Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Good
Based on 18 Reviews
8.2
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Niacin (Vitamin B-3)(from 640 mg of Inositol Hexanicotinate)
500 mg
3125%
Inositol (from 640 mg of Inositol Hexanicotinate)
135 mg
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Top Medical Research Studies
9
We investigated how inositol supplementation could counteract heart issues caused by lithium in mice. Our study involved four groups of mice to explore the varying effects of inositol. One group received lithium alone, another received lithium followed by inositol, a third group had both lithium and inositol from the start, and a control group had no treatment at all.
The results were promising. We found that inositol had a protective effect against the heart damage typically associated with lithium. Specifically, it helped improve heart function and reduced susceptibility to arrhythmias—irregular heartbeats. We also noted that inositol seemed to restore healthy levels of certain proteins crucial for heart health, helping to reduce cell enlargement and stress associated with hypertrophy.
Interestingly, the benefits of inositol were evident regardless of whether it was given alongside lithium or afterward as a treatment. These findings suggest that inositol could be a valuable addition to therapy for those facing lithium-induced cardiac issues, offering a potential pathway to better heart health.
The results were promising. We found that inositol had a protective effect against the heart damage typically associated with lithium. Specifically, it helped improve heart function and reduced susceptibility to arrhythmias—irregular heartbeats. We also noted that inositol seemed to restore healthy levels of certain proteins crucial for heart health, helping to reduce cell enlargement and stress associated with hypertrophy.
Interestingly, the benefits of inositol were evident regardless of whether it was given alongside lithium or afterward as a treatment. These findings suggest that inositol could be a valuable addition to therapy for those facing lithium-induced cardiac issues, offering a potential pathway to better heart health.
Read More
8
ITPP improves heart function in PH
We investigated the effects of myo-inositol trispyrophosphate (ITPP) on rats with pulmonary hypertension (PH), a condition that often leads to serious heart issues. To do this, we injected some rats with monocrotaline to induce PH and treated others with a placebo. For five weeks, we closely monitored their heart function using echocardiograms and other advanced techniques.
Our findings revealed that ITPP significantly reduced mortality linked to PH. While it didn't change the increasing resistance in the pulmonary vessels, ITPP importantly alleviated hypoxia within the right ventricle (RV), which is crucial for maintaining heart function. This reduction in RV hypoxia not only improved heart performance but also decreased stress on the heart’s structure.
Furthermore, we noticed that ITPP appeared to inhibit an increase in a specific protein associated with low oxygen levels, though it didn't affect the density of blood vessels in the RV. Overall, this suggests that enhancing oxygen delivery with ITPP could provide a crucial therapeutic avenue for improving heart health in patients suffering from pulmonary hypertension.
Our findings revealed that ITPP significantly reduced mortality linked to PH. While it didn't change the increasing resistance in the pulmonary vessels, ITPP importantly alleviated hypoxia within the right ventricle (RV), which is crucial for maintaining heart function. This reduction in RV hypoxia not only improved heart performance but also decreased stress on the heart’s structure.
Furthermore, we noticed that ITPP appeared to inhibit an increase in a specific protein associated with low oxygen levels, though it didn't affect the density of blood vessels in the RV. Overall, this suggests that enhancing oxygen delivery with ITPP could provide a crucial therapeutic avenue for improving heart health in patients suffering from pulmonary hypertension.
Read More
Most Useful Reviews
9
Back pain relief
25 people found this helpful
Very good! Since I started taking niacin for better sleep, my long-standing back pain has vanished. Initially, I had trouble lying on my back and woke frequently at night, but now I sleep soundly. My husband, who began taking it too, was informed by his doctor about a potential collagen disease. After extensive research, we decided to supplement with niacin, and the pain nearly disappeared the next day. It’s now essential for both of us.
Read More
9
Easy to use
2 people found this helpful
This brand is simple to take and has no negative reactions associated with niacin, all while helping to manage cardiovascular disease.
Read More
9
Blood vessel health
2 people found this helpful
I have coronary heart disease, with significant blockages in my blood vessels. Niacin is beneficial for clearing arteries; since taking it, the flushing has diminished. I feel confident in its efficacy without adverse reactions.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
- All Researches
9
We investigated how inositol supplementation could counteract heart issues caused by lithium in mice. Our study involved four groups of mice to explore the varying effects of inositol. One group received lithium alone, another received lithium followed by inositol, a third group had both lithium and inositol from the start, and a control group had no treatment at all.
The results were promising. We found that inositol had a protective effect against the heart damage typically associated with lithium. Specifically, it helped improve heart function and reduced susceptibility to arrhythmias—irregular heartbeats. We also noted that inositol seemed to restore healthy levels of certain proteins crucial for heart health, helping to reduce cell enlargement and stress associated with hypertrophy.
Interestingly, the benefits of inositol were evident regardless of whether it was given alongside lithium or afterward as a treatment. These findings suggest that inositol could be a valuable addition to therapy for those facing lithium-induced cardiac issues, offering a potential pathway to better heart health.
The results were promising. We found that inositol had a protective effect against the heart damage typically associated with lithium. Specifically, it helped improve heart function and reduced susceptibility to arrhythmias—irregular heartbeats. We also noted that inositol seemed to restore healthy levels of certain proteins crucial for heart health, helping to reduce cell enlargement and stress associated with hypertrophy.
Interestingly, the benefits of inositol were evident regardless of whether it was given alongside lithium or afterward as a treatment. These findings suggest that inositol could be a valuable addition to therapy for those facing lithium-induced cardiac issues, offering a potential pathway to better heart health.
Read More
8
ITPP improves heart function in PH
We investigated the effects of myo-inositol trispyrophosphate (ITPP) on rats with pulmonary hypertension (PH), a condition that often leads to serious heart issues. To do this, we injected some rats with monocrotaline to induce PH and treated others with a placebo. For five weeks, we closely monitored their heart function using echocardiograms and other advanced techniques.
Our findings revealed that ITPP significantly reduced mortality linked to PH. While it didn't change the increasing resistance in the pulmonary vessels, ITPP importantly alleviated hypoxia within the right ventricle (RV), which is crucial for maintaining heart function. This reduction in RV hypoxia not only improved heart performance but also decreased stress on the heart’s structure.
Furthermore, we noticed that ITPP appeared to inhibit an increase in a specific protein associated with low oxygen levels, though it didn't affect the density of blood vessels in the RV. Overall, this suggests that enhancing oxygen delivery with ITPP could provide a crucial therapeutic avenue for improving heart health in patients suffering from pulmonary hypertension.
Our findings revealed that ITPP significantly reduced mortality linked to PH. While it didn't change the increasing resistance in the pulmonary vessels, ITPP importantly alleviated hypoxia within the right ventricle (RV), which is crucial for maintaining heart function. This reduction in RV hypoxia not only improved heart performance but also decreased stress on the heart’s structure.
Furthermore, we noticed that ITPP appeared to inhibit an increase in a specific protein associated with low oxygen levels, though it didn't affect the density of blood vessels in the RV. Overall, this suggests that enhancing oxygen delivery with ITPP could provide a crucial therapeutic avenue for improving heart health in patients suffering from pulmonary hypertension.
Read More
User Reviews
USERS' SCORE
Good
Based on 18 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Back pain relief
25 people found this helpful
Very good! Since I started taking niacin for better sleep, my long-standing back pain has vanished. Initially, I had trouble lying on my back and woke frequently at night, but now I sleep soundly. My husband, who began taking it too, was informed by his doctor about a potential collagen disease. After extensive research, we decided to supplement with niacin, and the pain nearly disappeared the next day. It’s now essential for both of us.
Read More
9
Easy to use
2 people found this helpful
This brand is simple to take and has no negative reactions associated with niacin, all while helping to manage cardiovascular disease.
Read More
9
Blood vessel health
2 people found this helpful
I have coronary heart disease, with significant blockages in my blood vessels. Niacin is beneficial for clearing arteries; since taking it, the flushing has diminished. I feel confident in its efficacy without adverse reactions.
Read More
9
Supports heart health
1 people found this helpful
NOW Foods Niacin (Flush-Free) Double Strength has become vital to my strategy for cardiovascular health. Its robust formula has led to positive changes in my cholesterol levels and overall wellbeing since I started taking it daily.
Read More
9
Essential for health
Due to having collagen disease, niacin is essential for me. I have been taking it for about three years.
Read More
Frequently Asked Questions
7.5
Thyroid and heartbeat support
2 people found this helpful
After using niacin for a month, I noticed improvements in my heartbeat and thyroid disease management.
9
Supports heart health
1 people found this helpful
NOW Foods Niacin (Flush-Free) Double Strength has become vital to my strategy for cardiovascular health. Its robust formula has led to positive changes in my cholesterol levels and overall wellbeing since I started taking it daily.
9
Enhances energy levels
I've been using NOW Foods Niacin 500 mg for a few months and am impressed with the results. This high-potency supplement supports my energy and cardiovascular health, and I appreciate that it's vegan and free from common allergens.
9
Back pain relief
25 people found this helpful
Very good! Since I started taking niacin for better sleep, my long-standing back pain has vanished. Initially, I had trouble lying on my back and woke frequently at night, but now I sleep soundly. My husband, who began taking it too, was informed by his doctor about a potential collagen disease. After extensive research, we decided to supplement with niacin, and the pain nearly disappeared the next day. It’s now essential for both of us.
7.5
Cardiovascular health
5 people found this helpful
Very good! Niacin lowers LDL cholesterol and boosts HDL cholesterol. It can help prevent cardiovascular disease, treat Type 1 diabetes, enhance brain function, and may alleviate arthritis symptoms. Niacin is essential for metabolism and energy production, inhibiting fat breakdown. I take 500 mg daily at bedtime, with possible increases based on tolerance.
7.5
Enhanced cardiovascular health
3 people found this helpful
Doubling the niacin intake reportedly enhances its effects, improving cholesterol levels and reducing risks associated with cardiovascular disease.
7.5
Enhances circulation
I recently tried iHerb's niacin, which causes flushing. While the sensation was uncomfortable, I found it effective for promoting blood circulation and supporting cardiovascular health.
8
Cardiovascular benefits
11 people found this helpful
Niacin works remarkably! Known also as vitamin B3, it plays a crucial role in lipid and carbohydrate metabolism. I recommend it to patients to increase HDL levels in the blood, which helps reduce cardiovascular disease risks while maintaining skin and digestive health. However, individual intolerance may occur, so it’s important to monitor usage.
9
Blood vessel health
2 people found this helpful
I have coronary heart disease, with significant blockages in my blood vessels. Niacin is beneficial for clearing arteries; since taking it, the flushing has diminished. I feel confident in its efficacy without adverse reactions.
9
We investigated how inositol supplementation could counteract heart issues caused by lithium in mice. Our study involved four groups of mice to explore the varying effects of inositol. One group received lithium alone, another received lithium followed by inositol, a third group had both lithium and inositol from the start, and a control group had no treatment at all.
The results were promising. We found that inositol had a protective effect against the heart damage typically associated with lithium. Specifically, it helped improve heart function and reduced susceptibility to arrhythmias—irregular heartbeats. We also noted that inositol seemed to restore healthy levels of certain proteins crucial for heart health, helping to reduce cell enlargement and stress associated with hypertrophy.
Interestingly, the benefits of inositol were evident regardless of whether it was given alongside lithium or afterward as a treatment. These findings suggest that inositol could be a valuable addition to therapy for those facing lithium-induced cardiac issues, offering a potential pathway to better heart health.
The results were promising. We found that inositol had a protective effect against the heart damage typically associated with lithium. Specifically, it helped improve heart function and reduced susceptibility to arrhythmias—irregular heartbeats. We also noted that inositol seemed to restore healthy levels of certain proteins crucial for heart health, helping to reduce cell enlargement and stress associated with hypertrophy.
Interestingly, the benefits of inositol were evident regardless of whether it was given alongside lithium or afterward as a treatment. These findings suggest that inositol could be a valuable addition to therapy for those facing lithium-induced cardiac issues, offering a potential pathway to better heart health.
8
ITPP improves heart function in PH
We investigated the effects of myo-inositol trispyrophosphate (ITPP) on rats with pulmonary hypertension (PH), a condition that often leads to serious heart issues. To do this, we injected some rats with monocrotaline to induce PH and treated others with a placebo. For five weeks, we closely monitored their heart function using echocardiograms and other advanced techniques.
Our findings revealed that ITPP significantly reduced mortality linked to PH. While it didn't change the increasing resistance in the pulmonary vessels, ITPP importantly alleviated hypoxia within the right ventricle (RV), which is crucial for maintaining heart function. This reduction in RV hypoxia not only improved heart performance but also decreased stress on the heart’s structure.
Furthermore, we noticed that ITPP appeared to inhibit an increase in a specific protein associated with low oxygen levels, though it didn't affect the density of blood vessels in the RV. Overall, this suggests that enhancing oxygen delivery with ITPP could provide a crucial therapeutic avenue for improving heart health in patients suffering from pulmonary hypertension.
Our findings revealed that ITPP significantly reduced mortality linked to PH. While it didn't change the increasing resistance in the pulmonary vessels, ITPP importantly alleviated hypoxia within the right ventricle (RV), which is crucial for maintaining heart function. This reduction in RV hypoxia not only improved heart performance but also decreased stress on the heart’s structure.
Furthermore, we noticed that ITPP appeared to inhibit an increase in a specific protein associated with low oxygen levels, though it didn't affect the density of blood vessels in the RV. Overall, this suggests that enhancing oxygen delivery with ITPP could provide a crucial therapeutic avenue for improving heart health in patients suffering from pulmonary hypertension.
References
- L'Abbate S, Nicolini G, Forini F, Lepore E, Marchetti S, et al. Oral supplementation of inositols effectively recovered lithium-induced cardiac dysfunctions in mice. Biomed Pharmacother. 2024;178:117287. 10.1016/j.biopha.2024.117287
- Oknińska M, Paterek A, Grzanka M, Zajda K, Surzykiewicz M, et al. Myo-inositol trispyrophosphate prevents right ventricular failure and improves survival in monocrotaline-induced pulmonary hypertension in the rat. Br J Pharmacol. 2024;181:4050. 10.1111/bph.16482
