Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 38 Researches
7.9
USERS' SCORE
Good
Based on 20 Reviews
8
Supplement Facts
Serving Size: 2 Soft Gels
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%
Total Omega-3s♢
690 mg
†
EPA (Eicosapentaenoic Acid)
330 mg
†
DHA (Docosahexaenoic Acid)
220 mg
†
Top Medical Research Studies
9
We conducted a comprehensive trial to understand how different types of omega-3 fatty acids affect cholesterol levels and inflammation in adults struggling with high cholesterol.
Over 12 weeks, participants took various doses of omega-3s, including EPA and DHA, revealing notable benefits. Those receiving higher doses of EPA and DHA saw their triglycerides drop significantly—by up to 15.78%—compared to controls.
Interestingly, ALA supplementation did not lead to improvements in cholesterol or inflammation status, highlighting the superior role of EPA and DHA in managing these health issues.
Over 12 weeks, participants took various doses of omega-3s, including EPA and DHA, revealing notable benefits. Those receiving higher doses of EPA and DHA saw their triglycerides drop significantly—by up to 15.78%—compared to controls.
Interestingly, ALA supplementation did not lead to improvements in cholesterol or inflammation status, highlighting the superior role of EPA and DHA in managing these health issues.
Read More
9
Scallop oil significantly reduces cholesterol
We investigated how different oils, including newly produced scallop oil, fish oil, and krill oil, impact cholesterol levels in obese type II diabetic mice. Our study involved feeding these groups various high-fat diets for 42 days.
Remarkably, the scallop oil group showed a significant reduction in cholesterol levels in both serum and liver, while the fish oil and krill oil groups did not exhibit such benefits. The findings suggest that scallop oil might be a promising option for managing cholesterol and preventing related health issues.
Remarkably, the scallop oil group showed a significant reduction in cholesterol levels in both serum and liver, while the fish oil and krill oil groups did not exhibit such benefits. The findings suggest that scallop oil might be a promising option for managing cholesterol and preventing related health issues.
Read More
9
We examined how swapping a saturated fat diet for omega-3 polyunsaturated fatty acids (n-3PUFAs) affects cholesterol and bone health in hypercholesterolemic rats.
In our study, rats that shifted to an n-3PUFA diet saw a notable decrease in serum lipids. While the diet appeared to positively impact their bone loss linked to periodontitis, rats on the n-3PUFA diet showed results similar to those on a commercial diet, indicating no major advantage of fish oil over a balanced diet.
Overall, our findings suggest that while omega-3s can help with cholesterol, they don't offer significant improvements over typical diets in these conditions.
In our study, rats that shifted to an n-3PUFA diet saw a notable decrease in serum lipids. While the diet appeared to positively impact their bone loss linked to periodontitis, rats on the n-3PUFA diet showed results similar to those on a commercial diet, indicating no major advantage of fish oil over a balanced diet.
Overall, our findings suggest that while omega-3s can help with cholesterol, they don't offer significant improvements over typical diets in these conditions.
Read More
Most Useful Reviews
8
Meets safety standards
11 people found this helpful
Choosing Omega-3 was important for me. Key factors include the composition of EPA and DHA, the source of ingredients, and the form of absorption. This product meets all safety standards and is beneficial, although it’s not cheap. High-quality products usually come with a higher price.
Read More
9
Supports immune health
6 people found this helpful
I’m very pleased with Nordic Naturals' Omega. Unlike other brands, it has a pleasant lemon scent, and the quality is excellent. I take one capsule twice daily, and it supports my immune system and keeps my cholesterol levels in check. I highly recommend this manufacturer.
Read More
9
Reliable raw materials
4 people found this helpful
Nordic Omega-3 is trustworthy due to its use of quality raw materials like small fish. I’ve taken it for years, which has led to lower cholesterol and alleviated dry eyes. Although the capsules are large, they lack a fishy odour, and taking them with meals increases absorption.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 38 Researches
7.9
- All Researches
9
We aimed to understand how Antarctic krill oil (ESKO) affects cholesterol levels, particularly in relation to obesity. Through our study involving mice, we observed that ESKO helped reduce oxidative stress and improve cholesterol metabolism.
While a high-fat diet usually worsens cholesterol levels, ESKO demonstrated a protective effect by reducing fat accumulation and promoting better metabolic health. This suggests that krill oil could be a promising option for managing high cholesterol and obesity-related issues.
While a high-fat diet usually worsens cholesterol levels, ESKO demonstrated a protective effect by reducing fat accumulation and promoting better metabolic health. This suggests that krill oil could be a promising option for managing high cholesterol and obesity-related issues.
Read More
9
CA-rich fish oils lower cholesterol
We investigated whether cetoleic acid (CA), a healthy fat found in certain fish, can help lower cholesterol levels in rodents. Our systematic review included 12 studies, assessing how CA-rich fish oils influenced total cholesterol compared to regular diets.
The results showed a significant reduction in cholesterol levels in rodents that consumed CA-rich oils. However, it’s important to note that the risk of bias in the studies varied, making our conclusions tentative. Overall, these findings suggest CA-rich fish oils could play a beneficial role in heart health, but further research in humans is needed.
The results showed a significant reduction in cholesterol levels in rodents that consumed CA-rich oils. However, it’s important to note that the risk of bias in the studies varied, making our conclusions tentative. Overall, these findings suggest CA-rich fish oils could play a beneficial role in heart health, but further research in humans is needed.
Read More
9
Scallop oil significantly reduces cholesterol
We investigated how different oils, including newly produced scallop oil, fish oil, and krill oil, impact cholesterol levels in obese type II diabetic mice. Our study involved feeding these groups various high-fat diets for 42 days.
Remarkably, the scallop oil group showed a significant reduction in cholesterol levels in both serum and liver, while the fish oil and krill oil groups did not exhibit such benefits. The findings suggest that scallop oil might be a promising option for managing cholesterol and preventing related health issues.
Remarkably, the scallop oil group showed a significant reduction in cholesterol levels in both serum and liver, while the fish oil and krill oil groups did not exhibit such benefits. The findings suggest that scallop oil might be a promising option for managing cholesterol and preventing related health issues.
Read More
9
We examined the role of eicosapentaenoic acid (EPA), specifically icosapent ethyl, in reducing cardiovascular disease risks. Approved by the FDA, this omega-3 treatment showed a notable 25% reduction in major heart events for high-risk patients. These patients already had controlled cholesterol but elevated triglyceride levels.
Importantly, while EPA proved effective, mixed omega-3 products lacking substantial evidence for heart health did not provide the same benefits. We believe adding EPA-only formulations to cardiovascular prevention guidelines is essential for at-risk individuals.
Importantly, while EPA proved effective, mixed omega-3 products lacking substantial evidence for heart health did not provide the same benefits. We believe adding EPA-only formulations to cardiovascular prevention guidelines is essential for at-risk individuals.
Read More
9
8-HEPE benefits cholesterol management
We explored how 8-hydroxyeicosapentaenoic acid (8-HEPE), derived from Pacific krill, could improve cholesterol levels in mice commonly used for dyslipidemia studies.
Over eighteen weeks, mice on a high-cholesterol diet receiving 8-HEPE showed significantly higher levels of good HDL cholesterol, alongside lower levels of bad LDL cholesterol and liver triglycerides.
This suggests that 8-HEPE may enhance lipid profiles and liver health by influencing certain genes in macrophages. While promising, further research is needed to confirm these benefits in humans.
Over eighteen weeks, mice on a high-cholesterol diet receiving 8-HEPE showed significantly higher levels of good HDL cholesterol, alongside lower levels of bad LDL cholesterol and liver triglycerides.
This suggests that 8-HEPE may enhance lipid profiles and liver health by influencing certain genes in macrophages. While promising, further research is needed to confirm these benefits in humans.
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User Reviews
USERS' SCORE
Good
Based on 20 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
8
Meets safety standards
11 people found this helpful
Choosing Omega-3 was important for me. Key factors include the composition of EPA and DHA, the source of ingredients, and the form of absorption. This product meets all safety standards and is beneficial, although it’s not cheap. High-quality products usually come with a higher price.
Read More
9
Supports immune health
6 people found this helpful
I’m very pleased with Nordic Naturals' Omega. Unlike other brands, it has a pleasant lemon scent, and the quality is excellent. I take one capsule twice daily, and it supports my immune system and keeps my cholesterol levels in check. I highly recommend this manufacturer.
Read More
9
Reliable raw materials
4 people found this helpful
Nordic Omega-3 is trustworthy due to its use of quality raw materials like small fish. I’ve taken it for years, which has led to lower cholesterol and alleviated dry eyes. Although the capsules are large, they lack a fishy odour, and taking them with meals increases absorption.
Read More
9
Trusted brand
3 people found this helpful
We consistently choose this particular Omega-3 every year. The quality matches the price, as confirmed by English-speaking independent research. This brand produces a high-quality product, making it worth storing in the refrigerator for longevity.
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9
Perfect blood pressure
3 people found this helpful
My doctor recommended fish oil years ago, and this brand is my only choice now. It’s the only one without a fishy aftertaste, and it has improved my blood pressure and cholesterol levels, making it worth the investment.
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Frequently Asked Questions
9
Improved cholesterol
1 people found this helpful
Since taking this for three weeks, my hair loss has ceased, and my skin is less dry. Omega-3s are vital for human health, reducing bad cholesterol and lowering risks of heart conditions, while also improving cognitive function.
7.5
Improves cholesterol levels
4 people found this helpful
This Omega supplement significantly improved my leg heaviness, allowing better sleep. After three months, my HDL cholesterol levels were also healthy. I appreciate not experiencing any fishy aftertaste, and I plan to continue using it.
9
Effective for cholesterol
2 people found this helpful
I bought Omega 3 for my high cholesterol and triglycerides. It definitely works alongside my weight loss efforts. I lost 11 kg and observed improvements. This supplement, along with multivitamins, has positively influenced my cholesterol levels.
8
Normal cholesterol levels
3 people found this helpful
Our goal in body building is to prevent "rust" in Omega-3 levels. After a month, my cholesterol levels normalised, and I’ll continue using this product for its beneficial effects.
7.5
Hair and skin benefits
1 people found this helpful
This is the best omega-rich product I’ve tried. Despite previous bad tastes, this subtle lemon flavour works well—it's gentle on my stomach and has visibly improved my hair and skin along with its heart and cholesterol benefits.
9
Perfect blood pressure
3 people found this helpful
My doctor recommended fish oil years ago, and this brand is my only choice now. It’s the only one without a fishy aftertaste, and it has improved my blood pressure and cholesterol levels, making it worth the investment.
7.5
Quality but pricey
1 people found this helpful
I find this brand ideal. The capsules are large yet soft, with no unpleasant smell. I take two with breakfast for better absorption. Although the price is steep, it's justified by the quality, and my cholesterol levels have improved.
9
Eicosapentaenoic acid benefits cholesterol
We explored the effects of eicosapentaenoic acid (EPA), a specific type of omega-3 fatty acid, on cholesterol levels in a recent study involving real-world supplement consumers. Participants took AlmegaPL capsules, which contain high amounts of EPA and are free of the other omega-3 fatty acid, DHA. This setup allowed us to gain insights from those who are already incorporating EPA into their diets.
Throughout the study, we monitored key health markers such as triglycerides, total cholesterol, and various types of cholesterol at different stages of supplementation. We observed that after six months of taking this supplement, participants showed a significant reduction in remnant cholesterol and maintained healthy triglyceride levels. Notably, this decrease in cholesterol did not come at the expense of raising low-density lipoprotein (LDL) levels, which is often a concern with other treatments.
These encouraging results reveal that EPA can be a beneficial addition for individuals looking to manage their cholesterol levels effectively. Importantly, our findings highlight AlmegaPL's unique position as a natural, over-the-counter option for those seeking to improve their lipid profiles.
Throughout the study, we monitored key health markers such as triglycerides, total cholesterol, and various types of cholesterol at different stages of supplementation. We observed that after six months of taking this supplement, participants showed a significant reduction in remnant cholesterol and maintained healthy triglyceride levels. Notably, this decrease in cholesterol did not come at the expense of raising low-density lipoprotein (LDL) levels, which is often a concern with other treatments.
These encouraging results reveal that EPA can be a beneficial addition for individuals looking to manage their cholesterol levels effectively. Importantly, our findings highlight AlmegaPL's unique position as a natural, over-the-counter option for those seeking to improve their lipid profiles.
8
We examined the effects of eicosapentaenoic acid (EPA), an omega-3 fatty acid, on high cholesterol levels. In a systematic review of randomized controlled trials, we looked at studies involving at least 2 grams of EPA or its counterpart, docosahexaenoic acid (DHA).
Both EPA and DHA were found to lower triglyceride levels, with DHA appearing slightly more effective. Interestingly, we also saw that DHA increases high-density lipoprotein (HDL) cholesterol, which is known to promote heart health, while EPA does so as well, but to a lesser extent.
On the flip side, DHA has been observed to increase low-density lipoprotein (LDL) cholesterol, but it also enhances the size of LDL particles, making them less likely to contribute to artery blockages. Moreover, we noted that DHA might be more effective than EPA in reducing heart rate and blood pressure, which are essential factors in heart health.
Although both EPA and DHA show potential in promoting heart health by reducing inflammation and oxidative stress, the variations in their effects can make things complicated. We found that the evidence comparing EPA and DHA directly is limited, and more high-quality research is necessary to better understand their individual impacts on cholesterol and other cardiovascular risk factors.
Overall, while EPA has beneficial effects on cholesterol, further studies are needed to isolate these effects clearly from those of DHA.
Both EPA and DHA were found to lower triglyceride levels, with DHA appearing slightly more effective. Interestingly, we also saw that DHA increases high-density lipoprotein (HDL) cholesterol, which is known to promote heart health, while EPA does so as well, but to a lesser extent.
On the flip side, DHA has been observed to increase low-density lipoprotein (LDL) cholesterol, but it also enhances the size of LDL particles, making them less likely to contribute to artery blockages. Moreover, we noted that DHA might be more effective than EPA in reducing heart rate and blood pressure, which are essential factors in heart health.
Although both EPA and DHA show potential in promoting heart health by reducing inflammation and oxidative stress, the variations in their effects can make things complicated. We found that the evidence comparing EPA and DHA directly is limited, and more high-quality research is necessary to better understand their individual impacts on cholesterol and other cardiovascular risk factors.
Overall, while EPA has beneficial effects on cholesterol, further studies are needed to isolate these effects clearly from those of DHA.
9
We aimed to understand how Antarctic krill oil (ESKO) affects cholesterol levels, particularly in relation to obesity. Through our study involving mice, we observed that ESKO helped reduce oxidative stress and improve cholesterol metabolism.
While a high-fat diet usually worsens cholesterol levels, ESKO demonstrated a protective effect by reducing fat accumulation and promoting better metabolic health. This suggests that krill oil could be a promising option for managing high cholesterol and obesity-related issues.
While a high-fat diet usually worsens cholesterol levels, ESKO demonstrated a protective effect by reducing fat accumulation and promoting better metabolic health. This suggests that krill oil could be a promising option for managing high cholesterol and obesity-related issues.
9
We examined the impact of a highly purified eicosapentaenoic acid (EPA) formulation on cholesterol levels and overall heart health in individuals considered at high risk for cardiovascular issues. The study involved 226 patients who had high triglycerides and one or more cardiovascular risk factors, such as hypertension or diabetes.
Participants received 4 grams of EPA daily for three months alongside regular nutritional counseling. By tracking key health markers, we noted significant improvements in cholesterol levels, particularly in triglycerides and low-density lipoprotein (LDL). For instance, triglyceride levels dropped from an average of 2.97 mmol/L to 1.75 mmol/L in just three months.
Additionally, we found improvements in other important metrics, including total cholesterol and glucose levels, indicating that EPA supplementation may have broad benefits for cardiometabolic health. Although apolipoprotein A levels did not change significantly, the overall trend suggests that incorporating EPA could play a role in achieving better heart health outcomes.
Participants received 4 grams of EPA daily for three months alongside regular nutritional counseling. By tracking key health markers, we noted significant improvements in cholesterol levels, particularly in triglycerides and low-density lipoprotein (LDL). For instance, triglyceride levels dropped from an average of 2.97 mmol/L to 1.75 mmol/L in just three months.
Additionally, we found improvements in other important metrics, including total cholesterol and glucose levels, indicating that EPA supplementation may have broad benefits for cardiometabolic health. Although apolipoprotein A levels did not change significantly, the overall trend suggests that incorporating EPA could play a role in achieving better heart health outcomes.
8
We explored the possible benefits of omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in treatment for high cholesterol. While statins effectively reduce LDL cholesterol, some people still face risks from high triglycerides.
Large clinical trials are underway to fully assess the benefits of omega-3s. The results so far show that EPA can lower triglyceride levels and may help reduce cardiovascular events more effectively than other treatments. Though promising, further studies are needed to solidify their role in heart health for those with controlled LDL levels but high triglycerides.
Large clinical trials are underway to fully assess the benefits of omega-3s. The results so far show that EPA can lower triglyceride levels and may help reduce cardiovascular events more effectively than other treatments. Though promising, further studies are needed to solidify their role in heart health for those with controlled LDL levels but high triglycerides.
8
We assessed the effectiveness of omega-3-acid ethyl acetate, which includes docosahexaenoic acid (DHA), in managing high cholesterol, particularly focusing on patients with severe hypertriglyceridemia. In a carefully designed randomized, double-blind, placebo-controlled study, 239 participants were assigned to receive either omega-3 capsules or a placebo for 12 weeks.
Throughout the study period, we measured various cholesterol-related indicators at the start and after 4, 8, and 12 weeks. We observed significant reductions in triacylglycerols, total cholesterol, non-high-density lipoprotein cholesterol, very-low-density lipoprotein cholesterol, and apolipoprotein C-III in the omega-3 group compared to the placebo. These findings suggest that the combined omega-3 treatment, which prominently features DHA, can enhance lipid profiles in patients struggling with severe hypertriglyceridemia.
However, it’s important to note that there was no significant change observed in high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, or the LDL-C/HDL-C ratio between the two groups. Furthermore, the safety profile was similar across both groups, indicating that omega-3 capsules are generally well-tolerated. Overall, while DHA is part of the treatment, we could not isolate its specific impact on cholesterol levels due to the study’s design, which considered the effects of the omega-3 formulation collectively.
Throughout the study period, we measured various cholesterol-related indicators at the start and after 4, 8, and 12 weeks. We observed significant reductions in triacylglycerols, total cholesterol, non-high-density lipoprotein cholesterol, very-low-density lipoprotein cholesterol, and apolipoprotein C-III in the omega-3 group compared to the placebo. These findings suggest that the combined omega-3 treatment, which prominently features DHA, can enhance lipid profiles in patients struggling with severe hypertriglyceridemia.
However, it’s important to note that there was no significant change observed in high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, or the LDL-C/HDL-C ratio between the two groups. Furthermore, the safety profile was similar across both groups, indicating that omega-3 capsules are generally well-tolerated. Overall, while DHA is part of the treatment, we could not isolate its specific impact on cholesterol levels due to the study’s design, which considered the effects of the omega-3 formulation collectively.
8
We explored how eicosapentaenoic acid (EPA) impacts cholesterol, particularly focusing on its effects in patients with high triglyceride levels. Research indicates that hypertriglyceridaemia can contribute significantly to atherosclerotic cardiovascular disease (ASCVD), even in patients who have low levels of low-density lipoprotein cholesterol (LDL-C) due to treatments like statins.
While previous studies have shown mixed results regarding the effectiveness of triglyceride-lowering medications, EPA stands out in providing favorable outcomes for certain patient groups. It's worth noting that the combination of EPA with another substance, docosahexaenoic acid (DHA), has not demonstrated the same benefits.
The key takeaway is that while the search for efficient treatments continues, isolated EPA treatment has shown promise in reducing ASCVD risk, especially for patients struggling with high triglyceride levels. This suggests that as we develop our understanding of cholesterol management, EPA could be an important piece of the puzzle for those at risk.
While previous studies have shown mixed results regarding the effectiveness of triglyceride-lowering medications, EPA stands out in providing favorable outcomes for certain patient groups. It's worth noting that the combination of EPA with another substance, docosahexaenoic acid (DHA), has not demonstrated the same benefits.
The key takeaway is that while the search for efficient treatments continues, isolated EPA treatment has shown promise in reducing ASCVD risk, especially for patients struggling with high triglyceride levels. This suggests that as we develop our understanding of cholesterol management, EPA could be an important piece of the puzzle for those at risk.
References
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- Hirako S, Kim H, Iizuka Y, Matsumoto A. Fish oil consumption prevents hepatic lipid accumulation induced by high-cholesterol feeding in obese KK mice. Biomed Res. 2024;45:33. doi:10.2220/biomedres.45.33
- Mjaatveit M, Oldernes H, Gudbrandsen OA. Effects of diets containing fish oils or fish oil concentrates with high cetoleic acid content on the circulating cholesterol concentration in rodents. A systematic review and meta-analysis. Br J Nutr. 2024;131:606. doi:10.1017/S0007114523002118
- Zhang C, Wang X, Sun S, Fu Y, Wu Y, et al. Fat-1 expression alleviates atherosclerosis in transgenic rabbits. J Cell Mol Med. 2022;26:1306. doi:10.1111/jcmm.17188
- Sugimoto K, Hosomi R, Shimono T, Kanda S, Nishiyama T, et al. Comparison of the Cholesterol-Lowering Effect of Scallop Oil Prepared from the Internal Organs of the Japanese Giant Scallop (Patinopecten yessoensis), Fish Oil, and Krill Oil in Obese Type II Diabetic KK-A Mice. J Oleo Sci. 2021;70:965. doi:10.5650/jos.ess21032
- Jaca A, Durão S, Harbron J. Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease. S Afr Med J. 2020;110:1158. doi:10.7196/SAMJ.2020.v110i12.14730
- Trivedi K, Le V, Nelson JR. The case for adding eicosapentaenoic acid (icosapent ethyl) to the ABCs of cardiovascular disease prevention. Postgrad Med. 2021;133:28. doi:10.1080/00325481.2020.1783937
- Saito M, Ishida N, Yamada H, Ibi M, Hirose M. 8-HEPE-Concentrated Materials from Pacific Krill Improve Plasma Cholesterol Levels and Hepatic Steatosis in High Cholesterol Diet-Fed Low-Density Lipoprotein (LDL) Receptor-Deficient Mice. Biol Pharm Bull. 2020;43:919. doi:10.1248/bpb.b20-00162
- Llop-Talaveron J, Badía-Tahull M, Lozano-Andreu T, Rigo-Bonnin R, Virgili-Casas N, et al. Phytosterolemia and γ-glutamyl transferase in adults with parenteral nutrition: Fish versus vegetal lipids: A randomized clinical trial. Nutrition. 2020;70:110587. doi:10.1016/j.nut.2019.110587
- Antona ME, Ramos C, Stranges A, Monteiro AF, Gonzales Chaves MM, et al. Fish oil diet effects on alveolar bone loss, in hypercholesterolemic rats. Arch Oral Biol. 2020;109:104553. doi:10.1016/j.archoralbio.2019.104553
- Zhou Q, Zhang Z, Wang P, Zhang B, Chen C, et al. EPA+DHA, but not ALA, Improved Lipids and Inflammation Status in Hypercholesterolemic Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. Mol Nutr Food Res. 2019;63:e1801157. doi:10.1002/mnfr.201801157
- Bhatt DL, Steg PG, Miller M, Brinton EA, Jacobson TA, et al. Effects of Icosapent Ethyl on Total Ischemic Events: From REDUCE-IT. J Am Coll Cardiol. 2019;73:2791. doi:10.1016/j.jacc.2019.02.032
- Preston Mason R. New Insights into Mechanisms of Action for Omega-3 Fatty Acids in Atherothrombotic Cardiovascular Disease. Curr Atheroscler Rep. 2019;21:2. doi:10.1007/s11883-019-0762-1
- Vikøren LA, Drotningsvik A, Bergseth MT, Mjøs SA, Austgulen MH, et al. Intake of Baked Cod Fillet Resulted in Lower Serum Cholesterol and Higher Long Chain -3 PUFA Concentrations in Serum and Tissues in Hypercholesterolemic Obese Zucker fa/fa Rats. Nutrients. 2018;10. doi:10.3390/nu10070840
- Blom WAM, Koppenol WP, Hiemstra H, Stojakovic T, Scharnagl H, et al. A low-fat spread with added plant sterols and fish omega-3 fatty acids lowers serum triglyceride and LDL-cholesterol concentrations in individuals with modest hypercholesterolaemia and hypertriglyceridaemia. Eur J Nutr. 2019;58:1615. doi:10.1007/s00394-018-1706-1
- Shen J, Rastogi R, Guan L, Li F, Du H, et al. Omega-3 fatty acid supplement reduces activation of NADPH oxidase in intracranial atherosclerosis stenosis. Neurol Res. 2018;40:499. doi:10.1080/01616412.2018.1451290
- Yunoki K, Matsumi H, Miyoshi T, Kubo M, Hata Y, et al. Clinical Significance of Serum Omega-3 Fatty Acids on Endothelial Function in Patients with Coronary Artery Disease Under Statin Therapy. J Cardiovasc Dev Dis. 2025;12. doi:10.3390/jcdd12020060
- Aggarwal R, Bhatt DL, Steg PG, Miller M, Brinton EA, et al. Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial. J Am Heart Assoc. 2025;14:e038656. doi:10.1161/JAHA.124.038656
- Uthaiah NM, Venkataramareddy SR, Mudhol S, Sheikh AY. EPA-rich Nannochloropsis oceanica biomass regulates gut microbiota, alleviates inflammation and ameliorates liver fibrosis in rats. Food Res Int. 2025;202:115733. doi:10.1016/j.foodres.2025.115733
- Yoshikiyo K, Shimizu H, Nagato EG, Ishizuka S, Yamamoto T. Comparative Analysis of γ-Cyclodextrin, Perilla Oil, and Their Inclusion Complexes on Liver Injury and Dyslipidemia Associated with Elevated Gastrointestinal 12-Hydroxylated Bile Acid Levels. Molecules. 2025;30. doi:10.3390/molecules30020281
- Lamantia V, Bissonnette S, Beaudry M, Cyr Y, Rosiers CD, et al. EPA and DHA inhibit LDL-induced upregulation of human adipose tissue NLRP3 inflammasome/IL-1β pathway and its association with diabetes risk factors. Sci Rep. 2024;14:27146. doi:10.1038/s41598-024-73672-6
- Choi GY, Calder PC. The differential effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors: an updated systematic review of randomized controlled trials. Front Nutr. 2024;11:1423228. doi:10.3389/fnut.2024.1423228
- Bashir B, Schofield J, Downie P, France M, Ashcroft DM, et al. Beyond LDL-C: unravelling the residual atherosclerotic cardiovascular disease risk landscape-focus on hypertriglyceridaemia. Front Cardiovasc Med. 2024;11:1389106. doi:10.3389/fcvm.2024.1389106
- Lin YL, Wang CL, Chiang TI. Eicosapentaenoic acid supplementation alleviates pruritus, enhances skin moisture, and mitigates depression in maintenance hemodialysis patients. Front Nephrol. 2024;4:1365809. doi:10.3389/fneph.2024.1365809
- Omari M, Alkhalil M. Atherosclerosis Residual Lipid Risk-Overview of Existing and Future Pharmacotherapies. J Cardiovasc Dev Dis. 2024;11. doi:10.3390/jcdd11040126
- Szarek M, Bhatt DL, Miller M, Brinton EA, Jacobson TA, et al. Lipoprotein(a) Blood Levels and Cardiovascular Risk Reduction With Icosapent Ethyl. J Am Coll Cardiol. 2024;83:1529. doi:10.1016/j.jacc.2024.02.016
- Liakos CI, Lanaras L, Bristianou M, Papadopoulos DP. Pleiotropic beneficial cardiometabolic actions of a high-purity eicosapentaenoic acid product in high cardiovascular risk individuals. Lipids. 2024;59:67. doi:10.1002/lipd.12391
- Ganuza E, Etomi EH, Olson M, Whisner CM. Omega-3 eicosapentaenoic polar-lipid rich extract from microalgae decreases plasma triglycerides and cholesterol in a real-world normolipidemic supplement consumer population. Front Nutr. 2024;11:1293909. doi:10.3389/fnut.2024.1293909
- Kobayashi Y, Fujikawa T, Haruna A, Kawano R, Ozawa M, et al. Omega-3 Fatty Acids Reduce Remnant-like Lipoprotein Cholesterol and Improve the Ankle-Brachial Index of Hemodialysis Patients with Dyslipidemia: A Pilot Study. Medicina (Kaunas). 2023;60. doi:10.3390/medicina60010075
- Mueller PA, Bergstrom P, Rosario S, Heard M, Pamir N. Fish Oil Supplementation Modifies the Proteome, Lipidome, and Function of High-Density Lipoprotein: Findings from a Trial in Young Healthy Adults. J Nutr. 2024;154:1130. doi:10.1016/j.tjnut.2024.01.007
- Kaur G, Mason RP, Steg PG, Bhatt DL. Omega-3 fatty acids for cardiovascular event lowering. Eur J Prev Cardiol. 2024;31:1005. doi:10.1093/eurjpc/zwae003
- Chang Y, Xuan Y, Zhang R, Ding X, Zeng Q, et al. Effects of Dietary Schizochytrium Algae as ω-3 PUFA Source on the Egg-Laying Quail Performance, Serum Indexes, and Egg Yolk Fatty Acids Contents. Animals (Basel). 2024;15. doi:10.3390/ani15010021
- Li J, Guo J, Yuen M, Yuen H, Peng Q. The comparative effects of ω-7 fatty acid-rich sea buckthorn oil and ω-3 fatty acid-rich DHA algal oil on improving high-fat diet-induced hyperlipidemia. Food Funct. 2025;16:1241. doi:10.1039/d4fo04961f
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