning that while these enhancements were clear for headache severity and frequency, the effect on attack duration was less pronounced when we controlled for other factors.
Interestingly, when folic acid was taken without vitamin B6, there were no significant benefits observed compared to the placebo group. This suggests that while vitamin B6 plays a beneficial role when combined with folic acid, its isolated effect on migraines remains unclear and requires further exploration.
Our findings showed that combining folic acid with vitamin B6 resulted in notable improvements for participants. There was a significant decrease in headache severity, attack frequency, and the overall impact on their lives as recorded in headache diaries. However, it's worth mentioning that while these enhancements were clear for headache severity and frequency, the effect on attack duration was less pronounced when we controlled for other factors.
Interestingly, when folic acid was taken without vitamin B6, there were no significant benefits observed compared to the placebo group. This suggests that while vitamin B6 plays a beneficial role when combined with folic acid, its isolated effect on migraines remains unclear and requires further exploration.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.6
9.5
Managing migraine
I’m always pleased with this brand. Vitamin B6 aids me in managing migraine symptoms effectively.
8.8
Calm sleep
When I realised I couldn’t find the ideal Magnesium B6 composition, I took it separately and felt truly happy! At last, I can feel the effect. I take it at night for calmer sleep, as I struggle with insomnia. It has helped me recover after Covid, easing my migraines and neuralgia.
8.8
Easing insomnia
When I realised I wouldn’t find the perfect Magnesium B6, I took them separately and I’m just thrilled! It has effectively improved my sleep, helping me with my insomnia and easing my migraines as I recover from Covid.
8.8
Helpful vitamins
Great and Important Vitamins! I buy these for my son as he suffers from migraines. They are very helpful and are part of his regimen, as recommended by his neurologist. I highly recommend them!
8.3
Preventing migraine
I take Vitamin B6 to improve my memory and mood. I’ve noticed that with a course of Vitamin B6, my intercostal neuralgia is reduced and I rarely experience migraine attacks. Therefore, I highly recommend it.
