Infographics 
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.3
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Niacin (Vitamin B-3)(from 640 mg of Inositol Hexanicotinate)
500 mg
3125%
Inositol(from 640 mg of Inositol Hexanicotinate)
135 mg
â€
Top Medical Research Studies
9
We explored the effects of myo-inositol (MYO) on acne among young women diagnosed with polycystic ovary syndrome (PCOS). The study included 50 participants who underwent treatment with MYO for six months, focusing on its potential to improve the often frustrating skin issues linked to PCOS.
At the beginning and after the treatment period, we measured various factors including levels of hormones and insulin, as well as the severity of acne.
Remarkably, after three months of MYO therapy, we observed significant reductions in hormone levels associated with PCOS, particularly testosterone and insulin. After six months, both hirsutism and acne symptoms showed notable improvement among the participants.
This research highlights MYO as a promising, safe treatment option for alleviating acne symptoms in individuals with PCOS. Its ability to improve metabolic conditions while managing acne is a fascinating development for women seeking effective solutions for their skin concerns.
At the beginning and after the treatment period, we measured various factors including levels of hormones and insulin, as well as the severity of acne.
Remarkably, after three months of MYO therapy, we observed significant reductions in hormone levels associated with PCOS, particularly testosterone and insulin. After six months, both hirsutism and acne symptoms showed notable improvement among the participants.
This research highlights MYO as a promising, safe treatment option for alleviating acne symptoms in individuals with PCOS. Its ability to improve metabolic conditions while managing acne is a fascinating development for women seeking effective solutions for their skin concerns.
Read More
8
Niacinamide enhances acne treatment
We examined how niacinamide, a form of vitamin B3, impacts acne and similar skin issues. This included looking at its potential to soothe inflammatory conditions like acne and rosacea.
Our findings suggest that niacinamide has several benefits for the skin. It helps strengthen the epidermal barrier, which means it can reduce water loss and keep the skin hydrated. Additionally, niacinamide encourages the production of proteins like keratin and supports the synthesis of important fats known as ceramides.
Not only does niacinamide contribute to healthy skin, but it also works to improve surface texture and diminish the appearance of fine lines as we age. Importantly for acne sufferers, niacinamide shows promise in providing anti-inflammatory effects, making it a potential game-changer for those battling breakouts.
By incorporating niacinamide into skincare routines, individuals may see improvements in acne and overall skin health. Given its wide-ranging benefits, it's worth considering for anyone dealing with skin that is prone to issues.
Our findings suggest that niacinamide has several benefits for the skin. It helps strengthen the epidermal barrier, which means it can reduce water loss and keep the skin hydrated. Additionally, niacinamide encourages the production of proteins like keratin and supports the synthesis of important fats known as ceramides.
Not only does niacinamide contribute to healthy skin, but it also works to improve surface texture and diminish the appearance of fine lines as we age. Importantly for acne sufferers, niacinamide shows promise in providing anti-inflammatory effects, making it a potential game-changer for those battling breakouts.
By incorporating niacinamide into skincare routines, individuals may see improvements in acne and overall skin health. Given its wide-ranging benefits, it's worth considering for anyone dealing with skin that is prone to issues.
Read More
9.5
Myo-inositol improves adult acne
We conducted an open-label clinical study to explore how a peel-off facial mask containing myoinositol and trehalose-loaded liposomes could improve adult female acne (AFA). By applying the mask every other day for 60 days, we examined its effects on acne lesions, sebum production, and overall skin health.
During the study, we measured changes in the number of acne lesions and collected skin biopsy samples to analyze hormone levels and markers of autophagy—a process that helps the skin repair and rejuvenate itself. Our findings showed a significant reduction in various types of acne lesions, as well as a decrease in sebum production.
Notably, we observed a decrease in androgen levels in the skin, which is crucial since higher androgens can exacerbate acne. Additionally, levels of beclin-1, a marker associated with skin autophagy, increased, suggesting that the mask not only improved the appearance of acne but also encouraged healthier skin processes.
Overall, the peel-off mask with myoinositol effectively addresses some underlying factors contributing to acne in women, providing a promising option for those struggling with adult acne.
During the study, we measured changes in the number of acne lesions and collected skin biopsy samples to analyze hormone levels and markers of autophagy—a process that helps the skin repair and rejuvenate itself. Our findings showed a significant reduction in various types of acne lesions, as well as a decrease in sebum production.
Notably, we observed a decrease in androgen levels in the skin, which is crucial since higher androgens can exacerbate acne. Additionally, levels of beclin-1, a marker associated with skin autophagy, increased, suggesting that the mask not only improved the appearance of acne but also encouraged healthier skin processes.
Overall, the peel-off mask with myoinositol effectively addresses some underlying factors contributing to acne in women, providing a promising option for those struggling with adult acne.
Read More
Most Useful Reviews
8
Improved skin texture
1 people found this helpful
Niacin is vital for mental well-being, and as I experience flashes, I opted for niacinamide. Initially, I began taking it for cognitive benefits, yet I noticed a significant reduction in my acne and sebum production, resulting in more beautiful skin.
Read More
9
Effective for acne
The best supplement! It has enhanced my serotonin levels! I couldn't take the niacin without flashes, so I'm very thankful for this option! It also worked wonders for my back acne!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.3
- All Researches
9.5
Myo-inositol improves adult acne
We conducted an open-label clinical study to explore how a peel-off facial mask containing myoinositol and trehalose-loaded liposomes could improve adult female acne (AFA). By applying the mask every other day for 60 days, we examined its effects on acne lesions, sebum production, and overall skin health.
During the study, we measured changes in the number of acne lesions and collected skin biopsy samples to analyze hormone levels and markers of autophagy—a process that helps the skin repair and rejuvenate itself. Our findings showed a significant reduction in various types of acne lesions, as well as a decrease in sebum production.
Notably, we observed a decrease in androgen levels in the skin, which is crucial since higher androgens can exacerbate acne. Additionally, levels of beclin-1, a marker associated with skin autophagy, increased, suggesting that the mask not only improved the appearance of acne but also encouraged healthier skin processes.
Overall, the peel-off mask with myoinositol effectively addresses some underlying factors contributing to acne in women, providing a promising option for those struggling with adult acne.
During the study, we measured changes in the number of acne lesions and collected skin biopsy samples to analyze hormone levels and markers of autophagy—a process that helps the skin repair and rejuvenate itself. Our findings showed a significant reduction in various types of acne lesions, as well as a decrease in sebum production.
Notably, we observed a decrease in androgen levels in the skin, which is crucial since higher androgens can exacerbate acne. Additionally, levels of beclin-1, a marker associated with skin autophagy, increased, suggesting that the mask not only improved the appearance of acne but also encouraged healthier skin processes.
Overall, the peel-off mask with myoinositol effectively addresses some underlying factors contributing to acne in women, providing a promising option for those struggling with adult acne.
Read More
9
We explored the effectiveness of Tracnilâ„¢, a treatment that combines myo-inositol, folic acid, and vitamin D3, in managing acne for overweight women of menstruation age who display signs of polycystic ovary syndrome (PCOS). While these women had normal hormone levels, many experienced acne along with other symptoms like hirsutism and irregular menstrual cycles.
During our study, we assessed acne improvement through visible lesion counts and evaluated hirsutism using standardized scales. What we found was encouraging—Tracnil™ significantly reduced both inflammatory and non-inflammatory acne lesions within just eight weeks. Furthermore, we observed improvements in hirsutism and the regularization of menstrual cycles among the participants.
It’s worth noting that the treatment didn’t lead to major side effects, indicating that it is safe to use. While we cannot isolate the exact effect of inositol from the overall treatment, it appears to play a key role in modulating skin symptoms in this population, even without significant hormonal imbalances. We believe Tracnil™ could be a first-line option for addressing acne in women with PCOS in a straightforward, practical manner within a dermatologist's office.
During our study, we assessed acne improvement through visible lesion counts and evaluated hirsutism using standardized scales. What we found was encouraging—Tracnil™ significantly reduced both inflammatory and non-inflammatory acne lesions within just eight weeks. Furthermore, we observed improvements in hirsutism and the regularization of menstrual cycles among the participants.
It’s worth noting that the treatment didn’t lead to major side effects, indicating that it is safe to use. While we cannot isolate the exact effect of inositol from the overall treatment, it appears to play a key role in modulating skin symptoms in this population, even without significant hormonal imbalances. We believe Tracnil™ could be a first-line option for addressing acne in women with PCOS in a straightforward, practical manner within a dermatologist's office.
Read More
9
We explored the effects of myo-inositol (MYO) on acne among young women diagnosed with polycystic ovary syndrome (PCOS). The study included 50 participants who underwent treatment with MYO for six months, focusing on its potential to improve the often frustrating skin issues linked to PCOS.
At the beginning and after the treatment period, we measured various factors including levels of hormones and insulin, as well as the severity of acne.
Remarkably, after three months of MYO therapy, we observed significant reductions in hormone levels associated with PCOS, particularly testosterone and insulin. After six months, both hirsutism and acne symptoms showed notable improvement among the participants.
This research highlights MYO as a promising, safe treatment option for alleviating acne symptoms in individuals with PCOS. Its ability to improve metabolic conditions while managing acne is a fascinating development for women seeking effective solutions for their skin concerns.
At the beginning and after the treatment period, we measured various factors including levels of hormones and insulin, as well as the severity of acne.
Remarkably, after three months of MYO therapy, we observed significant reductions in hormone levels associated with PCOS, particularly testosterone and insulin. After six months, both hirsutism and acne symptoms showed notable improvement among the participants.
This research highlights MYO as a promising, safe treatment option for alleviating acne symptoms in individuals with PCOS. Its ability to improve metabolic conditions while managing acne is a fascinating development for women seeking effective solutions for their skin concerns.
Read More
8
Niacinamide enhances acne treatment
We examined how niacinamide, a form of vitamin B3, impacts acne and similar skin issues. This included looking at its potential to soothe inflammatory conditions like acne and rosacea.
Our findings suggest that niacinamide has several benefits for the skin. It helps strengthen the epidermal barrier, which means it can reduce water loss and keep the skin hydrated. Additionally, niacinamide encourages the production of proteins like keratin and supports the synthesis of important fats known as ceramides.
Not only does niacinamide contribute to healthy skin, but it also works to improve surface texture and diminish the appearance of fine lines as we age. Importantly for acne sufferers, niacinamide shows promise in providing anti-inflammatory effects, making it a potential game-changer for those battling breakouts.
By incorporating niacinamide into skincare routines, individuals may see improvements in acne and overall skin health. Given its wide-ranging benefits, it's worth considering for anyone dealing with skin that is prone to issues.
Our findings suggest that niacinamide has several benefits for the skin. It helps strengthen the epidermal barrier, which means it can reduce water loss and keep the skin hydrated. Additionally, niacinamide encourages the production of proteins like keratin and supports the synthesis of important fats known as ceramides.
Not only does niacinamide contribute to healthy skin, but it also works to improve surface texture and diminish the appearance of fine lines as we age. Importantly for acne sufferers, niacinamide shows promise in providing anti-inflammatory effects, making it a potential game-changer for those battling breakouts.
By incorporating niacinamide into skincare routines, individuals may see improvements in acne and overall skin health. Given its wide-ranging benefits, it's worth considering for anyone dealing with skin that is prone to issues.
Read More
We embarked on a study to examine the effectiveness of inositol when used alongside metformin for women struggling with acne related to polycystic ovary syndrome (PCOS). Our research involved a randomized trial with two groups: one group received metformin alone, while the other combined metformin with myoinositol and D-chiro-inositol over a six-month period.
After analyzing the results, we observed that the group receiving the combined treatment showed a statistically significant improvement in their acne scores. Notably, the group taking both metformin and inositol experienced better skin outcomes compared to the group on metformin alone. Furthermore, additional metabolic and hormonal improvements were noted in this combined therapy group as well.
However, it’s essential to point out that our study did not isolate the effects of inositol alone on acne. So, while the combination showed promise for improving acne among women with PCOS, we're not claiming that inositol on its own is a guaranteed solution. Further research with a larger sample size and a focus on inositol's individual impact will be crucial for confirming these findings.
After analyzing the results, we observed that the group receiving the combined treatment showed a statistically significant improvement in their acne scores. Notably, the group taking both metformin and inositol experienced better skin outcomes compared to the group on metformin alone. Furthermore, additional metabolic and hormonal improvements were noted in this combined therapy group as well.
However, it’s essential to point out that our study did not isolate the effects of inositol alone on acne. So, while the combination showed promise for improving acne among women with PCOS, we're not claiming that inositol on its own is a guaranteed solution. Further research with a larger sample size and a focus on inositol's individual impact will be crucial for confirming these findings.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8
Improved skin texture
1 people found this helpful
Niacin is vital for mental well-being, and as I experience flashes, I opted for niacinamide. Initially, I began taking it for cognitive benefits, yet I noticed a significant reduction in my acne and sebum production, resulting in more beautiful skin.
Read More
9
Effective for acne
The best supplement! It has enhanced my serotonin levels! I couldn't take the niacin without flashes, so I'm very thankful for this option! It also worked wonders for my back acne!
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Markovics A, Tóth KF, Sós KE, Magi J, Gyöngyösi A, et al. Nicotinic acid suppresses sebaceous lipogenesis of human sebocytes via activating hydroxycarboxylic acid receptor 2 (HCA ). J Cell Mol Med. 2019;23:6203. 10.1111/jcmm.14505
- Gehring W. Nicotinic acid/niacinamide and the skin. J Cosmet Dermatol. 2004;3:88.
- Bahadur A, Arora H, Ravi AK, Naithani M, Bahurupi Y, et al. Comparison of Clinical, Metabolic and Hormonal Effects of Metformin Versus Combined Therapy of Metformin With Myoinositol Plus D-Chiro-Inositol in Women With Polycystic Ovary Syndrome (PCOS): A Randomized Controlled Trial. Cureus. 2021;13:e15510. 10.7759/cureus.15510
- Ramanan EA, Ravi S, Anbu KRR, Michael M. Efficacy and Safety of Tracnilâ„¢ Administration in Patients with Dermatological Manifestations of PCOS: An Open-Label Single-Arm Study. Dermatol Res Pract. 2020;2020:7019126. 10.1155/2020/7019126
- Advani K, Batra M, Tajpuriya S, Gupta R, Saraswat A, et al. Efficacy of combination therapy of inositols, antioxidants and vitamins in obese and non-obese women with polycystic ovary syndrome: an observational study. J Obstet Gynaecol. 2020;40:96. 10.1080/01443615.2019.1604644
- Tolino E, Skroza N, Mambrin A, Bernardini N, Zuber S, et al. Novel combination for the treatment of acne differentiated based on gender: a new step towards personalized treatment. G Ital Dermatol Venereol. 2018;153:866. 10.23736/S0392-0488.18.05710-3
- Fabbrocini G, Capasso C, Donnarumma M, Cantelli M, Le Maître M, et al. A peel-off facial mask comprising myoinositol and trehalose-loaded liposomes improves adult female acne by reducing local hyperandrogenism and activating autophagy. J Cosmet Dermatol. 2017;16:480. 10.1111/jocd.12340
- Formuso C, Stracquadanio M, Ciotta L. Myo-inositol vs. D-chiro inositol in PCOS treatment. Minerva Ginecol. 2015;67:321.
- Zacchè MM, Caputo L, Filippis S, Zacchè G, Dindelli M, et al. Efficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndrome. Gynecol Endocrinol. 2009;25:508. 10.1080/09513590903015544
- Pezza M, Carlomagno V, Sammarco E, Trischitta A, Ceddia C, et al. Association of Myo-Inositol and Microlipodispersed Magnesium in Androgen-Dependent Dermatological Diseases: A Retrospective Study. Pharmaceuticals (Basel). 2025;18. 10.3390/ph18020251
