Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
USERS' SCORE
Moderately Good
Based on 23 Reviews
7.6
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Inositol
500 mg
**

Top Medical Research Studies

7
Myo-Inositol Support in Menopause
We investigated whether small extracellular vesicles (sEVs) derived from human palatine tonsil mesenchymal stem cells could boost myo-inositol levels in the context of menopause. This was particularly interesting given that menopausal women are prone to chronic inflammation due to physiological changes and related issues like metabolic syndrome.

To explore this, we treated mice with lipopolysaccharides (LPS) to simulate inflammation and assessed how the inclusion of T-MSC sEVs influenced myo-inositol production. After treatment, we measured levels of proteins involved in inositol synthesis in skeletal muscle and checked the serum for inositol levels.

Our findings are encouraging and suggest that T-MSC sEVs might help mitigate some effects of chronic inflammation linked to menopause. By supporting skeletal muscle mass and maintaining myo-inositol levels, these sEVs could be an effective strategy for improving metabolic health in menopausal women. This study sheds light on a potential new approach to tackle metabolic disturbances during this life stage.
Read More
9
We conducted a study to see if myo-inositol, recognized for its insulin-sensitizing properties, could help postmenopausal women dealing with metabolic syndrome. Eighty women participated in a controlled trial, engaging in a modified diet combined with either myo-inositol supplementation or a placebo for six months.

Our findings were promising. Women who took myo-inositol experienced notable improvements in several health markers. Specifically, there was a reduction in both systolic and diastolic blood pressure, along with significant drops in the HOMA index—an important measure of insulin resistance—cholesterol levels, and triglycerides. In fact, those taking myo-inositol saw a remarkable 75% decrease in insulin resistance and a 20% reduction in triglycerides.

The results suggest that myo-inositol could be a valuable option for improving the health of postmenopausal women suffering from metabolic syndrome. This is encouraging news for those looking for effective ways to manage their health during menopause.
Read More
9
Myo-inositol improves menopausal symptoms
We undertook a retrospective clinical study examining how myo-inositol, along with cocoa polyphenols and soy isoflavones, influences menopausal symptoms in women with metabolic syndrome. Analyzing data from 200 menopausal women, we focused on the effects of a daily supplement over a period of six months.

Our findings indicated significant improvements in both vasomotor symptoms, like hot flushes, and overall metabolic health. For instance, the number of women experiencing frequent hot flushes reduced dramatically, with more women reporting only a few flushes after supplementation. Additionally, we noted a decrease in moderate depression symptoms among participants.

On the metabolic side, women showed improvements in body mass index and waist circumference, paralleling a reduction in the percentage of those categorized as overweight or obese. We also observed a reduction in the number of participants suffering from non-insulin dependent diabetes, suggesting a positive impact of the supplement on metabolic health.

These encouraging results point to the potential benefits of myo-inositol and its accompanying compounds for managing menopausal symptoms and metabolic issues. However, we recognize the need for further controlled clinical trials to fully understand the effectiveness of these natural supplements.
Read More

Most Useful Reviews

9
Cycle support
26 people found this helpful
I am 40 and have a family history of early menopause. This supplement has helped me resume my cycle after a three-month delay. I took one capsule daily, and after three weeks, I saw positive results in my tests regarding menopause. I hope to maintain these results moving forward.
Read More
7.5
Mental health improvement
9 people found this helpful
I discovered this supplement for its benefits related to infertility, menopause, and anxiety. It has alleviated my irritability and anxiety. I will continue taking it daily alongside omega 3 and vitamins C and E. I even plan to increase my intake to two tablets. I wholeheartedly recommend it to women!
Read More
7.5
Cholesterol support
9 people found this helpful
I’m a 52-year-old woman taking this supplement to support my health during menopause, particularly with cholesterol and hair quality. It seems to help with my irritability as well. This is my third bottle, and I feel calmer, which is vital during this stage of life.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
  • All Researches
9
Myo-inositol improves menopausal symptoms
We undertook a retrospective clinical study examining how myo-inositol, along with cocoa polyphenols and soy isoflavones, influences menopausal symptoms in women with metabolic syndrome. Analyzing data from 200 menopausal women, we focused on the effects of a daily supplement over a period of six months.

Our findings indicated significant improvements in both vasomotor symptoms, like hot flushes, and overall metabolic health. For instance, the number of women experiencing frequent hot flushes reduced dramatically, with more women reporting only a few flushes after supplementation. Additionally, we noted a decrease in moderate depression symptoms among participants.

On the metabolic side, women showed improvements in body mass index and waist circumference, paralleling a reduction in the percentage of those categorized as overweight or obese. We also observed a reduction in the number of participants suffering from non-insulin dependent diabetes, suggesting a positive impact of the supplement on metabolic health.

These encouraging results point to the potential benefits of myo-inositol and its accompanying compounds for managing menopausal symptoms and metabolic issues. However, we recognize the need for further controlled clinical trials to fully understand the effectiveness of these natural supplements.
Read More
9
We conducted a study to see if myo-inositol, recognized for its insulin-sensitizing properties, could help postmenopausal women dealing with metabolic syndrome. Eighty women participated in a controlled trial, engaging in a modified diet combined with either myo-inositol supplementation or a placebo for six months.

Our findings were promising. Women who took myo-inositol experienced notable improvements in several health markers. Specifically, there was a reduction in both systolic and diastolic blood pressure, along with significant drops in the HOMA index—an important measure of insulin resistance—cholesterol levels, and triglycerides. In fact, those taking myo-inositol saw a remarkable 75% decrease in insulin resistance and a 20% reduction in triglycerides.

The results suggest that myo-inositol could be a valuable option for improving the health of postmenopausal women suffering from metabolic syndrome. This is encouraging news for those looking for effective ways to manage their health during menopause.
Read More
This study explored how a new supplement, featuring myo-inositol, cocoa polyphenols, and soy isoflavones, affects cardiovascular risk markers in postmenopausal women dealing with metabolic syndrome. We recruited 60 women and divided them into two groups: one received the supplement, while the other got a placebo for six months.

During this period, we looked at various health indicators such as glucose levels, triglycerides, and specific proteins associated with inflammation and bone health. By the six-month mark, we observed meaningful improvements in glucose, triglycerides, visfatin, resistin, and bone-specific alkaline phosphatase (bone-ALP) for those taking the supplement compared to the placebo group.

However, levels of HDL cholesterol and adiponectin did not show any significant differences between the two groups. Overall, while the combination of ingredients in the supplement improved several biomarkers tied to metabolic syndrome, it’s challenging to pinpoint the specific contribution of myo-inositol alone due to the complexity of the formulation.
Read More
8
Inositol aids menopausal metabolic health
We conducted a six-month randomized placebo-controlled trial involving 155 postmenopausal women with metabolic syndrome, specifically those at risk for breast cancer. Our goal was to see how the combination of inositol and alpha lipoic acid impacts insulin resistance and other metabolic features related to menopause.

Participants were assigned to either a treatment group, taking inositol and alpha lipoic acid, or a placebo group. They all followed a low-calorie diet. We focused on primary outcomes such as reducing the HOMA-IR index and lowering triglyceride levels, as well as secondary outcomes like improving HDL cholesterol and reducing body measurements.

The results showed that this combination can significantly improve insulin sensitivity and help with metabolic syndrome symptoms. Given that metabolic syndrome is a modifiable risk factor for breast cancer, this suggests that incorporating inositol and alpha lipoic acid could be beneficial for those looking to improve their health during menopause.
Read More
7
Myo-Inositol Support in Menopause
We investigated whether small extracellular vesicles (sEVs) derived from human palatine tonsil mesenchymal stem cells could boost myo-inositol levels in the context of menopause. This was particularly interesting given that menopausal women are prone to chronic inflammation due to physiological changes and related issues like metabolic syndrome.

To explore this, we treated mice with lipopolysaccharides (LPS) to simulate inflammation and assessed how the inclusion of T-MSC sEVs influenced myo-inositol production. After treatment, we measured levels of proteins involved in inositol synthesis in skeletal muscle and checked the serum for inositol levels.

Our findings are encouraging and suggest that T-MSC sEVs might help mitigate some effects of chronic inflammation linked to menopause. By supporting skeletal muscle mass and maintaining myo-inositol levels, these sEVs could be an effective strategy for improving metabolic health in menopausal women. This study sheds light on a potential new approach to tackle metabolic disturbances during this life stage.
Read More

User Reviews

USERS' SCORE
Moderately Good
Based on 23 Reviews
7.6
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Cycle support
26 people found this helpful
I am 40 and have a family history of early menopause. This supplement has helped me resume my cycle after a three-month delay. I took one capsule daily, and after three weeks, I saw positive results in my tests regarding menopause. I hope to maintain these results moving forward.
Read More
7.5
Mental health improvement
9 people found this helpful
I discovered this supplement for its benefits related to infertility, menopause, and anxiety. It has alleviated my irritability and anxiety. I will continue taking it daily alongside omega 3 and vitamins C and E. I even plan to increase my intake to two tablets. I wholeheartedly recommend it to women!
Read More
7.5
Cholesterol support
9 people found this helpful
I’m a 52-year-old woman taking this supplement to support my health during menopause, particularly with cholesterol and hair quality. It seems to help with my irritability as well. This is my third bottle, and I feel calmer, which is vital during this stage of life.
Read More
9
Significant relief
7 people found this helpful
So far so brilliant! I couldn't afford this elsewhere, and it has helped me immensely, especially after my hysterectomy and entering menopause at such a young age (due to cancer). I'll continue purchasing it, and my friends are now doing the same.
Read More
9
Hormonal balance
1 people found this helpful
I have been using this inositol supplement daily and it has significantly improved my hormonal balance, which is crucial in early menopause. My emotional state has stabilised, and I've noticed a positive change. I also bought it for my daughter, and she reports similar improvements.
Read More

Frequently Asked Questions

9
Cycle support
26 people found this helpful
I am 40 and have a family history of early menopause. This supplement has helped me resume my cycle after a three-month delay. I took one capsule daily, and after three weeks, I saw positive results in my tests regarding menopause. I hope to maintain these results moving forward.
9
Reduced menopausal symptoms
I am 45 and experiencing the first signs of menopause. After taking one capsule at night, my hot flashes have decreased significantly, and my skin has improved. The supplement seems to be balancing my menstrual cycle as well.
9
Sleeping aid
1 people found this helpful
I learned about this supplement from a menopause podcast for better sleep. After taking it for three weeks, I no longer need melatonin and I'm sleeping well most nights. It has truly made a difference in managing my sleep issues.
9
PMS relief
Inositol is excellent for PMS and menopause. I recommend a dosage of 2000mg daily for noticeable effects; 5000mg may be needed for chronic conditions.
7.5
Cholesterol support
9 people found this helpful
I’m a 52-year-old woman taking this supplement to support my health during menopause, particularly with cholesterol and hair quality. It seems to help with my irritability as well. This is my third bottle, and I feel calmer, which is vital during this stage of life.
7.5
Mental health improvement
9 people found this helpful
I discovered this supplement for its benefits related to infertility, menopause, and anxiety. It has alleviated my irritability and anxiety. I will continue taking it daily alongside omega 3 and vitamins C and E. I even plan to increase my intake to two tablets. I wholeheartedly recommend it to women!
10
Menstruation resumed
I was diagnosed with menopause and hadn’t had my period for four and a half months. However, after taking this supplement, I started menstruating again, first at the end of last year and then a month later. I’m genuinely touched by its effectiveness.
9
Weight management
I started taking Inositol for weight gain from menopause, and I’ve lost weight in recent months. I will continue using it.
7.5
Pregnancy planning
This is a vital women's vitamin, especially for those planning pregnancy or experiencing menopause. I noticed it helps with weight loss.
6
Postponed menopause
145 people found this helpful
Inositol has been essential for my health and beauty, especially as I experience menopausal changes. As we age, our bodies struggle to synthesise it due to various factors. This supplement helps to delay menopause and its issues. I take two capsules and combine it with choline for improved hormone synthesis. I believe this is the best inositol option available. I hope you find my review helpful and would appreciate a "yes" if it is!
7.5
Supports women's health
This supplement is excellent for maintaining women's health during the initial stages of menopause and menstrual cycle disorders. The packaging is convenient, and the necessary ingredients ensure high quality.
9
Myo-inositol improves menopausal symptoms
We undertook a retrospective clinical study examining how myo-inositol, along with cocoa polyphenols and soy isoflavones, influences menopausal symptoms in women with metabolic syndrome. Analyzing data from 200 menopausal women, we focused on the effects of a daily supplement over a period of six months.

Our findings indicated significant improvements in both vasomotor symptoms, like hot flushes, and overall metabolic health. For instance, the number of women experiencing frequent hot flushes reduced dramatically, with more women reporting only a few flushes after supplementation. Additionally, we noted a decrease in moderate depression symptoms among participants.

On the metabolic side, women showed improvements in body mass index and waist circumference, paralleling a reduction in the percentage of those categorized as overweight or obese. We also observed a reduction in the number of participants suffering from non-insulin dependent diabetes, suggesting a positive impact of the supplement on metabolic health.

These encouraging results point to the potential benefits of myo-inositol and its accompanying compounds for managing menopausal symptoms and metabolic issues. However, we recognize the need for further controlled clinical trials to fully understand the effectiveness of these natural supplements.
9
We conducted a study to see if myo-inositol, recognized for its insulin-sensitizing properties, could help postmenopausal women dealing with metabolic syndrome. Eighty women participated in a controlled trial, engaging in a modified diet combined with either myo-inositol supplementation or a placebo for six months.

Our findings were promising. Women who took myo-inositol experienced notable improvements in several health markers. Specifically, there was a reduction in both systolic and diastolic blood pressure, along with significant drops in the HOMA index—an important measure of insulin resistance—cholesterol levels, and triglycerides. In fact, those taking myo-inositol saw a remarkable 75% decrease in insulin resistance and a 20% reduction in triglycerides.

The results suggest that myo-inositol could be a valuable option for improving the health of postmenopausal women suffering from metabolic syndrome. This is encouraging news for those looking for effective ways to manage their health during menopause.
7
Inositol enhances metformin effects
We conducted a study to explore how myo-inositol interacts with metformin in postmenopausal women who have prediabetes. Our research included two groups of women: one group taking myo-inositol and the other not.

Both groups were treated with metformin for six months to see how these treatments would affect different hormone levels, particularly gonadotropins, which are crucial for reproductive health. We found that the women taking myo-inositol experienced a stronger decrease in certain hormone levels compared to those who didn't.

While the results suggest that myo-inositol may enhance the effects of metformin, it's important to note that our study involved a small group of participants. This limits our ability to draw broader conclusions, especially about how this combination might work in premenopausal women.

Overall, the insights gained could be beneficial for postmenopausal women considering treatment options for hormone regulation associated with menopause.
We enrolled eighty postmenopausal women suffering from metabolic syndrome to explore the effects of myo-inositol on various health parameters over a twelve-month period. All participants followed a low-energy diet and were randomly assigned to receive either 2 grams of myo-inositol twice daily or a placebo. Throughout the study, we monitored several health indicators, including blood glucose, insulin levels, and cholesterol.

After twelve months, we observed significant improvements in nearly all parameters for those taking myo-inositol, with only body mass index and waist circumference not showing notable changes. Encouragingly, 20% of the women in the myo-inositol group no longer met the criteria for metabolic syndrome by the end of the study, compared to just one woman in the placebo group.

While this study focused on metabolic syndrome rather than menopause symptoms, the findings suggest that myo-inositol may help enhance insulin sensitivity in postmenopausal women. However, we did not specifically investigate the direct effects on menopause symptoms, making it challenging to draw conclusions about its overall impact in this area.

References

  1. Cho KA, Kim YH, Woo SY, Ryu KH. Tonsil-Derived Mesenchymal Stem Cell-Derived Small Extracellular Vesicles (sEVs) Restore Myo-Inositol Production in LPS-Treated Skeletal Muscle. Tissue Eng Regen Med. 2025. doi:10.1007/s13770-025-00709-w
  2. Mainini G, Ercolano S, De Simone R, Iavarone I, Lizza R, et al. Dietary Supplementation of Myo-Inositol, Cocoa Polyphenols, and Soy Isoflavones Improves Vasomotor Symptoms and Metabolic Profile in Menopausal Women with Metabolic Syndrome: A Retrospective Clinical Study. Medicina (Kaunas). 2024;60. doi:10.3390/medicina60040598
  3. Krysiak R, Kowalcze K, Okopień B. Myo-Inositol Enhances the Inhibitory Effect of Metformin on Gonadotropin Levels in Postmenopausal Women. Gynecol Obstet Invest. 2022;87:373. doi:10.1159/000527365
  4. D'Anna R, Santamaria A, Giorgianni G, Vaiarelli A, Gullo G, et al. Myo-inositol and melatonin in the menopausal transition. Gynecol Endocrinol. 2017;33:279. doi:10.1080/09513590.2016.1254613
  5. D'Anna R, Santamaria A, Cannata ML, Interdonato ML, Giorgianni GM, et al. Effects of a new flavonoid and Myo-inositol supplement on some biomarkers of cardiovascular risk in postmenopausal women: a randomized trial. Int J Endocrinol. 2014;2014:653561. doi:10.1155/2014/653561
  6. Parazzini F. Resveratrol, inositol, vitamin D and K in the prevention of cardiovascular and osteoporotic risk: a novel approach in peri- and postmenopause. Minerva Ginecol. 2014;66:513.
  7. Capasso I, Esposito E, Maurea N, Montella M, Crispo A, et al. Combination of inositol and alpha lipoic acid in metabolic syndrome-affected women: a randomized placebo-controlled trial. Trials. 2013;14:273. doi:10.1186/1745-6215-14-273
  8. Santamaria A, Giordano D, Corrado F, Pintaudi B, Interdonato ML, et al. One-year effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome. Climacteric. 2012;15:490. doi:10.3109/13697137.2011.631063
  9. Giordano D, Corrado F, Santamaria A, Quattrone S, Pintaudi B, et al. Effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome: a perspective, randomized, placebo-controlled study. Menopause. 2011;18:102. doi:10.1097/gme.0b013e3181e8e1b1
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