Last update
2/28/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.8
Supplement Facts
Serving Size: 2 Soft Gels
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%
Saturated Fat
0 g
0%
Trans Fat
0 g
†
Vitamin D3 (cholecalciferol)
10 mcg (400 IU)
67%
Total Omega-3s♦
830 mg
†
EPA (Eicosapentaenoic Acid)
205 mg
†
DHA (Docosahexaenoic Acid)
480 mg
†
Top Medical Research Studies
9
We aimed to understand whether vitamin D3 can have a beneficial effect on reflux esophagitis (RE), a condition caused by stomach acid irritating the esophagus. To explore this, we conducted experiments on seventy male Sprague-Dawley rats, dividing them into groups to study both acute and chronic forms of RE. We treated some of these rats with varying doses of vitamin D3, while others did not receive this treatment, allowing us to compare differences in inflammation levels.
The results showed that the levels of important pro-inflammatory proteins—IL-1β, IL-6, and IL-8—were significantly elevated in the rats suffering from RE. However, when we treated the rats with vitamin D3, we observed a notable reduction in these inflammatory markers, but only in the acute RE group. Unfortunately, similar benefits were not evident in the chronic RE group, and vitamin D3 did not improve the overall condition of the esophagus on a structural level.
Interestingly, our histopathological examinations revealed varying degrees of esophageal damage, regardless of vitamin D3 treatment. While elevated serum calcium levels were noted following vitamin D3 treatment, this did not translate into improvements in chronic RE cases. Overall, our findings point to a potential protective role of vitamin D3 in early-stage reflux esophagitis, suggesting that it might help manage inflammation at the beginning of this condition.
The results showed that the levels of important pro-inflammatory proteins—IL-1β, IL-6, and IL-8—were significantly elevated in the rats suffering from RE. However, when we treated the rats with vitamin D3, we observed a notable reduction in these inflammatory markers, but only in the acute RE group. Unfortunately, similar benefits were not evident in the chronic RE group, and vitamin D3 did not improve the overall condition of the esophagus on a structural level.
Interestingly, our histopathological examinations revealed varying degrees of esophageal damage, regardless of vitamin D3 treatment. While elevated serum calcium levels were noted following vitamin D3 treatment, this did not translate into improvements in chronic RE cases. Overall, our findings point to a potential protective role of vitamin D3 in early-stage reflux esophagitis, suggesting that it might help manage inflammation at the beginning of this condition.
Read More
Most Useful Reviews
9
Great for reflux
This product is easy to take and perfect during pregnancy, with no reflux.
Read More
9
No reflux complaints
I’ve been taking this since becoming pregnant, and I have no complaints—no reflux at all.
Read More
0
No more burping
1 people found this helpful
Best out of the 8 different types I've tried. These were the only ones that didn't cause burping, acid reflux, or upset my stomach. Highly recommend.
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
- All Researches
9
We aimed to understand whether vitamin D3 can have a beneficial effect on reflux esophagitis (RE), a condition caused by stomach acid irritating the esophagus. To explore this, we conducted experiments on seventy male Sprague-Dawley rats, dividing them into groups to study both acute and chronic forms of RE. We treated some of these rats with varying doses of vitamin D3, while others did not receive this treatment, allowing us to compare differences in inflammation levels.
The results showed that the levels of important pro-inflammatory proteins—IL-1β, IL-6, and IL-8—were significantly elevated in the rats suffering from RE. However, when we treated the rats with vitamin D3, we observed a notable reduction in these inflammatory markers, but only in the acute RE group. Unfortunately, similar benefits were not evident in the chronic RE group, and vitamin D3 did not improve the overall condition of the esophagus on a structural level.
Interestingly, our histopathological examinations revealed varying degrees of esophageal damage, regardless of vitamin D3 treatment. While elevated serum calcium levels were noted following vitamin D3 treatment, this did not translate into improvements in chronic RE cases. Overall, our findings point to a potential protective role of vitamin D3 in early-stage reflux esophagitis, suggesting that it might help manage inflammation at the beginning of this condition.
The results showed that the levels of important pro-inflammatory proteins—IL-1β, IL-6, and IL-8—were significantly elevated in the rats suffering from RE. However, when we treated the rats with vitamin D3, we observed a notable reduction in these inflammatory markers, but only in the acute RE group. Unfortunately, similar benefits were not evident in the chronic RE group, and vitamin D3 did not improve the overall condition of the esophagus on a structural level.
Interestingly, our histopathological examinations revealed varying degrees of esophageal damage, regardless of vitamin D3 treatment. While elevated serum calcium levels were noted following vitamin D3 treatment, this did not translate into improvements in chronic RE cases. Overall, our findings point to a potential protective role of vitamin D3 in early-stage reflux esophagitis, suggesting that it might help manage inflammation at the beginning of this condition.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Great for reflux
This product is easy to take and perfect during pregnancy, with no reflux.
Read More
9
No reflux complaints
I’ve been taking this since becoming pregnant, and I have no complaints—no reflux at all.
Read More
0
No more burping
1 people found this helpful
Best out of the 8 different types I've tried. These were the only ones that didn't cause burping, acid reflux, or upset my stomach. Highly recommend.
Read More
7.5
Relieves reflux symptoms
I love this brand, and the flavour helps with pregnancy reflux.
Read More
Frequently Asked Questions
9
No reflux complaints
I’ve been taking this since becoming pregnant, and I have no complaints—no reflux at all.
9
Great for reflux
This product is easy to take and perfect during pregnancy, with no reflux.
9
We aimed to understand whether vitamin D3 can have a beneficial effect on reflux esophagitis (RE), a condition caused by stomach acid irritating the esophagus. To explore this, we conducted experiments on seventy male Sprague-Dawley rats, dividing them into groups to study both acute and chronic forms of RE. We treated some of these rats with varying doses of vitamin D3, while others did not receive this treatment, allowing us to compare differences in inflammation levels.
The results showed that the levels of important pro-inflammatory proteins—IL-1β, IL-6, and IL-8—were significantly elevated in the rats suffering from RE. However, when we treated the rats with vitamin D3, we observed a notable reduction in these inflammatory markers, but only in the acute RE group. Unfortunately, similar benefits were not evident in the chronic RE group, and vitamin D3 did not improve the overall condition of the esophagus on a structural level.
Interestingly, our histopathological examinations revealed varying degrees of esophageal damage, regardless of vitamin D3 treatment. While elevated serum calcium levels were noted following vitamin D3 treatment, this did not translate into improvements in chronic RE cases. Overall, our findings point to a potential protective role of vitamin D3 in early-stage reflux esophagitis, suggesting that it might help manage inflammation at the beginning of this condition.
The results showed that the levels of important pro-inflammatory proteins—IL-1β, IL-6, and IL-8—were significantly elevated in the rats suffering from RE. However, when we treated the rats with vitamin D3, we observed a notable reduction in these inflammatory markers, but only in the acute RE group. Unfortunately, similar benefits were not evident in the chronic RE group, and vitamin D3 did not improve the overall condition of the esophagus on a structural level.
Interestingly, our histopathological examinations revealed varying degrees of esophageal damage, regardless of vitamin D3 treatment. While elevated serum calcium levels were noted following vitamin D3 treatment, this did not translate into improvements in chronic RE cases. Overall, our findings point to a potential protective role of vitamin D3 in early-stage reflux esophagitis, suggesting that it might help manage inflammation at the beginning of this condition.
References
- Wei J, Zhang J, Jiang Y, Lian T, Zhang P, et al. Elevated Pro-inflammatory Cytokine Levels in Acute Reflux Esophagitis Are Reduced by 1,25 Dihydroxy Vitamin D3. In Vivo. 2023;37:79. 10.21873/invivo.13056
Data last updated:
