Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.3
USERS' SCORE
Moderately Good
Based on 15 Reviews
7.8
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin C (as Ascorbic Acid)
250 mg
278%
Vitamin E (as d-alpha Tocopheryl Succinate)
20 mg
133%
Alpha Lipoic Acid
100 mg
†
Top Medical Research Studies
8
We aimed to understand how alpha-lipoic acid (LA) affects wound healing in diabetic conditions. The study involved five groups of mice: healthy controls, wounded healthy mice, wounded diabetic mice, and two groups of wounded diabetic mice treated with different doses of LA for 14 days.
Our findings indicated that LA plays a significant role in improving the healing process. It works by balancing the levels of anti-inflammatory and pro-inflammatory factors that are essential for wound recovery. Specifically, we saw effects on various immune cell types that are vital for healing, indicating that LA may help to enhance recovery in diabetic wounds.
This study highlights the potential of LA as a supportive treatment option for wound healing in diabetic patients, ultimately aiming to reduce the risk of infections and improve overall recovery from injuries.
Our findings indicated that LA plays a significant role in improving the healing process. It works by balancing the levels of anti-inflammatory and pro-inflammatory factors that are essential for wound recovery. Specifically, we saw effects on various immune cell types that are vital for healing, indicating that LA may help to enhance recovery in diabetic wounds.
This study highlights the potential of LA as a supportive treatment option for wound healing in diabetic patients, ultimately aiming to reduce the risk of infections and improve overall recovery from injuries.
Read More
8
We examined the effects of vitamin C supplementation on diabetes, focusing specifically on glycemic control and insulin resistance. Our analysis included a comprehensive review of fourteen systematic reviews and meta-analyses that assessed five different water-soluble vitamins: B-1, B-3, biotin, B-9 (folic acid), and C.
The findings revealed that vitamin C can significantly improve glycemic control in individuals with type 2 diabetes. We noticed reductions in fasting blood glucose levels and HbA1c, especially when supplementation lasted longer than 30 days. This is promising news for those managing diabetes, as it suggests that incorporating vitamin C could be beneficial.
Furthermore, we found that folic acid also plays a role in improving insulin resistance. However, there is a clear need for more well-designed randomized controlled trials to solidify these findings and develop a deeper understanding of the relationship between water-soluble vitamins and diabetes management.
The findings revealed that vitamin C can significantly improve glycemic control in individuals with type 2 diabetes. We noticed reductions in fasting blood glucose levels and HbA1c, especially when supplementation lasted longer than 30 days. This is promising news for those managing diabetes, as it suggests that incorporating vitamin C could be beneficial.
Furthermore, we found that folic acid also plays a role in improving insulin resistance. However, there is a clear need for more well-designed randomized controlled trials to solidify these findings and develop a deeper understanding of the relationship between water-soluble vitamins and diabetes management.
Read More
8
We explored the relationship between dietary antioxidants, particularly vitamin C, and diabetes risk using data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2011 to 2018. This study sought to understand how different levels of dietary antioxidants might influence the prevalence of diabetes among adults in the U.S.
Our analysis involved 7,982 participants with a mean age of 47 years, comprising roughly equal numbers of men and women. Through comprehensive dietary recall interviews, we calculated the Composite Dietary Antioxidant Index (CDAI) based on the intake of key antioxidants, including vitamin C. The results revealed that higher intake of vitamin C was linked to a lower prevalence of diabetes, a finding that felt significant.
Specifically, we found that as vitamin C intake increased, the risk of diabetes decreased, particularly among women. Other antioxidants like zinc showed a trend towards reduced risk, but the data for vitamin C was clearer. Overall, our findings highlight vitamin C's potential role in reducing diabetes risk, supporting the idea that a balanced diet rich in antioxidants can be beneficial for our health.
Our analysis involved 7,982 participants with a mean age of 47 years, comprising roughly equal numbers of men and women. Through comprehensive dietary recall interviews, we calculated the Composite Dietary Antioxidant Index (CDAI) based on the intake of key antioxidants, including vitamin C. The results revealed that higher intake of vitamin C was linked to a lower prevalence of diabetes, a finding that felt significant.
Specifically, we found that as vitamin C intake increased, the risk of diabetes decreased, particularly among women. Other antioxidants like zinc showed a trend towards reduced risk, but the data for vitamin C was clearer. Overall, our findings highlight vitamin C's potential role in reducing diabetes risk, supporting the idea that a balanced diet rich in antioxidants can be beneficial for our health.
Read More
Most Useful Reviews
9
Increases activity levels
26 people found this helpful
This product is excellent for individuals with diabetes, nerve issues, and other health concerns. I discovered the benefits of alpha lipoic acid while searching for diabetes solutions. It has helped relieve my stress and fatigue—especially in the mornings. It aids in preventing tissue damage related to various conditions, while also supporting diabetic neuropathy prevention.
Read More
9
Calms neuropathy symptoms
5 people found this helpful
Great stuff! If you have neuropathy from diabetes, Alpha Lipoic Acid really calms the nerves. I take it daily and have noticed a significant difference.
Read More
9
Supports diabetes management
4 people found this helpful
Lipic acid is an organosulfur compound crucial for many enzyme complexes. It regulates lipid and carbohydrate metabolism, positively impacts cholesterol levels, and enhances liver function. It also helps in detoxification and has beneficial effects for type 2 diabetes.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.3
- All Researches
8
We aimed to understand how alpha-lipoic acid (LA) affects wound healing in diabetic conditions. The study involved five groups of mice: healthy controls, wounded healthy mice, wounded diabetic mice, and two groups of wounded diabetic mice treated with different doses of LA for 14 days.
Our findings indicated that LA plays a significant role in improving the healing process. It works by balancing the levels of anti-inflammatory and pro-inflammatory factors that are essential for wound recovery. Specifically, we saw effects on various immune cell types that are vital for healing, indicating that LA may help to enhance recovery in diabetic wounds.
This study highlights the potential of LA as a supportive treatment option for wound healing in diabetic patients, ultimately aiming to reduce the risk of infections and improve overall recovery from injuries.
Our findings indicated that LA plays a significant role in improving the healing process. It works by balancing the levels of anti-inflammatory and pro-inflammatory factors that are essential for wound recovery. Specifically, we saw effects on various immune cell types that are vital for healing, indicating that LA may help to enhance recovery in diabetic wounds.
This study highlights the potential of LA as a supportive treatment option for wound healing in diabetic patients, ultimately aiming to reduce the risk of infections and improve overall recovery from injuries.
Read More
8
We set out to explore how alpha-lipoic acid (LA) could help in the healing of diabetic wounds, which often struggle to heal due to a mix of factors like high blood sugar and infections. In our investigation, we combined LA with a specialized peptide using a unique self-assembly process that didn’t require extra help from outside sources.
This new combination was then placed into a microneedle patch made from hyaluronic acid (HA), allowing for a steady release of LA. We found that this patch was effective in fighting off harmful bacteria such as S. aureus and E. coli, which are common culprits in infections.
Furthermore, we observed that the sustained release of LA not only reduced harmful reactive oxygen species but also encouraged helpful immune responses and new blood vessel formation. This indicates a considerable improvement in tissue regeneration for wounds in diabetic patients. Overall, our findings suggest this multifunctional microneedle approach could significantly enhance healing in diabetic skin infections and showcases the considerable potential of combining LA in innovative treatment strategies.
This new combination was then placed into a microneedle patch made from hyaluronic acid (HA), allowing for a steady release of LA. We found that this patch was effective in fighting off harmful bacteria such as S. aureus and E. coli, which are common culprits in infections.
Furthermore, we observed that the sustained release of LA not only reduced harmful reactive oxygen species but also encouraged helpful immune responses and new blood vessel formation. This indicates a considerable improvement in tissue regeneration for wounds in diabetic patients. Overall, our findings suggest this multifunctional microneedle approach could significantly enhance healing in diabetic skin infections and showcases the considerable potential of combining LA in innovative treatment strategies.
Read More
8
We examined the effects of vitamin C supplementation on diabetes, focusing specifically on glycemic control and insulin resistance. Our analysis included a comprehensive review of fourteen systematic reviews and meta-analyses that assessed five different water-soluble vitamins: B-1, B-3, biotin, B-9 (folic acid), and C.
The findings revealed that vitamin C can significantly improve glycemic control in individuals with type 2 diabetes. We noticed reductions in fasting blood glucose levels and HbA1c, especially when supplementation lasted longer than 30 days. This is promising news for those managing diabetes, as it suggests that incorporating vitamin C could be beneficial.
Furthermore, we found that folic acid also plays a role in improving insulin resistance. However, there is a clear need for more well-designed randomized controlled trials to solidify these findings and develop a deeper understanding of the relationship between water-soluble vitamins and diabetes management.
The findings revealed that vitamin C can significantly improve glycemic control in individuals with type 2 diabetes. We noticed reductions in fasting blood glucose levels and HbA1c, especially when supplementation lasted longer than 30 days. This is promising news for those managing diabetes, as it suggests that incorporating vitamin C could be beneficial.
Furthermore, we found that folic acid also plays a role in improving insulin resistance. However, there is a clear need for more well-designed randomized controlled trials to solidify these findings and develop a deeper understanding of the relationship between water-soluble vitamins and diabetes management.
Read More
8
We explored the relationship between dietary antioxidants, particularly vitamin C, and diabetes risk using data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2011 to 2018. This study sought to understand how different levels of dietary antioxidants might influence the prevalence of diabetes among adults in the U.S.
Our analysis involved 7,982 participants with a mean age of 47 years, comprising roughly equal numbers of men and women. Through comprehensive dietary recall interviews, we calculated the Composite Dietary Antioxidant Index (CDAI) based on the intake of key antioxidants, including vitamin C. The results revealed that higher intake of vitamin C was linked to a lower prevalence of diabetes, a finding that felt significant.
Specifically, we found that as vitamin C intake increased, the risk of diabetes decreased, particularly among women. Other antioxidants like zinc showed a trend towards reduced risk, but the data for vitamin C was clearer. Overall, our findings highlight vitamin C's potential role in reducing diabetes risk, supporting the idea that a balanced diet rich in antioxidants can be beneficial for our health.
Our analysis involved 7,982 participants with a mean age of 47 years, comprising roughly equal numbers of men and women. Through comprehensive dietary recall interviews, we calculated the Composite Dietary Antioxidant Index (CDAI) based on the intake of key antioxidants, including vitamin C. The results revealed that higher intake of vitamin C was linked to a lower prevalence of diabetes, a finding that felt significant.
Specifically, we found that as vitamin C intake increased, the risk of diabetes decreased, particularly among women. Other antioxidants like zinc showed a trend towards reduced risk, but the data for vitamin C was clearer. Overall, our findings highlight vitamin C's potential role in reducing diabetes risk, supporting the idea that a balanced diet rich in antioxidants can be beneficial for our health.
Read More
7
We explored the potential benefits of alpha-lipoic acid (ALA) for those with type 2 diabetes (T2DM) and nerve complications, known as neuropathy. In our study, we focused on how ALA affects advanced end glycation products (AGEs), which are harmful compounds that can worsen the condition by damaging blood vessels and nerve tissues.
Our six-month intervention involved 54 T2DM patients with neuropathy who continued their prescribed medications while taking 600 mg of ALA daily. We contrasted their results with a control group of 24 matched patients without neuropathy.
We observed that ALA treatment significantly reduced the levels of AGEs, demonstrating its efficacy in lowering these harmful substances in individuals with diabetes (from 11.89 to 10.95 AU/μg). However, we noted that ALA did not influence other markers like soluble AGE receptor (sRAGE) levels or the AGEs/sRAGE ratio.
Additionally, we found correlations indicating that as AGEs decreased, improvements were noted in nerve function and other health markers. Overall, results suggest that ALA could be a beneficial treatment option for improving diabetic neuropathy and enhancing endothelial function, although it doesn't isolate its benefits from other existing diabetes medications.
Our six-month intervention involved 54 T2DM patients with neuropathy who continued their prescribed medications while taking 600 mg of ALA daily. We contrasted their results with a control group of 24 matched patients without neuropathy.
We observed that ALA treatment significantly reduced the levels of AGEs, demonstrating its efficacy in lowering these harmful substances in individuals with diabetes (from 11.89 to 10.95 AU/μg). However, we noted that ALA did not influence other markers like soluble AGE receptor (sRAGE) levels or the AGEs/sRAGE ratio.
Additionally, we found correlations indicating that as AGEs decreased, improvements were noted in nerve function and other health markers. Overall, results suggest that ALA could be a beneficial treatment option for improving diabetic neuropathy and enhancing endothelial function, although it doesn't isolate its benefits from other existing diabetes medications.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 15 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Increases activity levels
26 people found this helpful
This product is excellent for individuals with diabetes, nerve issues, and other health concerns. I discovered the benefits of alpha lipoic acid while searching for diabetes solutions. It has helped relieve my stress and fatigue—especially in the mornings. It aids in preventing tissue damage related to various conditions, while also supporting diabetic neuropathy prevention.
Read More
9
Calms neuropathy symptoms
5 people found this helpful
Great stuff! If you have neuropathy from diabetes, Alpha Lipoic Acid really calms the nerves. I take it daily and have noticed a significant difference.
Read More
9
Supports diabetes management
4 people found this helpful
Lipic acid is an organosulfur compound crucial for many enzyme complexes. It regulates lipid and carbohydrate metabolism, positively impacts cholesterol levels, and enhances liver function. It also helps in detoxification and has beneficial effects for type 2 diabetes.
Read More
9
Improves glycated hemoglobin
2 people found this helpful
Excellent! I gave this to my father, who has diabetes. His glycated hemoglobin levels improved, and we didn't alter any other aspects of his treatment.
Read More
9
Prevents diabetes onset
2 people found this helpful
This quality drug has a preventive effect against diabetes mellitus due to its protective role on the pancreas. As a potent antioxidant, alpha-lipoic acid shields the body from heavy metals. Regular use can slow the signs of ageing, and many doctors recommend it for optimal benefits.
Read More
Frequently Asked Questions
7.5
Improves diabetes control
2 people found this helpful
I have taken this for a long time, alongside my prescribed medications. I stopped for a while to see the effects, and my diabetes control lessened. Upon resuming it, my diabetes management improved significantly.
7.5
Positive for gestational diabetes
2 people found this helpful
I began taking this after being diagnosed with gestational diabetes based on a recommendation. So far, it seems to be positively influencing my condition, and it is a high-quality product.
9
Improves glycated hemoglobin
2 people found this helpful
Excellent! I gave this to my father, who has diabetes. His glycated hemoglobin levels improved, and we didn't alter any other aspects of his treatment.
9
Increases activity levels
26 people found this helpful
This product is excellent for individuals with diabetes, nerve issues, and other health concerns. I discovered the benefits of alpha lipoic acid while searching for diabetes solutions. It has helped relieve my stress and fatigue—especially in the mornings. It aids in preventing tissue damage related to various conditions, while also supporting diabetic neuropathy prevention.
7.5
Treats insulin resistance
6 people found this helpful
Excellent product! It aids in digesting carbohydrates and lowering diabetes levels, thus helping with insulin resistance and weight management. I feel satiated for up to six hours after taking it.
7.5
Strengthens immune system
Excellent! Alpha lipoic acid helps to boost the immune system and improve overall body tone, and may assist with symptoms associated with diabetes and high cholesterol.
4
Decreases sugar levels
38 people found this helpful
Alpha lipoic acid contains both natural and synthetic forms. Taking over 600 mg daily is as effective as 1200 mg, but it’s essential to maintain a two-hour gap with other supplements. It aids in restoring vitamins C and E, glutathione, and coenzyme Q10. Although I experienced a decline at 300 mg initially, starting with smaller doses seemed more effective. Long-term use might lower biotin levels, and it can reduce sugar levels in type 1 and 2 diabetes.
7
We explored the potential benefits of alpha-lipoic acid (ALA) for those with type 2 diabetes (T2DM) and nerve complications, known as neuropathy. In our study, we focused on how ALA affects advanced end glycation products (AGEs), which are harmful compounds that can worsen the condition by damaging blood vessels and nerve tissues.
Our six-month intervention involved 54 T2DM patients with neuropathy who continued their prescribed medications while taking 600 mg of ALA daily. We contrasted their results with a control group of 24 matched patients without neuropathy.
We observed that ALA treatment significantly reduced the levels of AGEs, demonstrating its efficacy in lowering these harmful substances in individuals with diabetes (from 11.89 to 10.95 AU/μg). However, we noted that ALA did not influence other markers like soluble AGE receptor (sRAGE) levels or the AGEs/sRAGE ratio.
Additionally, we found correlations indicating that as AGEs decreased, improvements were noted in nerve function and other health markers. Overall, results suggest that ALA could be a beneficial treatment option for improving diabetic neuropathy and enhancing endothelial function, although it doesn't isolate its benefits from other existing diabetes medications.
Our six-month intervention involved 54 T2DM patients with neuropathy who continued their prescribed medications while taking 600 mg of ALA daily. We contrasted their results with a control group of 24 matched patients without neuropathy.
We observed that ALA treatment significantly reduced the levels of AGEs, demonstrating its efficacy in lowering these harmful substances in individuals with diabetes (from 11.89 to 10.95 AU/μg). However, we noted that ALA did not influence other markers like soluble AGE receptor (sRAGE) levels or the AGEs/sRAGE ratio.
Additionally, we found correlations indicating that as AGEs decreased, improvements were noted in nerve function and other health markers. Overall, results suggest that ALA could be a beneficial treatment option for improving diabetic neuropathy and enhancing endothelial function, although it doesn't isolate its benefits from other existing diabetes medications.
8
We aimed to understand how alpha-lipoic acid (LA) affects wound healing in diabetic conditions. The study involved five groups of mice: healthy controls, wounded healthy mice, wounded diabetic mice, and two groups of wounded diabetic mice treated with different doses of LA for 14 days.
Our findings indicated that LA plays a significant role in improving the healing process. It works by balancing the levels of anti-inflammatory and pro-inflammatory factors that are essential for wound recovery. Specifically, we saw effects on various immune cell types that are vital for healing, indicating that LA may help to enhance recovery in diabetic wounds.
This study highlights the potential of LA as a supportive treatment option for wound healing in diabetic patients, ultimately aiming to reduce the risk of infections and improve overall recovery from injuries.
Our findings indicated that LA plays a significant role in improving the healing process. It works by balancing the levels of anti-inflammatory and pro-inflammatory factors that are essential for wound recovery. Specifically, we saw effects on various immune cell types that are vital for healing, indicating that LA may help to enhance recovery in diabetic wounds.
This study highlights the potential of LA as a supportive treatment option for wound healing in diabetic patients, ultimately aiming to reduce the risk of infections and improve overall recovery from injuries.
8
We set out to explore how alpha-lipoic acid (LA) could help in the healing of diabetic wounds, which often struggle to heal due to a mix of factors like high blood sugar and infections. In our investigation, we combined LA with a specialized peptide using a unique self-assembly process that didn’t require extra help from outside sources.
This new combination was then placed into a microneedle patch made from hyaluronic acid (HA), allowing for a steady release of LA. We found that this patch was effective in fighting off harmful bacteria such as S. aureus and E. coli, which are common culprits in infections.
Furthermore, we observed that the sustained release of LA not only reduced harmful reactive oxygen species but also encouraged helpful immune responses and new blood vessel formation. This indicates a considerable improvement in tissue regeneration for wounds in diabetic patients. Overall, our findings suggest this multifunctional microneedle approach could significantly enhance healing in diabetic skin infections and showcases the considerable potential of combining LA in innovative treatment strategies.
This new combination was then placed into a microneedle patch made from hyaluronic acid (HA), allowing for a steady release of LA. We found that this patch was effective in fighting off harmful bacteria such as S. aureus and E. coli, which are common culprits in infections.
Furthermore, we observed that the sustained release of LA not only reduced harmful reactive oxygen species but also encouraged helpful immune responses and new blood vessel formation. This indicates a considerable improvement in tissue regeneration for wounds in diabetic patients. Overall, our findings suggest this multifunctional microneedle approach could significantly enhance healing in diabetic skin infections and showcases the considerable potential of combining LA in innovative treatment strategies.
References
- Csiha S, Hernyák M, Molnár Á, Lőrincz H, Katkó M, et al. Alpha-Lipoic Acid Treatment Reduces the Levels of Advanced End Glycation Products in Type 2 Diabetes Patients with Neuropathy. Biomedicines. 2025;13. doi:10.3390/biomedicines13020438
- Zoheir KMA, Ali NI, Ashour AE, Kishta MS, Othman SI, et al. Lipoic acid improves wound healing through its immunomodulatory and anti-inflammatory effects in a diabetic mouse model. J Diabetes Metab Disord. 2025;24:56. doi:10.1007/s40200-025-01559-y
- Lu Q, Tang X, Tao B, Huang K, Li K, et al. Multifunctional hyaluronic acid microneedle patch enhances diabetic wound healing in diabetic infections. Int J Biol Macromol. 2025;296:139685. doi:10.1016/j.ijbiomac.2025.139685
- Chai Y, Chen C, Yin X, Wang X, Yu W, et al. Effects of water-soluble vitamins on glycemic control and insulin resistance in adult type 2 diabetes: an umbrella review of meta-analyses. Asia Pac J Clin Nutr. 2025;34:118. doi:10.6133/apjcn.202502_34(1).0012
- Morampudi RK, Neelakandan V, Naveen Kumar B, Indla E. Evaluation of Cognitive and Synaptic Restoration in Diabetic Rats Treated With Emblica officinalis, Clitoria ternatea, Vitamin C, and Metformin. Cureus. 2024;16:e75866. doi:10.7759/cureus.75866
- Zhou L, Xu X, Li Y, Zhang S, Xie H. Association between dietary antioxidant levels and diabetes: a cross-sectional study. Front Nutr. 2024;11:1478815. doi:10.3389/fnut.2024.1478815
