Bifidobacterium longum protects against pneumoniaControl of Klebsiella pneumoniae pulmonary infection and immunomodulation by oral treatment with the commensal probiotic Bifidobacterium longum 5(1A).
We explored how the probiotic Bifidobacterium longum 5(1A) can affect pneumonia caused by Klebsiella pneumoniae in mice. Our study showed that this treatment led to a quicker resolution of lung inflammation and significantly reduced the bacterial load, ultimately saving 100% of the mice from death.
This protective effect was linked to the activation of the Toll-like receptor signaling pathway. In particular, B. longum 5(1A) helped balance the body's inflammatory response, promoting a faster recovery in the lungs. Overall, our findings suggest that this probiotic could play a beneficial role in enhancing lung health during infections.
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Symbiotics lower postoperative infectionsPerioperative synbiotics administration decreases postoperative infections in patients with colorectal cancer: a randomized, double-blind clinical trial.
We explored how administering symbiotics, which include Lactobacillus acidophilus, impacts infection rates following colorectal surgery. In a randomized trial with 91 patients, those receiving symbiotics experienced a notable drop in infections compared to the placebo group. Specifically, only 2% of patients on symbiotics developed surgical site infections, whereas 21.4% in the control group did. This indicates that perioperative symbiotic treatment could be beneficial during surgical recovery. However, further research is necessary to confirm these findings.
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L-C-dots show promise against pneumoniaSynergistic antibacterial effects of carbon dots derived from Lactobacillus acidophilus alone and in combination against carbapenem-resistant Klebsiella pneumoniae.
We examined how carbon dots sourced from Lactobacillus acidophilus might tackle carbapenem-resistant Klebsiella pneumoniae, a tough pneumonia-causing bacteria. Our tests showed that these carbon dots, known as L-C-dots, have strong antibacterial properties and can even work well with regular antibiotics.
Importantly, L-C-dots not only inhibited bacterial growth but also prevented biofilm formation, which is often a barrier to successful treatment. They even helped reduce the expression of specific genes linked to biofilm development.
This research suggests that L-C-dots could be a valuable addition to our arsenal against resistant pneumonia infections.
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Probiotics reduce respiratory infectionsRole of multi-strain probiotics in preventing severity and frequency of recurrent respiratory tract infections in children.
We explored the potential of probiotics, specifically Lactobacillus acidophilus, in reducing the severity and frequency of respiratory tract infections in children. Conducted at Abbassi Shaheed Hospital, our study analyzed 70 children over six months who received probiotics for two weeks.
Our results showed a significant decline in respiratory symptoms and infections among the participants. Overall, this suggests that probiotics can indeed play a beneficial role in supporting children's respiratory health.
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Probiotics reduce pneumonia ratesA four-probiotic preparation for ventilator-associated pneumonia in multi-trauma patients: results of a randomized clinical trial.
We explored the impact of a specific combination of probiotics on preventing ventilator-associated pneumonia (VAP) in critically injured patients on mechanical ventilation. In a randomized, placebo-controlled trial, patients received either a probiotic formula or a placebo during their treatment.
The results were promising; those who received the probiotics showed a lower incidence of VAP and sepsis, along with shorter ICU stays. This suggests that using probiotics might be a helpful strategy for protecting vulnerable patients from these infections while in intensive care.
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