5/24/2025
Last update
5/24/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.4
USERS' SCORE
Moderately Good
Based on 18 Reviews
7.9
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Vitamin D2 (as Ergocalciferol - a vegetarian source)
10 mcg (400 IU)
50%
Calcium (from Calcium Citrate)
600 mg
46%
Magnesium (from Magnesium Oxide and Magnesium Aspartate)
300 mg
71%
Zinc (from Zinc AAC*)
15 mg
136%
Copper (from Copper AAC*)
1 mg
111%
Manganese (from Manganese AAC*)
5 mg
217%
Top Medical Research Studies
7
Calcium citrate improves bone density
We conducted a well-designed trial involving 1,471 healthy postmenopausal women to explore the effects of calcium citrate on bone density and fracture rates over five years.
While we found that calcium significantly improved bone density, with noted benefits in spine and hip areas, the impact on actual fracture prevention was less clear.
Notably, longer-term compliance was an issue, which may have diminished its effectiveness. Ultimately, while calcium citrate appears to help with bone health, its role in preventing fractures remains uncertain.
While we found that calcium significantly improved bone density, with noted benefits in spine and hip areas, the impact on actual fracture prevention was less clear.
Notably, longer-term compliance was an issue, which may have diminished its effectiveness. Ultimately, while calcium citrate appears to help with bone health, its role in preventing fractures remains uncertain.
Read More
8
Calcium citrate improved osteoporosis outcomes
We investigated the scenario of a patient with renal tubular acidosis type 2, Fanconi's syndrome, and osteoporosis resulting from vitamin D and calcium deficiency. Through meticulous reviews of clinical and lab findings, we noted substantial improvements after 24 months of vitamin D and calcium therapy.
By the end of the treatment, the patient's lumbar spine and femoral neck bone density scores improved significantly, indicating a positive response to calcium citrate. This suggests that calcium may play a valuable role in addressing osteoporosis associated with nutritional deficiencies.
By the end of the treatment, the patient's lumbar spine and femoral neck bone density scores improved significantly, indicating a positive response to calcium citrate. This suggests that calcium may play a valuable role in addressing osteoporosis associated with nutritional deficiencies.
Read More
7
Calcium citrate benefits bone turnover
We examined how calcium citrate, along with other calcium supplements, impacts bone health in postmenopausal women. Over a three-month period, we found that calcium citrate notably increased serum calcium levels for up to eight hours after ingestion and maintained these effects consistently.
When compared to microcrystalline hydroxyapatite, both calcium citrate and carbonate led to similar decreases in bone turnover markers, suggesting they are effective for bone health. However, none of the supplements demonstrated a significant advantage in improving bone turnover beyond these initial effects.
When compared to microcrystalline hydroxyapatite, both calcium citrate and carbonate led to similar decreases in bone turnover markers, suggesting they are effective for bone health. However, none of the supplements demonstrated a significant advantage in improving bone turnover beyond these initial effects.
Read More
Most Useful Reviews
10
No osteoporosis
16 people found this helpful
This has been my go-to for the last 40 years, recommended by my physician. After my last bone density study, I was pleased to hear I have no osteoporosis, and I'm now 82 years old!
Read More
9
Effective calcium citrate
2 people found this helpful
I prefer this calcium citrate for its excellent formulation, making it easier than taking calcium with other components separately, which aid in better calcium absorption. Citrate absorbs better with fewer side effects than cheaper options. I have grade 2 osteoporosis and need calcium regularly. Since starting this, my bones and joints no longer ache as they did before.
Read More
10
Strengthened bones
1 people found this helpful
Excellent drug for osteoporosis! I bought it for my 68-year-old mother to boost her calcium levels. We were thrilled with the results; after about a year of use, her calcium levels increased, her bones became stronger, and her fracture risk dropped significantly. The composition improves calcium absorption; we took two tablets nightly for ten days each month without any side effects. I highly recommend this product!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.4
- All Researches
9
We investigated the long-term effects of calcium citrate and sodium fluoride compared to intravenous ibandronate in patients with osteoporosis due to Crohn's disease. In a study involving 66 participants, both treatment groups showed improvement in bone density over a 3.5-year follow-up. However, while ibandronate is established in reducing fracture rates, sodium fluoride’s effectiveness in this regard remains unproven. Overall, our findings suggest that intravenous ibandronate is a safe and beneficial option for treating osteoporosis in these patients.
Read More
8
We assessed how calcium from cladodes impacts osteoporosis using an ovariectomized rat model, which mimics postmenopausal bone loss.
In our study, we distributed 35 female rats into various groups, with some receiving calcium citrate supplementation.
The results were promising! Calcium from cladodes was found to be bioavailable, enhancing the physical, densitometric, biomechanical, and microstructural aspects of the bones.
This indicates that incorporating cladodes into the diet could potentially help prevent osteoporosis and improve overall bone health.
In our study, we distributed 35 female rats into various groups, with some receiving calcium citrate supplementation.
The results were promising! Calcium from cladodes was found to be bioavailable, enhancing the physical, densitometric, biomechanical, and microstructural aspects of the bones.
This indicates that incorporating cladodes into the diet could potentially help prevent osteoporosis and improve overall bone health.
Read More
8
We set out to determine if combining bovine collagen peptides (CPs) with calcium citrate provides better protection against bone loss than using them alone. In our study, ovariectomized rats received different treatments over three months.
The results showed that both CPs and the combination of CPs with calcium citrate significantly improved bone density and architecture. Notably, the combined treatment offered the most robust protection, suggesting it could be an effective strategy for addressing osteoporosis, particularly in postmenopausal women.
The results showed that both CPs and the combination of CPs with calcium citrate significantly improved bone density and architecture. Notably, the combined treatment offered the most robust protection, suggesting it could be an effective strategy for addressing osteoporosis, particularly in postmenopausal women.
Read More
8
We explored how different forms of calcium citrate affect absorption in patients post-gastric bypass. In a study involving 15 patients, we compared the absorption of liquid potassium-calcium-citrate (PCC) with that of a tablet form, Citracal Petite. Results showed that PCC delivered more calcium into the bloodstream and effectively reduced parathyroid hormone levels.
This suggests that for those who have had gastric bypass surgery, switching to PCC may help better support bone health by enhancing calcium bioavailability.
This suggests that for those who have had gastric bypass surgery, switching to PCC may help better support bone health by enhancing calcium bioavailability.
Read More
8
Calcium citrate aids osteoporosis treatment
We explored the impact of calcium citrate combined with vitamin D on osteoporosis treatment. Research indicates that this combination is effective in lowering non-vertebral and hip fracture rates, particularly when taken at specific dosages. Moreover, many women receiving treatment for osteoporosis face inadequate vitamin D levels, highlighting the importance of this nutrient in conjunction with calcium.
Additionally, calcium citrate is better absorbed than other forms, promoting better patient compliance. Taken between meals, it can reduce digestive discomfort, making it more appealing for treatment.
Additionally, calcium citrate is better absorbed than other forms, promoting better patient compliance. Taken between meals, it can reduce digestive discomfort, making it more appealing for treatment.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 18 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
10
No osteoporosis
16 people found this helpful
This has been my go-to for the last 40 years, recommended by my physician. After my last bone density study, I was pleased to hear I have no osteoporosis, and I'm now 82 years old!
Read More
9
Effective calcium citrate
2 people found this helpful
I prefer this calcium citrate for its excellent formulation, making it easier than taking calcium with other components separately, which aid in better calcium absorption. Citrate absorbs better with fewer side effects than cheaper options. I have grade 2 osteoporosis and need calcium regularly. Since starting this, my bones and joints no longer ache as they did before.
Read More
10
Strengthened bones
1 people found this helpful
Excellent drug for osteoporosis! I bought it for my 68-year-old mother to boost her calcium levels. We were thrilled with the results; after about a year of use, her calcium levels increased, her bones became stronger, and her fracture risk dropped significantly. The composition improves calcium absorption; we took two tablets nightly for ten days each month without any side effects. I highly recommend this product!
Read More
9
Good for bones
Calcium citrate is a good product for treating osteoporosis. However, the tablets are quite large and difficult to chew.
Read More
6
Calcium intake caution
44 people found this helpful
Be careful with calcium! This highly bioavailable form is only critical if your bones are affected by osteoporosis; otherwise, it is generally unnecessary for healthy bones. Calcium is needed for bone restoration and growth in children. However, if bones are damaged, calcium won’t help without agents that support bone health. I would advise taking calcium alongside vitamins D and K, and after testing for calcium levels to avoid excess. I hope my review helps you; be healthy and happy!
Read More
Frequently Asked Questions
10
Strengthened bones
1 people found this helpful
Excellent drug for osteoporosis! I bought it for my 68-year-old mother to boost her calcium levels. We were thrilled with the results; after about a year of use, her calcium levels increased, her bones became stronger, and her fracture risk dropped significantly. The composition improves calcium absorption; we took two tablets nightly for ten days each month without any side effects. I highly recommend this product!
9
Visible results
4 people found this helpful
This amazing product has worked wonders! I bought it for osteoporosis prevention and my nails. At 64, I've taken many calcium supplements, but this one improved my nails in just two weeks! The quality-price ratio is excellent, and although it contains vitamin D2 instead of D3, I trust the manufacturer and take vitamin D3 separately.
9
Effective calcium citrate
2 people found this helpful
I prefer this calcium citrate for its excellent formulation, making it easier than taking calcium with other components separately, which aid in better calcium absorption. Citrate absorbs better with fewer side effects than cheaper options. I have grade 2 osteoporosis and need calcium regularly. Since starting this, my bones and joints no longer ache as they did before.
6
Calcium intake caution
44 people found this helpful
Be careful with calcium! This highly bioavailable form is only critical if your bones are affected by osteoporosis; otherwise, it is generally unnecessary for healthy bones. Calcium is needed for bone restoration and growth in children. However, if bones are damaged, calcium won’t help without agents that support bone health. I would advise taking calcium alongside vitamins D and K, and after testing for calcium levels to avoid excess. I hope my review helps you; be healthy and happy!
7.5
Calcium for prevention
The best calcium! Calcium is essential for preventing osteoporosis, as everyone knows. I purchased it based on my doctor's recommendation. Its composition includes magnesium and D2, enhancing absorption. It’s not nauseating and is easy to take.
7
Recommended for women
3 people found this helpful
Calcium is vital for bone health, especially for women during menopause to prevent osteoporosis and for growing children. Calcium citrate is well absorbed and reduces the risk of kidney stones, even with prolonged use. I recommend citrated forms of calcium as they are effective. Take one large tablet twice daily with meals. If this review helps, please like it.
8
We assessed how calcium from cladodes impacts osteoporosis using an ovariectomized rat model, which mimics postmenopausal bone loss.
In our study, we distributed 35 female rats into various groups, with some receiving calcium citrate supplementation.
The results were promising! Calcium from cladodes was found to be bioavailable, enhancing the physical, densitometric, biomechanical, and microstructural aspects of the bones.
This indicates that incorporating cladodes into the diet could potentially help prevent osteoporosis and improve overall bone health.
In our study, we distributed 35 female rats into various groups, with some receiving calcium citrate supplementation.
The results were promising! Calcium from cladodes was found to be bioavailable, enhancing the physical, densitometric, biomechanical, and microstructural aspects of the bones.
This indicates that incorporating cladodes into the diet could potentially help prevent osteoporosis and improve overall bone health.
8
We set out to determine if combining bovine collagen peptides (CPs) with calcium citrate provides better protection against bone loss than using them alone. In our study, ovariectomized rats received different treatments over three months.
The results showed that both CPs and the combination of CPs with calcium citrate significantly improved bone density and architecture. Notably, the combined treatment offered the most robust protection, suggesting it could be an effective strategy for addressing osteoporosis, particularly in postmenopausal women.
The results showed that both CPs and the combination of CPs with calcium citrate significantly improved bone density and architecture. Notably, the combined treatment offered the most robust protection, suggesting it could be an effective strategy for addressing osteoporosis, particularly in postmenopausal women.
7
Calcium citrate benefits bone turnover
We examined how calcium citrate, along with other calcium supplements, impacts bone health in postmenopausal women. Over a three-month period, we found that calcium citrate notably increased serum calcium levels for up to eight hours after ingestion and maintained these effects consistently.
When compared to microcrystalline hydroxyapatite, both calcium citrate and carbonate led to similar decreases in bone turnover markers, suggesting they are effective for bone health. However, none of the supplements demonstrated a significant advantage in improving bone turnover beyond these initial effects.
When compared to microcrystalline hydroxyapatite, both calcium citrate and carbonate led to similar decreases in bone turnover markers, suggesting they are effective for bone health. However, none of the supplements demonstrated a significant advantage in improving bone turnover beyond these initial effects.
8
Calcium citrate aids osteoporosis treatment
We explored the impact of calcium citrate combined with vitamin D on osteoporosis treatment. Research indicates that this combination is effective in lowering non-vertebral and hip fracture rates, particularly when taken at specific dosages. Moreover, many women receiving treatment for osteoporosis face inadequate vitamin D levels, highlighting the importance of this nutrient in conjunction with calcium.
Additionally, calcium citrate is better absorbed than other forms, promoting better patient compliance. Taken between meals, it can reduce digestive discomfort, making it more appealing for treatment.
Additionally, calcium citrate is better absorbed than other forms, promoting better patient compliance. Taken between meals, it can reduce digestive discomfort, making it more appealing for treatment.
7
Calcium citrate improves bone density
We conducted a well-designed trial involving 1,471 healthy postmenopausal women to explore the effects of calcium citrate on bone density and fracture rates over five years.
While we found that calcium significantly improved bone density, with noted benefits in spine and hip areas, the impact on actual fracture prevention was less clear.
Notably, longer-term compliance was an issue, which may have diminished its effectiveness. Ultimately, while calcium citrate appears to help with bone health, its role in preventing fractures remains uncertain.
While we found that calcium significantly improved bone density, with noted benefits in spine and hip areas, the impact on actual fracture prevention was less clear.
Notably, longer-term compliance was an issue, which may have diminished its effectiveness. Ultimately, while calcium citrate appears to help with bone health, its role in preventing fractures remains uncertain.
References
- Quintero-García M, Gutiérrez-Cortez E, Rojas-Molina A, Mendoza-Ávila M, Del Real A, et al. Calcium Bioavailability of Cladodes in an Ovariectomized Rat Model of Postmenopausal Bone Loss. Nutrients. 2020;12. 10.3390/nu12051431
- Liu J, Wang Y, Song S, Wang X, Qin Y, et al. Combined oral administration of bovine collagen peptides with calcium citrate inhibits bone loss in ovariectomized rats. PLoS One. 2015;10:e0135019. 10.1371/journal.pone.0135019
- Erfanian A, Mirhosseini H, Rasti B, Hair-Bejo M, Bin Mustafa S, et al. Absorption and Bioavailability of Nano-Size Reduced Calcium Citrate Fortified Milk Powder in Ovariectomized and Ovariectomized-Osteoporosis Rats. J Agric Food Chem. 2015;63:5795. 10.1021/acs.jafc.5b01468
- Bristow SM, Gamble GD, Stewart A, Horne L, House ME, et al. Acute and 3-month effects of microcrystalline hydroxyapatite, calcium citrate and calcium carbonate on serum calcium and markers of bone turnover: a randomised controlled trial in postmenopausal women. Br J Nutr. 2014;112:1611. 10.1017/S0007114514002785
- Sakhaee K, Pak C. Superior calcium bioavailability of effervescent potassium calcium citrate over tablet formulation of calcium citrate after Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2013;9:743. 10.1016/j.soard.2011.11.011
- Klaus J, Reinshagen M, Herdt K, Adler G, von Boyen GB, et al. Intravenous ibandronate or sodium-fluoride--a 3.5 years study on bone density and fractures in Crohn's disease patients with osteoporosis. J Gastrointestin Liver Dis. 2011;20:141.
- Sakhaee K, Griffith C, Pak CY. Biochemical control of bone loss and stone-forming propensity by potassium-calcium citrate after bariatric surgery. Surg Obes Relat Dis. 2012;8:67. 10.1016/j.soard.2011.05.001
- Quesada Gómez JM, Blanch Rubió J, Díaz Curiel M, Díez Pérez A. Calcium citrate and vitamin D in the treatment of osteoporosis. Clin Drug Investig. 2011;31:285.
- Yendt ER, Kovacs KA, Jones G. Secondary hyperparathyroidism in primary osteoporosis and osteopenia: optimizing calcium and vitamin D intakes to levels recommended by expert panels may not be sufficient for correction. Clin Endocrinol (Oxf). 2008;69:855. 10.1111/j.1365-2265.2008.03261.x
- Taylor HC, Elbadawy EH. Renal tubular acidosis type 2 with Fanconi's syndrome, osteomalacia, osteoporosis, and secondary hyperaldosteronism in an adult consequent to vitamin D and calcium deficiency: effect of vitamin D and calcium citrate therapy. Endocr Pract. 2006;12:559.
- Reid IR, Mason B, Horne A, Ames R, Reid HE, et al. Randomized controlled trial of calcium in healthy older women. Am J Med. 2006;119:777.
- Vescini F, Buffa A, La Manna G, Ciavatti A, Rizzoli E, et al. Long-term potassium citrate therapy and bone mineral density in idiopathic calcium stone formers. J Endocrinol Invest. 2005;28:218.
- Going S, Lohman T, Houtkooper L, Metcalfe L, Flint-Wagner H, et al. Effects of exercise on bone mineral density in calcium-replete postmenopausal women with and without hormone replacement therapy. Osteoporos Int. 2003;14:637.
