Last update
5/26/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 17 Researches
6.8
USERS' SCORE
Moderately Good
Based on 53 Reviews
7.8
Supplement Facts
Serving Size: 3 Veg Capsules
Amount Per Serving
%DV
Calories
5
Total Carbohydrate
1.5 g
<1%**
Total Sugars
1.5 g
†
D-Mannose
1.5 g (1,500 mg)
†
Top Medical Research Studies
9.5
D-Mannose shows effective UTI treatment
We evaluated a D-mannose-based dietary supplement, the DAPAD complex, to see if it could effectively treat uncomplicated E. coli urinary tract infections (UTIs).
Conducted as a randomized, double-blind trial in India, our study involved 70 nonmenopausal women.
The results were promising: at day six, the DAPAD group showed much higher clinical resolution (34.3% vs. 0%) and effective bacteriological resolution (85.7% vs. 14.3%).
By day 35, symptoms were completely resolved for all in the DAPAD group, while the placebo group still had patients with moderate or severe symptoms.
Conducted as a randomized, double-blind trial in India, our study involved 70 nonmenopausal women.
The results were promising: at day six, the DAPAD group showed much higher clinical resolution (34.3% vs. 0%) and effective bacteriological resolution (85.7% vs. 14.3%).
By day 35, symptoms were completely resolved for all in the DAPAD group, while the placebo group still had patients with moderate or severe symptoms.
Read More
9
We explored the effectiveness of D-mannose alongside other nonantibiotic approaches for preventing urinary tract infections (UTIs). Our analysis included 50 randomized controlled trials involving over 10,000 participants.
Results showed that D-mannose significantly reduced UTI incidence, with a notable risk ratio. Other interventions like vaccines, probiotics, and cranberry also demonstrated effectiveness compared to placebo. Importantly, side effects were minimal and comparable across groups.
These findings support D-mannose as a valuable preventive option against UTIs.
Results showed that D-mannose significantly reduced UTI incidence, with a notable risk ratio. Other interventions like vaccines, probiotics, and cranberry also demonstrated effectiveness compared to placebo. Importantly, side effects were minimal and comparable across groups.
These findings support D-mannose as a valuable preventive option against UTIs.
Read More
1
We set out to see if d-mannose could help prevent recurrent urinary tract infections (UTIs) in women. This study involved 830 participants from 99 primary care centers in the UK and followed them over six months.
Unfortunately, the results showed that taking daily d-mannose did not significantly lower the number of women who experienced further UTIs compared to those taking a placebo.
Given these findings, d-mannose is not recommended as a preventive measure for recurrent UTIs in women.
Unfortunately, the results showed that taking daily d-mannose did not significantly lower the number of women who experienced further UTIs compared to those taking a placebo.
Given these findings, d-mannose is not recommended as a preventive measure for recurrent UTIs in women.
Read More
Most Useful Reviews
10
Life-saver supplement
50 people found this helpful
A traveler's life-saver! During two trips to India, I experienced dreadful urinary tract infections. Thankfully, I had access to a doctor who prescribed antibiotics. However, the pain and stress were overwhelming. Prior to another trip, I learned about D-Mannose and decided to try it, having antibiotics as a backup. Since using D-Mannose, I have not suffered from a UTI despite living in a place with questionable water quality. Recently, I felt symptoms after a long journey without a restroom, but with D-Mannose and a cranberry supplement, the UTI did not develop. I travel with D-Mannose at all times. I recommend it to anyone suffering from travel-related UTIs; it’s a game changer. This supplement allows me to travel comfortably without the constant fear of infections.
Read More
9
Pain relief achieved
10 people found this helpful
Urinary tract infection life saver in a day. Cures urinary tract infection and vaginal infection in about half an hour. The painful ones that make you feel as though your intestines are going to fall out. I was so unwell for six months after relocating to Florida, where the water is really different. I was unable to have intimacy; everything felt inflamed and itchy. Doctors suggested I might have an STD and gave me injections that only worsened my condition. Then, I found this on a Hungarian website. After mixing it with water, my stomach pain vanished, and I was completely healed after taking it three times daily. I utilise various NOW products, including castor oil gel for regular bowel health and oregano oil capsules when I have a stomach bug.
Read More
9
No side effects
9 people found this helpful
D-Mannose has been crucial for managing my recurrent cystitis. Unlike antibiotics, which upset my gastrointestinal tract, this product offers relief without any side effects. I take it at the first sign of urinary tract infection symptoms, and it effectively keeps the condition at bay.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 17 Researches
6.8
- All Researches
9.5
D-Mannose shows effective UTI treatment
We evaluated a D-mannose-based dietary supplement, the DAPAD complex, to see if it could effectively treat uncomplicated E. coli urinary tract infections (UTIs).
Conducted as a randomized, double-blind trial in India, our study involved 70 nonmenopausal women.
The results were promising: at day six, the DAPAD group showed much higher clinical resolution (34.3% vs. 0%) and effective bacteriological resolution (85.7% vs. 14.3%).
By day 35, symptoms were completely resolved for all in the DAPAD group, while the placebo group still had patients with moderate or severe symptoms.
Conducted as a randomized, double-blind trial in India, our study involved 70 nonmenopausal women.
The results were promising: at day six, the DAPAD group showed much higher clinical resolution (34.3% vs. 0%) and effective bacteriological resolution (85.7% vs. 14.3%).
By day 35, symptoms were completely resolved for all in the DAPAD group, while the placebo group still had patients with moderate or severe symptoms.
Read More
9
We explored the effectiveness of D-mannose alongside other nonantibiotic approaches for preventing urinary tract infections (UTIs). Our analysis included 50 randomized controlled trials involving over 10,000 participants.
Results showed that D-mannose significantly reduced UTI incidence, with a notable risk ratio. Other interventions like vaccines, probiotics, and cranberry also demonstrated effectiveness compared to placebo. Importantly, side effects were minimal and comparable across groups.
These findings support D-mannose as a valuable preventive option against UTIs.
Results showed that D-mannose significantly reduced UTI incidence, with a notable risk ratio. Other interventions like vaccines, probiotics, and cranberry also demonstrated effectiveness compared to placebo. Importantly, side effects were minimal and comparable across groups.
These findings support D-mannose as a valuable preventive option against UTIs.
Read More
9
We examined the strategies for diagnosing and managing recurrent urinary tract infections (rUTI). Our systematic literature search revealed that while antibiotics are highly effective for prevention, they come with significant side effects.
Interestingly, non-antibiotic options like d mannose showed promise, significantly reducing infection rates with minimal risk. This makes d mannose a potential alternative for those seeking to avoid antibiotics.
Overall, rUTI management requires a tailored approach, especially for vulnerable populations like the elderly.
Interestingly, non-antibiotic options like d mannose showed promise, significantly reducing infection rates with minimal risk. This makes d mannose a potential alternative for those seeking to avoid antibiotics.
Overall, rUTI management requires a tailored approach, especially for vulnerable populations like the elderly.
Read More
9
We explored the impact of a "care bundle" approach on recurrent urinary tract infections (rUTIs) in women, combining behavioral strategies, probiotics, D-mannose, and cranberry extract. Over six months, we observed a striking 76% reduction in urinary tract infections and over 90% less antibiotic use.
Most women reported significant improvements in their quality of life, indicating that this multi-faceted treatment is promising. However, further studies with larger groups are necessary to confirm these positive outcomes for additional safety and effectiveness.
Most women reported significant improvements in their quality of life, indicating that this multi-faceted treatment is promising. However, further studies with larger groups are necessary to confirm these positive outcomes for additional safety and effectiveness.
Read More
8
We aimed to uncover how D-Mannose influences the ability of drug-resistant E. coli to adhere to bladder cells. In our study, we compared clinical strains from asymptomatic bacteriuria with a standard strain. We discovered that D-Mannose significantly reduced the adhesive capacity of multidrug-resistant E. coli, similar to symptomatic strains. This suggests that D-Mannose may effectively alter the mechanisms of bacterial adhesion in urinary tract infections, providing a promising avenue for future treatment approaches.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 53 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
10
Life-saver supplement
50 people found this helpful
A traveler's life-saver! During two trips to India, I experienced dreadful urinary tract infections. Thankfully, I had access to a doctor who prescribed antibiotics. However, the pain and stress were overwhelming. Prior to another trip, I learned about D-Mannose and decided to try it, having antibiotics as a backup. Since using D-Mannose, I have not suffered from a UTI despite living in a place with questionable water quality. Recently, I felt symptoms after a long journey without a restroom, but with D-Mannose and a cranberry supplement, the UTI did not develop. I travel with D-Mannose at all times. I recommend it to anyone suffering from travel-related UTIs; it’s a game changer. This supplement allows me to travel comfortably without the constant fear of infections.
Read More
9
Pain relief achieved
10 people found this helpful
Urinary tract infection life saver in a day. Cures urinary tract infection and vaginal infection in about half an hour. The painful ones that make you feel as though your intestines are going to fall out. I was so unwell for six months after relocating to Florida, where the water is really different. I was unable to have intimacy; everything felt inflamed and itchy. Doctors suggested I might have an STD and gave me injections that only worsened my condition. Then, I found this on a Hungarian website. After mixing it with water, my stomach pain vanished, and I was completely healed after taking it three times daily. I utilise various NOW products, including castor oil gel for regular bowel health and oregano oil capsules when I have a stomach bug.
Read More
9
No side effects
9 people found this helpful
D-Mannose has been crucial for managing my recurrent cystitis. Unlike antibiotics, which upset my gastrointestinal tract, this product offers relief without any side effects. I take it at the first sign of urinary tract infection symptoms, and it effectively keeps the condition at bay.
Read More
10
Quick results
8 people found this helpful
This works! After years of frequent urinary tract infections, D-Mannose was a game changer. After following the instructions for an infection, I noticed a significant improvement within days. Now, I take one a day and have been UTI-free for years. I highly recommend this supplement.
Read More
7.5
Remarkable results
8 people found this helpful
D-Mannose is an incredible supplement for urinary tract discomfort. For years, I suffered from a persistent urinary infection that was exacerbated with antibiotics. Although it wasn’t an instant remedy, over time, D-Mannose improved my condition significantly. I have now gone an entire year without infections. This may be coincidental, but I believe the supplement helped immensely.
Read More
Frequently Asked Questions
9
We explored the effectiveness of D-mannose alongside other nonantibiotic approaches for preventing urinary tract infections (UTIs). Our analysis included 50 randomized controlled trials involving over 10,000 participants.
Results showed that D-mannose significantly reduced UTI incidence, with a notable risk ratio. Other interventions like vaccines, probiotics, and cranberry also demonstrated effectiveness compared to placebo. Importantly, side effects were minimal and comparable across groups.
These findings support D-mannose as a valuable preventive option against UTIs.
Results showed that D-mannose significantly reduced UTI incidence, with a notable risk ratio. Other interventions like vaccines, probiotics, and cranberry also demonstrated effectiveness compared to placebo. Importantly, side effects were minimal and comparable across groups.
These findings support D-mannose as a valuable preventive option against UTIs.
7
We explored the potential of d-mannose and cranberry in preventing urinary tract infections (UTIs). The review highlights that both of these natural products may help by blocking harmful bacteria from attaching to the bladder walls.
Some studies, however, reported limited effects, primarily due to small sample sizes and design flaws. While there is promise in using d-mannose as a preventive strategy for UTIs, more robust research is needed to confirm its effectiveness and determine the best usage.
Some studies, however, reported limited effects, primarily due to small sample sizes and design flaws. While there is promise in using d-mannose as a preventive strategy for UTIs, more robust research is needed to confirm its effectiveness and determine the best usage.
1
We set out to see if d-mannose could help prevent recurrent urinary tract infections (UTIs) in women. This study involved 830 participants from 99 primary care centers in the UK and followed them over six months.
Unfortunately, the results showed that taking daily d-mannose did not significantly lower the number of women who experienced further UTIs compared to those taking a placebo.
Given these findings, d-mannose is not recommended as a preventive measure for recurrent UTIs in women.
Unfortunately, the results showed that taking daily d-mannose did not significantly lower the number of women who experienced further UTIs compared to those taking a placebo.
Given these findings, d-mannose is not recommended as a preventive measure for recurrent UTIs in women.
4
d-Mannose shows limited UTI benefit
We aimed to investigate whether d-mannose could help prevent recurrent urinary tract infections (UTIs) in postmenopausal women already using vaginal estrogen therapy (VET).
In our randomized controlled trial involving 57 participants, we found that d-mannose was well tolerated, but the results suggested it didn’t significantly improve UTI prevention compared to VET alone.
The cumulative UTI incidence was 41.1% in the d-mannose group versus 50.4% in the control, but this difference wasn't powerful enough to support a strong conclusion.
More research is definitely needed to fully assess d-mannose's benefits.
In our randomized controlled trial involving 57 participants, we found that d-mannose was well tolerated, but the results suggested it didn’t significantly improve UTI prevention compared to VET alone.
The cumulative UTI incidence was 41.1% in the d-mannose group versus 50.4% in the control, but this difference wasn't powerful enough to support a strong conclusion.
More research is definitely needed to fully assess d-mannose's benefits.
2
d-Mannose ineffective for UTI prevention
We conducted a double-blind randomized trial to determine if d-Mannose combined with Proanthocyanidins could reduce urinary tract infections (UTIs) in kidney transplant recipients.
Over 60 participants took either the combination or Proanthocyanidins alone for three months.
Unfortunately, the study found that this non-antibiotic approach did not significantly lower UTI or asymptomatic bacteriuria rates compared to Proanthocyanidins alone.
With 27% experiencing UTI episodes, it appears that while d-Mannose and PAC are promising, they are not effective in preventing UTIs in this patient group.
Over 60 participants took either the combination or Proanthocyanidins alone for three months.
Unfortunately, the study found that this non-antibiotic approach did not significantly lower UTI or asymptomatic bacteriuria rates compared to Proanthocyanidins alone.
With 27% experiencing UTI episodes, it appears that while d-Mannose and PAC are promising, they are not effective in preventing UTIs in this patient group.
9
We explored the impact of a "care bundle" approach on recurrent urinary tract infections (rUTIs) in women, combining behavioral strategies, probiotics, D-mannose, and cranberry extract. Over six months, we observed a striking 76% reduction in urinary tract infections and over 90% less antibiotic use.
Most women reported significant improvements in their quality of life, indicating that this multi-faceted treatment is promising. However, further studies with larger groups are necessary to confirm these positive outcomes for additional safety and effectiveness.
Most women reported significant improvements in their quality of life, indicating that this multi-faceted treatment is promising. However, further studies with larger groups are necessary to confirm these positive outcomes for additional safety and effectiveness.
References
- Han Z, Yi X, Li J, Liao D, Ai J. Nonantibiotic prophylaxis for urinary tract infections: a network meta-analysis of randomized controlled trials. Infection. 2024. 10.1007/s15010-024-02357-z
- Ioannou P, Baliou S. The Molecular Mechanisms and Therapeutic Potential of Cranberry, D-Mannose, and Flavonoids against Infectious Diseases: The Example of Urinary Tract Infections. Antibiotics (Basel). 2024;13. 10.3390/antibiotics13070593
- Boeri L, De Lorenzis E, Lucignani G, Turetti M, Silvani C, et al. Oral preparation of hyaluronic acid, chondroitin sulfate, N-acetylglucosamine, and vitamin C improves sexual and urinary symptoms in participants with recurrent urinary tract infections: a randomized crossover trial. J Sex Med. 2024;21:627. 10.1093/jsxmed/qdae052
- Schmiemann G, Kranz J, Mandraka F, Schubert S, Wagenlehner F, et al. The Diagnosis, Treatment, and Prevention of Recurrent Urinary Tract Infection. Dtsch Arztebl Int. 2024;121:373. 10.3238/arztebl.m2024.0068
- Rau M, Santelli A, Martí S, Díaz MI, Sabé N, et al. Randomized clinical trial of non-antibiotic prophylaxis with d-Mannose plus Proanthocyanidins vs. Proanthocyanidins alone for urinary tract infections and asymptomatic bacteriuria in de novo kidney transplant recipients: The Manotras study. Nefrologia (Engl Ed). 2024;44:408. 10.1016/j.nefroe.2024.02.011
- Hayward G, Mort S, Hay AD, Moore M, Thomas NPB, et al. d-Mannose for Prevention of Recurrent Urinary Tract Infection Among Women: A Randomized Clinical Trial. JAMA Intern Med. 2024;184:619. 10.1001/jamainternmed.2024.0264
- Ghosh A, Mukherjee M. Type 1 fimbrial phase variation in multidrug-resistant asymptomatic uropathogenic Escherichia coli clinical isolates upon adherence to HTB-4 cells. Folia Microbiol (Praha). 2024;69:1185. 10.1007/s12223-024-01159-y
- Joshi CS, Salazar AM, Wang C, Ligon MM, Chappidi RR, et al. D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-1β-driven pyroptotic uroepithelial cell shedding in the murine bladder. Dev Cell. 2024;59:33. 10.1016/j.devcel.2023.11.017
- Venturini S, Reffo I, Avolio M, Basaglia G, Del Fabro G, et al. The Management of Recurrent Urinary Tract Infection: Non-Antibiotic Bundle Treatment. Probiotics Antimicrob Proteins. 2024;16:1857. 10.1007/s12602-023-10141-y
- Faustino M, Silva S, Costa EM, Pereira AM, Pereira JO, et al. Effect of Mannan Oligosaccharides Extracts in Uropathogenic Adhesion in Human Bladder Cells. Pathogens. 2023;12. 10.3390/pathogens12070885
- Al-Shukri AS, Maksimova AV, Dub NI, Kostyukov SV, Manchenko AA, et al. [Prevention of the development of catheter-associated urinary system infections in the early postoperative period]. Urologiia. 2023. PubMed
- Quattrone C, Manfredi C, Napolitano L, Ferraro A, Distefano C, et al. D-Mannose Plus to Prevent Urinary Tract Infections and Discomfort after Cystoscopy: A Single-Center Prospective Randomized Pilot Study. Medicina (Kaunas). 2023;59. 10.3390/medicina59061165
- Lenger SM, Chu CM, Ghetti C, Durkin MJ, Jennings Z, et al. d-Mannose for Recurrent Urinary Tract Infection Prevention in Postmenopausal Women Using Vaginal Estrogen: A Randomized Controlled Trial. Urogynecology (Phila). 2023;29:367. 10.1097/SPV.0000000000001270
- Nashivochnikova NA, Leanovich VE. [Clinical and pathogenetic aspects of the treatment and prevention of pyelonephritis in children]. Urologiia. 2022. PubMed
- Salvatore S, Ruffolo AF, Stabile G, Casiraghi A, Zito G, et al. A Randomized Controlled Trial Comparing a New D-Mannose-based Dietary Supplement to Placebo for the Treatment of Uncomplicated Escherichia coli Urinary Tract Infections. Eur Urol Focus. 2023;9:654. 10.1016/j.euf.2022.12.013
- Gu R, Liu H, Hu M, Zhu Y, Liu X, et al. D-Mannose prevents bone loss under weightlessness. J Transl Med. 2023;21:8. 10.1186/s12967-022-03870-1
- Konesan J, Liu L, Mansfield KJ. The Clinical Trial Outcomes of Cranberry, D-Mannose and NSAIDs in the Prevention or Management of Uncomplicated Urinary Tract Infections in Women: A Systematic Review. Pathogens. 2022;11. 10.3390/pathogens11121471
