' 
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7
USERS' SCORE
Good
Based on 4 Reviews
8.5
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Niacin (Vitamin B-3)(from 640 mg of Inositol Hexanicotinate)
500 mg
3125%
Inositol(from 640 mg of Inositol Hexanicotinate)
135 mg
†
Top Medical Research Studies
8
Myo-inositol: Depression treatment potential
Cyclitols: From Basic Understanding to Their Association with Neurodegeneration.
Relates to depression treatment exploration
We explored the potential of inositol, particularly Myo-inositol (MI), as a treatment option for depression, especially in individuals dealing with neurodegenerative disorders. The literature suggests that MI and its derivatives are vital in various cellular functions, including signal transmission and osmoregulation.
While our focus was primarily on neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's, the interesting twist is how inositol may also help alleviate depressive symptoms. Research indicates that dietary supplementation with MI can have promising effects on mental health, suggesting a connection between inositol levels and mood enhancement.
However, despite the encouraging findings, much remains to be discovered. The relationship between inositol treatment and its effectiveness in treating depression is still being closely examined. Overall, it appears that while inositol shows potential, more comprehensive studies are needed to fully understand its benefits and mechanisms related specifically to depression.
While our focus was primarily on neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's, the interesting twist is how inositol may also help alleviate depressive symptoms. Research indicates that dietary supplementation with MI can have promising effects on mental health, suggesting a connection between inositol levels and mood enhancement.
However, despite the encouraging findings, much remains to be discovered. The relationship between inositol treatment and its effectiveness in treating depression is still being closely examined. Overall, it appears that while inositol shows potential, more comprehensive studies are needed to fully understand its benefits and mechanisms related specifically to depression.
Read More
8
Myo-Inositol and Depression Relief
Dietary Supplementation of Myo-Inositol, Cocoa Polyphenols, and Soy Isoflavones Improves Vasomotor Symptoms and Metabolic Profile in Menopausal Women with Metabolic Syndrome: A Retrospective Clinical Study.
Moderate relevance to inositol effects
We conducted a detailed analysis of the effects of myo-inositol, alongside cocoa polyphenols and soy isoflavones, on managing symptoms of depression in menopausal women with metabolic syndrome.
In this study, 200 participants were observed over a six-month period while taking a daily supplement. At the beginning, many reported moderate depression symptoms. After six months, we noted a significant reduction, with only 56% of women reporting similar symptoms compared to 87% at the start.
This improvement in mood is quite promising and suggests that myo-inositol can play a key role in alleviating depressive symptoms during menopause. While the study focused on a specific group of women, the results indicate a potential for using natural compounds to ease their struggles.
In this study, 200 participants were observed over a six-month period while taking a daily supplement. At the beginning, many reported moderate depression symptoms. After six months, we noted a significant reduction, with only 56% of women reporting similar symptoms compared to 87% at the start.
This improvement in mood is quite promising and suggests that myo-inositol can play a key role in alleviating depressive symptoms during menopause. While the study focused on a specific group of women, the results indicate a potential for using natural compounds to ease their struggles.
Read More
8
Inositol's role in depression unclear
Comparative Efficacy of Omega-3 Fatty Acid with Other Interventions for Depression in Children and Adolescents: A Systematic Review and Network Meta-Analysis.
Inositol's isolated effect obscured
We explored the role of inositol in alleviating depression among children and adolescents. This systematic review gathered data from nine studies involving 561 participants, focusing on the effectiveness of omega-3 fatty acids alongside inositol in combating depressive symptoms.
Our analysis found that while inositol is often included with omega-3 in combination therapies, its isolated effect on depression could not be clearly established. The results indicated that when omega-3 is combined with inositol, it showed promising efficacy, acting as a potential support for traditional therapies.
However, we noted that there was no significant improvement in depression symptoms compared to placebo treatments when evaluating these interventions individually. Ultimately, omega-3 paired with psychoeducational psychotherapy emerged as the most effective approach, but the impact of inositol on its own remains inconclusive.
These findings suggest a need for future studies to assess inositol individually, helping us better understand its potential in managing depression.
Our analysis found that while inositol is often included with omega-3 in combination therapies, its isolated effect on depression could not be clearly established. The results indicated that when omega-3 is combined with inositol, it showed promising efficacy, acting as a potential support for traditional therapies.
However, we noted that there was no significant improvement in depression symptoms compared to placebo treatments when evaluating these interventions individually. Ultimately, omega-3 paired with psychoeducational psychotherapy emerged as the most effective approach, but the impact of inositol on its own remains inconclusive.
These findings suggest a need for future studies to assess inositol individually, helping us better understand its potential in managing depression.
Read More
Most Useful Reviews
8.8
Improved sleep quality
It's working! I'm taking one after dinner. I previously had terrible flushing with niacin, which is why I opted for this one. I'm sleeping better than before, and I'm less depressed. I've been on medication for over 20 years due to recurrent depression, yet I'm told I'm fine. Since megavitamin therapy is a lengthy process and encompasses various supplements aside from niacin, I plan to stick with this for the time being.
Read More
9.5
Medication-free progress
For those feeling down, I was on medication for depression, but after starting this, I was able to stop my medication altogether. It likely depends on the individual, but I believe it's worth a try!
Read More
9.5
Calmness and sleep
Yes, this product is excellent. Niacin is beneficial for many issues, particularly anxiety and depression. It helps maintain my calmness, keeps me level-headed, and promotes restful sleep.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7
- All Researches
8
Inositol's role in depression unclear
Comparative Efficacy of Omega-3 Fatty Acid with Other Interventions for Depression in Children and Adolescents: A Systematic Review and Network Meta-Analysis.
Inositol's isolated effect obscured
We explored the role of inositol in alleviating depression among children and adolescents. This systematic review gathered data from nine studies involving 561 participants, focusing on the effectiveness of omega-3 fatty acids alongside inositol in combating depressive symptoms.
Our analysis found that while inositol is often included with omega-3 in combination therapies, its isolated effect on depression could not be clearly established. The results indicated that when omega-3 is combined with inositol, it showed promising efficacy, acting as a potential support for traditional therapies.
However, we noted that there was no significant improvement in depression symptoms compared to placebo treatments when evaluating these interventions individually. Ultimately, omega-3 paired with psychoeducational psychotherapy emerged as the most effective approach, but the impact of inositol on its own remains inconclusive.
These findings suggest a need for future studies to assess inositol individually, helping us better understand its potential in managing depression.
Our analysis found that while inositol is often included with omega-3 in combination therapies, its isolated effect on depression could not be clearly established. The results indicated that when omega-3 is combined with inositol, it showed promising efficacy, acting as a potential support for traditional therapies.
However, we noted that there was no significant improvement in depression symptoms compared to placebo treatments when evaluating these interventions individually. Ultimately, omega-3 paired with psychoeducational psychotherapy emerged as the most effective approach, but the impact of inositol on its own remains inconclusive.
These findings suggest a need for future studies to assess inositol individually, helping us better understand its potential in managing depression.
Read More
8
Myo-Inositol and Depression Relief
Dietary Supplementation of Myo-Inositol, Cocoa Polyphenols, and Soy Isoflavones Improves Vasomotor Symptoms and Metabolic Profile in Menopausal Women with Metabolic Syndrome: A Retrospective Clinical Study.
Moderate relevance to inositol effects
We conducted a detailed analysis of the effects of myo-inositol, alongside cocoa polyphenols and soy isoflavones, on managing symptoms of depression in menopausal women with metabolic syndrome.
In this study, 200 participants were observed over a six-month period while taking a daily supplement. At the beginning, many reported moderate depression symptoms. After six months, we noted a significant reduction, with only 56% of women reporting similar symptoms compared to 87% at the start.
This improvement in mood is quite promising and suggests that myo-inositol can play a key role in alleviating depressive symptoms during menopause. While the study focused on a specific group of women, the results indicate a potential for using natural compounds to ease their struggles.
In this study, 200 participants were observed over a six-month period while taking a daily supplement. At the beginning, many reported moderate depression symptoms. After six months, we noted a significant reduction, with only 56% of women reporting similar symptoms compared to 87% at the start.
This improvement in mood is quite promising and suggests that myo-inositol can play a key role in alleviating depressive symptoms during menopause. While the study focused on a specific group of women, the results indicate a potential for using natural compounds to ease their struggles.
Read More
8
Myo-inositol: Depression treatment potential
Cyclitols: From Basic Understanding to Their Association with Neurodegeneration.
Relates to depression treatment exploration
We explored the potential of inositol, particularly Myo-inositol (MI), as a treatment option for depression, especially in individuals dealing with neurodegenerative disorders. The literature suggests that MI and its derivatives are vital in various cellular functions, including signal transmission and osmoregulation.
While our focus was primarily on neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's, the interesting twist is how inositol may also help alleviate depressive symptoms. Research indicates that dietary supplementation with MI can have promising effects on mental health, suggesting a connection between inositol levels and mood enhancement.
However, despite the encouraging findings, much remains to be discovered. The relationship between inositol treatment and its effectiveness in treating depression is still being closely examined. Overall, it appears that while inositol shows potential, more comprehensive studies are needed to fully understand its benefits and mechanisms related specifically to depression.
While our focus was primarily on neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's, the interesting twist is how inositol may also help alleviate depressive symptoms. Research indicates that dietary supplementation with MI can have promising effects on mental health, suggesting a connection between inositol levels and mood enhancement.
However, despite the encouraging findings, much remains to be discovered. The relationship between inositol treatment and its effectiveness in treating depression is still being closely examined. Overall, it appears that while inositol shows potential, more comprehensive studies are needed to fully understand its benefits and mechanisms related specifically to depression.
Read More
4
No significant effect on depression
Maternal mood, anxiety and mental health functioning after combined myo-inositol, probiotics, micronutrient supplementation from preconception: Findings from the NiPPeR RCT.
Combined supplements studied
We explored the impact of a specific blend of myo-inositol, probiotics, and micronutrients on mental health for women planning for conception and during pregnancy. In a double-blind randomized controlled trial involving over 600 participants, we assessed mental wellbeing through recognized scales both during pregnancy and after childbirth. Our aim was to find out if this supplement could improve mood and reduce anxiety levels.
While we monitored changes in mood and anxiety symptoms using standardized questionnaires, the results showed no significant differences between the group taking the supplement and the control group receiving standard micronutrients. This indicates that, at least in this study, the combined supplement did not appear to have a notable effect on lowering depression or anxiety during pregnancy.
However, we did find a small improvement in overall mental health functioning, as measured by the Short-Form Health Survey, from preconception to six months post-delivery for those in the intervention group. This suggests that while myo-inositol and its companions may not directly impact mood and anxiety, there could be some beneficial effects on broader mental health after delivery.
While we monitored changes in mood and anxiety symptoms using standardized questionnaires, the results showed no significant differences between the group taking the supplement and the control group receiving standard micronutrients. This indicates that, at least in this study, the combined supplement did not appear to have a notable effect on lowering depression or anxiety during pregnancy.
However, we did find a small improvement in overall mental health functioning, as measured by the Short-Form Health Survey, from preconception to six months post-delivery for those in the intervention group. This suggests that while myo-inositol and its companions may not directly impact mood and anxiety, there could be some beneficial effects on broader mental health after delivery.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Improved sleep quality
It's working! I'm taking one after dinner. I previously had terrible flushing with niacin, which is why I opted for this one. I'm sleeping better than before, and I'm less depressed. I've been on medication for over 20 years due to recurrent depression, yet I'm told I'm fine. Since megavitamin therapy is a lengthy process and encompasses various supplements aside from niacin, I plan to stick with this for the time being.
Read More
9.5
Medication-free progress
For those feeling down, I was on medication for depression, but after starting this, I was able to stop my medication altogether. It likely depends on the individual, but I believe it's worth a try!
9.5
Calmness and sleep
Yes, this product is excellent. Niacin is beneficial for many issues, particularly anxiety and depression. It helps maintain my calmness, keeps me level-headed, and promotes restful sleep.
6.3
Enhanced supplementation
I have been using this product for five years. It's convenient as it doesn’t cause redness, and the capsules are easy to swallow. Having depression, I find that taking it alongside various nutritional supplements has improved my condition, and I intend to continue using it in the future.
Read More
