Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 55 Researches
8.2
USERS' SCORE
Good
Based on 6 Reviews
8.3
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Blend of Probiotic Bacteria:Lactobacillus acidophilus (La-14),Bifidobacterium lactis (Bl-04),Bifidobacterium longum (Bl-05)
8 Billion CFU
*
Top Medical Research Studies
8
We investigated the impact of a probiotic ice cream containing engineered bacteria on pollen allergies in mice. After sensitizing the mice, we treated them with this unique ice cream for four weeks. The results were promising! The ice cream significantly lowered serum IgE levels, which are linked to allergic reactions. Additionally, beneficial cytokines increased while the levels of a harmful cytokine decreased. Overall, our findings suggest that this probiotic ice cream could improve allergy responses, particularly with Th1 and Treg involvement.
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9
Lactobacillus KBL409 reduces atopic dermatitis
We explored the effects of Lactobacillus acidophilus KBL409 on atopic dermatitis (AD) using a house dust mite-induced mouse model. The treatment notably lowered dermatitis symptoms and reduced immune cell infiltration in the skin. Additionally, it decreased levels of specific immune markers and increased anti-inflammatory responses.
L. acidophilus KBL409 also positively influenced gut microbiota and certain metabolites. The findings suggest that this probiotic may offer a promising approach to managing AD through immune system modulation and gut health improvement.
L. acidophilus KBL409 also positively influenced gut microbiota and certain metabolites. The findings suggest that this probiotic may offer a promising approach to managing AD through immune system modulation and gut health improvement.
Read More
9
We conducted a thorough investigation to see how Lactobacillus acidophilus L-92 affects skin symptoms in adults with atopic dermatitis. In this double-blind study involving 50 participants, we compared this probiotic against a placebo over 24 weeks.
Our findings showed that those taking L-92 experienced significant improvements in skin condition compared to the placebo group. There were reductions in symptoms and overall severity, with no adverse effects reported. This suggests that L-92 may help manage inflammation linked to allergies.
Our findings showed that those taking L-92 experienced significant improvements in skin condition compared to the placebo group. There were reductions in symptoms and overall severity, with no adverse effects reported. This suggests that L-92 may help manage inflammation linked to allergies.
Read More
Most Useful Reviews
7.5
Skin and gut health
12 people found this helpful
My persistent diarrhoea and constipation have ceased, and my skin has improved markedly. This product seems to have alleviated my allergies too. I believe that maintaining a healthy gut is crucial to overall wellbeing, and this supplement is recommended even for those in good health.
Read More
9
Allergy improvement
10 people found this helpful
I have a wheat allergy and began taking several supplements for my leaky gut. After three months, my wheat allergy vanished! I'm thrilled to eat anything now. While I cannot ascertain the effect of this product alone, my gut health has definitely improved. I store it in the fridge and consume it before bed, and the size is easy to drink.
Read More
7.5
Reduced allergies
5 people found this helpful
I take Woman's Probiotic and Bioslee in the morning and this in the evening. My house dust allergies and hay fever have improved significantly. I wish to continue using it long-term.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 55 Researches
8.2
- All Researches
9.5
We sought to understand if Bifiform Kids, a probiotic, could help prevent respiratory infections in children with recurrent infections and gastrointestinal allergy symptoms. In our controlled trial with 92 children aged 4 to 5, those taking the probiotic showed a significant 3-fold reduction in respiratory infections compared to the control group.
After 21 days, there were notable immune system improvements, including an increase in protective IgA levels and a decrease in allergic IgE. These findings suggest that Bifiform Kids is effective for preventing respiratory infections in children facing allergic issues.
After 21 days, there were notable immune system improvements, including an increase in protective IgA levels and a decrease in allergic IgE. These findings suggest that Bifiform Kids is effective for preventing respiratory infections in children facing allergic issues.
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9
Lactobacillus KBL409 reduces atopic dermatitis
We explored the effects of Lactobacillus acidophilus KBL409 on atopic dermatitis (AD) using a house dust mite-induced mouse model. The treatment notably lowered dermatitis symptoms and reduced immune cell infiltration in the skin. Additionally, it decreased levels of specific immune markers and increased anti-inflammatory responses.
L. acidophilus KBL409 also positively influenced gut microbiota and certain metabolites. The findings suggest that this probiotic may offer a promising approach to managing AD through immune system modulation and gut health improvement.
L. acidophilus KBL409 also positively influenced gut microbiota and certain metabolites. The findings suggest that this probiotic may offer a promising approach to managing AD through immune system modulation and gut health improvement.
Read More
9
We investigated the effects of Lactobacillus acidophilus on allergies, particularly its peptidoglycan derived from dairy. In a mouse model of β-lactoglobulin allergy, we discovered that this peptidoglycan helped lower IgE production and promoted a healthier immune response. It also appeared to influence specific immune signaling pathways that help manage allergic reactions.
However, while the results showed promise, they were conducted in a controlled lab setting and further studies are needed to understand how these effects translate to humans.
However, while the results showed promise, they were conducted in a controlled lab setting and further studies are needed to understand how these effects translate to humans.
Read More
9
We conducted a thorough investigation to see how Lactobacillus acidophilus L-92 affects skin symptoms in adults with atopic dermatitis. In this double-blind study involving 50 participants, we compared this probiotic against a placebo over 24 weeks.
Our findings showed that those taking L-92 experienced significant improvements in skin condition compared to the placebo group. There were reductions in symptoms and overall severity, with no adverse effects reported. This suggests that L-92 may help manage inflammation linked to allergies.
Our findings showed that those taking L-92 experienced significant improvements in skin condition compared to the placebo group. There were reductions in symptoms and overall severity, with no adverse effects reported. This suggests that L-92 may help manage inflammation linked to allergies.
Read More
9
Lactobacillus acidophilus may reduce allergies
Our study assessed how Lactobacillus acidophilus in probiotic Dahi affects allergies, particularly cow milk allergy in mice. Mice were given two types of probiotic Dahi before being exposed to whey proteins.
The results were promising; we found that the probiotic treatment reduced allergy-related immune responses. Specifically, it lowered certain IgE levels and shifted the immune response from a Th2-type to a Th1-type, which is generally more protective against allergens.
While further research is needed, these findings suggest that probiotics could be a potential avenue for managing food allergies.
The results were promising; we found that the probiotic treatment reduced allergy-related immune responses. Specifically, it lowered certain IgE levels and shifted the immune response from a Th2-type to a Th1-type, which is generally more protective against allergens.
While further research is needed, these findings suggest that probiotics could be a potential avenue for managing food allergies.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Skin and gut health
12 people found this helpful
My persistent diarrhoea and constipation have ceased, and my skin has improved markedly. This product seems to have alleviated my allergies too. I believe that maintaining a healthy gut is crucial to overall wellbeing, and this supplement is recommended even for those in good health.
Read More
9
Allergy improvement
10 people found this helpful
I have a wheat allergy and began taking several supplements for my leaky gut. After three months, my wheat allergy vanished! I'm thrilled to eat anything now. While I cannot ascertain the effect of this product alone, my gut health has definitely improved. I store it in the fridge and consume it before bed, and the size is easy to drink.
Read More
7.5
Reduced allergies
5 people found this helpful
I take Woman's Probiotic and Bioslee in the morning and this in the evening. My house dust allergies and hay fever have improved significantly. I wish to continue using it long-term.
Read More
7.5
No allergy symptoms
5 people found this helpful
After trying many products for my histamine intolerance and Mast Cell Activation Syndrome, I found this to be the best. It's free from milk and soy, causing no allergy symptoms. I appreciate that it doesn't disturb my sleep, and I've had no constipation or side effects. I highly recommend it!
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7.5
Improved allergies
1 people found this helpful
The probiotics bought for the elderly can help with allergic tendencies. A doctor recommended this product to improve such conditions.
Read More
Frequently Asked Questions
7.5
Reduced allergies
5 people found this helpful
I take Woman's Probiotic and Bioslee in the morning and this in the evening. My house dust allergies and hay fever have improved significantly. I wish to continue using it long-term.
9
Allergy improvement
10 people found this helpful
I have a wheat allergy and began taking several supplements for my leaky gut. After three months, my wheat allergy vanished! I'm thrilled to eat anything now. While I cannot ascertain the effect of this product alone, my gut health has definitely improved. I store it in the fridge and consume it before bed, and the size is easy to drink.
7.5
Skin and gut health
12 people found this helpful
My persistent diarrhoea and constipation have ceased, and my skin has improved markedly. This product seems to have alleviated my allergies too. I believe that maintaining a healthy gut is crucial to overall wellbeing, and this supplement is recommended even for those in good health.
7.5
No allergy symptoms
5 people found this helpful
After trying many products for my histamine intolerance and Mast Cell Activation Syndrome, I found this to be the best. It's free from milk and soy, causing no allergy symptoms. I appreciate that it doesn't disturb my sleep, and I've had no constipation or side effects. I highly recommend it!
9
Lactobacillus KBL409 reduces atopic dermatitis
We explored the effects of Lactobacillus acidophilus KBL409 on atopic dermatitis (AD) using a house dust mite-induced mouse model. The treatment notably lowered dermatitis symptoms and reduced immune cell infiltration in the skin. Additionally, it decreased levels of specific immune markers and increased anti-inflammatory responses.
L. acidophilus KBL409 also positively influenced gut microbiota and certain metabolites. The findings suggest that this probiotic may offer a promising approach to managing AD through immune system modulation and gut health improvement.
L. acidophilus KBL409 also positively influenced gut microbiota and certain metabolites. The findings suggest that this probiotic may offer a promising approach to managing AD through immune system modulation and gut health improvement.
8
We aimed to assess how probiotic supplementation, particularly using Lactobacillus acidophilus, can help treat adult atopic dermatitis (AD). After analyzing nine studies, we found that specific probiotics, including L. acidophilus, provided some benefits, especially for those with moderate to severe AD.
However, changes in skin severity did not significantly improve patients’ quality of life. Importantly, the effectiveness of probiotics varied by strain, and there are still many unknowns about the best dosage and treatment duration.
However, changes in skin severity did not significantly improve patients’ quality of life. Importantly, the effectiveness of probiotics varied by strain, and there are still many unknowns about the best dosage and treatment duration.
8
We investigated the potential of Lactobacillus acidophilus KLDS 1.0738 to alleviate allergic inflammation, focusing on its ability to influence a specific inflammatory pathway in macrophages. By treating β-lactoglobulin-induced macrophages with viable L. acidophilus, we found that it effectively reduced inflammation by inhibiting the TLR4/NF-κB signaling pathway. This strain outperformed other probiotics in its effectiveness. Additionally, it was linked to increased levels of miR-146a, a molecule that regulates inflammation. These findings suggest that probiotics could play a significant role in managing milk allergies, particularly in infants.
8
Probiotics beneficial for eczema treatment
We examined the use of probiotics in alleviating symptoms of atopic dermatitis in children. Through a thorough review of multiple studies, we found that certain probiotic strains, particularly Mix1 and Mix6, significantly improved allergic symptoms compared to a placebo.
Although evidence was strongest for Mix1 among the strains assessed, Mix6 showed promising potential as well. Conversely, while Lactobacillus casei DN-114001 indicated some benefit, the certainty of this effect was lower.
Overall, specific probiotic preparations do seem to help in managing allergies associated with pediatric atopic dermatitis.
Although evidence was strongest for Mix1 among the strains assessed, Mix6 showed promising potential as well. Conversely, while Lactobacillus casei DN-114001 indicated some benefit, the certainty of this effect was lower.
Overall, specific probiotic preparations do seem to help in managing allergies associated with pediatric atopic dermatitis.
References
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- Husein-ElAhmed H, Steinhoff M. Effects of probiotic supplementation in adult with atopic dermatitis: a systematic review with meta-analysis. Clin Exp Dermatol. 2023;49:46. 10.1093/ced/llad318
- Li A, Yang J, Zhang C, Chi H, Zhang C, et al. Lactobacillus acidophilus KLDS 1.0738 inhibits TLR4/NF-κB inflammatory pathway in β-lactoglobulin-induced macrophages via modulating miR-146a. J Food Biochem. 2021;45:e13662. 10.1111/jfbc.13662
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- Wang JJ, Zhang QM, Ni WW, Zhang X, Li Y, et al. Modulatory effect of Lactobacillus acidophilus KLDS 1.0738 on intestinal short-chain fatty acids metabolism and GPR41/43 expression in β-lactoglobulin-sensitized mice. Microbiol Immunol. 2019;63:303. 10.1111/1348-0421.12723
- Nakata J, Hirota T, Umemura H, Nakagawa T, Kando N, et al. Additive effect of L-92 on children with atopic dermatitis concomitant with food allergy. Asia Pac Allergy. 2019;9:e18. 10.5415/apallergy.2019.9.e18
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- Shandilya UK, Sharma A, Kapila R, Kansal VK. Probiotic Dahi containing Lactobacillus acidophilus and Bifidobacterium bifidum modulates immunoglobulin levels and cytokines expression in whey proteins sensitised mice. J Sci Food Agric. 2016;96:3180. 10.1002/jsfa.7497
- Simpson MR, Dotterud CK, Storrø O, Johnsen R, Øien T. Perinatal probiotic supplementation in the prevention of allergy related disease: 6 year follow up of a randomised controlled trial. BMC Dermatol. 2015;15:13. 10.1186/s12895-015-0030-1
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- Niu X, Yin X, Wu X, Zhang Q, Jiang Y, et al. Heat-Killed BBMN68 in Pasteurized Yogurt Alleviates Mugwort Pollen-Induced Allergic Airway Responses through Gut Microbiota Modulation in a Murine Model. Foods. 2023;12. 10.3390/foods12102049
- Feíto-Rodríguez M, Ramírez-Boscà A, Vidal-Asensi S, Fernández-Nieto D, Ros-Cervera G, et al. Randomized double-blind placebo-controlled clinical trial to evaluate the effect of a mixture of probiotic strains on symptom severity and use of corticosteroids in children and adolescents with atopic dermatitis. Clin Exp Dermatol. 2023;48:495. 10.1093/ced/llad007
- Fang Z, Pan T, Li L, Wang H, Zhu J, et al. mediated tryptophan metabolism to improve atopic dermatitis via the gut-skin axis. Gut Microbes. 2022;14:2044723. 10.1080/19490976.2022.2044723
- Santos SS, Miranda VC, Trindade LM, Cardoso VN, Reis DC, et al. Bifidobacterium longum subsp. longum 5 Attenuates Signs of Inflammation in a Murine Model of Food Allergy. Probiotics Antimicrob Proteins. 2023;15:63. 10.1007/s12602-021-09846-9
- Pyclik MJ, Srutkova D, Razim A, Hermanova P, Svabova T, et al. Viability Status-Dependent Effect of ssp CCM 7952 on Prevention of Allergic Inflammation in Mouse Model. Front Immunol. 2021;12:707728. 10.3389/fimmu.2021.707728
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- Wang H, He Y, Dang D, Feng L, Huang L, et al. subsp. CCFM1274 relieved allergic asthma symptoms by modifying intestinal tryptophan metabolism in mice. Food Funct. 2024;15:8810. 10.1039/d4fo01079e
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- Li L, Wen X, Gong Y, Chen Y, Xu J, et al. HMGN2 and Histone H1.2: potential targets of a novel probiotic mixture for seasonal allergic rhinitis. Front Microbiol. 2023;14:1202858. 10.3389/fmicb.2023.1202858
- Komulainen M, Saros L, Vahlberg T, Nermes M, Jartti T, et al. Maternal fish oil and/or probiotics intervention: Allergic diseases in children up to two years old. Pediatr Allergy Immunol. 2023;34:e14004. 10.1111/pai.14004
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- Anania C, Di Marino VP, Olivero F, De Canditiis D, Brindisi G, et al. Treatment with a Probiotic Mixture Containing Subsp. BB12 and L3 for the Prevention of Allergic Rhinitis Symptoms in Children: A Randomized Controlled Trial. Nutrients. 2021;13. 10.3390/nu13041315
- Tan-Lim CSC, Esteban-Ipac NAR, Recto MST, Castor MAR, Casis-Hao RJ, et al. Comparative effectiveness of probiotic strains on the prevention of pediatric atopic dermatitis: A systematic review and network meta-analysis. Pediatr Allergy Immunol. 2021;32:1255. 10.1111/pai.13514
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- Lee JY, Park JY, Jeong Y, Kang CH. Anti-Inflammatory Response in TNFα/IFNγ-Induced HaCaT Keratinocytes and Probiotic Properties of MG4644, MG4693, and MG5474. J Microbiol Biotechnol. 2023;33:1039. 10.4014/jmb.2301.01028
- Baek J, Kim JH, Kim W. Potential Anti-Allergy and Immunomodulatory Properties of LB 1022 Observed In Vitro and in an Atopic Dermatitis Mouse Model. J Microbiol Biotechnol. 2023;33:823. 10.4014/jmb.2301.01019
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- Lee DH, Park HK, Lee HR, Sohn H, Sim S, et al. Immunoregulatory effects of Lactococcus lactis-derived extracellular vesicles in allergic asthma. Clin Transl Allergy. 2022;12:e12138. 10.1002/clt2.12138
- Lee MF, Chiang CH, Lin SJ, Wu CS, Chen YH. Effectiveness and safety of oral lactococci-based vaccine encoding triple common allergens to prevent airway allergy in mice. PLoS One. 2021;16:e0261333. 10.1371/journal.pone.0261333
- El Mecherfi KE, Lupi R, Cherkaoui M, Albuquerque MAC, Todorov SD, et al. Fermentation of Gluten by Lactococcus lactis LLGKC18 Reduces its Antigenicity and Allergenicity. Probiotics Antimicrob Proteins. 2022;14:779. 10.1007/s12602-021-09808-1
- Zhang K, Mirza WA, Ni P, Yu M, Wang C, et al. Recombination Lactococcus lactis expressing Helicobacter pylori neutrophil-activating protein A attenuates food allergy symptoms in mice. FEMS Microbiol Lett. 2021;368. 10.1093/femsle/fnab034
- Cervantes-García D, Jiménez M, Rivas-Santiago CE, Gallegos-Alcalá P, Hernández-Mercado A, et al. Lactococcus lactis NZ9000 Prevents Asthmatic Airway Inflammation and Remodelling in Rats through the Improvement of Intestinal Barrier Function and Systemic TGF-β Production. Int Arch Allergy Immunol. 2021;182:277. 10.1159/000511146
- de Lacerda LB, Rios WM, Masson AP, Brandão IT, Milani TM, et al. Oral administration of Hsp65-producing Lactococcus lactis attenuates allergic asthma in a murine model. J Appl Microbiol. 2021;130:2075. 10.1111/jam.14913
- Vasiee A, Falah F, Sankian M, Tabatabaei-Yazdi F, Mortazavi SA. Oral Immunotherapy Using Probiotic Ice Cream Containing Recombinant Food-Grade Which Inhibited Allergic Responses in a BALB/c Mouse Model. J Immunol Res. 2020;2020:2635230. 10.1155/2020/2635230
- Suzuki T, Nishiyama K, Kawata K, Sugimoto K, Isome M, et al. Effect of the 11/19-B1 Strain on Atopic Dermatitis in a Clinical Test and Mouse Model. Nutrients. 2020;12. 10.3390/nu12030763
- Chan CJ, Yong YS, Song AAL, Abdul Rahim R, In LLA, et al. Lactococcus lactis harbouring Ara h 2.02 alleviates allergen-specific Th2-associated responses in sensitized mice. J Appl Microbiol. 2020;128:862. 10.1111/jam.14524
- Jin M, Lee S, Choi YA, Jang HJ, Lee SW, et al. Lactococcus lactis KR-050L extract suppresses house dust mite induced-atopic skin inflammation through inhibition of keratinocyte and mast cell activation. J Appl Microbiol. 2019;126:230. 10.1111/jam.14116
