NOW Supplements D-Mannose Powder

We explored how D-mannose could help prevent urinary tract infections and discomfort in patients undergoing cystoscopy. In a well-structured study with 32 patients, those receiving D-mannose experienced significantly fewer UTIs and less severe urinary symptoms compared to those who did not receive treatment.

While the treatment showed promise by reducing the number of infections and pain, no major difference was found in overall quality of life scores between the groups. This indicates D-mannose could be beneficial for specific discomforts related to the procedure.

Infection-free living

Most Useful Review

53 people found this helpful

An AMAZING product! I endured chronic bladder infections for almost five years, trying numerous antibiotics and alternative treatments. Then, someone recommended D-Mannose, and I thought "why not?" I bought it, and within hours, my symptoms vanished. I'm now free from infections, antibiotics, and yeast infection. D-Mannose is fantastic; I wish I'd known about it five years ago.

Bacterial Infection details

87 people found this helpful

D'Mannose literally saved my life! Following numerous infections and treatments with limited success, a discussion with my sister-in-law about her positive experience with D'Mannose led me to try it. I meticulously followed the regimen and observed drastic relief from the UTI symptoms after the first day, feeling normal once again. It's now been over five years since I had a UTI, and I attribute this revival to D'Mannose!

Urinary Tract Infection details

SCIENTIFIC SCORE

Questionable

Based on 17 Researches

D-Mannose shows effective UTI treatment

Salvatore S, Ruffolo AF, Stabile G, Casiraghi A, Zito G, et al. A Randomized Controlled Trial Comparing a New D-Mannose-based Dietary Supplement to Placebo for the Treatment of Uncomplicated Escherichia coli Urinary Tract Infections. Eur Urol Focus. 2023;9:654. doi:10.1016/j.euf.2022.12.013

We evaluated a D-mannose-based dietary supplement, the DAPAD complex, to see if it could effectively treat uncomplicated E. coli urinary tract infections (UTIs).

Conducted as a randomized, double-blind trial in India, our study involved 70 nonmenopausal women.

The results were promising: at day six, the DAPAD group showed much higher clinical resolution (34.3% vs. 0%) and effective bacteriological resolution (85.7% vs. 14.3%).

By day 35, symptoms were completely resolved for all in the DAPAD group, while the placebo group still had patients with moderate or severe symptoms.

Saved my marriage

Most Useful Review

62 people found this helpful

D-Mannose has been outstanding for my chronic UTIs. For over 8 years, I suffered severe bladder infections, especially after intercourse. Despite seeing various doctors and being prescribed multiple antibiotics, nothing worked. I started taking a teaspoon daily with water and an extra one after intercourse. If I showed any symptoms, I would take one every few hours until they disappeared, typically in just one day. The addition of pure aloe vera juice and probiotics enhanced my results. My costly doctor visits and prescriptions are now a thing of the past. This combination has truly changed my life and my marriage!

Kidney Infection details

Effective against infections

Most Useful Review

35 people found this helpful

Life saver! I had a severe kidney infection a year ago, and since then, I suffered three consecutive UTI episodes. I tried antibiotics repetitively, yet they failed to eliminate the nasty infection. Then I discovered D-Mannose and decided to give it a go due to the positive Amazon reviews. Initially, the capsules proved ineffective, but the powder worked after carefully following instructions from another reviewer. I took four doses daily for three months, gradually reducing to two doses, plus an extra dose after sex. My recent urine test showed no bacteria! This natural solution is a godsend, provided you follow the instructions carefully. Trust me; this is far superior to antibiotics!

Menopause details

SCIENTIFIC SCORE

Moderately Effective

Based on 3 Researches

D-mannose aids menopausal UTI management

Mainini G, Passaro M, Schiattarella A, Franciscis P, Donna MCD, et al. Prevention and treatment of cystitis during menopause: efficacy of a nutraceutical containing D-mannose, inulin, cranberry, bearberry, and . Prz Menopauzalny. 2020;19:130. doi:10.5114/pm.2020.99567

We evaluated the effectiveness of a nutraceutical compound featuring D-mannose, along with cranberry, bearberry, and inulin, in treating recurrent urinary tract infections (UTIs) among menopausal women. In our cohort study, women took this treatment for ten days each month.

At six months, there was a notable decrease in women experiencing recurrent UTIs compared to their baseline. Additionally, at the twelve-month mark, more participants in the treatment group reported being infection-free and showed significant improvement in UTI-related symptoms.

Effective for UTIs

Most Useful Review

8 people found this helpful

It works! After suffering for months from a nasty UTI treated with multiple antibiotics, I experienced persistent urinary issues that felt like a low-grade infection. Following extensive research, I discovered that D-Mannose could effectively eliminate UTIs. I tried NOW D-Mannose Powder, taking it every three hours for three days and then reducing to three times a day. Within 24 hours, my bladder irritation and pain showed remarkable improvement, hitting its best within six days. I can't believe my urologist didn’t suggest it. Anyone battling UTIs, especially those due to menopause, should certainly consider trying this product. It's easy to take with a mild sweetness and no side effects.

Cardiovascular Disease details

SCIENTIFIC SCORE

Moderately Effective

Based on 2 Researches

Targeted therapy shows promise

Lee SY, Kim JH, Song JW, Min JS, Kim HJ, et al. Macrophage-mannose-receptor-targeted photoactivatable agent for in vivo imaging and treatment of atherosclerosis. Int J Pharm. 2024;654:123951. doi:10.1016/j.ijpharm.2024.123951

We explored a new targeted agent designed to treat atherosclerosis by focusing on macrophage-mannose receptors. This study tested the effectiveness and safety of a specially formulated nanoagent in a mouse model of atherosclerosis.

The agent showed a notable reduction in inflammation within the arterial plaques while being well-tolerated in terms of toxicity. We found it had good imaging capabilities, allowing for better visualization of macrophages linked to atherosclerosis.

Overall, this promising approach may improve both the diagnosis and treatment of cardiovascular diseases linked to atherosclerosis.

Chronic cystitis beaten

Most Useful Review

15 people found this helpful

D-Mannose has been life-changing for me! This simple saccharide binds E. coli in the bladder, preventing outbreaks of cystitis. I take three capsules at the first signs of an attack, stopping the bacterial growth effectively. After ceasing hormonal pills—previously taken for over a year—I was relieved not to face another bout of cystitis after three months. My experience has positively transformed my life, and I hope my review encourages others to try it!

We explored the impact of D-mannose on intervertebral disc degeneration (IVDD), a condition often accompanied by significant pain. The study utilized various sophisticated methods to demonstrate that D-mannose acts primarily through a gene called TXNIP, which influences glutamine metabolism.

Though our findings suggest that D-mannose has promise in alleviating IVDD’s symptoms, we also acknowledge that it has not shown significant pain-relieving effects compared to traditional treatments. Further research may be needed to fully understand its therapeutic potential for pain management.

Miracle solution

Most Useful Review

22 people found this helpful

Years of torment resolved with Mannosa! After suffering chronic cystitis for six years, the condition became unbearable with frequent infections and severe bone pain. Traditional treatments seemed futile, but after using Mannosa, my symptoms dwindled significantly within months. I took a small dosage before bed, and if I felt discomfort, a quick drink of Mannosa alleviated it immediately. Now I rarely use it, opting for prevention when needed, and I highly recommend it for anyone who shares this affliction.

High Cholesterol details

1 people found this helpful

Thank you very much for this product! I used to suffer from postcoital cystitis and frequently relied on antibiotics. Now, thanks to D-Mannose, I've completely forgotten what cystitis feels like! I highly recommend it!

Back Pain details

95 people found this helpful

Cured symptoms of chronic UTI of 4 years in just a day! My daughter suffered bladder pain, urgency, spasms, and burning for four long years, costing her school and work. After numerous doctors and ineffective treatments, I turned to D-Mannose, following a detailed regimen. To our amazement, she was almost symptom-free by the second day. No more pain or burning after four years of suffering!

Candidiasis details

57 people found this helpful

Thanks to the creator, this is a miracle powder! I have suffered from chronic cystitis for three years, constantly having acute flare-ups treated with antibiotics, which ultimately harmed my microflora and led to constant thrush. After trying D-mannose, I felt immediate relief after the first dose. I took two capsules in the morning and evening. During my first course, while I had a cold, my symptoms persisted but eventually subsided after additional treatment. Now, cystitis is hardly an issue; I only take mannose after intimate activities. I've ordered more for future needs. Those with similar issues should try this instead of relying on antibiotics!

Cold Sores details

2 people found this helpful

Massive results! I cannot believe how effective this powder is! Since I've been taking it for about a month, primarily around the time of intercourse, I haven’t had any urinary tract issues. It comes as a white powder with little taste. The dosage is one teaspoon, and it dissolves well in cold water. I read many reviews before trying it, but my fertility consultant mentioned its benefits.

Food Poisoning details

19 people found this helpful

It works! Buy D-mannose and give it a try! If you suffer from cystitis repeatedly and antibiotics do not help, and E. coli continuously resides in your urine, then try D-mannose. I only take one teaspoon a day, sometimes less, and nothing bothers me. It's a shame that in Russia we are overloaded with antibiotics.

SCIENTIFIC SCORE

Moderately Effective

Based on 5 Researches

d-mannose may alleviate psoriasis

Jiang Q, Wei B, You M, Zhou X. d-mannose blocks the interaction between keratinocytes and Th17 cells to alleviate psoriasis by inhibiting HIF-1α/CCL20 in mice. Int Immunopharmacol. 2023;118:110087. doi:10.1016/j.intimp.2023.110087

We explored whether d-mannose can help alleviate psoriasis, an autoimmune condition that causes significant discomfort. Our study demonstrated that both oral and topical applications of d-mannose were effective in reducing psoriasis symptoms in mice.

We discovered that it works by lowering levels of a protein called HIF-1α and the chemokine CCL20 in skin cells. This inhibition interrupts the harmful cycle between keratinocytes and Th17 immune cells. Overall, this suggests d-mannose could be a helpful treatment option for managing psoriasis.

Cystitis relief

Most Useful Review

57 people found this helpful

Thanks to the creator, for this is a MIRACLE powder. I've suffered with chronic cystitis for 3 years, experiencing monthly flare-ups. I relied on antibiotics like ciprofloxacin, which destroyed my microflora and led to constant thrush. Desperate for relief, I stumbled upon D-mannose. I ordered a small jar and felt relief after my first dose. I took two capsules morning and evening, and importantly, now, I only need D-mannose after intercourse. My symptoms have lessened significantly, and I no longer suffer from cystitis. I have since ordered larger jars as backups. Why isn’t this product prescribed in Russia? I wish everyone good health!