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SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.2
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 2 Soft Gels
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%
Saturated Fat
0 g
0%
Trans Fat
0 g
†
Vitamin D3 (cholecalciferol)
10 mcg (400 IU)
67%
Total Omega-3s♦
830 mg
†
EPA (Eicosapentaenoic Acid)
205 mg
†
DHA (Docosahexaenoic Acid)
480 mg
†
Top Medical Research Studies
9
DHA's potential in gout inflammation
DHA protects against monosodium urate-induced inflammation through modulation of oxidative stress.
Direct relevance to gout treatment
We explored how docosahexaenoic acid (DHA) might help manage inflammation related to gout, specifically by examining its effects on monosodium urate (MSU) phagocytized by immune cells. Our study revealed that DHA significantly reduced the production and release of key inflammatory markers like interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in cell experiments.
We also observed that DHA helps lessen the production of harmful reactive oxygen species (ROS) that can contribute to inflammation. Notably, DHA aided the movement of a critical protein, nuclear factor E2-related factor 2 (Nrf2), into the cell nucleus, which then promoted the expression of several protective antioxidant enzymes. This is important because these enzymes play a vital role in maintaining cellular balance and mitigating oxidative stress.
Additionally, DHA improved mitochondrial function that was impaired by MSU, highlighting its protective effects. In real-world settings, when we administered DHA-rich microalgal oil to laboratory mice, we noted a decrease in the number of neutrophils, or inflammation-prone white blood cells, alongside lowered inflammatory responses.
Overall, our findings suggest that DHA or its rich sources like microalgal oil could be a valuable natural option for preventing inflammation linked to gout by tackling oxidative stress effectively.
We also observed that DHA helps lessen the production of harmful reactive oxygen species (ROS) that can contribute to inflammation. Notably, DHA aided the movement of a critical protein, nuclear factor E2-related factor 2 (Nrf2), into the cell nucleus, which then promoted the expression of several protective antioxidant enzymes. This is important because these enzymes play a vital role in maintaining cellular balance and mitigating oxidative stress.
Additionally, DHA improved mitochondrial function that was impaired by MSU, highlighting its protective effects. In real-world settings, when we administered DHA-rich microalgal oil to laboratory mice, we noted a decrease in the number of neutrophils, or inflammation-prone white blood cells, alongside lowered inflammatory responses.
Overall, our findings suggest that DHA or its rich sources like microalgal oil could be a valuable natural option for preventing inflammation linked to gout by tackling oxidative stress effectively.
Read More
8
Vitamins D3 and B2 inhibit gout
The inhibitory kinetics and mechanism of dietary vitamins D3 and B2 on xanthine oxidase.
Direct relation to gout treatment
We investigated how dietary vitamins D3 and B2 can influence gout by inhibiting an enzyme called xanthine oxidase (XO), which plays a significant role in gout development. Through various analytical techniques, we found that vitamin D3 works by fitting into the active site of XO, effectively blocking it from interacting with its substrate, xanthine. This action is due to D3’s ability to form bonds with the enzyme, which leads to a more compact structure that restrains xanthine binding.
On the other hand, vitamin B2 showed a mixed-type inhibition. It binds near the active site, impacting the enzyme's flexibility and structure. This alteration can fold over sections that block substrate access, thereby reducing the enzyme's activity. Remarkably, we noted a synergistic effect when both vitamins were present, heightening their ability to inhibit XO within specific concentration ranges.
Our findings shed light on how vitamins D3 and B2 could be valuable in the dietary management of gout, especially regarding their potential roles as supplementary treatments. Overall, we believe these insights might encourage further exploration into the use of vitamins in supporting gout therapies.
On the other hand, vitamin B2 showed a mixed-type inhibition. It binds near the active site, impacting the enzyme's flexibility and structure. This alteration can fold over sections that block substrate access, thereby reducing the enzyme's activity. Remarkably, we noted a synergistic effect when both vitamins were present, heightening their ability to inhibit XO within specific concentration ranges.
Our findings shed light on how vitamins D3 and B2 could be valuable in the dietary management of gout, especially regarding their potential roles as supplementary treatments. Overall, we believe these insights might encourage further exploration into the use of vitamins in supporting gout therapies.
Read More
8
Eicosapentaenoic acid influences urate
Omega-3 Polyunsaturated Fatty Acids Inhibit the Function of Human URAT1, a Renal Urate Re-Absorber.
Study highlights EPA's potential
We set out to explore how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, affects the body’s ability to manage urate levels, which is crucial for individuals dealing with gout. Gout is often a result of high serum urate, and the kidney plays a significant role in regulating this through a specialized transporter called URAT1.
Our investigation was focused on the inhibitory effects of various fatty acids on URAT1, using a lab setup with cells that express this transporter. Among the 25 fatty acids we examined, EPA stood out with its notable ability to inhibit URAT1. Specifically, we found that EPA had a half maximal inhibitory concentration value of 6.0 μM, indicating its potent effect compared to other fatty acids.
While these findings are promising, with indicators that EPA could assist in reducing urate re-absorption, further clinical studies are necessary to truly understand its potential as a treatment for gout. We didn’t directly assess clinical outcomes related to gout in patients, so more research will clarify whether EPA can really be employed as a uricosuric agent, helping those suffering from this condition.
Our investigation was focused on the inhibitory effects of various fatty acids on URAT1, using a lab setup with cells that express this transporter. Among the 25 fatty acids we examined, EPA stood out with its notable ability to inhibit URAT1. Specifically, we found that EPA had a half maximal inhibitory concentration value of 6.0 μM, indicating its potent effect compared to other fatty acids.
While these findings are promising, with indicators that EPA could assist in reducing urate re-absorption, further clinical studies are necessary to truly understand its potential as a treatment for gout. We didn’t directly assess clinical outcomes related to gout in patients, so more research will clarify whether EPA can really be employed as a uricosuric agent, helping those suffering from this condition.
Read More
Most Useful Reviews
8.8
Preventive treatment
I took this during my pregnancy; the composition is what I needed, particularly for gout and vitamin D in a preventive dose.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.2
9
DHA's potential in gout inflammation
DHA protects against monosodium urate-induced inflammation through modulation of oxidative stress.
Direct relevance to gout treatment
We explored how docosahexaenoic acid (DHA) might help manage inflammation related to gout, specifically by examining its effects on monosodium urate (MSU) phagocytized by immune cells. Our study revealed that DHA significantly reduced the production and release of key inflammatory markers like interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in cell experiments.
We also observed that DHA helps lessen the production of harmful reactive oxygen species (ROS) that can contribute to inflammation. Notably, DHA aided the movement of a critical protein, nuclear factor E2-related factor 2 (Nrf2), into the cell nucleus, which then promoted the expression of several protective antioxidant enzymes. This is important because these enzymes play a vital role in maintaining cellular balance and mitigating oxidative stress.
Additionally, DHA improved mitochondrial function that was impaired by MSU, highlighting its protective effects. In real-world settings, when we administered DHA-rich microalgal oil to laboratory mice, we noted a decrease in the number of neutrophils, or inflammation-prone white blood cells, alongside lowered inflammatory responses.
Overall, our findings suggest that DHA or its rich sources like microalgal oil could be a valuable natural option for preventing inflammation linked to gout by tackling oxidative stress effectively.
We also observed that DHA helps lessen the production of harmful reactive oxygen species (ROS) that can contribute to inflammation. Notably, DHA aided the movement of a critical protein, nuclear factor E2-related factor 2 (Nrf2), into the cell nucleus, which then promoted the expression of several protective antioxidant enzymes. This is important because these enzymes play a vital role in maintaining cellular balance and mitigating oxidative stress.
Additionally, DHA improved mitochondrial function that was impaired by MSU, highlighting its protective effects. In real-world settings, when we administered DHA-rich microalgal oil to laboratory mice, we noted a decrease in the number of neutrophils, or inflammation-prone white blood cells, alongside lowered inflammatory responses.
Overall, our findings suggest that DHA or its rich sources like microalgal oil could be a valuable natural option for preventing inflammation linked to gout by tackling oxidative stress effectively.
Read More
8
Vitamins D3 and B2 inhibit gout
The inhibitory kinetics and mechanism of dietary vitamins D3 and B2 on xanthine oxidase.
Direct relation to gout treatment
We investigated how dietary vitamins D3 and B2 can influence gout by inhibiting an enzyme called xanthine oxidase (XO), which plays a significant role in gout development. Through various analytical techniques, we found that vitamin D3 works by fitting into the active site of XO, effectively blocking it from interacting with its substrate, xanthine. This action is due to D3’s ability to form bonds with the enzyme, which leads to a more compact structure that restrains xanthine binding.
On the other hand, vitamin B2 showed a mixed-type inhibition. It binds near the active site, impacting the enzyme's flexibility and structure. This alteration can fold over sections that block substrate access, thereby reducing the enzyme's activity. Remarkably, we noted a synergistic effect when both vitamins were present, heightening their ability to inhibit XO within specific concentration ranges.
Our findings shed light on how vitamins D3 and B2 could be valuable in the dietary management of gout, especially regarding their potential roles as supplementary treatments. Overall, we believe these insights might encourage further exploration into the use of vitamins in supporting gout therapies.
On the other hand, vitamin B2 showed a mixed-type inhibition. It binds near the active site, impacting the enzyme's flexibility and structure. This alteration can fold over sections that block substrate access, thereby reducing the enzyme's activity. Remarkably, we noted a synergistic effect when both vitamins were present, heightening their ability to inhibit XO within specific concentration ranges.
Our findings shed light on how vitamins D3 and B2 could be valuable in the dietary management of gout, especially regarding their potential roles as supplementary treatments. Overall, we believe these insights might encourage further exploration into the use of vitamins in supporting gout therapies.
Read More
8
Vitamin D3 levels not beneficial
Decreased serum concentrations of 1,25(OH)2-vitamin D3 in patients with gout.
Relationship between vitamin D3 and gout
We assessed the relationship between vitamin D3 levels and gout by examining 114 male patients with primary gout and 51 healthy male controls. Our findings revealed that patients with gout had significantly lower serum levels of 1,25(OH)2-vitamin D3 compared to the control group. In fact, the concentrations were 38.4 pg/mL for gout patients versus 44.4 pg/mL for the controls.
Interestingly, we did not observe any notable differences in the levels of 25(OH)-vitamin D3 or parathyroid hormone (PTH) between the two groups, indicating that the lower levels of vitamin D3 specifically pertained to the active form relevant to calcium metabolism and bone health. Moreover, we found that uric acid levels were considerably higher in gout patients and that there was a significant negative correlation between uric acid and vitamin D3 levels.
After treating patients with uric acid-lowering medications such as allopurinol or benzbromarone for a year, we noted a significant increase in serum levels of 1,25(OH)2-vitamin D3, while the concentrations of 25(OH)-vitamin D3 and PTH remained unchanged. This suggests that high levels of uric acid may inhibit the activity of the enzyme responsible for converting vitamin D to its active form, rather than indicating that vitamin D directly impacts gout symptoms.
Overall, while we found a clear relationship showcasing lower vitamin D3 levels associated with gout, the study does not suggest that vitamin D3 treatment directly benefits gout management. Consequently, it seems that addressing uric acid levels may be the more pressing treatment approach in gout management.
Interestingly, we did not observe any notable differences in the levels of 25(OH)-vitamin D3 or parathyroid hormone (PTH) between the two groups, indicating that the lower levels of vitamin D3 specifically pertained to the active form relevant to calcium metabolism and bone health. Moreover, we found that uric acid levels were considerably higher in gout patients and that there was a significant negative correlation between uric acid and vitamin D3 levels.
After treating patients with uric acid-lowering medications such as allopurinol or benzbromarone for a year, we noted a significant increase in serum levels of 1,25(OH)2-vitamin D3, while the concentrations of 25(OH)-vitamin D3 and PTH remained unchanged. This suggests that high levels of uric acid may inhibit the activity of the enzyme responsible for converting vitamin D to its active form, rather than indicating that vitamin D directly impacts gout symptoms.
Overall, while we found a clear relationship showcasing lower vitamin D3 levels associated with gout, the study does not suggest that vitamin D3 treatment directly benefits gout management. Consequently, it seems that addressing uric acid levels may be the more pressing treatment approach in gout management.
Read More
8
Eicosapentaenoic acid influences urate
Omega-3 Polyunsaturated Fatty Acids Inhibit the Function of Human URAT1, a Renal Urate Re-Absorber.
Study highlights EPA's potential
We set out to explore how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, affects the body’s ability to manage urate levels, which is crucial for individuals dealing with gout. Gout is often a result of high serum urate, and the kidney plays a significant role in regulating this through a specialized transporter called URAT1.
Our investigation was focused on the inhibitory effects of various fatty acids on URAT1, using a lab setup with cells that express this transporter. Among the 25 fatty acids we examined, EPA stood out with its notable ability to inhibit URAT1. Specifically, we found that EPA had a half maximal inhibitory concentration value of 6.0 μM, indicating its potent effect compared to other fatty acids.
While these findings are promising, with indicators that EPA could assist in reducing urate re-absorption, further clinical studies are necessary to truly understand its potential as a treatment for gout. We didn’t directly assess clinical outcomes related to gout in patients, so more research will clarify whether EPA can really be employed as a uricosuric agent, helping those suffering from this condition.
Our investigation was focused on the inhibitory effects of various fatty acids on URAT1, using a lab setup with cells that express this transporter. Among the 25 fatty acids we examined, EPA stood out with its notable ability to inhibit URAT1. Specifically, we found that EPA had a half maximal inhibitory concentration value of 6.0 μM, indicating its potent effect compared to other fatty acids.
While these findings are promising, with indicators that EPA could assist in reducing urate re-absorption, further clinical studies are necessary to truly understand its potential as a treatment for gout. We didn’t directly assess clinical outcomes related to gout in patients, so more research will clarify whether EPA can really be employed as a uricosuric agent, helping those suffering from this condition.
Read More
8
Exploration of DHA and gout
Dissecting the causal effect between gut microbiota, DHA, and urate metabolism: A large-scale bidirectional Mendelian randomization.
Study supports DHA's potential effects
We investigated the connection between gut microbiota, docosahexaenoic acid (DHA), and urate metabolism to see how they interact and affect conditions like gout. The study utilized extensive data from a large number of participants, pulling information from various databases focusing on microbiota taxa, gout prevalence, and urate levels.
Our findings highlight that the gut microbiota plays a significant role in hosting urate metabolism; specifically, we observed that certain microbiota taxa had a common causal effect on both gout and urate levels. Notably, two specific bacterial groups showed protective effects on urate levels, linked to the increased presence of DHA.
This indicates that changes in our gut bacteria could not only improve urate metabolism but might also signal changes in gout risk. However, while DHA appears to be involved in this process, the link is complex and warrants further exploration to better understand its influence on gout treatment and prevention.
Our findings highlight that the gut microbiota plays a significant role in hosting urate metabolism; specifically, we observed that certain microbiota taxa had a common causal effect on both gout and urate levels. Notably, two specific bacterial groups showed protective effects on urate levels, linked to the increased presence of DHA.
This indicates that changes in our gut bacteria could not only improve urate metabolism but might also signal changes in gout risk. However, while DHA appears to be involved in this process, the link is complex and warrants further exploration to better understand its influence on gout treatment and prevention.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Preventive treatment
I took this during my pregnancy; the composition is what I needed, particularly for gout and vitamin D in a preventive dose.
