Reviewed By
Infographics 
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 8 Reviews
8.1
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Astragalus Root Extract(Astragalus membranaceus) (Standardized to min 70% Polysaccharides)
500 mg
**
Top Medical Research Studies
8
Astragaloside IV benefits diabetic nephropathy
We explored how astragaloside IV (AS-IV), a natural compound from the Astragalus root, impacts diabetic nephropathy (DN) and its symptoms. In our observations, AS-IV treatment showed promise in alleviating DN symptoms in mice, leading to improvements in several health markers, including body weight and kidney function indicators such as urine microalbumin and serum creatinine levels.
We noted that AS-IV seemed to reduce the progression of DN by lowering apoptosis, the process of programmed cell death that often contributes to kidney issues in diabetes. Our research revealed that AS-IV affects specific epigenetic modifications, particularly H3 lysine 4 monomethylation (H3K4me1), a mechanism tied to gene expression regulation.
Through our analyses, we pinpointed a gene, MAP4K3, which was elevated in DN conditions but decreased following AS-IV treatment. Silencing this gene led to reduced cell death in kidney cells exposed to high glucose levels, indicating that AS-IV might counteract the harmful effects of diabetes on kidney health. Overall, our findings suggest that AS-IV could play a significant role in protecting against diabetes-related kidney damage, offering a hopeful avenue for future therapies in diabetic nephropathy.
We noted that AS-IV seemed to reduce the progression of DN by lowering apoptosis, the process of programmed cell death that often contributes to kidney issues in diabetes. Our research revealed that AS-IV affects specific epigenetic modifications, particularly H3 lysine 4 monomethylation (H3K4me1), a mechanism tied to gene expression regulation.
Through our analyses, we pinpointed a gene, MAP4K3, which was elevated in DN conditions but decreased following AS-IV treatment. Silencing this gene led to reduced cell death in kidney cells exposed to high glucose levels, indicating that AS-IV might counteract the harmful effects of diabetes on kidney health. Overall, our findings suggest that AS-IV could play a significant role in protecting against diabetes-related kidney damage, offering a hopeful avenue for future therapies in diabetic nephropathy.
Read More
7
We explored the effectiveness of astragalus root as part of a broader treatment approach for diabetes. In a study utilizing streptozotocin-induced diabetic mice, we found that extracts containing astragalus root exhibited antihyperglycemic and insulinotropic activities, particularly when combined with other key ingredients like stephania root.
Although we did not test astragalus root in isolation, it played a significant role in enhancing the overall efficacy of the treatment. Essentially, the presence of formononetin in astragalus could amplify the actions of other compounds, like fangchinoline from stephania, which is pivotal for reducing blood sugar levels.
These combined effects suggest that astragalus root is an important player in the fight against diabetes, though its individual contributions require further investigation.
Although we did not test astragalus root in isolation, it played a significant role in enhancing the overall efficacy of the treatment. Essentially, the presence of formononetin in astragalus could amplify the actions of other compounds, like fangchinoline from stephania, which is pivotal for reducing blood sugar levels.
These combined effects suggest that astragalus root is an important player in the fight against diabetes, though its individual contributions require further investigation.
Read More
Most Useful Reviews
7.5
Diabetes management support
60 people found this helpful
An investment in my health! As I turn 50, I realised the importance of taking better care of myself. I chose this astragalus product for its quality and benefits, including regulating diabetes. These supplements may not provide overnight changes but support gradual, consistent healing over time.
Read More
9
Protects against complications
1 people found this helpful
A wonderful plant that protects the kidneys and retina from the complications associated with diabetes. Excellent quality and reasonable price. I highly recommend it.
Read More
8
Essential for kidney health
This excellent supplement is of the best quality and helps my kidneys function better. I have diabetes, so this supplement is essential for my health at my age.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
- All Researches
8
Astragaloside IV benefits diabetic nephropathy
We explored how astragaloside IV (AS-IV), a natural compound from the Astragalus root, impacts diabetic nephropathy (DN) and its symptoms. In our observations, AS-IV treatment showed promise in alleviating DN symptoms in mice, leading to improvements in several health markers, including body weight and kidney function indicators such as urine microalbumin and serum creatinine levels.
We noted that AS-IV seemed to reduce the progression of DN by lowering apoptosis, the process of programmed cell death that often contributes to kidney issues in diabetes. Our research revealed that AS-IV affects specific epigenetic modifications, particularly H3 lysine 4 monomethylation (H3K4me1), a mechanism tied to gene expression regulation.
Through our analyses, we pinpointed a gene, MAP4K3, which was elevated in DN conditions but decreased following AS-IV treatment. Silencing this gene led to reduced cell death in kidney cells exposed to high glucose levels, indicating that AS-IV might counteract the harmful effects of diabetes on kidney health. Overall, our findings suggest that AS-IV could play a significant role in protecting against diabetes-related kidney damage, offering a hopeful avenue for future therapies in diabetic nephropathy.
We noted that AS-IV seemed to reduce the progression of DN by lowering apoptosis, the process of programmed cell death that often contributes to kidney issues in diabetes. Our research revealed that AS-IV affects specific epigenetic modifications, particularly H3 lysine 4 monomethylation (H3K4me1), a mechanism tied to gene expression regulation.
Through our analyses, we pinpointed a gene, MAP4K3, which was elevated in DN conditions but decreased following AS-IV treatment. Silencing this gene led to reduced cell death in kidney cells exposed to high glucose levels, indicating that AS-IV might counteract the harmful effects of diabetes on kidney health. Overall, our findings suggest that AS-IV could play a significant role in protecting against diabetes-related kidney damage, offering a hopeful avenue for future therapies in diabetic nephropathy.
Read More
7
We explored the effectiveness of astragalus root as part of a broader treatment approach for diabetes. In a study utilizing streptozotocin-induced diabetic mice, we found that extracts containing astragalus root exhibited antihyperglycemic and insulinotropic activities, particularly when combined with other key ingredients like stephania root.
Although we did not test astragalus root in isolation, it played a significant role in enhancing the overall efficacy of the treatment. Essentially, the presence of formononetin in astragalus could amplify the actions of other compounds, like fangchinoline from stephania, which is pivotal for reducing blood sugar levels.
These combined effects suggest that astragalus root is an important player in the fight against diabetes, though its individual contributions require further investigation.
Although we did not test astragalus root in isolation, it played a significant role in enhancing the overall efficacy of the treatment. Essentially, the presence of formononetin in astragalus could amplify the actions of other compounds, like fangchinoline from stephania, which is pivotal for reducing blood sugar levels.
These combined effects suggest that astragalus root is an important player in the fight against diabetes, though its individual contributions require further investigation.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Diabetes management support
60 people found this helpful
An investment in my health! As I turn 50, I realised the importance of taking better care of myself. I chose this astragalus product for its quality and benefits, including regulating diabetes. These supplements may not provide overnight changes but support gradual, consistent healing over time.
Read More
9
Protects against complications
1 people found this helpful
A wonderful plant that protects the kidneys and retina from the complications associated with diabetes. Excellent quality and reasonable price. I highly recommend it.
Read More
8
Essential for kidney health
This excellent supplement is of the best quality and helps my kidneys function better. I have diabetes, so this supplement is essential for my health at my age.
Read More
7.5
Reduces blood pressure
Hokurei Astragalus dilates blood vessels, promoting overall blood circulation and nutrient supply. It helps to lower high blood pressure and treat diabetes and related conditions. Additionally, it acts as a diuretic and helps with nephritis while also protecting the liver and exhibiting antibacterial effects.
Read More
7.5
Normalises metabolic processes
I purchased astragalus extract to boost my immune system, taking it alongside cat's claw. Astragalus is beneficial not just for immunity; it lowers renal and arterial pressure, normalising the metabolic processes disrupted by diabetes. Its antibacterial properties help combat various infections while supporting the nervous system as an adaptogen.
Read More
Frequently Asked Questions
7.5
Improves diabetes condition
I ordered it for my daughter-in-law's father, who has diabetes. This is our second order, and we are satisfied with the quality. The effects were noticeable, and improvements were felt, which led us to make a second purchase.
7.5
Enhances kidney health
This product is good for diabetes and kidneys. It's enhanced and beneficial for kidney and blood sugar health. The packaging is excellent, making it suitable for everyone, while the quality is commendable.
8
Essential for kidney health
This excellent supplement is of the best quality and helps my kidneys function better. I have diabetes, so this supplement is essential for my health at my age.
9
Protects against complications
1 people found this helpful
A wonderful plant that protects the kidneys and retina from the complications associated with diabetes. Excellent quality and reasonable price. I highly recommend it.
7.5
Reduces blood pressure
Hokurei Astragalus dilates blood vessels, promoting overall blood circulation and nutrient supply. It helps to lower high blood pressure and treat diabetes and related conditions. Additionally, it acts as a diuretic and helps with nephritis while also protecting the liver and exhibiting antibacterial effects.
7.5
Normalises metabolic processes
I purchased astragalus extract to boost my immune system, taking it alongside cat's claw. Astragalus is beneficial not just for immunity; it lowers renal and arterial pressure, normalising the metabolic processes disrupted by diabetes. Its antibacterial properties help combat various infections while supporting the nervous system as an adaptogen.
7
We explored the effectiveness of astragalus root as part of a broader treatment approach for diabetes. In a study utilizing streptozotocin-induced diabetic mice, we found that extracts containing astragalus root exhibited antihyperglycemic and insulinotropic activities, particularly when combined with other key ingredients like stephania root.
Although we did not test astragalus root in isolation, it played a significant role in enhancing the overall efficacy of the treatment. Essentially, the presence of formononetin in astragalus could amplify the actions of other compounds, like fangchinoline from stephania, which is pivotal for reducing blood sugar levels.
These combined effects suggest that astragalus root is an important player in the fight against diabetes, though its individual contributions require further investigation.
Although we did not test astragalus root in isolation, it played a significant role in enhancing the overall efficacy of the treatment. Essentially, the presence of formononetin in astragalus could amplify the actions of other compounds, like fangchinoline from stephania, which is pivotal for reducing blood sugar levels.
These combined effects suggest that astragalus root is an important player in the fight against diabetes, though its individual contributions require further investigation.
8
Astragaloside IV benefits diabetic nephropathy
We explored how astragaloside IV (AS-IV), a natural compound from the Astragalus root, impacts diabetic nephropathy (DN) and its symptoms. In our observations, AS-IV treatment showed promise in alleviating DN symptoms in mice, leading to improvements in several health markers, including body weight and kidney function indicators such as urine microalbumin and serum creatinine levels.
We noted that AS-IV seemed to reduce the progression of DN by lowering apoptosis, the process of programmed cell death that often contributes to kidney issues in diabetes. Our research revealed that AS-IV affects specific epigenetic modifications, particularly H3 lysine 4 monomethylation (H3K4me1), a mechanism tied to gene expression regulation.
Through our analyses, we pinpointed a gene, MAP4K3, which was elevated in DN conditions but decreased following AS-IV treatment. Silencing this gene led to reduced cell death in kidney cells exposed to high glucose levels, indicating that AS-IV might counteract the harmful effects of diabetes on kidney health. Overall, our findings suggest that AS-IV could play a significant role in protecting against diabetes-related kidney damage, offering a hopeful avenue for future therapies in diabetic nephropathy.
We noted that AS-IV seemed to reduce the progression of DN by lowering apoptosis, the process of programmed cell death that often contributes to kidney issues in diabetes. Our research revealed that AS-IV affects specific epigenetic modifications, particularly H3 lysine 4 monomethylation (H3K4me1), a mechanism tied to gene expression regulation.
Through our analyses, we pinpointed a gene, MAP4K3, which was elevated in DN conditions but decreased following AS-IV treatment. Silencing this gene led to reduced cell death in kidney cells exposed to high glucose levels, indicating that AS-IV might counteract the harmful effects of diabetes on kidney health. Overall, our findings suggest that AS-IV could play a significant role in protecting against diabetes-related kidney damage, offering a hopeful avenue for future therapies in diabetic nephropathy.
References
- Fan Y, Fan H, Li P, Liu Q, Huang L, et al. Mitogen-activating protein kinase kinase kinase kinase-3, inhibited by Astragaloside IV through H3 lysine 4 monomethylation, promotes the progression of diabetic nephropathy by inducing apoptosis. Bioengineered. 2022;13:11517. 10.1080/21655979.2022.2068822
- Kobayashi S. [Pharmacological Mechanisms of Boiogito and Bofutsushosan in Diabetes and Obesity Models]. Yakugaku Zasshi. 2018;138:389. 10.1248/yakushi.17-00168
