We explored the effectiveness of vitamin E alongside isotretinoin, a common treatment for severe acne. In an investigator-blinded, randomized study involving 82 patients, participants were divided into two groups. One group received isotretinoin alone, while the other combined it with 800 IU of vitamin E, over a period of 16 weeks.
Our main goal was to determine whether vitamin E could reduce the side-effects associated with isotretinoin, which are often bothersome for patients. Throughout the study, we assessed various mucocutaneous side effects, such as facial dryness and redness, as well as changes in serum lipid and liver enzyme levels.
Ultimately, we found no significant difference in the incidence or severity of side effects between the two treatment groups. This indicates that vitamin E did not provide any noticeable benefit when added to isotretinoin therapy for acne vulgaris.
While vitamin E is often suggested as a remedy to lighten the side effects of medications, our findings suggest that its use alongside isotretinoin may not be helpful.
Read More
2
Vitamin E ineffective for acne therapy
Concomitant administration of vitamin E does not change the side effects of isotretinoin as used in acne vulgaris: a randomized trial.
We conducted a study to assess whether vitamin E could help reduce the side effects associated with isotretinoin, a common treatment for severe acne. In this double-blind, randomized trial, we assigned 140 participants to receive either isotretinoin paired with a daily dose of 800 IU of vitamin E or a placebo over 20 weeks.
We closely monitored the participants for any side effects such as dry eyes and dry lips. Despite our hopes, the addition of vitamin E did not show any significant improvement in the side effects experienced by those taking isotretinoin. In essence, we found that vitamin E had little to no effect in alleviating the discomfort associated with isotretinoin treatment for acne.
This study thoroughly evaluated the potential benefits of combining vitamin E with isotretinoin but ultimately concluded that the vitamin does not mitigate the adverse side effects of the medication. It’s clear that vitamin E alone might not be the miracle solution for easing isotretinoin side effects as some had hoped.
Read More
9
Vitamin E may reduce acne lesions
Addressing Free Radical Oxidation in Acne Vulgaris.
We explored the effects of vitamin E on acne by conducting an open-label study with 17 patients who had mild to moderate acne vulgaris. Over eight weeks, these patients followed a standard regimen involving salicylic acid and benzoyl peroxide, with the addition of topical vitamin E in sunflower seed oil.
Throughout the study, we observed that all participants experienced clinical improvements, including a reduction in the number of acne lesions. Interestingly, significant improvements were noted as early as Week 2, indicating that vitamin E may play a beneficial role in managing acne symptoms. Furthermore, patients reported positive feedback regarding the ease of application and tolerability of the treatment.
Although we cannot definitively say vitamin E is a cure for acne, our findings suggest that it may help alleviate some symptoms when used alongside established treatments. This research sheds light on the potential of topical antioxidants like vitamin E in the ongoing battle against acne, inviting further exploration into their effectiveness and role in skincare.
Read More
Most Useful Reviews
10
No acne experienced
5 people found this helpful
Excellent vitamins! I'm very satisfied as my skin is now radiant. I had persistent acne before, but after three weeks of taking these vitamins, I no longer had any at all.
Read More
9
Healthy skin attained
3 people found this helpful
After prolonged prednisone use, my skin was in a dreadful state, but following two weeks of taking vitamin E, my acne disappeared, oiliness reduced, and my skin looks healthy and beautiful. I took one capsule daily.
Read More
6
Redness reduced
23 people found this helpful
With the help of this and some vitamins, I tackled acne and facial redness. Unfortunately, a surgical procedure and the recovery period stopped me from completing the course, but after two weeks the redness vanished and I had significantly fewer acne spots. Highly recommend!
A randomized, double-blind, placebo-controlled trial to determine the efficacy and safety of lactoferrin with vitamin E and zinc as an oral therapy for mild to moderate acne vulgaris.
We observed how a combination of lactoferrin, vitamin E, and zinc might affect mild to moderate acne. In a rigorously designed study, 168 participants aged 13 to 40 were randomly assigned to receive either a treatment capsule containing these ingredients or a placebo twice a day over the course of three months.
The results showcased that those taking the lactoferrin combination saw a notable reduction in acne lesions—an early 14.5% improvement after just two weeks, reaching a maximum of 28.5% reduction by week ten. While vitamin E was part of the treatment, it’s essential to understand that it was combined with lactoferrin and zinc. This means we can't pinpoint vitamin E's specific role in the improvements observed.
Throughout the trial, no adverse effects were reported, reinforcing the safety of the treatment. Overall, this study presents promising findings for those struggling with mild to moderate acne, particularly with the effective dosing of lactoferrin alongside vitamin E and zinc.
Read More
9
Vitamin E may reduce acne lesions
Addressing Free Radical Oxidation in Acne Vulgaris.
We explored the effects of vitamin E on acne by conducting an open-label study with 17 patients who had mild to moderate acne vulgaris. Over eight weeks, these patients followed a standard regimen involving salicylic acid and benzoyl peroxide, with the addition of topical vitamin E in sunflower seed oil.
Throughout the study, we observed that all participants experienced clinical improvements, including a reduction in the number of acne lesions. Interestingly, significant improvements were noted as early as Week 2, indicating that vitamin E may play a beneficial role in managing acne symptoms. Furthermore, patients reported positive feedback regarding the ease of application and tolerability of the treatment.
Although we cannot definitively say vitamin E is a cure for acne, our findings suggest that it may help alleviate some symptoms when used alongside established treatments. This research sheds light on the potential of topical antioxidants like vitamin E in the ongoing battle against acne, inviting further exploration into their effectiveness and role in skincare.
Read More
9
Vitamin E shows positive acne effects
Modulation of sebum oxidation and interleukin-1α levels associates with clinical improvement of mild comedonal acne.
We looked into how a combination of RetinSphere® and vitamin E affects mild comedonal acne (MCA). In our study, we measured important factors like sebum oxidation and inflammatory markers before and after treatment in 18 patients with MCA and 10 healthy controls.
Our findings showed that while the amount of sebum and squalene was similar before treatment between the groups, patients with MCA had higher levels of lipid peroxidation and oxidized squalene. These elevated markers contribute to inflammation and acne formation.
After 4 weeks, there was a notable decrease in oxidized lipids and inflammation markers in the lesions, bringing them in line with unaffected areas. These changes were accompanied by visible clinical improvement in the patients by the 8-week mark.
Yet, it’s important to recognize that while vitamin E was part of the treatment mix, this study did not isolate its specific effects. Thus, while we observed positive results, we cannot definitively attribute all improvements directly to vitamin E alone.
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8
Vitamin E aids isotretinoin therapy
A dietary supplement to reduce side effects of oral isotretinoin therapy in acne patients.
We investigated the potential of a dietary supplement containing vitamin E and other ingredients to alleviate side effects from oral isotretinoin therapy in acne patients. The study involved forty-eight participants with nodular acne, divided into two groups. One group received isotretinoin combined with the supplement, while the other only received isotretinoin for six months.
Our findings revealed that the group taking the dietary supplement reported fewer side effects, experiencing less dryness and redness of the skin, as well as improved hydration levels. Participants also showed increased adherence to their treatment regimen when supplemented, which is encouraging for those battling the challenges of acne and its treatment.
The supplement's formulation, enriched with vitamin E and other antioxidants, seems to support skin health during isotretinoin therapy, helping to mitigate common discomforts like dry skin and erythema. This suggests that vitamin E plays a beneficial role when included in a combination supplement, enhancing overall treatment experience for patients undergoing isotretinoin therapy.
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8
Vitamin E linked to acne severity
Does the plasma level of vitamins A and E affect acne condition?
We aimed to understand how plasma levels of vitamins A and E relate to acne conditions. To do this, we compared vitamin concentrations in 100 newly diagnosed acne patients with 100 healthy individuals of similar age. We utilized high-performance liquid chromatography to ensure accurate measurements, and acne severity was evaluated using the Global Acne Grading System.
Our findings revealed that acne patients had noticeably lower levels of both vitamin A and vitamin E compared to the controls. Specifically, vitamin A levels were 336.5 µg/L for patients versus 418.1 µg/L for healthy individuals, while vitamin E levels were 5.4 mg/L in patients against 5.9 mg/L in controls.
Additionally, we observed a clear link: as the severity of acne increased, the plasma levels of vitamins A and E tended to decrease. This suggests that these vitamins may play a role in the condition's progression, highlighting their potential importance in acne management.
However, it's essential to consider that while the correlation between low vitamin levels and acne severity is significant, the study does not confirm that vitamin E supplementation alone can effectively treat acne.
Excellent vitamins! I'm very satisfied as my skin is now radiant. I had persistent acne before, but after three weeks of taking these vitamins, I no longer had any at all.
Read More
9
Healthy skin attained
3 people found this helpful
After prolonged prednisone use, my skin was in a dreadful state, but following two weeks of taking vitamin E, my acne disappeared, oiliness reduced, and my skin looks healthy and beautiful. I took one capsule daily.
Read More
6
Redness reduced
23 people found this helpful
With the help of this and some vitamins, I tackled acne and facial redness. Unfortunately, a surgical procedure and the recovery period stopped me from completing the course, but after two weeks the redness vanished and I had significantly fewer acne spots. Highly recommend!
Read More
7.5
Skin problems improved
My skin has become clearer thanks to these supplements, effectively reducing issues like acne and redness. I didn't mind their size or taste as I took them with water!
Read More
7.5
Skin quality improved
11 people found this helpful
Vitamin E boosts skin turnover! I took it for beauty alongside vitamin C, which improved my inner dryness and cured my acne. Initially, I didn't notice any smell, but it developed after six months. Though expensive, the consistent positive effects make it worth considering another purchase.
Read More
Frequently Asked Questions
Acne is a common skin condition that affects people of all ages, though it's especially prevalent among teenagers and young adults. It occurs when hair follicles become clogged with oil and dead skin cells, leading to the formation of pimples, blackheads, and cysts. The main factors contributing to acne include excess oil production, hormonal changes, and the presence of bacteria on the skin. Acne can manifest in various forms, from mild cases with just a few breakouts to more severe forms that can cause significant inflammation and scarring.
Treatment for acne varies depending on its severity and can range from over-the-counter topical treatments like benzoyl peroxide and salicylic acid to prescription medications including retinoids and antibiotics. Lifestyle adjustments, such as maintaining a balanced diet and proper skin hygiene, may also contribute to managing and reducing breakouts. Despite being a common skin issue, the psychological impact of acne should not be underestimated, as it can affect self-esteem and overall quality of life.
Vitamin E is a fat-soluble nutrient that plays a crucial role in various bodily functions, primarily acting as an antioxidant. This means it helps to neutralize free radicals, which are unstable molecules that can cause oxidative stress, leading to cellular damage. Vitamin E is not just one compound, but a group of several related compounds, with tocopherols and tocotrienols being the most studied forms. These compounds are found in various foods, including nuts, seeds, and green leafy vegetables, making it relatively easy to obtain sufficient amounts through a balanced diet.
Research suggests that Vitamin E may contribute to immune function, skin health, and the overall maintenance of cardiovascular health. While most people can get enough Vitamin E from their diet, supplements may be necessary for those with specific deficiencies or conditions that impair absorption. However, it’s important to consult a healthcare provider before starting any supplement regimen, as excessive intake of Vitamin E can lead to adverse effects. Overall, maintaining adequate Vitamin E levels is essential for promoting long-term health and preventing potential deficiencies.
Vitamin E is often touted for its potential benefits in skin health, including acne management. This fat-soluble antioxidant can help reduce oxidative stress and inflammation in the skin, which may be beneficial for those dealing with acne. Additionally, it’s known for its moisturizing properties, potentially aiding in the repair of the skin barrier, which is crucial for those suffering from acne. However, while some users report improvements in their skin texture and appearance when using Vitamin E topically, scientific studies supporting its effectiveness specifically for treating acne are limited.
It's important to note that while Vitamin E may provide some benefits, it is not a standalone solution for acne treatment. Individuals struggling with persistent acne should consult with a dermatologist to discuss a comprehensive skincare regimen that may include other proven treatments, such as benzoyl peroxide, salicylic acid, retinoids, or prescription medications. Always conduct a patch test prior to introducing any new product into your routine, as some individuals may experience irritation or breakouts from oilier formulations.
Based on user reviews, individuals taking this supplement for acne typically begin to see positive results within two to three weeks. For instance, one user reported a complete disappearance of persistent acne after three weeks of use Read Review. Another reviewer mentioned experiencing significant improvements, including reduced acne and oiliness, after just two weeks of taking the supplement Read Review.
It's worth noting that while many users express satisfaction with the speed of results, individual experiences may vary. Some reported that in as little as two weeks, they noticed fewer acne spots and a reduction in facial redness Read Review. Overall, for those considering these supplements for acne, it seems a timeframe of two to three weeks is a good estimate for initial results.
Vitamin E's role in acne treatment is an area of ongoing investigation, with some studies suggesting potential benefits while others indicate limited effectiveness. Research has found that patients with acne often have significantly lower serum levels of vitamin E compared to healthy individuals, which raises questions about its involvement in skin health [1]. In an open-label study, topical vitamin E showed promise when used alongside established treatments like salicylic acid and benzoyl peroxide, with participants reporting improvements in acne symptoms over eight weeks [3]. However, it’s crucial to note that this study did not establish vitamin E as a standalone treatment for acne.
Conversely, numerous clinical trials assessing vitamin E in conjunction with isotretinoin—one of the most effective treatments for severe acne—have generally found no significant benefits in reducing side effects or enhancing treatment efficacy [12]. While some formulations containing vitamin E, selenium, and other antioxidants seem to help certain patients temporarily [16], the overarching consensus across multiple studies is that vitamin E's direct impact on acne treatment remains inconclusive, necessitating further exploration into its potential benefits in skin care [13].
Based on user reviews, many individuals have reported notable improvements in their skin condition after using supplemental vitamins, particularly in relation to acne and overall skin radiance. For example, one user noted that their persistent acne had completely disappeared within just three weeks of taking the vitamins, leading to a much more radiant complexion Read Review. Another reviewer experienced a dramatic effect, citing a reduction in both acne and oiliness after two weeks, resulting in healthier-looking skin Read Review.
Additionally, several users have mentioned alleviation of facial redness alongside acne reduction. One individual reported a significant decrease in redness and fewer acne spots after a two-week period, despite a prior surgical procedure that hindered their full treatment regimen Read Review. Overall, while results can vary from person to person, these testimonials suggest that many users have found success in addressing skin issues like acne and redness with these supplements.
Users have had positive experiences combining this supplement with others to effectively manage acne and improve overall skin health. For instance, one user mentioned that alongside these vitamins, they used vitamin E, which significantly helped in reducing their acne and improving skin texture, leading to a beautifully healthy appearance Read Review. Another user reported that they tackled both acne and facial redness with the help of this supplement and additional vitamins, resulting in fewer acne spots within just two weeks Read Review.
Additionally, users have noted that taking other supplements, like vitamin C, alongside this product has enhanced their skin's moisture and supported the treatment of acne Read Review. This synergy seems to contribute to clearer skin overall, with various users commenting on the reduction of acne and improved radiance when combining these vitamin supplements in their skincare routine. While individual results may vary, it appears that many have found that pairing these supplements can yield even better results for acne management.
Users report positive outcomes when taking Vitamin E for treating acne, with several noting that regular doses can yield significant improvements in skin condition. One user specifically mentioned that after two weeks of taking one capsule daily, their acne had disappeared, and their skin appeared healthy and beautiful Read Review. Another user experienced clearer skin and reduced issues like acne and redness, indicating that consistent use may also contribute to long-term skin health Read Review.
While specific dosage amounts weren't consistently detailed across reviews, the discovery of benefits like reduced acne after two weeks of supplementation suggests that users may find success with daily doses. For example, one user reported a complete lack of acne after three weeks of taking their vitamins Read Review. Overall, while the exact right dose for everyone might vary, taking Vitamin E daily appears to positively impact skin clarity and acne issues for many users.
10
No acne experienced
5 people found this helpful
Excellent vitamins! I'm very satisfied as my skin is now radiant. I had persistent acne before, but after three weeks of taking these vitamins, I no longer had any at all.
9
Healthy skin attained
3 people found this helpful
After prolonged prednisone use, my skin was in a dreadful state, but following two weeks of taking vitamin E, my acne disappeared, oiliness reduced, and my skin looks healthy and beautiful. I took one capsule daily.
6
Redness reduced
23 people found this helpful
With the help of this and some vitamins, I tackled acne and facial redness. Unfortunately, a surgical procedure and the recovery period stopped me from completing the course, but after two weeks the redness vanished and I had significantly fewer acne spots. Highly recommend!
7.5
Skin quality improved
11 people found this helpful
Vitamin E boosts skin turnover! I took it for beauty alongside vitamin C, which improved my inner dryness and cured my acne. Initially, I didn't notice any smell, but it developed after six months. Though expensive, the consistent positive effects make it worth considering another purchase.
7.5
Skin problems improved
My skin has become clearer thanks to these supplements, effectively reducing issues like acne and redness. I didn't mind their size or taste as I took them with water!
7
Vitamin E levels lower in acne
Serum vitamin E levels and chronic inflammatory skin diseases: A systematic review and meta-analysis.
We examined the relationship between serum vitamin E levels and acne as part of a broader investigation into chronic inflammatory skin diseases. Our analysis included a number of studies that focused on vitamin E in patients, comparing their serum levels with those of healthy individuals.
The findings revealed that patients with acne had significantly lower levels of serum vitamin E compared to controls. This supports the idea that vitamin E might play a role in skin health, although we must note that the study did not delve into how vitamin E treatment specifically improves acne.
In short, while the lower vitamin E levels in acne patients are noteworthy, the study leaves us without conclusive evidence of vitamin E’s direct impact on treating acne. We highlight the importance of evaluating vitamin E status as part of managing skin health across various conditions, including acne.
9
Vitamin E may reduce acne lesions
Addressing Free Radical Oxidation in Acne Vulgaris.
We explored the effects of vitamin E on acne by conducting an open-label study with 17 patients who had mild to moderate acne vulgaris. Over eight weeks, these patients followed a standard regimen involving salicylic acid and benzoyl peroxide, with the addition of topical vitamin E in sunflower seed oil.
Throughout the study, we observed that all participants experienced clinical improvements, including a reduction in the number of acne lesions. Interestingly, significant improvements were noted as early as Week 2, indicating that vitamin E may play a beneficial role in managing acne symptoms. Furthermore, patients reported positive feedback regarding the ease of application and tolerability of the treatment.
Although we cannot definitively say vitamin E is a cure for acne, our findings suggest that it may help alleviate some symptoms when used alongside established treatments. This research sheds light on the potential of topical antioxidants like vitamin E in the ongoing battle against acne, inviting further exploration into their effectiveness and role in skincare.
1
No significant benefit of vitamin E
Vitamin E does not reduce the side-effects of isotretinoin in the treatment of acne vulgaris.
We explored the effectiveness of vitamin E alongside isotretinoin, a common treatment for severe acne. In an investigator-blinded, randomized study involving 82 patients, participants were divided into two groups. One group received isotretinoin alone, while the other combined it with 800 IU of vitamin E, over a period of 16 weeks.
Our main goal was to determine whether vitamin E could reduce the side-effects associated with isotretinoin, which are often bothersome for patients. Throughout the study, we assessed various mucocutaneous side effects, such as facial dryness and redness, as well as changes in serum lipid and liver enzyme levels.
Ultimately, we found no significant difference in the incidence or severity of side effects between the two treatment groups. This indicates that vitamin E did not provide any noticeable benefit when added to isotretinoin therapy for acne vulgaris.
While vitamin E is often suggested as a remedy to lighten the side effects of medications, our findings suggest that its use alongside isotretinoin may not be helpful.
7
Vitamin E's fleeting anti-acne effects
Erythrocyte glutathione peroxidase activity in acne vulgaris and the effect of selenium and vitamin E treatment.
We explored the effects of vitamin E, alongside selenium, on acne treatment in a group of patients. The study assessed the activity of an enzyme called glutathione-peroxidase (GSH-Px) in men and women with acne. It involved 42 men with severe acne and 47 women, some of whom were using oral contraceptives.
Interestingly, we found that men with severe acne had lower GSH-Px levels compared to control groups. Women with acne, on the other hand, showed no significant differences when excluding those on oral contraceptives. This observation is notable, as female participants using the pill generally exhibited higher GSH-Px levels.
During the trial, 29 patients took a combination of 0.2 mg of selenium and 10 mg of tocopheryl succinate, a form of vitamin E, twice a day for 6 to 12 weeks. Many patients, especially those suffering from pustular acne and low GSH-Px activity, reported positive results. We observed that the GSH-Px activity gradually increased during the treatment period. However, after stopping the treatment, these beneficial effects appeared to fade, as GSH-Px levels returned to their original states within 6 to 8 weeks, suggesting that while the combination treatment showed temporary efficacy, sustained improvement was not observed.
Overall, while the treatment with vitamin E and selenium did seem to help some patients, the transient nature of the benefits raises questions about the long-term effectiveness of vitamin E alone in treating acne.
4
Vitamin E shows mixed effects
Effect of alpha-tocopherol and N-acetylcysteine on benzoyl peroxide toxicity in human keratinocytes.
We explored how vitamin E, specifically alpha-tocopherol, impacts skin cells when exposed to benzoyl peroxide, a common acne treatment. During our investigation, we found that when skin cells, known as keratinocytes, were placed on a layer of alpha-tocopherol, they showed a protective response against the harmful effects of benzoyl peroxide. This suggests that vitamin E may help shield the skin from irritations associated with acne treatment.
However, we also discovered that when alpha-tocopherol was mixed with ethanol and added directly, it had the opposite effect, actually increasing the toxicity of benzoyl peroxide. This points to the importance of how vitamin E is applied; it needs to be done correctly for any potential benefits to shine through. Furthermore, incorporating another antioxidant, N-acetylcysteine, not only reduced cell damage but when paired with alpha-tocopherol, they worked together to provide even greater protection.
While we found that vitamin E can be beneficial, it’s important to note that this protection hinges on the method of application. Thus, understanding how to use vitamin E alongside other treatments could play a vital role in optimizing acne therapies in the future.
References
Liu X, Yang G, Luo M, Lan Q, Shi X, et al. Serum vitamin E levels and chronic inflammatory skin diseases: A systematic review and meta-analysis. PLoS One. 2021;16:e0261259. 10.1371/journal.pone.0261259
Chan H, Chan G, Santos J, Dee K, Co JK. A randomized, double-blind, placebo-controlled trial to determine the efficacy and safety of lactoferrin with vitamin E and zinc as an oral therapy for mild to moderate acne vulgaris. Int J Dermatol. 2017;56:686. 10.1111/ijd.13607
Fabbrocini G, Cameli N, Lorenzi S, De Padova MP, Marasca C, et al. A dietary supplement to reduce side effects of oral isotretinoin therapy in acne patients. G Ital Dermatol Venereol. 2014;149:441.
Capitanio B, Lora V, Ludovici M, Sinagra JL, Ottaviani M, et al. Modulation of sebum oxidation and interleukin-1α levels associates with clinical improvement of mild comedonal acne. J Eur Acad Dermatol Venereol. 2014;28:1792. 10.1111/jdv.12431
Goforoushan F, Azimi H, Goldust M. Efficacy of vitamin E to prevent dermal complications of isotretinoin. Pak J Biol Sci. 2013;16:548.
Ozuguz P, Dogruk Kacar S, Ekiz O, Takci Z, Balta I, et al. Evaluation of serum vitamins A and E and zinc levels according to the severity of acne vulgaris. Cutan Ocul Toxicol. 2014;33:99. 10.3109/15569527.2013.808656
Aktürk AŞ, Güzel S, Bulca S, Demirsoy EO, Bayramgürler D, et al. Effects of isotretinoin on serum vitamin E levels in patients with acne. Int J Dermatol. 2013;52:363. 10.1111/j.1365-4632.2012.05676.x
Erturan İ, Naziroğlu M, Akkaya VB. Isotretinoin treatment induces oxidative toxicity in blood of patients with acne vulgaris: a clinical pilot study. Cell Biochem Funct. 2012;30:552. 10.1002/cbf.2830
El-Akawi Z, Abdel-Latif N, Abdul-Razzak K. Does the plasma level of vitamins A and E affect acne condition?. Clin Exp Dermatol. 2006;31:430.
Strumia R. Dermatologic signs in patients with eating disorders. Am J Clin Dermatol. 2005;6:165.
Kus S, Gün D, Demirçay Z, Sur H. Vitamin E does not reduce the side-effects of isotretinoin in the treatment of acne vulgaris. Int J Dermatol. 2005;44:248.
Bellei E, Rota C, Bergamini S, Manfredini P, Albertazzi A, et al. Effect of alpha-tocopherol and N-acetylcysteine on benzoyl peroxide toxicity in human keratinocytes. J Biochem Mol Toxicol. 2004;18:107.
Weber SU, Thiele JJ, Han N, Luu C, Valacchi G, et al. Topical alpha-tocotrienol supplementation inhibits lipid peroxidation but fails to mitigate increased transepidermal water loss after benzoyl peroxide treatment of human skin. Free Radic Biol Med. 2003;34:170.
Strauss JS, Gottlieb AB, Jones T, Koo JY, Leyden JJ, et al. Concomitant administration of vitamin E does not change the side effects of isotretinoin as used in acne vulgaris: a randomized trial. J Am Acad Dermatol. 2000;43:777.
Michaëlsson G, Edqvist LE. Erythrocyte glutathione peroxidase activity in acne vulgaris and the effect of selenium and vitamin E treatment. Acta Derm Venereol. 1984;64:9.