Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.1
USERS' SCORE
Good
Based on 5 Reviews
8.3
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl and pyridoxal-5-phosphate)
50 mg
2,941%
Top Medical Research Studies
7
We delved into the relationship between migraine and vitamins known to lower homocysteine levels, specifically B6, folate, and B12. Our systematic search revealed twelve articles, indicating that while managing acute migraines didn’t yield strong results, B6 supplementation showed significant benefits in preventing migraine with aura when compared to placebo.
Unfortunately, folate alone didn’t perform better than placebo for migraines, and data on migraines without aura was limited. Overall, these vitamins seem to have a safe profile, especially for migraine with aura in adults, although more high-quality trials are needed for broader conclusions.
Unfortunately, folate alone didn’t perform better than placebo for migraines, and data on migraines without aura was limited. Overall, these vitamins seem to have a safe profile, especially for migraine with aura in adults, although more high-quality trials are needed for broader conclusions.
Read More
9
We conducted a thorough investigation into how vitamin B6, along with other B vitamins, influences the occurrence and severity of migraines in women. The study was carefully designed as a six-month, randomized, double-blind, placebo-controlled trial involving 206 female patients diagnosed with migraine with aura.
By analyzing the effects of daily vitamin B supplementation—specifically vitamins B6, B9, and B12—we observed a significant reduction in homocysteine levels, a factor linked to migraine intensity. Moreover, the participants who received vitamin supplementation experienced decreased headache severity and lower migraine disability compared to those who received a placebo.
Furthermore, we found that the genetic makeup of the participants played a role in their response to the treatment. Carriers of certain gene variants showed an even greater improvement in their migraine symptoms, indicating that both MTHFR and MTRR gene variants independently contributed to the effectiveness of vitamin B6 supplementation.
Overall, we were encouraged to find that vitamin B6, combined with other B vitamins, can lead to meaningful relief for women suffering from migraines, depending on their genetic profile. This knowledge could lead to more personalized treatment approaches in managing migraine symptoms.
By analyzing the effects of daily vitamin B supplementation—specifically vitamins B6, B9, and B12—we observed a significant reduction in homocysteine levels, a factor linked to migraine intensity. Moreover, the participants who received vitamin supplementation experienced decreased headache severity and lower migraine disability compared to those who received a placebo.
Furthermore, we found that the genetic makeup of the participants played a role in their response to the treatment. Carriers of certain gene variants showed an even greater improvement in their migraine symptoms, indicating that both MTHFR and MTRR gene variants independently contributed to the effectiveness of vitamin B6 supplementation.
Overall, we were encouraged to find that vitamin B6, combined with other B vitamins, can lead to meaningful relief for women suffering from migraines, depending on their genetic profile. This knowledge could lead to more personalized treatment approaches in managing migraine symptoms.
Read More
8
We conducted a compelling study to find out how vitamin B6, along with other B vitamins, affects those who suffer from migraine headaches. Our research involved a structured, randomized, double-blind, placebo-controlled trial with 120 women experiencing episodic migraines. Participants were divided into groups that received either individual B vitamins like B1, B6, B12, and B9, a vitamin B complex, or a placebo for a duration of 12 weeks.
Throughout the study, we carefully monitored the frequency of headache attacks, the amount of abortive medication used, and the overall impact of migraines on daily life through questionnaires. The findings were quite promising—women taking vitamin B6, along with the other B vitamins, experienced a significant reduction in headache attacks compared to those on the placebo.
Furthermore, those receiving vitamins also reported improvements in migraine-related disability and a decrease in their reliance on abortive drugs. While our results highlight the potential benefit of B vitamins, including B6, in managing migraines, further research is essential to solidify these findings and determine the best treatment strategies.
Throughout the study, we carefully monitored the frequency of headache attacks, the amount of abortive medication used, and the overall impact of migraines on daily life through questionnaires. The findings were quite promising—women taking vitamin B6, along with the other B vitamins, experienced a significant reduction in headache attacks compared to those on the placebo.
Furthermore, those receiving vitamins also reported improvements in migraine-related disability and a decrease in their reliance on abortive drugs. While our results highlight the potential benefit of B vitamins, including B6, in managing migraines, further research is essential to solidify these findings and determine the best treatment strategies.
Read More
Most Useful Reviews
7.5
Helpful vitamins
3 people found this helpful
Great and Important Vitamins! I buy these for my son as he suffers from migraines. They are very helpful and are part of his regimen, as recommended by his neurologist. I highly recommend them!
Read More
9
Managing migraine
I’m always pleased with this brand. Vitamin B6 aids me in managing migraine symptoms effectively.
Read More
9
Preventing migraine
I take Vitamin B6 to improve my memory and mood. I’ve noticed that with a course of Vitamin B6, my intercostal neuralgia is reduced and I rarely experience migraine attacks. Therefore, I highly recommend it.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.1
- All Researches
9.5
In examining the role of vitamin B6 in migraine treatment, we delved into a unique regimen combining vitamin B complex with zinc sulfate. The study highlighted a group of 30 individuals suffering from migraines who were administered 75 mg of zinc sulfate daily for six weeks, alongside vitamin B-complex and vitamin A or E during the first ten days. This approach led to promising outcomes, with a significant number of participants showing relief from their migraine symptoms.
While vitamin B6 was part of the treatment protocol, it wasn't evaluated independently within the analysis. This lack of isolation makes it challenging to gauge the specific impact of vitamin B6 on migraine effectiveness.
Overall, the study suggests that there is potential for dietary interventions, particularly involving zinc and B vitamins, in alleviating migraine symptoms. However, more structured studies would be needed to determine the precise effectiveness of vitamin B6 on its own. Monitoring mineral levels may also enhance recovery strategies for individuals affected by migraines.
While vitamin B6 was part of the treatment protocol, it wasn't evaluated independently within the analysis. This lack of isolation makes it challenging to gauge the specific impact of vitamin B6 on migraine effectiveness.
Overall, the study suggests that there is potential for dietary interventions, particularly involving zinc and B vitamins, in alleviating migraine symptoms. However, more structured studies would be needed to determine the precise effectiveness of vitamin B6 on its own. Monitoring mineral levels may also enhance recovery strategies for individuals affected by migraines.
Read More
9
We conducted a thorough investigation into how vitamin B6, along with other B vitamins, influences the occurrence and severity of migraines in women. The study was carefully designed as a six-month, randomized, double-blind, placebo-controlled trial involving 206 female patients diagnosed with migraine with aura.
By analyzing the effects of daily vitamin B supplementation—specifically vitamins B6, B9, and B12—we observed a significant reduction in homocysteine levels, a factor linked to migraine intensity. Moreover, the participants who received vitamin supplementation experienced decreased headache severity and lower migraine disability compared to those who received a placebo.
Furthermore, we found that the genetic makeup of the participants played a role in their response to the treatment. Carriers of certain gene variants showed an even greater improvement in their migraine symptoms, indicating that both MTHFR and MTRR gene variants independently contributed to the effectiveness of vitamin B6 supplementation.
Overall, we were encouraged to find that vitamin B6, combined with other B vitamins, can lead to meaningful relief for women suffering from migraines, depending on their genetic profile. This knowledge could lead to more personalized treatment approaches in managing migraine symptoms.
By analyzing the effects of daily vitamin B supplementation—specifically vitamins B6, B9, and B12—we observed a significant reduction in homocysteine levels, a factor linked to migraine intensity. Moreover, the participants who received vitamin supplementation experienced decreased headache severity and lower migraine disability compared to those who received a placebo.
Furthermore, we found that the genetic makeup of the participants played a role in their response to the treatment. Carriers of certain gene variants showed an even greater improvement in their migraine symptoms, indicating that both MTHFR and MTRR gene variants independently contributed to the effectiveness of vitamin B6 supplementation.
Overall, we were encouraged to find that vitamin B6, combined with other B vitamins, can lead to meaningful relief for women suffering from migraines, depending on their genetic profile. This knowledge could lead to more personalized treatment approaches in managing migraine symptoms.
Read More
8
We conducted a compelling study to find out how vitamin B6, along with other B vitamins, affects those who suffer from migraine headaches. Our research involved a structured, randomized, double-blind, placebo-controlled trial with 120 women experiencing episodic migraines. Participants were divided into groups that received either individual B vitamins like B1, B6, B12, and B9, a vitamin B complex, or a placebo for a duration of 12 weeks.
Throughout the study, we carefully monitored the frequency of headache attacks, the amount of abortive medication used, and the overall impact of migraines on daily life through questionnaires. The findings were quite promising—women taking vitamin B6, along with the other B vitamins, experienced a significant reduction in headache attacks compared to those on the placebo.
Furthermore, those receiving vitamins also reported improvements in migraine-related disability and a decrease in their reliance on abortive drugs. While our results highlight the potential benefit of B vitamins, including B6, in managing migraines, further research is essential to solidify these findings and determine the best treatment strategies.
Throughout the study, we carefully monitored the frequency of headache attacks, the amount of abortive medication used, and the overall impact of migraines on daily life through questionnaires. The findings were quite promising—women taking vitamin B6, along with the other B vitamins, experienced a significant reduction in headache attacks compared to those on the placebo.
Furthermore, those receiving vitamins also reported improvements in migraine-related disability and a decrease in their reliance on abortive drugs. While our results highlight the potential benefit of B vitamins, including B6, in managing migraines, further research is essential to solidify these findings and determine the best treatment strategies.
Read More
8
Vitamin B6 shows promise in migraine
We conducted a double-blind, randomized placebo-controlled trial to assess how vitamin B6, when combined with folic acid, influences migraine characteristics, specifically in those experiencing migraine with aura. In our study, 95 participants between 18 and 65 years old were evaluated in Isfahan, Iran, to observe the effects of these supplements on headache severity, frequency, and duration over three months.
Our findings showed that combining folic acid with vitamin B6 resulted in notable improvements for participants. There was a significant decrease in headache severity, attack frequency, and the overall impact on their lives as recorded in headache diaries. However, it's worth mentioning that while these enhancements were clear for headache severity and frequency, the effect on attack duration was less pronounced when we controlled for other factors.
Interestingly, when folic acid was taken without vitamin B6, there were no significant benefits observed compared to the placebo group. This suggests that while vitamin B6 plays a beneficial role when combined with folic acid, its isolated effect on migraines remains unclear and requires further exploration.
Our findings showed that combining folic acid with vitamin B6 resulted in notable improvements for participants. There was a significant decrease in headache severity, attack frequency, and the overall impact on their lives as recorded in headache diaries. However, it's worth mentioning that while these enhancements were clear for headache severity and frequency, the effect on attack duration was less pronounced when we controlled for other factors.
Interestingly, when folic acid was taken without vitamin B6, there were no significant benefits observed compared to the placebo group. This suggests that while vitamin B6 plays a beneficial role when combined with folic acid, its isolated effect on migraines remains unclear and requires further exploration.
Read More
8
We examined how vitamin B6, along with other vitamins, affects migraines, particularly its role in reducing disability, frequency, and severity of migraine episodes. In a randomized, double-blind placebo-controlled trial, we observed 52 patients with migraines that included aura. Over six months, participants received a daily supplementation of vitamins, including 25 mg of vitamin B6.
Our findings revealed that vitamin supplementation lowered homocysteine levels by 39%, which was significantly better than the placebo group. More importantly, we noted a decrease in migraine disability from 60% to 30% among those taking the vitamins, indicating that patients could experience less disruption in their lives from migraines.
We also recorded a reduction in headache frequency and pain severity with vitamin B6 supplementation. Notably, carriers of a specific genetic variant (MTHFR C677T) showed a greater response to treatment, suggesting that genetics could influence how effective the vitamin therapy might be. However, it’s essential to note that the isolated effect of vitamin B6 alone couldn't be fully assessed due to the combination of vitamins administered.
Ultimately, our study suggests that vitamin B6, alongside other B vitamins, may play a valuable role in managing migraines for some patients. It opens up the possibility of larger studies to further investigate if this vitamin treatment can serve as a safe and effective preventive measure for migraines.
Our findings revealed that vitamin supplementation lowered homocysteine levels by 39%, which was significantly better than the placebo group. More importantly, we noted a decrease in migraine disability from 60% to 30% among those taking the vitamins, indicating that patients could experience less disruption in their lives from migraines.
We also recorded a reduction in headache frequency and pain severity with vitamin B6 supplementation. Notably, carriers of a specific genetic variant (MTHFR C677T) showed a greater response to treatment, suggesting that genetics could influence how effective the vitamin therapy might be. However, it’s essential to note that the isolated effect of vitamin B6 alone couldn't be fully assessed due to the combination of vitamins administered.
Ultimately, our study suggests that vitamin B6, alongside other B vitamins, may play a valuable role in managing migraines for some patients. It opens up the possibility of larger studies to further investigate if this vitamin treatment can serve as a safe and effective preventive measure for migraines.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Helpful vitamins
3 people found this helpful
Great and Important Vitamins! I buy these for my son as he suffers from migraines. They are very helpful and are part of his regimen, as recommended by his neurologist. I highly recommend them!
Read More
9
Managing migraine
I’m always pleased with this brand. Vitamin B6 aids me in managing migraine symptoms effectively.
Read More
9
Preventing migraine
I take Vitamin B6 to improve my memory and mood. I’ve noticed that with a course of Vitamin B6, my intercostal neuralgia is reduced and I rarely experience migraine attacks. Therefore, I highly recommend it.
Read More
7.5
Calm sleep
13 people found this helpful
When I realised I couldn’t find the ideal Magnesium B6 composition, I took it separately and felt truly happy! At last, I can feel the effect. I take it at night for calmer sleep, as I struggle with insomnia. It has helped me recover after Covid, easing my migraines and neuralgia.
Read More
7.5
Easing insomnia
When I realised I wouldn’t find the perfect Magnesium B6, I took them separately and I’m just thrilled! It has effectively improved my sleep, helping me with my insomnia and easing my migraines as I recover from Covid.
Read More
Frequently Asked Questions
9
Preventing migraine
I take Vitamin B6 to improve my memory and mood. I’ve noticed that with a course of Vitamin B6, my intercostal neuralgia is reduced and I rarely experience migraine attacks. Therefore, I highly recommend it.
7.5
Calm sleep
13 people found this helpful
When I realised I couldn’t find the ideal Magnesium B6 composition, I took it separately and felt truly happy! At last, I can feel the effect. I take it at night for calmer sleep, as I struggle with insomnia. It has helped me recover after Covid, easing my migraines and neuralgia.
9
Managing migraine
I’m always pleased with this brand. Vitamin B6 aids me in managing migraine symptoms effectively.
7.5
Easing insomnia
When I realised I wouldn’t find the perfect Magnesium B6, I took them separately and I’m just thrilled! It has effectively improved my sleep, helping me with my insomnia and easing my migraines as I recover from Covid.
8
We conducted a compelling study to find out how vitamin B6, along with other B vitamins, affects those who suffer from migraine headaches. Our research involved a structured, randomized, double-blind, placebo-controlled trial with 120 women experiencing episodic migraines. Participants were divided into groups that received either individual B vitamins like B1, B6, B12, and B9, a vitamin B complex, or a placebo for a duration of 12 weeks.
Throughout the study, we carefully monitored the frequency of headache attacks, the amount of abortive medication used, and the overall impact of migraines on daily life through questionnaires. The findings were quite promising—women taking vitamin B6, along with the other B vitamins, experienced a significant reduction in headache attacks compared to those on the placebo.
Furthermore, those receiving vitamins also reported improvements in migraine-related disability and a decrease in their reliance on abortive drugs. While our results highlight the potential benefit of B vitamins, including B6, in managing migraines, further research is essential to solidify these findings and determine the best treatment strategies.
Throughout the study, we carefully monitored the frequency of headache attacks, the amount of abortive medication used, and the overall impact of migraines on daily life through questionnaires. The findings were quite promising—women taking vitamin B6, along with the other B vitamins, experienced a significant reduction in headache attacks compared to those on the placebo.
Furthermore, those receiving vitamins also reported improvements in migraine-related disability and a decrease in their reliance on abortive drugs. While our results highlight the potential benefit of B vitamins, including B6, in managing migraines, further research is essential to solidify these findings and determine the best treatment strategies.
7
We delved into the relationship between migraine and vitamins known to lower homocysteine levels, specifically B6, folate, and B12. Our systematic search revealed twelve articles, indicating that while managing acute migraines didn’t yield strong results, B6 supplementation showed significant benefits in preventing migraine with aura when compared to placebo.
Unfortunately, folate alone didn’t perform better than placebo for migraines, and data on migraines without aura was limited. Overall, these vitamins seem to have a safe profile, especially for migraine with aura in adults, although more high-quality trials are needed for broader conclusions.
Unfortunately, folate alone didn’t perform better than placebo for migraines, and data on migraines without aura was limited. Overall, these vitamins seem to have a safe profile, especially for migraine with aura in adults, although more high-quality trials are needed for broader conclusions.
8
Vitamin B6 shows promise in migraine
We conducted a double-blind, randomized placebo-controlled trial to assess how vitamin B6, when combined with folic acid, influences migraine characteristics, specifically in those experiencing migraine with aura. In our study, 95 participants between 18 and 65 years old were evaluated in Isfahan, Iran, to observe the effects of these supplements on headache severity, frequency, and duration over three months.
Our findings showed that combining folic acid with vitamin B6 resulted in notable improvements for participants. There was a significant decrease in headache severity, attack frequency, and the overall impact on their lives as recorded in headache diaries. However, it's worth mentioning that while these enhancements were clear for headache severity and frequency, the effect on attack duration was less pronounced when we controlled for other factors.
Interestingly, when folic acid was taken without vitamin B6, there were no significant benefits observed compared to the placebo group. This suggests that while vitamin B6 plays a beneficial role when combined with folic acid, its isolated effect on migraines remains unclear and requires further exploration.
Our findings showed that combining folic acid with vitamin B6 resulted in notable improvements for participants. There was a significant decrease in headache severity, attack frequency, and the overall impact on their lives as recorded in headache diaries. However, it's worth mentioning that while these enhancements were clear for headache severity and frequency, the effect on attack duration was less pronounced when we controlled for other factors.
Interestingly, when folic acid was taken without vitamin B6, there were no significant benefits observed compared to the placebo group. This suggests that while vitamin B6 plays a beneficial role when combined with folic acid, its isolated effect on migraines remains unclear and requires further exploration.
3
In a recent well-structured study, we explored the effects of vitamin supplementation on migraine with aura in female patients. Over six months, 300 participants took part in a randomized, double-blind, placebo-controlled trial where they received either daily vitamins containing 1 mg of folic acid, along with vitamin B6 and B12, or a placebo.
We found that this vitamin combination did not lead to significant reductions in homocysteine levels—a compound often linked to migraines. Additionally, participants receiving the vitamins did not report a decrease in migraine frequency, severity, or disability compared to those on placebo.
Overall, our findings suggest that while vitamin B6 is part of this treatment approach, its isolated impact on alleviating migraine symptoms remains unclear given the lack of significant results. The lower dose of folic acid appears to be less effective than previously tested higher doses.
We found that this vitamin combination did not lead to significant reductions in homocysteine levels—a compound often linked to migraines. Additionally, participants receiving the vitamins did not report a decrease in migraine frequency, severity, or disability compared to those on placebo.
Overall, our findings suggest that while vitamin B6 is part of this treatment approach, its isolated impact on alleviating migraine symptoms remains unclear given the lack of significant results. The lower dose of folic acid appears to be less effective than previously tested higher doses.
8
We examined how vitamin B6, along with other vitamins, affects migraines, particularly its role in reducing disability, frequency, and severity of migraine episodes. In a randomized, double-blind placebo-controlled trial, we observed 52 patients with migraines that included aura. Over six months, participants received a daily supplementation of vitamins, including 25 mg of vitamin B6.
Our findings revealed that vitamin supplementation lowered homocysteine levels by 39%, which was significantly better than the placebo group. More importantly, we noted a decrease in migraine disability from 60% to 30% among those taking the vitamins, indicating that patients could experience less disruption in their lives from migraines.
We also recorded a reduction in headache frequency and pain severity with vitamin B6 supplementation. Notably, carriers of a specific genetic variant (MTHFR C677T) showed a greater response to treatment, suggesting that genetics could influence how effective the vitamin therapy might be. However, it’s essential to note that the isolated effect of vitamin B6 alone couldn't be fully assessed due to the combination of vitamins administered.
Ultimately, our study suggests that vitamin B6, alongside other B vitamins, may play a valuable role in managing migraines for some patients. It opens up the possibility of larger studies to further investigate if this vitamin treatment can serve as a safe and effective preventive measure for migraines.
Our findings revealed that vitamin supplementation lowered homocysteine levels by 39%, which was significantly better than the placebo group. More importantly, we noted a decrease in migraine disability from 60% to 30% among those taking the vitamins, indicating that patients could experience less disruption in their lives from migraines.
We also recorded a reduction in headache frequency and pain severity with vitamin B6 supplementation. Notably, carriers of a specific genetic variant (MTHFR C677T) showed a greater response to treatment, suggesting that genetics could influence how effective the vitamin therapy might be. However, it’s essential to note that the isolated effect of vitamin B6 alone couldn't be fully assessed due to the combination of vitamins administered.
Ultimately, our study suggests that vitamin B6, alongside other B vitamins, may play a valuable role in managing migraines for some patients. It opens up the possibility of larger studies to further investigate if this vitamin treatment can serve as a safe and effective preventive measure for migraines.
References
- Liampas IN, Siokas V, Aloizou AM, Tsouris Z, Dastamani M, et al. Pyridoxine, folate and cobalamin for migraine: A systematic review. Acta Neurol Scand. 2020;142:108. doi:10.1111/ane.13251
- Nematgorgani S, Razeghi-Jahromi S, Jafari E, Togha M, Rafiee P, et al. B vitamins and their combination could reduce migraine headaches: A randomized double-blind controlled trial. Curr J Neurol. 2022;21:105. doi:10.18502/cjn.v21i2.10494
- Askari G, Nasiri M, Mozaffari-Khosravi H, Rezaie M, Bagheri-Bidakhavidi M, et al. The effects of folic acid and pyridoxine supplementation on characteristics of migraine attacks in migraine patients with aura: A double-blind, randomized placebo-controlled, clinical trial. Nutrition. 2017;38:74. doi:10.1016/j.nut.2017.01.007
- Woods E, Dawson C, Senthil L, Geberhiwot T. Cerebral venous thrombosis as the first presentation of classical homocystinuria in an adult patient. BMJ Case Rep. 2017;2017. doi:10.1136/bcr-2016-217477
- Menon S, Nasir B, Avgan N, Ghassabian S, Oliver C, et al. The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patients. J Headache Pain. 2016;17:60. doi:10.1186/s10194-016-0652-7
- Menon S, Lea RA, Roy B, Hanna M, Wee S, et al. Genotypes of the MTHFR C677T and MTRR A66G genes act independently to reduce migraine disability in response to vitamin supplementation. Pharmacogenet Genomics. 2012;22:741. doi:10.1097/FPC.0b013e3283576b6b
- Dhillon KS, Singh J, Lyall JS. A new horizon into the pathobiology, etiology and treatment of migraine. Med Hypotheses. 2011;77:147. doi:10.1016/j.mehy.2011.03.050
- Lea R, Colson N, Quinlan S, Macmillan J, Griffiths L. The effects of vitamin supplementation and MTHFR (C677T) genotype on homocysteine-lowering and migraine disability. Pharmacogenet Genomics. 2009;19:422. doi:10.1097/FPC.0b013e32832af5a3
