Infographics 
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.3
USERS' SCORE
Good
Based on 6 Reviews
8.1
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Niacin (Vitamin B-3)(from 640 mg of Inositol Hexanicotinate)
500 mg
3125%
Inositol (from 640 mg of Inositol Hexanicotinate)
135 mg
†
Top Medical Research Studies
9
We explored the effects of myo-inositol (MYO) on acne among young women diagnosed with polycystic ovary syndrome (PCOS). The study included 50 participants who underwent treatment with MYO for six months, focusing on its potential to improve the often frustrating skin issues linked to PCOS.
At the beginning and after the treatment period, we measured various factors including levels of hormones and insulin, as well as the severity of acne.
Remarkably, after three months of MYO therapy, we observed significant reductions in hormone levels associated with PCOS, particularly testosterone and insulin. After six months, both hirsutism and acne symptoms showed notable improvement among the participants.
This research highlights MYO as a promising, safe treatment option for alleviating acne symptoms in individuals with PCOS. Its ability to improve metabolic conditions while managing acne is a fascinating development for women seeking effective solutions for their skin concerns.
At the beginning and after the treatment period, we measured various factors including levels of hormones and insulin, as well as the severity of acne.
Remarkably, after three months of MYO therapy, we observed significant reductions in hormone levels associated with PCOS, particularly testosterone and insulin. After six months, both hirsutism and acne symptoms showed notable improvement among the participants.
This research highlights MYO as a promising, safe treatment option for alleviating acne symptoms in individuals with PCOS. Its ability to improve metabolic conditions while managing acne is a fascinating development for women seeking effective solutions for their skin concerns.
Read More
8
Niacinamide enhances acne treatment
We examined how niacinamide, a form of vitamin B3, impacts acne and similar skin issues. This included looking at its potential to soothe inflammatory conditions like acne and rosacea.
Our findings suggest that niacinamide has several benefits for the skin. It helps strengthen the epidermal barrier, which means it can reduce water loss and keep the skin hydrated. Additionally, niacinamide encourages the production of proteins like keratin and supports the synthesis of important fats known as ceramides.
Not only does niacinamide contribute to healthy skin, but it also works to improve surface texture and diminish the appearance of fine lines as we age. Importantly for acne sufferers, niacinamide shows promise in providing anti-inflammatory effects, making it a potential game-changer for those battling breakouts.
By incorporating niacinamide into skincare routines, individuals may see improvements in acne and overall skin health. Given its wide-ranging benefits, it's worth considering for anyone dealing with skin that is prone to issues.
Our findings suggest that niacinamide has several benefits for the skin. It helps strengthen the epidermal barrier, which means it can reduce water loss and keep the skin hydrated. Additionally, niacinamide encourages the production of proteins like keratin and supports the synthesis of important fats known as ceramides.
Not only does niacinamide contribute to healthy skin, but it also works to improve surface texture and diminish the appearance of fine lines as we age. Importantly for acne sufferers, niacinamide shows promise in providing anti-inflammatory effects, making it a potential game-changer for those battling breakouts.
By incorporating niacinamide into skincare routines, individuals may see improvements in acne and overall skin health. Given its wide-ranging benefits, it's worth considering for anyone dealing with skin that is prone to issues.
Read More
9.5
Myo-inositol improves adult acne
We conducted an open-label clinical study to explore how a peel-off facial mask containing myoinositol and trehalose-loaded liposomes could improve adult female acne (AFA). By applying the mask every other day for 60 days, we examined its effects on acne lesions, sebum production, and overall skin health.
During the study, we measured changes in the number of acne lesions and collected skin biopsy samples to analyze hormone levels and markers of autophagy—a process that helps the skin repair and rejuvenate itself. Our findings showed a significant reduction in various types of acne lesions, as well as a decrease in sebum production.
Notably, we observed a decrease in androgen levels in the skin, which is crucial since higher androgens can exacerbate acne. Additionally, levels of beclin-1, a marker associated with skin autophagy, increased, suggesting that the mask not only improved the appearance of acne but also encouraged healthier skin processes.
Overall, the peel-off mask with myoinositol effectively addresses some underlying factors contributing to acne in women, providing a promising option for those struggling with adult acne.
During the study, we measured changes in the number of acne lesions and collected skin biopsy samples to analyze hormone levels and markers of autophagy—a process that helps the skin repair and rejuvenate itself. Our findings showed a significant reduction in various types of acne lesions, as well as a decrease in sebum production.
Notably, we observed a decrease in androgen levels in the skin, which is crucial since higher androgens can exacerbate acne. Additionally, levels of beclin-1, a marker associated with skin autophagy, increased, suggesting that the mask not only improved the appearance of acne but also encouraged healthier skin processes.
Overall, the peel-off mask with myoinositol effectively addresses some underlying factors contributing to acne in women, providing a promising option for those struggling with adult acne.
Read More
Most Useful Reviews
9
Reduced pimples
1 people found this helpful
I purchased this on my cosmetologist's recommendation! Niacinamide helps regulate sebum production, and its antimicrobial and anti-inflammatory properties lessen the activity of acne-causing bacteria. It diminishes redness, reduces the number of spots, and aids in healing acne scars. After taking it for a month, I noticed significantly fewer spots on my face; it could be my new skincare routine or these vitamins.
Read More
9
Effective for adults
This is a product I order monthly for my younger brother, who still battles acne despite being an adult. It's effective; those with severe acne should consider regular use.
Read More
7.5
Skin condition improved
I bought flash-free niacin due to a lack of niacinamide. I mix the contents of one capsule with yogurt. Starting with a lower dosage, I increased it gradually to 250mg over three weeks. I've noticed a reduction in acne, and my skin appears better, along with a boost in mood. I intend to continue this for some time, as I see effective results.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.3
- All Researches
9.5
Myo-inositol improves adult acne
We conducted an open-label clinical study to explore how a peel-off facial mask containing myoinositol and trehalose-loaded liposomes could improve adult female acne (AFA). By applying the mask every other day for 60 days, we examined its effects on acne lesions, sebum production, and overall skin health.
During the study, we measured changes in the number of acne lesions and collected skin biopsy samples to analyze hormone levels and markers of autophagy—a process that helps the skin repair and rejuvenate itself. Our findings showed a significant reduction in various types of acne lesions, as well as a decrease in sebum production.
Notably, we observed a decrease in androgen levels in the skin, which is crucial since higher androgens can exacerbate acne. Additionally, levels of beclin-1, a marker associated with skin autophagy, increased, suggesting that the mask not only improved the appearance of acne but also encouraged healthier skin processes.
Overall, the peel-off mask with myoinositol effectively addresses some underlying factors contributing to acne in women, providing a promising option for those struggling with adult acne.
During the study, we measured changes in the number of acne lesions and collected skin biopsy samples to analyze hormone levels and markers of autophagy—a process that helps the skin repair and rejuvenate itself. Our findings showed a significant reduction in various types of acne lesions, as well as a decrease in sebum production.
Notably, we observed a decrease in androgen levels in the skin, which is crucial since higher androgens can exacerbate acne. Additionally, levels of beclin-1, a marker associated with skin autophagy, increased, suggesting that the mask not only improved the appearance of acne but also encouraged healthier skin processes.
Overall, the peel-off mask with myoinositol effectively addresses some underlying factors contributing to acne in women, providing a promising option for those struggling with adult acne.
Read More
9
We explored the effectiveness of Tracnil™, a treatment that combines myo-inositol, folic acid, and vitamin D3, in managing acne for overweight women of menstruation age who display signs of polycystic ovary syndrome (PCOS). While these women had normal hormone levels, many experienced acne along with other symptoms like hirsutism and irregular menstrual cycles.
During our study, we assessed acne improvement through visible lesion counts and evaluated hirsutism using standardized scales. What we found was encouraging—Tracnil™ significantly reduced both inflammatory and non-inflammatory acne lesions within just eight weeks. Furthermore, we observed improvements in hirsutism and the regularization of menstrual cycles among the participants.
It’s worth noting that the treatment didn’t lead to major side effects, indicating that it is safe to use. While we cannot isolate the exact effect of inositol from the overall treatment, it appears to play a key role in modulating skin symptoms in this population, even without significant hormonal imbalances. We believe Tracnil™ could be a first-line option for addressing acne in women with PCOS in a straightforward, practical manner within a dermatologist's office.
During our study, we assessed acne improvement through visible lesion counts and evaluated hirsutism using standardized scales. What we found was encouraging—Tracnil™ significantly reduced both inflammatory and non-inflammatory acne lesions within just eight weeks. Furthermore, we observed improvements in hirsutism and the regularization of menstrual cycles among the participants.
It’s worth noting that the treatment didn’t lead to major side effects, indicating that it is safe to use. While we cannot isolate the exact effect of inositol from the overall treatment, it appears to play a key role in modulating skin symptoms in this population, even without significant hormonal imbalances. We believe Tracnil™ could be a first-line option for addressing acne in women with PCOS in a straightforward, practical manner within a dermatologist's office.
Read More
9
We explored the effects of myo-inositol (MYO) on acne among young women diagnosed with polycystic ovary syndrome (PCOS). The study included 50 participants who underwent treatment with MYO for six months, focusing on its potential to improve the often frustrating skin issues linked to PCOS.
At the beginning and after the treatment period, we measured various factors including levels of hormones and insulin, as well as the severity of acne.
Remarkably, after three months of MYO therapy, we observed significant reductions in hormone levels associated with PCOS, particularly testosterone and insulin. After six months, both hirsutism and acne symptoms showed notable improvement among the participants.
This research highlights MYO as a promising, safe treatment option for alleviating acne symptoms in individuals with PCOS. Its ability to improve metabolic conditions while managing acne is a fascinating development for women seeking effective solutions for their skin concerns.
At the beginning and after the treatment period, we measured various factors including levels of hormones and insulin, as well as the severity of acne.
Remarkably, after three months of MYO therapy, we observed significant reductions in hormone levels associated with PCOS, particularly testosterone and insulin. After six months, both hirsutism and acne symptoms showed notable improvement among the participants.
This research highlights MYO as a promising, safe treatment option for alleviating acne symptoms in individuals with PCOS. Its ability to improve metabolic conditions while managing acne is a fascinating development for women seeking effective solutions for their skin concerns.
Read More
8
Niacinamide enhances acne treatment
We examined how niacinamide, a form of vitamin B3, impacts acne and similar skin issues. This included looking at its potential to soothe inflammatory conditions like acne and rosacea.
Our findings suggest that niacinamide has several benefits for the skin. It helps strengthen the epidermal barrier, which means it can reduce water loss and keep the skin hydrated. Additionally, niacinamide encourages the production of proteins like keratin and supports the synthesis of important fats known as ceramides.
Not only does niacinamide contribute to healthy skin, but it also works to improve surface texture and diminish the appearance of fine lines as we age. Importantly for acne sufferers, niacinamide shows promise in providing anti-inflammatory effects, making it a potential game-changer for those battling breakouts.
By incorporating niacinamide into skincare routines, individuals may see improvements in acne and overall skin health. Given its wide-ranging benefits, it's worth considering for anyone dealing with skin that is prone to issues.
Our findings suggest that niacinamide has several benefits for the skin. It helps strengthen the epidermal barrier, which means it can reduce water loss and keep the skin hydrated. Additionally, niacinamide encourages the production of proteins like keratin and supports the synthesis of important fats known as ceramides.
Not only does niacinamide contribute to healthy skin, but it also works to improve surface texture and diminish the appearance of fine lines as we age. Importantly for acne sufferers, niacinamide shows promise in providing anti-inflammatory effects, making it a potential game-changer for those battling breakouts.
By incorporating niacinamide into skincare routines, individuals may see improvements in acne and overall skin health. Given its wide-ranging benefits, it's worth considering for anyone dealing with skin that is prone to issues.
Read More
We embarked on a study to examine the effectiveness of inositol when used alongside metformin for women struggling with acne related to polycystic ovary syndrome (PCOS). Our research involved a randomized trial with two groups: one group received metformin alone, while the other combined metformin with myoinositol and D-chiro-inositol over a six-month period.
After analyzing the results, we observed that the group receiving the combined treatment showed a statistically significant improvement in their acne scores. Notably, the group taking both metformin and inositol experienced better skin outcomes compared to the group on metformin alone. Furthermore, additional metabolic and hormonal improvements were noted in this combined therapy group as well.
However, it’s essential to point out that our study did not isolate the effects of inositol alone on acne. So, while the combination showed promise for improving acne among women with PCOS, we're not claiming that inositol on its own is a guaranteed solution. Further research with a larger sample size and a focus on inositol's individual impact will be crucial for confirming these findings.
After analyzing the results, we observed that the group receiving the combined treatment showed a statistically significant improvement in their acne scores. Notably, the group taking both metformin and inositol experienced better skin outcomes compared to the group on metformin alone. Furthermore, additional metabolic and hormonal improvements were noted in this combined therapy group as well.
However, it’s essential to point out that our study did not isolate the effects of inositol alone on acne. So, while the combination showed promise for improving acne among women with PCOS, we're not claiming that inositol on its own is a guaranteed solution. Further research with a larger sample size and a focus on inositol's individual impact will be crucial for confirming these findings.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced pimples
1 people found this helpful
I purchased this on my cosmetologist's recommendation! Niacinamide helps regulate sebum production, and its antimicrobial and anti-inflammatory properties lessen the activity of acne-causing bacteria. It diminishes redness, reduces the number of spots, and aids in healing acne scars. After taking it for a month, I noticed significantly fewer spots on my face; it could be my new skincare routine or these vitamins.
Read More
9
Effective for adults
This is a product I order monthly for my younger brother, who still battles acne despite being an adult. It's effective; those with severe acne should consider regular use.
Read More
7.5
Skin condition improved
I bought flash-free niacin due to a lack of niacinamide. I mix the contents of one capsule with yogurt. Starting with a lower dosage, I increased it gradually to 250mg over three weeks. I've noticed a reduction in acne, and my skin appears better, along with a boost in mood. I intend to continue this for some time, as I see effective results.
Read More
7.5
Great for skin
1 people found this helpful
This product is excellent and does not elevate heart rate. It significantly benefits the skin, especially in tackling acne.
Read More
6
Supports skin health
1 people found this helpful
Niacin (vitamin B3) is a vital water-soluble vitamin with numerous functions in the body. It supports energy metabolism by converting food to energy and promotes skin health while helping to treat acne and other skin issues. Additionally, it can lower bad cholesterol (LDL) and increase good cholesterol (HDL). You can obtain niacin from foods like meat, fish, nuts, and grains or in supplement form for improved overall health.
Read More
Frequently Asked Questions
9
Reduced pimples
1 people found this helpful
I purchased this on my cosmetologist's recommendation! Niacinamide helps regulate sebum production, and its antimicrobial and anti-inflammatory properties lessen the activity of acne-causing bacteria. It diminishes redness, reduces the number of spots, and aids in healing acne scars. After taking it for a month, I noticed significantly fewer spots on my face; it could be my new skincare routine or these vitamins.
7.5
Skin condition improved
I bought flash-free niacin due to a lack of niacinamide. I mix the contents of one capsule with yogurt. Starting with a lower dosage, I increased it gradually to 250mg over three weeks. I've noticed a reduction in acne, and my skin appears better, along with a boost in mood. I intend to continue this for some time, as I see effective results.
9
Effective for adults
This is a product I order monthly for my younger brother, who still battles acne despite being an adult. It's effective; those with severe acne should consider regular use.
7.5
Great for skin
1 people found this helpful
This product is excellent and does not elevate heart rate. It significantly benefits the skin, especially in tackling acne.
9
We explored the effects of myo-inositol (MYO) on acne among young women diagnosed with polycystic ovary syndrome (PCOS). The study included 50 participants who underwent treatment with MYO for six months, focusing on its potential to improve the often frustrating skin issues linked to PCOS.
At the beginning and after the treatment period, we measured various factors including levels of hormones and insulin, as well as the severity of acne.
Remarkably, after three months of MYO therapy, we observed significant reductions in hormone levels associated with PCOS, particularly testosterone and insulin. After six months, both hirsutism and acne symptoms showed notable improvement among the participants.
This research highlights MYO as a promising, safe treatment option for alleviating acne symptoms in individuals with PCOS. Its ability to improve metabolic conditions while managing acne is a fascinating development for women seeking effective solutions for their skin concerns.
At the beginning and after the treatment period, we measured various factors including levels of hormones and insulin, as well as the severity of acne.
Remarkably, after three months of MYO therapy, we observed significant reductions in hormone levels associated with PCOS, particularly testosterone and insulin. After six months, both hirsutism and acne symptoms showed notable improvement among the participants.
This research highlights MYO as a promising, safe treatment option for alleviating acne symptoms in individuals with PCOS. Its ability to improve metabolic conditions while managing acne is a fascinating development for women seeking effective solutions for their skin concerns.
8
Niacinamide enhances acne treatment
We examined how niacinamide, a form of vitamin B3, impacts acne and similar skin issues. This included looking at its potential to soothe inflammatory conditions like acne and rosacea.
Our findings suggest that niacinamide has several benefits for the skin. It helps strengthen the epidermal barrier, which means it can reduce water loss and keep the skin hydrated. Additionally, niacinamide encourages the production of proteins like keratin and supports the synthesis of important fats known as ceramides.
Not only does niacinamide contribute to healthy skin, but it also works to improve surface texture and diminish the appearance of fine lines as we age. Importantly for acne sufferers, niacinamide shows promise in providing anti-inflammatory effects, making it a potential game-changer for those battling breakouts.
By incorporating niacinamide into skincare routines, individuals may see improvements in acne and overall skin health. Given its wide-ranging benefits, it's worth considering for anyone dealing with skin that is prone to issues.
Our findings suggest that niacinamide has several benefits for the skin. It helps strengthen the epidermal barrier, which means it can reduce water loss and keep the skin hydrated. Additionally, niacinamide encourages the production of proteins like keratin and supports the synthesis of important fats known as ceramides.
Not only does niacinamide contribute to healthy skin, but it also works to improve surface texture and diminish the appearance of fine lines as we age. Importantly for acne sufferers, niacinamide shows promise in providing anti-inflammatory effects, making it a potential game-changer for those battling breakouts.
By incorporating niacinamide into skincare routines, individuals may see improvements in acne and overall skin health. Given its wide-ranging benefits, it's worth considering for anyone dealing with skin that is prone to issues.
8
Inositol aids acne treatment efficacy
This study aimed to explore the effects of a combination therapy that includes myo-inositol, D-chiro-inositol, and other agents on acne in women with polycystic ovary syndrome (PCOS). Over a 12-week period, we observed significant improvements in acne symptoms not only in obese women but also in those who are lean.
The combination therapy also involved antioxidants and vitamins, creating a holistic approach to managing PCOS. While the focus was on the overall benefits for menstrual health and body weight, the positive effects on acne were quite notable.
Our findings suggest that those suffering from acne due to PCOS may benefit from including inositol in their treatment plan. This study reinforces the idea that a multi-faceted approach to PCOS management can lead to better outcomes in various symptoms, including skin issues like acne.
The combination therapy also involved antioxidants and vitamins, creating a holistic approach to managing PCOS. While the focus was on the overall benefits for menstrual health and body weight, the positive effects on acne were quite notable.
Our findings suggest that those suffering from acne due to PCOS may benefit from including inositol in their treatment plan. This study reinforces the idea that a multi-faceted approach to PCOS management can lead to better outcomes in various symptoms, including skin issues like acne.
References
- Markovics A, Tóth KF, Sós KE, Magi J, Gyöngyösi A, et al. Nicotinic acid suppresses sebaceous lipogenesis of human sebocytes via activating hydroxycarboxylic acid receptor 2 (HCA ). J Cell Mol Med. 2019;23:6203. 10.1111/jcmm.14505
- Gehring W. Nicotinic acid/niacinamide and the skin. J Cosmet Dermatol. 2004;3:88.
- Bahadur A, Arora H, Ravi AK, Naithani M, Bahurupi Y, et al. Comparison of Clinical, Metabolic and Hormonal Effects of Metformin Versus Combined Therapy of Metformin With Myoinositol Plus D-Chiro-Inositol in Women With Polycystic Ovary Syndrome (PCOS): A Randomized Controlled Trial. Cureus. 2021;13:e15510. 10.7759/cureus.15510
- Ramanan EA, Ravi S, Anbu KRR, Michael M. Efficacy and Safety of Tracnil™ Administration in Patients with Dermatological Manifestations of PCOS: An Open-Label Single-Arm Study. Dermatol Res Pract. 2020;2020:7019126. 10.1155/2020/7019126
- Advani K, Batra M, Tajpuriya S, Gupta R, Saraswat A, et al. Efficacy of combination therapy of inositols, antioxidants and vitamins in obese and non-obese women with polycystic ovary syndrome: an observational study. J Obstet Gynaecol. 2020;40:96. 10.1080/01443615.2019.1604644
- Tolino E, Skroza N, Mambrin A, Bernardini N, Zuber S, et al. Novel combination for the treatment of acne differentiated based on gender: a new step towards personalized treatment. G Ital Dermatol Venereol. 2018;153:866. 10.23736/S0392-0488.18.05710-3
- Fabbrocini G, Capasso C, Donnarumma M, Cantelli M, Le Maître M, et al. A peel-off facial mask comprising myoinositol and trehalose-loaded liposomes improves adult female acne by reducing local hyperandrogenism and activating autophagy. J Cosmet Dermatol. 2017;16:480. 10.1111/jocd.12340
- Formuso C, Stracquadanio M, Ciotta L. Myo-inositol vs. D-chiro inositol in PCOS treatment. Minerva Ginecol. 2015;67:321.
- Zacchè MM, Caputo L, Filippis S, Zacchè G, Dindelli M, et al. Efficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndrome. Gynecol Endocrinol. 2009;25:508. 10.1080/09513590903015544
- Pezza M, Carlomagno V, Sammarco E, Trischitta A, Ceddia C, et al. Association of Myo-Inositol and Microlipodispersed Magnesium in Androgen-Dependent Dermatological Diseases: A Retrospective Study. Pharmaceuticals (Basel). 2025;18. 10.3390/ph18020251
