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SCIENTIFIC SCORE
Possibly Effective
Based on 39 Researches
7.4
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 2 Soft Gels
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%
Saturated Fat
0 g
0%
Trans Fat
0 g
†
Vitamin D3 (cholecalciferol)
10 mcg (400 IU)
67%
Total Omega-3s♦
830 mg
†
EPA (Eicosapentaenoic Acid)
205 mg
†
DHA (Docosahexaenoic Acid)
480 mg
†
Top Medical Research Studies
9.5
Vitamin D3 ethosomes for psoriasis
Synthesis of vitamin D3 loaded ethosomes gel to cure chronic immune-mediated inflammatory skin disease: physical characterization, in vitro and ex vivo studies.
Strong focus on vitamin D3 effectiveness
We aimed to explore the effectiveness of a special gel infused with vitamin D3, known as an ethosome, in managing psoriasis. This inflammatory skin condition is driven by an overactive immune response, and vitamin D3 plays a crucial role in the growth and development of skin cells called keratinocytes, making it a promising treatment option.
In our research, we created formulas containing different amounts of soya lecithin, propylene glycol, and ethanol to optimize the ethosome gel. After careful testing, we found that these ethosomes had a remarkable drug encapsulation efficiency of 96.25%. They ranged in size from about 148 to 657 nanometers, showing a stable, negatively charged profile that suggests they are safe for use.
Further analyses confirmed that the ethosome gel effectively delivered vitamin D3 through the skin and maintained its stability over six months. The results indicated that an impressive percentage of the medication penetrated the skin barrier, which is essential for its effectiveness in treating psoriasis flare-ups. Our findings suggest that the ethosome formulation enhances the therapeutic potential of vitamin D3, offering a promising avenue for treating patients with psoriasis.
In our research, we created formulas containing different amounts of soya lecithin, propylene glycol, and ethanol to optimize the ethosome gel. After careful testing, we found that these ethosomes had a remarkable drug encapsulation efficiency of 96.25%. They ranged in size from about 148 to 657 nanometers, showing a stable, negatively charged profile that suggests they are safe for use.
Further analyses confirmed that the ethosome gel effectively delivered vitamin D3 through the skin and maintained its stability over six months. The results indicated that an impressive percentage of the medication penetrated the skin barrier, which is essential for its effectiveness in treating psoriasis flare-ups. Our findings suggest that the ethosome formulation enhances the therapeutic potential of vitamin D3, offering a promising avenue for treating patients with psoriasis.
Read More
8
EPA benefits psoriatic skin health
Eicosapentaenoic Acid Influences the Lipid Profile of an In Vitro Psoriatic Skin Model Produced with T Cells.
Direct effect on psoriasis treatment
We aimed to understand how eicosapentaenoic acid (EPA) affects psoriasis, a skin condition known for causing redness, irritation, and thickened skin. By creating skin models that reflect both healthy and psoriatic conditions, we were able to assess the impact of EPA directly on lipid profiles—a key factor in skin health.
Our research revealed that in psoriatic skin models, there was a notable increase in certain fatty acids linked to inflammation, such as arachidonic acid (AA) and linoleic acid (LA). However, when we supplemented the media with EPA, we noticed a significant shift. The levels of beneficial omega-3 fatty acids, including EPA, docosahexaenoic acid (DHA), and docosapentaenoic acid (DPA), rose in both epidermal and dermal tissues.
More importantly, the addition of EPA helped to balance the production of lipid mediators in the skin. We observed increases in several anti-inflammatory molecules, such as prostaglandin E (PGE) and 12-hydroxyeicosapentaenoic acid (12-HEPE), indicating a move toward a more stable and healthier skin environment. These results suggest that EPA could play an important role in managing psoriasis by promoting a healthier lipid balance in the skin, potentially easing symptoms and encouraging skin healing.
Our research revealed that in psoriatic skin models, there was a notable increase in certain fatty acids linked to inflammation, such as arachidonic acid (AA) and linoleic acid (LA). However, when we supplemented the media with EPA, we noticed a significant shift. The levels of beneficial omega-3 fatty acids, including EPA, docosahexaenoic acid (DHA), and docosapentaenoic acid (DPA), rose in both epidermal and dermal tissues.
More importantly, the addition of EPA helped to balance the production of lipid mediators in the skin. We observed increases in several anti-inflammatory molecules, such as prostaglandin E (PGE) and 12-hydroxyeicosapentaenoic acid (12-HEPE), indicating a move toward a more stable and healthier skin environment. These results suggest that EPA could play an important role in managing psoriasis by promoting a healthier lipid balance in the skin, potentially easing symptoms and encouraging skin healing.
Read More
9
Eicosapentaenoic acid benefits psoriasis
n-3 fatty acids in psoriasis.
Directly explores EPA's effects
We assessed the effects of eicosapentaenoic acid (EPA), an omega-3 fatty acid, on psoriasis through intravenous administration in a series of studies. The investigation aimed to understand whether replacing arachidonic acid, which has pro-inflammatory properties, with EPA could be beneficial for patients suffering from psoriasis.
Participants received daily infusions of either an EPA-based lipid emulsion or a conventional n-6 lipid emulsion. Throughout the studies, we closely monitored the clinical progression of psoriasis, along with specific inflammatory markers in the blood.
Our findings were notable: the group receiving the n-3 fatty acid treatment showed a significantly higher response rate. We observed a remarkable tenfold increase in specific products derived from neutrophils, indicating enhanced benefits from EPA. Additionally, plasma levels of EPA rose swiftly within just a few days of treatment.
In summary, our research suggests that intravenous administration of n-3 fatty acids effectively reduces psoriasis symptoms, likely due to alterations in inflammatory processes. This rapid response contrasts sharply with slower improvements seen with oral supplementation of fatty acids.
Participants received daily infusions of either an EPA-based lipid emulsion or a conventional n-6 lipid emulsion. Throughout the studies, we closely monitored the clinical progression of psoriasis, along with specific inflammatory markers in the blood.
Our findings were notable: the group receiving the n-3 fatty acid treatment showed a significantly higher response rate. We observed a remarkable tenfold increase in specific products derived from neutrophils, indicating enhanced benefits from EPA. Additionally, plasma levels of EPA rose swiftly within just a few days of treatment.
In summary, our research suggests that intravenous administration of n-3 fatty acids effectively reduces psoriasis symptoms, likely due to alterations in inflammatory processes. This rapid response contrasts sharply with slower improvements seen with oral supplementation of fatty acids.
Read More
Most Useful Reviews
8.8
Improved skin condition
Noticeable changes in my skin; I have psoriasis, and taking Omega has greatly aided me. I've not experienced side effects, such as pimples.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 39 Researches
7.4
9.5
Vitamin D3 ethosomes for psoriasis
Synthesis of vitamin D3 loaded ethosomes gel to cure chronic immune-mediated inflammatory skin disease: physical characterization, in vitro and ex vivo studies.
Strong focus on vitamin D3 effectiveness
We aimed to explore the effectiveness of a special gel infused with vitamin D3, known as an ethosome, in managing psoriasis. This inflammatory skin condition is driven by an overactive immune response, and vitamin D3 plays a crucial role in the growth and development of skin cells called keratinocytes, making it a promising treatment option.
In our research, we created formulas containing different amounts of soya lecithin, propylene glycol, and ethanol to optimize the ethosome gel. After careful testing, we found that these ethosomes had a remarkable drug encapsulation efficiency of 96.25%. They ranged in size from about 148 to 657 nanometers, showing a stable, negatively charged profile that suggests they are safe for use.
Further analyses confirmed that the ethosome gel effectively delivered vitamin D3 through the skin and maintained its stability over six months. The results indicated that an impressive percentage of the medication penetrated the skin barrier, which is essential for its effectiveness in treating psoriasis flare-ups. Our findings suggest that the ethosome formulation enhances the therapeutic potential of vitamin D3, offering a promising avenue for treating patients with psoriasis.
In our research, we created formulas containing different amounts of soya lecithin, propylene glycol, and ethanol to optimize the ethosome gel. After careful testing, we found that these ethosomes had a remarkable drug encapsulation efficiency of 96.25%. They ranged in size from about 148 to 657 nanometers, showing a stable, negatively charged profile that suggests they are safe for use.
Further analyses confirmed that the ethosome gel effectively delivered vitamin D3 through the skin and maintained its stability over six months. The results indicated that an impressive percentage of the medication penetrated the skin barrier, which is essential for its effectiveness in treating psoriasis flare-ups. Our findings suggest that the ethosome formulation enhances the therapeutic potential of vitamin D3, offering a promising avenue for treating patients with psoriasis.
Read More
9.5
Vitamin D3's role in psoriasis
Impact of topical emollient, steroids alone or combined with calcipotriol, on the immune infiltrate and clinical outcome in psoriasis.
Combined treatment effects evaluated
We conducted a study to better understand how topical treatments, particularly those involving vitamin D3, affect psoriasis. In our investigation, we focused on a group of 30 psoriasis patients, using a double-blind, randomized approach. This means neither the patients nor the researchers knew who received which treatment, ensuring an unbiased evaluation of their effects.
The treatments explored included a combination of Calcipotriol (a vitamin D3 analogue) and Betamethasone (a steroid), as well as Betamethasone alone and Clobetasol Propionate ointment. Through the analysis of skin biopsies before and after four weeks of treatment, we observed changes in skin inflammation, cellular infiltrate, and patients’ clinical scores for psoriasis severity.
While we noted that all treatments helped reduce skin thickness and improved patient scores, the greatest impact was seen with the combination of Calcipotriol and Betamethasone. This specific treatment effectively diminished the number of harmful immune cells that contribute to psoriasis flare-ups. However, the isolated effect of vitamin D3 alone wasn’t clearly established, as the most significant outcomes were tied to its use in combination with steroids.
Ultimately, our findings suggest that while vitamin D3 plays a role in psoriasis treatment, its benefits are most pronounced when paired with corticosteroids. This combination could potentially lead to enhanced long-term management of the disease, although the specific contribution of vitamin D3 alone remains uncertain.
The treatments explored included a combination of Calcipotriol (a vitamin D3 analogue) and Betamethasone (a steroid), as well as Betamethasone alone and Clobetasol Propionate ointment. Through the analysis of skin biopsies before and after four weeks of treatment, we observed changes in skin inflammation, cellular infiltrate, and patients’ clinical scores for psoriasis severity.
While we noted that all treatments helped reduce skin thickness and improved patient scores, the greatest impact was seen with the combination of Calcipotriol and Betamethasone. This specific treatment effectively diminished the number of harmful immune cells that contribute to psoriasis flare-ups. However, the isolated effect of vitamin D3 alone wasn’t clearly established, as the most significant outcomes were tied to its use in combination with steroids.
Ultimately, our findings suggest that while vitamin D3 plays a role in psoriasis treatment, its benefits are most pronounced when paired with corticosteroids. This combination could potentially lead to enhanced long-term management of the disease, although the specific contribution of vitamin D3 alone remains uncertain.
Read More
9.5
DHA shows promise for psoriasis
Effects of dietary supplementation with polyunsaturated ethyl ester lipids (Angiosan) in patients with psoriasis and psoriatic arthritis.
Combination treatment complicates evaluation
We evaluated the impact of docosahexaenoic acid (DHA) supplementation, alongside eicosapentaenoic acid (EPA), in patients suffering from chronic, stable psoriasis. This study involved 80 participants, 34 of whom also had psoriatic arthritis, and they were given specific doses of fatty acid ethyl esters for a period of eight weeks.
The results showed a noteworthy decrease in the Psoriasis Area Severity Index (PASI) scores, which went from an average of 3.56 before treatment to 1.24 after eight weeks. This significant reduction illustrates the potential effectiveness of DHA for managing symptoms of psoriasis, such as itching and plaque scaling.
It was particularly encouraging to see that seven patients were completely healed, with many others experiencing significant improvement. The majority of those with psoriatic arthritis reported feeling less joint pain during the study. Through our observations, it became clear that polyunsaturated ethyl ester lipids, like DHA, may serve as a valuable complement to traditional therapies for both psoriasis and psoriatic arthritis.
The results showed a noteworthy decrease in the Psoriasis Area Severity Index (PASI) scores, which went from an average of 3.56 before treatment to 1.24 after eight weeks. This significant reduction illustrates the potential effectiveness of DHA for managing symptoms of psoriasis, such as itching and plaque scaling.
It was particularly encouraging to see that seven patients were completely healed, with many others experiencing significant improvement. The majority of those with psoriatic arthritis reported feeling less joint pain during the study. Through our observations, it became clear that polyunsaturated ethyl ester lipids, like DHA, may serve as a valuable complement to traditional therapies for both psoriasis and psoriatic arthritis.
Read More
9
Calcipotriol more effective than calcitriol
Comparative evaluation of efficacy and safety of calcipotriol versus calcitriol ointment, both in combination with narrow-band ultraviolet B phototherapy in the treatment of stable plaque psoriasis.
Study confirms vitamin D3's role
We explored the effectiveness of two vitamin D analogues, calcipotriol and calcitriol, in treating stable plaque psoriasis when combined with narrow-band ultraviolet B (NBUVB) phototherapy. Our study involved thirty patients who were treated for 12 weeks, applying calcitriol ointment to one side and calcipotriol ointment to the other.
Throughout the trial, we observed significant improvements in skin conditions such as erythema, scaling, and overall plaque thickness with both treatments. Remarkably, those using calcipotriol showed quicker clearance of plaques and experienced fewer relapses compared to those using calcitriol.
Both treatments were found to be safe and well-tolerated, making them cosmetically appealing options. However, calcipotriol not only demonstrated a rapid onset of action but also maintained its efficacy more consistently over the treatment period.
Throughout the trial, we observed significant improvements in skin conditions such as erythema, scaling, and overall plaque thickness with both treatments. Remarkably, those using calcipotriol showed quicker clearance of plaques and experienced fewer relapses compared to those using calcitriol.
Both treatments were found to be safe and well-tolerated, making them cosmetically appealing options. However, calcipotriol not only demonstrated a rapid onset of action but also maintained its efficacy more consistently over the treatment period.
Read More
9
Eicosapentaenoic acid benefits psoriasis
n-3 fatty acids in psoriasis.
Directly explores EPA's effects
We assessed the effects of eicosapentaenoic acid (EPA), an omega-3 fatty acid, on psoriasis through intravenous administration in a series of studies. The investigation aimed to understand whether replacing arachidonic acid, which has pro-inflammatory properties, with EPA could be beneficial for patients suffering from psoriasis.
Participants received daily infusions of either an EPA-based lipid emulsion or a conventional n-6 lipid emulsion. Throughout the studies, we closely monitored the clinical progression of psoriasis, along with specific inflammatory markers in the blood.
Our findings were notable: the group receiving the n-3 fatty acid treatment showed a significantly higher response rate. We observed a remarkable tenfold increase in specific products derived from neutrophils, indicating enhanced benefits from EPA. Additionally, plasma levels of EPA rose swiftly within just a few days of treatment.
In summary, our research suggests that intravenous administration of n-3 fatty acids effectively reduces psoriasis symptoms, likely due to alterations in inflammatory processes. This rapid response contrasts sharply with slower improvements seen with oral supplementation of fatty acids.
Participants received daily infusions of either an EPA-based lipid emulsion or a conventional n-6 lipid emulsion. Throughout the studies, we closely monitored the clinical progression of psoriasis, along with specific inflammatory markers in the blood.
Our findings were notable: the group receiving the n-3 fatty acid treatment showed a significantly higher response rate. We observed a remarkable tenfold increase in specific products derived from neutrophils, indicating enhanced benefits from EPA. Additionally, plasma levels of EPA rose swiftly within just a few days of treatment.
In summary, our research suggests that intravenous administration of n-3 fatty acids effectively reduces psoriasis symptoms, likely due to alterations in inflammatory processes. This rapid response contrasts sharply with slower improvements seen with oral supplementation of fatty acids.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Improved skin condition
Noticeable changes in my skin; I have psoriasis, and taking Omega has greatly aided me. I've not experienced side effects, such as pimples.
