Last update
5/1/2026
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Infographics
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.9
USERS' SCORE
Moderately Good
Based on 16 Reviews
7.9
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Inositol
500 mg
**
Top Medical Research Studies
8
We aimed to evaluate how myo-inositol supplementation affects women with gestational diabetes through a meta-analysis of randomized controlled trials. Our search included multiple databases, leading to the analysis of four studies involving 317 participants. The results showed that myo-inositol significantly reduced the need for insulin and improved insulin sensitivity. However, it did not influence birth weight, cesarean delivery rates, or NICU admissions. These findings suggest myo-inositol could be a helpful addition to managing gestational diabetes, but further research is needed.
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9.5
We investigated the effectiveness of myoinositol supplements in preventing gestational diabetes mellitus (GDM) and its associated complications in pregnant women at high risk for GDM.
By reviewing data from eight randomized controlled trials involving around 1,795 participants, we found that inositol not only halved the incidence of GDM but also significantly reduced fasting and glucose levels in tests.
Furthermore, myoinositol appeared to lower the need for insulin and decrease the risk of conditions like preeclampsia and preterm birth. These findings suggest a promising role for myoinositol in GDM prevention.
By reviewing data from eight randomized controlled trials involving around 1,795 participants, we found that inositol not only halved the incidence of GDM but also significantly reduced fasting and glucose levels in tests.
Furthermore, myoinositol appeared to lower the need for insulin and decrease the risk of conditions like preeclampsia and preterm birth. These findings suggest a promising role for myoinositol in GDM prevention.
Read More
8
Myo-inositol improves glycemic control
This study explored the impact of myo-inositol (MI) supplementation on preventing gestational diabetes mellitus (GDM) in 200 pregnant women. Participants were divided into two groups: one receiving MI and folic acid, and the other receiving only folic acid.
The findings revealed that those taking MI had a significantly lower incidence of GDM compared to the control group. Additionally, those in the MI group showed better glycemic control and improved insulin sensitivity. Overall, integrating MI might offer an effective way to enhance the health of pregnant women and reduce GDM risk.
The findings revealed that those taking MI had a significantly lower incidence of GDM compared to the control group. Additionally, those in the MI group showed better glycemic control and improved insulin sensitivity. Overall, integrating MI might offer an effective way to enhance the health of pregnant women and reduce GDM risk.
Read More
Most Useful Reviews
8.5
Effective for diabetes
89 people found this helpful
This remedy is effective for managing diabetes and insulin resistance, particularly when taken with Berberine. I have found it to enhance the overall outcome of my treatment.
Read More
9
Mother's diabetes support
1 people found this helpful
It is very excellent. I recommended it before and have bought it for my mother four times now. It regulates her diabetes effectively when taken with Gynemia pills. She has noticed a marked difference, and I am grateful it has helped her.
Read More
9
Helpful for diabetes
Great for diabetes.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.9
- All Researches
9.5
We investigated the effectiveness of myoinositol supplements in preventing gestational diabetes mellitus (GDM) and its associated complications in pregnant women at high risk for GDM.
By reviewing data from eight randomized controlled trials involving around 1,795 participants, we found that inositol not only halved the incidence of GDM but also significantly reduced fasting and glucose levels in tests.
Furthermore, myoinositol appeared to lower the need for insulin and decrease the risk of conditions like preeclampsia and preterm birth. These findings suggest a promising role for myoinositol in GDM prevention.
By reviewing data from eight randomized controlled trials involving around 1,795 participants, we found that inositol not only halved the incidence of GDM but also significantly reduced fasting and glucose levels in tests.
Furthermore, myoinositol appeared to lower the need for insulin and decrease the risk of conditions like preeclampsia and preterm birth. These findings suggest a promising role for myoinositol in GDM prevention.
Read More
9
We evaluated the effectiveness of Xelaglifam, a new drug designed to activate specific receptors that help manage Type 2 diabetes. Our study compared its performance against another drug, Fasiglifam.
Through tests in the lab and on rats, we found that Xelaglifam boosts insulin secretion and lowers blood sugar levels effectively without causing hypoglycemia.
Additionally, its ability to improve glucose tolerance suggests it could be a valuable treatment option for those managing this condition, potentially working well alongside existing medications.
Through tests in the lab and on rats, we found that Xelaglifam boosts insulin secretion and lowers blood sugar levels effectively without causing hypoglycemia.
Additionally, its ability to improve glucose tolerance suggests it could be a valuable treatment option for those managing this condition, potentially working well alongside existing medications.
Read More
8
We explored the effects of ice plant extract and its compound D-pinitol on insulin secretion and blood sugar levels in diabetic rats. By utilizing the glucose-stimulated insulin secretion test and measuring various insulin-related factors, we discovered that both substances significantly boosted insulin secretion.
Additionally, ice plant extract helped reduce weight gain and improved glucose tolerance. These findings suggest that ice plant and D-pinitol could serve as beneficial functional foods for managing diabetes and supporting insulin signaling in the body.
Additionally, ice plant extract helped reduce weight gain and improved glucose tolerance. These findings suggest that ice plant and D-pinitol could serve as beneficial functional foods for managing diabetes and supporting insulin signaling in the body.
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8
Histatin 1 enhances diabetic wound healing
We explored how Histatin 1, found in human saliva, helps combat aging in human umbilical vein endothelial cells (HUVECs) to improve diabetic wound healing. The study revealed that this peptide reduces cell senescence and works by enhancing mitochondrial function and reducing oxidative stress.
In laboratory settings, Histatin 1 decreased markers of aging in cells and improved their function. Furthermore, in a mouse model of diabetes, it promoted wound healing through increased blood vessel formation.
Overall, Histatin 1 shows promise as a solution for improving skin repair in diabetic patients.
In laboratory settings, Histatin 1 decreased markers of aging in cells and improved their function. Furthermore, in a mouse model of diabetes, it promoted wound healing through increased blood vessel formation.
Overall, Histatin 1 shows promise as a solution for improving skin repair in diabetic patients.
Read More
8
Myo-inositol improves glycemic control
This study explored the impact of myo-inositol (MI) supplementation on preventing gestational diabetes mellitus (GDM) in 200 pregnant women. Participants were divided into two groups: one receiving MI and folic acid, and the other receiving only folic acid.
The findings revealed that those taking MI had a significantly lower incidence of GDM compared to the control group. Additionally, those in the MI group showed better glycemic control and improved insulin sensitivity. Overall, integrating MI might offer an effective way to enhance the health of pregnant women and reduce GDM risk.
The findings revealed that those taking MI had a significantly lower incidence of GDM compared to the control group. Additionally, those in the MI group showed better glycemic control and improved insulin sensitivity. Overall, integrating MI might offer an effective way to enhance the health of pregnant women and reduce GDM risk.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 16 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
8.5
Effective for diabetes
89 people found this helpful
This remedy is effective for managing diabetes and insulin resistance, particularly when taken with Berberine. I have found it to enhance the overall outcome of my treatment.
Read More
9
Mother's diabetes support
1 people found this helpful
It is very excellent. I recommended it before and have bought it for my mother four times now. It regulates her diabetes effectively when taken with Gynemia pills. She has noticed a marked difference, and I am grateful it has helped her.
Read More
9
Helpful for diabetes
Great for diabetes.
Read More
6
Achieved pregnancy
54 people found this helpful
I took inositol during one cycle, and it significantly impacted my ovulation experience. I even felt some discomfort, but ultimately, I achieved a long-desired pregnancy. I continue to use it to mitigate the risk of gestational diabetes, alongside noticing a reduction in my weight.
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7.5
Weight loss aid
22 people found this helpful
Inositol enhances the body's insulin sensitivity, making it crucial for managing diabetes and irregular periods. My prolonged use has led to noticeable weight loss and a reduction in abdominal volume. The quality of the product is excellent; around 70% of my medicines are from NOW brands. I confidently recommend this supplement for improved health.
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Frequently Asked Questions
8
Decreased appetite
1 people found this helpful
I ordered this as additional support for my mother's diabetes. Since taking it, her appetite has decreased, and her sugar levels are normal. She consumes 1 capsule daily to avoid overdose, as part of her comprehensive therapy.
7.5
Improves energy levels
Inositol helps lower my blood sugar and improves my diabetes condition. I take it in the morning with alpha lipoic acid. Although I can’t say much has changed dramatically, I feel a sense of internal energy and vitality now. My health has significantly improved, and I am very pleased. I recommend it.
7.5
Reduced risk during pregnancy
1 people found this helpful
During my pregnancy, taking myo-inositol significantly reduced the risk of gestational diabetes and insulin resistance in women with existing diabetes. It also protects the embryo against future diabetes and decreases preterm births. Studies show myo-inositol safely assists in treating idiopathic infertility in men by balancing gonadotropic hormones and enhancing sperm quality. As folate helps lower the risk of fetal neural tube defects, myo-inositol can decrease the occurrence of folate-resistant defects.
8.5
Effective for diabetes
89 people found this helpful
This remedy is effective for managing diabetes and insulin resistance, particularly when taken with Berberine. I have found it to enhance the overall outcome of my treatment.
9
Mother's diabetes support
1 people found this helpful
It is very excellent. I recommended it before and have bought it for my mother four times now. It regulates her diabetes effectively when taken with Gynemia pills. She has noticed a marked difference, and I am grateful it has helped her.
7.5
Lowers sugar levels
6 people found this helpful
Inositol effectively lowers sugar levels, proven through personal experience.
7.5
Effective in gestation
It is particularly effective for gestational diabetes, with a recommended dosage of 2 grams a day.
8
Myo-inositol improves glycemic control
This study explored the impact of myo-inositol (MI) supplementation on preventing gestational diabetes mellitus (GDM) in 200 pregnant women. Participants were divided into two groups: one receiving MI and folic acid, and the other receiving only folic acid.
The findings revealed that those taking MI had a significantly lower incidence of GDM compared to the control group. Additionally, those in the MI group showed better glycemic control and improved insulin sensitivity. Overall, integrating MI might offer an effective way to enhance the health of pregnant women and reduce GDM risk.
The findings revealed that those taking MI had a significantly lower incidence of GDM compared to the control group. Additionally, those in the MI group showed better glycemic control and improved insulin sensitivity. Overall, integrating MI might offer an effective way to enhance the health of pregnant women and reduce GDM risk.
8
We explored the effects of myo-inositol (MI) on diabetes using db/db mice, a common model for type 2 diabetes. Our findings showed that MI successfully lowered high blood glucose and insulin levels while improving insulin resistance, performing similarly to metformin.
Additionally, MI reduced triglycerides and cholesterol, demonstrating its potential benefits for metabolic health. Although it inhibited the formation of fat cells from stem cells, MI did not address obesity in these mice. Overall, our study suggests that MI may be a valuable supplemental treatment for managing diabetes-associated conditions.
Additionally, MI reduced triglycerides and cholesterol, demonstrating its potential benefits for metabolic health. Although it inhibited the formation of fat cells from stem cells, MI did not address obesity in these mice. Overall, our study suggests that MI may be a valuable supplemental treatment for managing diabetes-associated conditions.
8
We explored the effects of ice plant extract and its compound D-pinitol on insulin secretion and blood sugar levels in diabetic rats. By utilizing the glucose-stimulated insulin secretion test and measuring various insulin-related factors, we discovered that both substances significantly boosted insulin secretion.
Additionally, ice plant extract helped reduce weight gain and improved glucose tolerance. These findings suggest that ice plant and D-pinitol could serve as beneficial functional foods for managing diabetes and supporting insulin signaling in the body.
Additionally, ice plant extract helped reduce weight gain and improved glucose tolerance. These findings suggest that ice plant and D-pinitol could serve as beneficial functional foods for managing diabetes and supporting insulin signaling in the body.
9
We evaluated the effectiveness of Xelaglifam, a new drug designed to activate specific receptors that help manage Type 2 diabetes. Our study compared its performance against another drug, Fasiglifam.
Through tests in the lab and on rats, we found that Xelaglifam boosts insulin secretion and lowers blood sugar levels effectively without causing hypoglycemia.
Additionally, its ability to improve glucose tolerance suggests it could be a valuable treatment option for those managing this condition, potentially working well alongside existing medications.
Through tests in the lab and on rats, we found that Xelaglifam boosts insulin secretion and lowers blood sugar levels effectively without causing hypoglycemia.
Additionally, its ability to improve glucose tolerance suggests it could be a valuable treatment option for those managing this condition, potentially working well alongside existing medications.
References
- Lee D, Kim SJ, Choi YJ, Rho YH, Kang TS, et al. The Glucose-Lowering Effect of and D-Pinitol: Studies on Insulin Secretion in INS-1 Cells and the Reduction of Blood Glucose in Diabetic Rats. Nutrients. 2025;17. 10.3390/nu17010193
- Xian T, Liu Y, Ye Y, Peng B, Huang J, et al. Human salivary histatin 1 regulating IP3R1/GRP75/VDAC1 mediated mitochondrial-associated endoplasmic reticulum membranes (MAMs) inhibits cell senescence for diabetic wound repair. Free Radic Biol Med. 2024;225:164. 10.1016/j.freeradbiomed.2024.09.046
- Asimakopoulos G, Pergialiotis V, Antsaklis P, Theodora M, Loutradis D, et al. Effect of dietary myo-inositol supplementation on the insulin resistance and the prevention of gestational diabetes mellitus: an open-label, randomized controlled trial. Arch Gynecol Obstet. 2024;310:1895. 10.1007/s00404-024-07618-8
- Chen H, Xiong J, Li Z, Chen Y, Zhang M, et al. Influence of myo-inositol on metabolic status for gestational diabetes: a meta-analysis of randomized controlled trials. J Matern Fetal Neonatal Med. 2024;37:2228450. 10.1080/14767058.2023.2228450
- Yoon J, Lee DG, Song H, Hong D, Park JS, et al. Xelaglifam, a novel GPR40/FFAR1 agonist, exhibits enhanced β-arrestin recruitment and sustained glycemic control for type 2 diabetes. Biomed Pharmacother. 2024;177:117044. 10.1016/j.biopha.2024.117044
- Long L, Huang Q, Song T, Dai Z. Myo-inositol rescued insulin resistance and dyslipidemia in db/db mice. J Appl Biomed. 2024;22:74. 10.32725/jab.2024.009
- Aguilar-Guadarrama AB, Díaz-Román MA, Osorio-García M, Déciga-Campos M, Rios MY. Chemical Constituents from Agave applanata and Its Antihyperglycemic, Anti-inflammatory, and Antimicrobial Activities Associated with Its Tissue Repair Capability. Planta Med. 2024;90:397. 10.1055/a-2270-5527
- Citarrella R, Chianetta R, Amodeo S, Mirarchi L, Licata A, et al. Effectiveness of a Food Supplement Based on Glucomannan, D-Chiro-Inositol, Blume and Inulin in Patients with Metabolic Syndrome. Nutrients. 2024;16. 10.3390/nu16020249
- Factor PA, Corpuz H. The Efficacy and Safety of Myo-inositol Supplementation for the Prevention of Gestational Diabetes Mellitus in Overweight and Obese Pregnant Women: A Systematic Review and Meta-Analysis. J ASEAN Fed Endocr Soc. 2023;38:102. 10.15605/jafes.038.02.11
- Greff D, Váncsa S, Váradi A, Szinte J, Park S, et al. Myoinositols Prevent Gestational Diabetes Mellitus and Related Complications: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2023;15. 10.3390/nu15194224
