Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 3 Soft Gels
Amount Per Serving
%DV
Calories
35
Total Fat
3 g
4%
Saturated Fat
0.5 g
3%
Trans Fat
0 g
†
Cholesterol
15 mg
5%
Vitamin A
30 mcg RAE
3%
Total Omega-3s
750 mg
†
EPA (Eicosapentaenoic Acid)
240 mg
†
DHA (Docosahexaenoic Acid)
360 mg
†
Other Omega-3s
150 mg
†
Top Medical Research Studies
9
We set out to investigate how hypothyroidism affects cognitive function and whether omega-3 could provide a helpful boost in adult male rats. The study involved thirty rats, split into three groups: one as a control, another experiencing hypothyroidism, and the last group receiving omega-3 treatment.
The findings were quite striking. Rats with induced hypothyroidism showed significant memory problems, including difficulties in spatial learning and retention in various tests. These deficits were accompanied by lower levels of important brain chemicals and noticeable structural damage in the hippocampus, a key area for memory.
However, when we provided omega-3 supplements to one group, there was a remarkable turnaround. Those rats not only saw improvements in their memory but also regained some brain health. Omega-3 helped boost antioxidant levels, lessen structural issues in the brain, and reduce the expression of a protein linked to these damages.
All in all, our research suggests that omega-3 may serve as a protective ally against the cognitive challenges posed by hypothyroidism. This offers an exciting avenue for potential treatments that could benefit not just rats but perhaps humans facing similar hormonal challenges.
The findings were quite striking. Rats with induced hypothyroidism showed significant memory problems, including difficulties in spatial learning and retention in various tests. These deficits were accompanied by lower levels of important brain chemicals and noticeable structural damage in the hippocampus, a key area for memory.
However, when we provided omega-3 supplements to one group, there was a remarkable turnaround. Those rats not only saw improvements in their memory but also regained some brain health. Omega-3 helped boost antioxidant levels, lessen structural issues in the brain, and reduce the expression of a protein linked to these damages.
All in all, our research suggests that omega-3 may serve as a protective ally against the cognitive challenges posed by hypothyroidism. This offers an exciting avenue for potential treatments that could benefit not just rats but perhaps humans facing similar hormonal challenges.
Read More
8
Eicosapentaenoic acid supports hypothyroidism
We aimed to investigate how eicosapentaenoic acid ethyl ester, a form of omega-3 fatty acid derived from fish oil, influences thyroid function in patients with hypothyroidism. Interestingly, while it has generally been observed that plasma free fatty acid (FFA) levels remain normal in hypothyroid individuals, our findings indicated that some patients exhibited elevated FFA concentrations. This was compelling, as those with higher FFA levels showed milder symptoms of thyroid dysfunction compared to others with lower levels.
To delve deeper, we tested the effects of eicosapentaenoic acid in an animal model using hypothyroid rats. By administering eicosapentaenoic acid ethyl ester to these rats, we observed that it effectively inhibited the decline of thyroid hormone levels caused by a substance called MMI. Additionally, we noted that it positively influenced the structure of the thyroid follicles in these rats.
Our study suggests that eicosapentaenoic acid may not only support thyroid function but could also have potential benefits for managing conditions related to hypothyroidism. This opens up exciting possibilities for further research into natural treatments for thyroid health.
To delve deeper, we tested the effects of eicosapentaenoic acid in an animal model using hypothyroid rats. By administering eicosapentaenoic acid ethyl ester to these rats, we observed that it effectively inhibited the decline of thyroid hormone levels caused by a substance called MMI. Additionally, we noted that it positively influenced the structure of the thyroid follicles in these rats.
Our study suggests that eicosapentaenoic acid may not only support thyroid function but could also have potential benefits for managing conditions related to hypothyroidism. This opens up exciting possibilities for further research into natural treatments for thyroid health.
Read More
9
We explored the impact of omega 3 fatty acids (O3FA) on hypothyroidism triggered by bisphenol F (BPF), a chemical known to disrupt endocrine functions. The study involved 20 male Wistar rats, divided into groups to either receive BPF, O3FA, or a combination of both for a duration of 28 days. This design helped us assess the protective effects of O3FA against hypothyroidism-related testicular dysfunction.
Our findings revealed that both low and high doses of O3FA were effective in improving various indicators of reproductive health. Specifically, we observed enhancements in sperm quality and hormone levels, including testosterone and luteinizing hormone. Additionally, O3FA increased antioxidant defenses and reduced harmful markers associated with oxidative stress.
On a cellular level, we noted that O3FA countered BPF's adverse effects on critical processes in the body, including energy production and apoptosis (cell death). This was linked to restoring a balance between proteins that promote cell survival and those that trigger cell death. Overall, the study underscores the potential of omega 3 fatty acids as a therapeutic intervention for testicular dysfunction arising from hypothyroidism.
Our findings revealed that both low and high doses of O3FA were effective in improving various indicators of reproductive health. Specifically, we observed enhancements in sperm quality and hormone levels, including testosterone and luteinizing hormone. Additionally, O3FA increased antioxidant defenses and reduced harmful markers associated with oxidative stress.
On a cellular level, we noted that O3FA countered BPF's adverse effects on critical processes in the body, including energy production and apoptosis (cell death). This was linked to restoring a balance between proteins that promote cell survival and those that trigger cell death. Overall, the study underscores the potential of omega 3 fatty acids as a therapeutic intervention for testicular dysfunction arising from hypothyroidism.
Read More
Most Useful Reviews
9
Improved well-being
Excellent, it is the purest I have ever taken. It helps me a lot with my hypothyroidism, and I will certainly repeat my order.
Read More
7.5
Enhanced health
I have issues with my thyroid gland, specifically hypothyroidism, and my doctor insisted I take these vitamins. They have significantly improved my overall health, so much so that now my husband and son are also taking them. The shipping was free. Thank you.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7
- All Researches
9
We investigated the role of eicosapentaenoic acid (EPA), an omega-3 fatty acid, in the context of hypothyroidism and its effects on brain development. Our study used a rat model where hypothyroidism was induced, allowing us to examine how EPA influences neuronal health during this critical phase of development.
Through our research, we found that supplementing EPA, along with docosahexaenoic acid (DHA), significantly reduced signs of neuronal apoptosis, which is a controlled process of cell death that can be detrimental when excessive. Specifically, we observed decreases in DNA fragmentation and activation of an important mediator of cell death—caspase-3—in the cerebella of hypothyroid pups.
One of the key findings highlighted that EPA helped counteract increases in a pro-apoptotic protein called Bax. At the same time, levels of protective proteins, such as Bcl-2 and Bcl-x(L), were restored, which are crucial in promoting cell survival. Additionally, EPA supplementation normalized several important signaling pathways affected by thyroid hormone deficiency, which play vital roles in neuronal health.
Overall, our findings contribute valuable insight into how eicosapentaenoic acid can offer protective benefits for brain development during periods of stress caused by hypothyroidism, illuminating potential therapeutic pathways for ongoing investigations.
Through our research, we found that supplementing EPA, along with docosahexaenoic acid (DHA), significantly reduced signs of neuronal apoptosis, which is a controlled process of cell death that can be detrimental when excessive. Specifically, we observed decreases in DNA fragmentation and activation of an important mediator of cell death—caspase-3—in the cerebella of hypothyroid pups.
One of the key findings highlighted that EPA helped counteract increases in a pro-apoptotic protein called Bax. At the same time, levels of protective proteins, such as Bcl-2 and Bcl-x(L), were restored, which are crucial in promoting cell survival. Additionally, EPA supplementation normalized several important signaling pathways affected by thyroid hormone deficiency, which play vital roles in neuronal health.
Overall, our findings contribute valuable insight into how eicosapentaenoic acid can offer protective benefits for brain development during periods of stress caused by hypothyroidism, illuminating potential therapeutic pathways for ongoing investigations.
Read More
9
We explored the impact of omega 3 fatty acids (O3FA) on hypothyroidism triggered by bisphenol F (BPF), a chemical known to disrupt endocrine functions. The study involved 20 male Wistar rats, divided into groups to either receive BPF, O3FA, or a combination of both for a duration of 28 days. This design helped us assess the protective effects of O3FA against hypothyroidism-related testicular dysfunction.
Our findings revealed that both low and high doses of O3FA were effective in improving various indicators of reproductive health. Specifically, we observed enhancements in sperm quality and hormone levels, including testosterone and luteinizing hormone. Additionally, O3FA increased antioxidant defenses and reduced harmful markers associated with oxidative stress.
On a cellular level, we noted that O3FA countered BPF's adverse effects on critical processes in the body, including energy production and apoptosis (cell death). This was linked to restoring a balance between proteins that promote cell survival and those that trigger cell death. Overall, the study underscores the potential of omega 3 fatty acids as a therapeutic intervention for testicular dysfunction arising from hypothyroidism.
Our findings revealed that both low and high doses of O3FA were effective in improving various indicators of reproductive health. Specifically, we observed enhancements in sperm quality and hormone levels, including testosterone and luteinizing hormone. Additionally, O3FA increased antioxidant defenses and reduced harmful markers associated with oxidative stress.
On a cellular level, we noted that O3FA countered BPF's adverse effects on critical processes in the body, including energy production and apoptosis (cell death). This was linked to restoring a balance between proteins that promote cell survival and those that trigger cell death. Overall, the study underscores the potential of omega 3 fatty acids as a therapeutic intervention for testicular dysfunction arising from hypothyroidism.
Read More
9
We set out to investigate how hypothyroidism affects cognitive function and whether omega-3 could provide a helpful boost in adult male rats. The study involved thirty rats, split into three groups: one as a control, another experiencing hypothyroidism, and the last group receiving omega-3 treatment.
The findings were quite striking. Rats with induced hypothyroidism showed significant memory problems, including difficulties in spatial learning and retention in various tests. These deficits were accompanied by lower levels of important brain chemicals and noticeable structural damage in the hippocampus, a key area for memory.
However, when we provided omega-3 supplements to one group, there was a remarkable turnaround. Those rats not only saw improvements in their memory but also regained some brain health. Omega-3 helped boost antioxidant levels, lessen structural issues in the brain, and reduce the expression of a protein linked to these damages.
All in all, our research suggests that omega-3 may serve as a protective ally against the cognitive challenges posed by hypothyroidism. This offers an exciting avenue for potential treatments that could benefit not just rats but perhaps humans facing similar hormonal challenges.
The findings were quite striking. Rats with induced hypothyroidism showed significant memory problems, including difficulties in spatial learning and retention in various tests. These deficits were accompanied by lower levels of important brain chemicals and noticeable structural damage in the hippocampus, a key area for memory.
However, when we provided omega-3 supplements to one group, there was a remarkable turnaround. Those rats not only saw improvements in their memory but also regained some brain health. Omega-3 helped boost antioxidant levels, lessen structural issues in the brain, and reduce the expression of a protein linked to these damages.
All in all, our research suggests that omega-3 may serve as a protective ally against the cognitive challenges posed by hypothyroidism. This offers an exciting avenue for potential treatments that could benefit not just rats but perhaps humans facing similar hormonal challenges.
Read More
8
Eicosapentaenoic acid supports hypothyroidism
We aimed to investigate how eicosapentaenoic acid ethyl ester, a form of omega-3 fatty acid derived from fish oil, influences thyroid function in patients with hypothyroidism. Interestingly, while it has generally been observed that plasma free fatty acid (FFA) levels remain normal in hypothyroid individuals, our findings indicated that some patients exhibited elevated FFA concentrations. This was compelling, as those with higher FFA levels showed milder symptoms of thyroid dysfunction compared to others with lower levels.
To delve deeper, we tested the effects of eicosapentaenoic acid in an animal model using hypothyroid rats. By administering eicosapentaenoic acid ethyl ester to these rats, we observed that it effectively inhibited the decline of thyroid hormone levels caused by a substance called MMI. Additionally, we noted that it positively influenced the structure of the thyroid follicles in these rats.
Our study suggests that eicosapentaenoic acid may not only support thyroid function but could also have potential benefits for managing conditions related to hypothyroidism. This opens up exciting possibilities for further research into natural treatments for thyroid health.
To delve deeper, we tested the effects of eicosapentaenoic acid in an animal model using hypothyroid rats. By administering eicosapentaenoic acid ethyl ester to these rats, we observed that it effectively inhibited the decline of thyroid hormone levels caused by a substance called MMI. Additionally, we noted that it positively influenced the structure of the thyroid follicles in these rats.
Our study suggests that eicosapentaenoic acid may not only support thyroid function but could also have potential benefits for managing conditions related to hypothyroidism. This opens up exciting possibilities for further research into natural treatments for thyroid health.
Read More
8
We examined the effects of omega-3 fatty acids on heart muscle function in hypothyroid rats through a detailed investigation involving both hypothyroid and euthyroid (normal thyroid) groups. The rats were fed diets rich in either n-6 or n-3 fatty acids to observe how these dietary fats influenced their heart's response to beta-adrenoceptor agonists—substances that stimulate heart contraction.
Our findings revealed that in hypothyroid rats on an n-6 diet, the heart's maximum contractile strength was significantly reduced compared to euthyroid controls. Specifically, their ability to develop tension in response to stimulation was only 54% above resting levels, while euthyroid rats showed a far better response at 160%. Interestingly, hypothyroid rats on the n-3 diet did experience an improvement, with tension levels rising to 105% above resting levels, but this was still lower than the 399% seen in healthy controls.
We also evaluated how the heart's beta-adrenoceptors—the sites that respond to hormones like adrenaline—behaved differently. While the overall number of receptors remained constant regardless of thyroid state or diet, their function appeared to be altered, particularly in hypothyroid rats on the n-6 diet.
Importantly, our observation indicates that incorporating n-3 fatty acids in the diet can enhance heart muscle function in hypothyroid conditions, showing potential for dietary interventions in managing this condition. However, it's clear that other factors also play a significant role in heart health in hypothyroidism.
Our findings revealed that in hypothyroid rats on an n-6 diet, the heart's maximum contractile strength was significantly reduced compared to euthyroid controls. Specifically, their ability to develop tension in response to stimulation was only 54% above resting levels, while euthyroid rats showed a far better response at 160%. Interestingly, hypothyroid rats on the n-3 diet did experience an improvement, with tension levels rising to 105% above resting levels, but this was still lower than the 399% seen in healthy controls.
We also evaluated how the heart's beta-adrenoceptors—the sites that respond to hormones like adrenaline—behaved differently. While the overall number of receptors remained constant regardless of thyroid state or diet, their function appeared to be altered, particularly in hypothyroid rats on the n-6 diet.
Importantly, our observation indicates that incorporating n-3 fatty acids in the diet can enhance heart muscle function in hypothyroid conditions, showing potential for dietary interventions in managing this condition. However, it's clear that other factors also play a significant role in heart health in hypothyroidism.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved well-being
Excellent, it is the purest I have ever taken. It helps me a lot with my hypothyroidism, and I will certainly repeat my order.
Read More
7.5
Enhanced health
I have issues with my thyroid gland, specifically hypothyroidism, and my doctor insisted I take these vitamins. They have significantly improved my overall health, so much so that now my husband and son are also taking them. The shipping was free. Thank you.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Sinha RA, Khare P, Rai A, Maurya SK, Pathak A, et al. Anti-apoptotic role of omega-3-fatty acids in developing brain: perinatal hypothyroid rat cerebellum as apoptotic model. Int J Dev Neurosci. 2009;27:377. doi:10.1016/j.ijdevneu.2009.02.003
- Makino M, Oda N, Miura N, Imamura S, Yamamoto K, et al. Effect of eicosapentaenoic acid ethyl ester on hypothyroid function. J Endocrinol. 2001;171:259.
- Simonides WS, van Hardeveld C. Effects of hypothyroidism on the distribution and fatty acyl composition of phospholipids in sarcoplasmic reticulum of fast skeletal muscle of the rat. Biochim Biophys Acta. 1987;924:204.
- Odetayo AF, Olayaki LA. Omega 3 fatty acids preserve testicular function by ameliorating BPF-induced dysthyroidism: role of p53/Bcl-2 signaling and proton pump activities. JBRA Assist Reprod. 2024;28:471. doi:10.5935/1518-0557.20240033
- Abd Allah ES, Gomaa AM, Sayed MM. The effect of omega-3 on cognition in hypothyroid adult male rats. Acta Physiol Hung. 2014;101:362. doi:10.1556/APhysiol.101.2014.3.11
- Walter R, Dunn ME, d'Anjou MA, Lécuyer M. Nonsurgical resolution of gallbladder mucocele in two dogs. J Am Vet Med Assoc. 2008;232:1688. doi:10.2460/javma.232.11.1688
- Serebriakova OV, Govorin AV, Prosianik VI, Baksheeva EV. [Fatty acid composition of the blood serum and erythrocyte membrane lipids in patients with hypothyroidism and left ventricular diastolic dysfunction]. Klin Med (Mosk). 2008;86:40.
- Pehowich DJ. Thyroid hormone status and membrane n-3 fatty acid content influence mitochondrial proton leak. Biochim Biophys Acta. 1999;1411:192.
- Pehowich DJ. Hypothyroid state and membrane fatty acid composition influence cardiac mitochondrial pyruvate oxidation. Biochim Biophys Acta. 1995;1235:231.
- Awumey EM, Paton DM, Pehowich DJ. Thyroid status and dietary fatty acids affect beta-adrenoceptor agonist stimulation of tension development in rat myocardium. J Auton Pharmacol. 1995;15:73.
- Awumey EM, Pehowich DJ. N-3 and N-6 fatty acids modulate the inotropic response to calcium in hypothyroid rat papillary muscle. J Cardiovasc Pharmacol. 1995;25:473.
