' 
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Astragalus Root Extract(Astragalus membranaceus) (Standardized to min 70% Polysaccharides)
500 mg
**
Top Medical Research Studies
8
Astragaloside IV benefits diabetic nephropathy
Mitogen-activating protein kinase kinase kinase kinase-3, inhibited by Astragaloside IV through H3 lysine 4 monomethylation, promotes the progression of diabetic nephropathy by inducing apoptosis.
Focused effects on diabetic nephropathy
We explored how astragaloside IV (AS-IV), a natural compound from the Astragalus root, impacts diabetic nephropathy (DN) and its symptoms. In our observations, AS-IV treatment showed promise in alleviating DN symptoms in mice, leading to improvements in several health markers, including body weight and kidney function indicators such as urine microalbumin and serum creatinine levels.
We noted that AS-IV seemed to reduce the progression of DN by lowering apoptosis, the process of programmed cell death that often contributes to kidney issues in diabetes. Our research revealed that AS-IV affects specific epigenetic modifications, particularly H3 lysine 4 monomethylation (H3K4me1), a mechanism tied to gene expression regulation.
Through our analyses, we pinpointed a gene, MAP4K3, which was elevated in DN conditions but decreased following AS-IV treatment. Silencing this gene led to reduced cell death in kidney cells exposed to high glucose levels, indicating that AS-IV might counteract the harmful effects of diabetes on kidney health. Overall, our findings suggest that AS-IV could play a significant role in protecting against diabetes-related kidney damage, offering a hopeful avenue for future therapies in diabetic nephropathy.
We noted that AS-IV seemed to reduce the progression of DN by lowering apoptosis, the process of programmed cell death that often contributes to kidney issues in diabetes. Our research revealed that AS-IV affects specific epigenetic modifications, particularly H3 lysine 4 monomethylation (H3K4me1), a mechanism tied to gene expression regulation.
Through our analyses, we pinpointed a gene, MAP4K3, which was elevated in DN conditions but decreased following AS-IV treatment. Silencing this gene led to reduced cell death in kidney cells exposed to high glucose levels, indicating that AS-IV might counteract the harmful effects of diabetes on kidney health. Overall, our findings suggest that AS-IV could play a significant role in protecting against diabetes-related kidney damage, offering a hopeful avenue for future therapies in diabetic nephropathy.
Read More
7
Astragalus root aids diabetes treatment
[Pharmacological Mechanisms of Boiogito and Bofutsushosan in Diabetes and Obesity Models].
Significant role in treatment efficacy
We explored the effectiveness of astragalus root as part of a broader treatment approach for diabetes. In a study utilizing streptozotocin-induced diabetic mice, we found that extracts containing astragalus root exhibited antihyperglycemic and insulinotropic activities, particularly when combined with other key ingredients like stephania root.
Although we did not test astragalus root in isolation, it played a significant role in enhancing the overall efficacy of the treatment. Essentially, the presence of formononetin in astragalus could amplify the actions of other compounds, like fangchinoline from stephania, which is pivotal for reducing blood sugar levels.
These combined effects suggest that astragalus root is an important player in the fight against diabetes, though its individual contributions require further investigation.
Although we did not test astragalus root in isolation, it played a significant role in enhancing the overall efficacy of the treatment. Essentially, the presence of formononetin in astragalus could amplify the actions of other compounds, like fangchinoline from stephania, which is pivotal for reducing blood sugar levels.
These combined effects suggest that astragalus root is an important player in the fight against diabetes, though its individual contributions require further investigation.
Read More
Most Useful Reviews
8.8
Diabetes management support
An investment in my health! As I turn 50, I realised the importance of taking better care of myself. I chose this astragalus product for its quality and benefits, including regulating diabetes. These supplements may not provide overnight changes but support gradual, consistent healing over time.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
- All Researches
8
Astragaloside IV benefits diabetic nephropathy
Mitogen-activating protein kinase kinase kinase kinase-3, inhibited by Astragaloside IV through H3 lysine 4 monomethylation, promotes the progression of diabetic nephropathy by inducing apoptosis.
Focused effects on diabetic nephropathy
We explored how astragaloside IV (AS-IV), a natural compound from the Astragalus root, impacts diabetic nephropathy (DN) and its symptoms. In our observations, AS-IV treatment showed promise in alleviating DN symptoms in mice, leading to improvements in several health markers, including body weight and kidney function indicators such as urine microalbumin and serum creatinine levels.
We noted that AS-IV seemed to reduce the progression of DN by lowering apoptosis, the process of programmed cell death that often contributes to kidney issues in diabetes. Our research revealed that AS-IV affects specific epigenetic modifications, particularly H3 lysine 4 monomethylation (H3K4me1), a mechanism tied to gene expression regulation.
Through our analyses, we pinpointed a gene, MAP4K3, which was elevated in DN conditions but decreased following AS-IV treatment. Silencing this gene led to reduced cell death in kidney cells exposed to high glucose levels, indicating that AS-IV might counteract the harmful effects of diabetes on kidney health. Overall, our findings suggest that AS-IV could play a significant role in protecting against diabetes-related kidney damage, offering a hopeful avenue for future therapies in diabetic nephropathy.
We noted that AS-IV seemed to reduce the progression of DN by lowering apoptosis, the process of programmed cell death that often contributes to kidney issues in diabetes. Our research revealed that AS-IV affects specific epigenetic modifications, particularly H3 lysine 4 monomethylation (H3K4me1), a mechanism tied to gene expression regulation.
Through our analyses, we pinpointed a gene, MAP4K3, which was elevated in DN conditions but decreased following AS-IV treatment. Silencing this gene led to reduced cell death in kidney cells exposed to high glucose levels, indicating that AS-IV might counteract the harmful effects of diabetes on kidney health. Overall, our findings suggest that AS-IV could play a significant role in protecting against diabetes-related kidney damage, offering a hopeful avenue for future therapies in diabetic nephropathy.
Read More
7
Astragalus root aids diabetes treatment
[Pharmacological Mechanisms of Boiogito and Bofutsushosan in Diabetes and Obesity Models].
Significant role in treatment efficacy
We explored the effectiveness of astragalus root as part of a broader treatment approach for diabetes. In a study utilizing streptozotocin-induced diabetic mice, we found that extracts containing astragalus root exhibited antihyperglycemic and insulinotropic activities, particularly when combined with other key ingredients like stephania root.
Although we did not test astragalus root in isolation, it played a significant role in enhancing the overall efficacy of the treatment. Essentially, the presence of formononetin in astragalus could amplify the actions of other compounds, like fangchinoline from stephania, which is pivotal for reducing blood sugar levels.
These combined effects suggest that astragalus root is an important player in the fight against diabetes, though its individual contributions require further investigation.
Although we did not test astragalus root in isolation, it played a significant role in enhancing the overall efficacy of the treatment. Essentially, the presence of formononetin in astragalus could amplify the actions of other compounds, like fangchinoline from stephania, which is pivotal for reducing blood sugar levels.
These combined effects suggest that astragalus root is an important player in the fight against diabetes, though its individual contributions require further investigation.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Diabetes management support
An investment in my health! As I turn 50, I realised the importance of taking better care of myself. I chose this astragalus product for its quality and benefits, including regulating diabetes. These supplements may not provide overnight changes but support gradual, consistent healing over time.
Read More
