Last update
3/26/2026
Reviewed By
Infographics
Overview
SCIENTIFIC SCORE
Questionable
Based on 21 Researches
6.9
USERS' SCORE
Good
Based on 2 Reviews
8.4
Supplement Facts
Serving Size: 2 Soft Gels
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%
Saturated Fat
0 g
0%
Trans Fat
0 g
†
Vitamin D3 (cholecalciferol)
25 mcg (1000 IU)
125%
Total Omega-3s♦
1280 mg
†
EPA (Eicosapentaenoic Acid)
650 mg
†
DHA (Docosahexaenoic Acid)
450 mg
†
Top Medical Research Studies
9
We observed that omega-3 fatty acids, particularly EPA and DHA, could be beneficial for patients struggling with acne. Over 16 weeks, 60 participants followed a Mediterranean diet and received algae-derived omega-3 supplements.
We found that most patients initially had low omega-3 levels, but these rose significantly during the study. Acne severity showed notable improvement, especially in those achieving optimal omega-3 levels. Though four patients reported worsened appearance, overall quality of life improved for the majority.
We found that most patients initially had low omega-3 levels, but these rose significantly during the study. Acne severity showed notable improvement, especially in those achieving optimal omega-3 levels. Though four patients reported worsened appearance, overall quality of life improved for the majority.
Read More
8
We systematically reviewed studies on how omega-3 and omega-6 fatty acids affect acne. Our findings indicate that omega-3s may help reduce acne, while some omega-6s could exacerbate it.
Additionally, our genetic analysis explored how these fatty acids interact with key enzymes related to acne. However, it's important to note that the study's population was limited primarily to Europeans, which may not reflect the broader community.
More diverse research is needed to fully understand these effects across different groups.
Additionally, our genetic analysis explored how these fatty acids interact with key enzymes related to acne. However, it's important to note that the study's population was limited primarily to Europeans, which may not reflect the broader community.
More diverse research is needed to fully understand these effects across different groups.
Read More
8
We examined how omega-3 fatty acids and gamma-linolenic acid could help with acne in a well-structured 10-week study. Involving 45 participants with mild to moderate acne, we compared those taking omega-3, those taking gamma-linolenic acid, and a control group.
The findings were promising: both omega-3 and gamma-linolenic acid showed a significant reduction in both inflammatory and non-inflammatory acne lesions. Participants also reported noticeable improvements in their skin. Importantly, no severe side effects were noted, indicating these supplements might be a beneficial addition to existing acne treatments.
The findings were promising: both omega-3 and gamma-linolenic acid showed a significant reduction in both inflammatory and non-inflammatory acne lesions. Participants also reported noticeable improvements in their skin. Importantly, no severe side effects were noted, indicating these supplements might be a beneficial addition to existing acne treatments.
Read More
Most Useful Reviews
9
Acne relief achieved
I tried various treatments, including creams and tretinoin tablets, for my acne, but the issue recurred after stopping. However, this product has been my saviour, as it seems my Vitamin D3 deficiency was the main cause of my acne.
Read More
7
Improved hair growth
I experienced significant hair loss, but after consuming fish oil for a month, I noticed the growth of baby hairs—this felt miraculous. I had also been on a restrictive diet, leading to nutrient deficiencies affecting my concentration and memory. After a month of fish oil, those issues resolved, and my mood improved. Additionally, my skin healed faster from acne pigmentation and felt softer. I'm increasing my dosage on my next purchase, hoping for continued positive results.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 21 Researches
6.9
- All Researches
9
We observed that omega-3 fatty acids, particularly EPA and DHA, could be beneficial for patients struggling with acne. Over 16 weeks, 60 participants followed a Mediterranean diet and received algae-derived omega-3 supplements.
We found that most patients initially had low omega-3 levels, but these rose significantly during the study. Acne severity showed notable improvement, especially in those achieving optimal omega-3 levels. Though four patients reported worsened appearance, overall quality of life improved for the majority.
We found that most patients initially had low omega-3 levels, but these rose significantly during the study. Acne severity showed notable improvement, especially in those achieving optimal omega-3 levels. Though four patients reported worsened appearance, overall quality of life improved for the majority.
Read More
9
We investigated the effectiveness of Tracnil™, which combines myo-inositol, folic acid, and vitamin D3, on acne and other dermatological issues in overweight women with conditions related to Polycystic Ovary Syndrome (PCOS). Our findings showed that participants experienced a significant reduction in both inflammatory and non-inflammatory acne lesions within just eight weeks.
Notably, alongside improvements in acne, we observed positive changes in hirsutism—excess hair growth—and menstrual irregularities. Throughout the study, participants' safety was closely monitored, showing minimal adverse effects, while hormone levels remained stable despite our subjects initially having normal readings.
This leads us to believe that Tracnil™ may help regulate the body's response to sex hormones or perform other essential functions in managing PCOS symptoms, even when hormonal levels are not significantly abnormal. Therefore, we suggest that Tracnil™ could be an effective first-line treatment option for addressing dermatological concerns related to PCOS, simplifying treatment for those affected.
Notably, alongside improvements in acne, we observed positive changes in hirsutism—excess hair growth—and menstrual irregularities. Throughout the study, participants' safety was closely monitored, showing minimal adverse effects, while hormone levels remained stable despite our subjects initially having normal readings.
This leads us to believe that Tracnil™ may help regulate the body's response to sex hormones or perform other essential functions in managing PCOS symptoms, even when hormonal levels are not significantly abnormal. Therefore, we suggest that Tracnil™ could be an effective first-line treatment option for addressing dermatological concerns related to PCOS, simplifying treatment for those affected.
Read More
8
We systematically reviewed studies on how omega-3 and omega-6 fatty acids affect acne. Our findings indicate that omega-3s may help reduce acne, while some omega-6s could exacerbate it.
Additionally, our genetic analysis explored how these fatty acids interact with key enzymes related to acne. However, it's important to note that the study's population was limited primarily to Europeans, which may not reflect the broader community.
More diverse research is needed to fully understand these effects across different groups.
Additionally, our genetic analysis explored how these fatty acids interact with key enzymes related to acne. However, it's important to note that the study's population was limited primarily to Europeans, which may not reflect the broader community.
More diverse research is needed to fully understand these effects across different groups.
Read More
8
We investigated whether omega-3 fatty acids could help manage acne by influencing gut bacteria. Over 12 weeks, untreated acne patients were divided into two groups: one received omega-3 supplements while the other didn’t. We also tested in rats with an acne model. The findings indicated that omega-3 increased gut bacteria diversity and enhanced beneficial bacteria linked to anti-inflammatory effects. However, despite these promising changes, we did not observe a significant overall impact on acne improvement in patients.
Read More
8
We examined how omega-3 fatty acids and gamma-linolenic acid could help with acne in a well-structured 10-week study. Involving 45 participants with mild to moderate acne, we compared those taking omega-3, those taking gamma-linolenic acid, and a control group.
The findings were promising: both omega-3 and gamma-linolenic acid showed a significant reduction in both inflammatory and non-inflammatory acne lesions. Participants also reported noticeable improvements in their skin. Importantly, no severe side effects were noted, indicating these supplements might be a beneficial addition to existing acne treatments.
The findings were promising: both omega-3 and gamma-linolenic acid showed a significant reduction in both inflammatory and non-inflammatory acne lesions. Participants also reported noticeable improvements in their skin. Importantly, no severe side effects were noted, indicating these supplements might be a beneficial addition to existing acne treatments.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Acne relief achieved
I tried various treatments, including creams and tretinoin tablets, for my acne, but the issue recurred after stopping. However, this product has been my saviour, as it seems my Vitamin D3 deficiency was the main cause of my acne.
Read More
7
Improved hair growth
I experienced significant hair loss, but after consuming fish oil for a month, I noticed the growth of baby hairs—this felt miraculous. I had also been on a restrictive diet, leading to nutrient deficiencies affecting my concentration and memory. After a month of fish oil, those issues resolved, and my mood improved. Additionally, my skin healed faster from acne pigmentation and felt softer. I'm increasing my dosage on my next purchase, hoping for continued positive results.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Zhang L, Li Y, Pu Y, Dang T, Shi Q, et al. Exploring clinical and genetic evidence in association between unsaturated fatty acids and acne. Eur J Nutr. 2025;64:130. 10.1007/s00394-025-03647-4
- Guertler A, Neu K, Lill D, Clanner-Engelshofen B, French LE, et al. Exploring the potential of omega-3 fatty acids in acne patients: A prospective intervention study. J Cosmet Dermatol. 2024;23:3295. 10.1111/jocd.16434
- Huang Y, Liu F, Lai J, Jiang S, Tan X, et al. The adjuvant treatment role of ω-3 fatty acids by regulating gut microbiota positively in the acne vulgaris. J Dermatolog Treat. 2024;35:2299107. 10.1080/09546634.2023.2299107
- Zainab Z, Malik NA, Obaid S, Malik S, Aftab K, et al. Effectiveness Of Oral Omega 3 In Reducing Mucocutaneous Side Effects Of Oral Isotretinoin In Patients With Acne Vulgaris. J Ayub Med Coll Abbottabad. 2021;33:60. PubMed
- Thomsen BJ, Chow EY, Sapijaszko MJ. The Potential Uses of Omega-3 Fatty Acids in Dermatology: A Review. J Cutan Med Surg. 2020;24:481. 10.1177/1203475420929925
- Aslan İ, Özcan F, Karaarslan T, Kıraç E, Aslan M. Decreased eicosapentaenoic acid levels in acne vulgaris reveals the presence of a proinflammatory state. Prostaglandins Other Lipid Mediat. 2017;128-129:1. 10.1016/j.prostaglandins.2016.12.001
- Jung JY, Kwon HH, Hong JS, Yoon JY, Park MS, et al. Effect of dietary supplementation with omega-3 fatty acid and gamma-linolenic acid on acne vulgaris: a randomised, double-blind, controlled trial. Acta Derm Venereol. 2014;94:521. 10.2340/00015555-1802
- Khayef G, Young J, Burns-Whitmore B, Spalding T. Effects of fish oil supplementation on inflammatory acne. Lipids Health Dis. 2012;11:165. 10.1186/1476-511X-11-165
- Kim BR, Kim G, Jin SP, Choi CW, Kim J, et al. The causal association between polyunsaturated fatty acids and acne: A two-sample Mendelian randomization study. Br J Dermatol. 2025. 10.1093/bjd/ljaf052
- Dahlan NH, Sitohang IBS, Indriatmi W, Wibowo H, Enggy LE. Correlation Between Reduced IL-1β Levels in Acne Lesions and the Decrease in Acne Inflammatory Lesions Following Topical Vitamin D Administration: A Double-Blind Randomized Controlled Trial. Clin Cosmet Investig Dermatol. 2024;17:2183. 10.2147/CCID.S475068
- Singh A, Dorjay K, Sinha S, Chitkara A. The interplay of vitamin D and body mass index in acne patients vs. controls. J Cosmet Dermatol. 2021;20:3689. 10.1111/jocd.14034
- Ramanan EA, Ravi S, Anbu KRR, Michael M. Efficacy and Safety of Tracnil™ Administration in Patients with Dermatological Manifestations of PCOS: An Open-Label Single-Arm Study. Dermatol Res Pract. 2020;2020:7019126. 10.1155/2020/7019126
- Abd-Elmaged WM, Nada EA, Hassan MH, Elsadek BEM, Abdelrahim EA, et al. Lesional and circulating levels of interleukin-17 and 25-hydroxycholecalciferol in active acne vulgaris: Correlation to disease severity. J Cosmet Dermatol. 2019;18:671. 10.1111/jocd.12715
- Sardana K, Verma G. and the Th1/Th17 Axis, Implications in Acne Pathogenesis and Treatment. Indian J Dermatol. 2017;62:392. 10.4103/ijd.IJD_483_16
- Zouboulis CC, Seltmann H, Abdel-Naser MB, Hossini AM, Menon GK, et al. Effects of Extracellular Calcium and 1,25 dihydroxyvitamin D3 on Sebaceous Gland Cells In vitro and In vivo. Acta Derm Venereol. 2017;97:313. 10.2340/00015555-2525
- Lim SK, Ha JM, Lee YH, Lee Y, Seo YJ, et al. Comparison of Vitamin D Levels in Patients with and without Acne: A Case-Control Study Combined with a Randomized Controlled Trial. PLoS One. 2016;11:e0161162. 10.1371/journal.pone.0161162
- Nieves NJ, Ahrens JM, Plum LA, DeLuca HF, Clagett-Dame M. Identification of a unique subset of 2-methylene-19-nor analogs of vitamin D with comedolytic activity in the rhino mouse. J Invest Dermatol. 2010;130:2359. 10.1038/jid.2010.142
- Reichrath J. Vitamin D and the skin: an ancient friend, revisited. Exp Dermatol. 2007;16:618. PubMed
- Hayashi N, Watanabe H, Yasukawa H, Uratsuji H, Kanazawa H, et al. Comedolytic effect of topically applied active vitamin D3 analogue on pseudocomedones in the rhino mouse. Br J Dermatol. 2006;155:895. PubMed
- Desbois AP, Lawlor KC. Antibacterial activity of long-chain polyunsaturated fatty acids against Propionibacterium acnes and Staphylococcus aureus. Mar Drugs. 2013;11:4544. 10.3390/md11114544
- Rubin MG, Kim K, Logan AC. Acne vulgaris, mental health and omega-3 fatty acids: a report of cases. Lipids Health Dis. 2008;7:36. 10.1186/1476-511X-7-36
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