Supplement Facts
Serving Size: About 1/4 cup (31 g)
Amount Per Serving
%DV
Calories
180
Total Fat
13 g
17%
Saturated Fat
3 g
15%
Trans Fat
0 g
Cholesterol
0 mg
0%
Sodium
0 mg
0%
Total Carbohydrate
4 g
1%
Dietary Fiber
2 g
7%
Total Sugars
0 g
Includes 0g Added Sugars
0%
Protein
11g
Vit. D
0 mcg
0%
Calcium
8 mg
0%
Iron
4 mg
20%
Potassium
243 mg
6%
The product is found useful for the following medical conditions
Anemia details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 7 Reviews
8.5
8
In our exploration of how protein treatments can improve anemia, we focused on the impact of romiplostim, a thrombopoietin receptor agonist, on patients suffering from aplastic anemia (AA) who were either refractory to or intolerant of eltrombopag (EPAG). We studied a group of 18 patients, most of whom had severe AA, who transitioned from EPAG to romiplostim for at least three months.
Remarkably, 72% of these patients responded positively to romiplostim, with many showing improvement in their blood cell counts within the first three months. Of these, half demonstrated a trilineage response, meaning their blood counts improved across multiple cell types. However, we noticed that those who initiated romiplostim a significant time after their initial AA diagnosis tended to struggle to respond effectively.
In instances where treatment with romiplostim was interrupted, we observed that some patients relapsed into thrombocytopenia, suggesting that romiplostim plays a critical role in maintaining blood counts. Overall, our findings indicate that romiplostim can be a valuable option for patients who do not benefit from other treatments, bringing renewed hope in the management of this challenging condition.
Remarkably, 72% of these patients responded positively to romiplostim, with many showing improvement in their blood cell counts within the first three months. Of these, half demonstrated a trilineage response, meaning their blood counts improved across multiple cell types. However, we noticed that those who initiated romiplostim a significant time after their initial AA diagnosis tended to struggle to respond effectively.
In instances where treatment with romiplostim was interrupted, we observed that some patients relapsed into thrombocytopenia, suggesting that romiplostim plays a critical role in maintaining blood counts. Overall, our findings indicate that romiplostim can be a valuable option for patients who do not benefit from other treatments, bringing renewed hope in the management of this challenging condition.
9
Helps iron deficiency
Most Useful Review
Amazing! It’s excellent for those who suffer from anaemia and iron deficiency. I always order it.
Cardiovascular Disease details
SCIENTIFIC SCORE
Likely Very Effective
Based on 2 Researches
9
USERS' SCORE
Good
Based on 4 Reviews
8.5
9
We investigated how Maresin 1, a protein known for its anti-inflammatory and antioxidant properties, impacts heart injury caused by ischemia/reperfusion (IRI). This condition often arises when blood supply returns to the heart after being restricted, leading to damage.
Using a mouse model for cardiac IRI and an in vitro approach with neonatal rat ventricle myocytes, we aimed to uncover the effects of Maresin 1 on pyroptosis, a type of cell death associated with inflammation. Our findings showed that Maresin 1 significantly reduced the size of heart tissue damage in mice while also lowering the levels of harmful cell death and inflammation.
Moreover, we observed that Maresin 1 works through a specific biological pathway involving SIRT1 and other proteins, helping to curb inflammatory responses during heart attacks. In isolated heart cells, it improved cell health and decreased the damage typically seen with ischemia. These results highlight Maresin 1 as a potential therapeutic option for improving heart recovery after ischemic events.
Using a mouse model for cardiac IRI and an in vitro approach with neonatal rat ventricle myocytes, we aimed to uncover the effects of Maresin 1 on pyroptosis, a type of cell death associated with inflammation. Our findings showed that Maresin 1 significantly reduced the size of heart tissue damage in mice while also lowering the levels of harmful cell death and inflammation.
Moreover, we observed that Maresin 1 works through a specific biological pathway involving SIRT1 and other proteins, helping to curb inflammatory responses during heart attacks. In isolated heart cells, it improved cell health and decreased the damage typically seen with ischemia. These results highlight Maresin 1 as a potential therapeutic option for improving heart recovery after ischemic events.
9
Strengthens immunity
Most Useful Review
5 people found this helpful
I ordered pumpkin seeds for the first time. They are excellent quality, not too large, but clean and perfect. The whole family enjoys them, and I provide them daily due to their valuable composition. Pumpkin seeds contain essential nutrients that can help fight cancer and boost immunity, making them beneficial for treating cardiovascular disease. Regular consumption aids the gastrointestinal system, lowers blood pressure, and strengthens blood vessels. The numerous benefits are significant, and I will certainly reorder them. Wishing everyone good health!
Constipation details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8
USERS' SCORE
Good
Based on 5 Reviews
8.5
7
Diabetes management beverage study
Our exploration into the management of diabetes and its complications led us to develop a unique beverage formulation. This drink combines stevia glycoside, mogroside V, and sodium hyaluronate, known as SMH-B, which offers a sweet taste without affecting blood sugar levels.
In our study, we found SMH-B to be more than just enjoyable; it plays a key role in addressing various health issues related to diabetes. These include improving skin moisture and elasticity, alleviating constipation, and even reducing signs of depression.
Importantly, we observed that SMH-B helped lower blood glucose and lipid levels as well, proving to be a multifaceted approach to diabetes management. Such findings indicate that integrating protein in our beverage formulation could possibly enhance digestive health and symptomatic relief for those struggling with constipation.
In our study, we found SMH-B to be more than just enjoyable; it plays a key role in addressing various health issues related to diabetes. These include improving skin moisture and elasticity, alleviating constipation, and even reducing signs of depression.
Importantly, we observed that SMH-B helped lower blood glucose and lipid levels as well, proving to be a multifaceted approach to diabetes management. Such findings indicate that integrating protein in our beverage formulation could possibly enhance digestive health and symptomatic relief for those struggling with constipation.
9
Highly beneficial
Most Useful Review
5 people found this helpful
I first ordered pumpkin seeds and found them excellent in quality. They’re not large but very clean, and the package was impressive in volume. My family enjoys eating them, and I give them a bit each day as they're beneficial for health. They are said to aid in fighting constipation and boosting immunity. Plus, they contain valuable nutrients like zinc and magnesium. The benefits of pumpkin seeds are immense, and I will certainly purchase them again.
Kidney Stones details
SCIENTIFIC SCORE
Likely Very Effective
Based on 3 Researches
9
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
We explored how a specific type of treatment called prolyl hydroxylase domain inhibitors, particularly roxadustat, impacts the formation of kidney stones. The study used both lab-based experiments and live mouse models to understand how this treatment might help reduce the damaging inflammation associated with the formation of calcium oxalate crystals in the kidneys.
In the lab, we subjected murine renal tubular cells to roxadustat while exposing them to calcium oxalate crystals. Our findings showed that roxadustat effectively limited the adhesion of these harmful crystals to the cells and decreased levels of various proinflammatory proteins that can worsen kidney damage. Additionally, we looked at the interaction between these cells and immune macrophages, noting that roxadustat reduced the inflammatory response in this group as well.
In our in vivo trials with mice, we injected them with roxadustat and found that those treated with the drug had significantly fewer calcium oxalate deposits in their kidneys compared to those receiving saline. Overall, roxadustat appeared to reduce both kidney inflammation and the formation of stones, suggesting it could be a promising treatment option for preventing kidney stones in humans as well.
In the lab, we subjected murine renal tubular cells to roxadustat while exposing them to calcium oxalate crystals. Our findings showed that roxadustat effectively limited the adhesion of these harmful crystals to the cells and decreased levels of various proinflammatory proteins that can worsen kidney damage. Additionally, we looked at the interaction between these cells and immune macrophages, noting that roxadustat reduced the inflammatory response in this group as well.
In our in vivo trials with mice, we injected them with roxadustat and found that those treated with the drug had significantly fewer calcium oxalate deposits in their kidneys compared to those receiving saline. Overall, roxadustat appeared to reduce both kidney inflammation and the formation of stones, suggesting it could be a promising treatment option for preventing kidney stones in humans as well.
9
Natural diuretic benefit
Most Useful Review
Pumpkin seeds are a potent natural diuretic. They assist in eliminating kidney stones and can help prevent urolithiasis. Traditional remedies often recommend a decoction of crushed pumpkin and flax seeds for urinary issues, cystitis, cholecystitis, and various bladder concerns.
Nausea details
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 2 Reviews
8.5
8
We explored the effects of dietary protein on managing nausea and vomiting during pregnancy (NVP), a common condition affecting many expectant mothers. The study found that incorporating protein-rich foods can have a positive impact. Protein helps stabilize gastric motility, which in turn may reduce feelings of nausea and vomiting.
Additionally, we discovered that a diet rich in fruits, vegetables, and protein sources offers further benefits. By addressing nutritional deficiencies through protein intake, women may experience better overall well-being during this challenging time.
While we examined various dietary strategies, the role of protein stands out as particularly beneficial and can be integrated with other treatments. This combined approach enhances maternal comfort and contributes positively to fetal health, ensuring a healthier pregnancy journey.
Additionally, we discovered that a diet rich in fruits, vegetables, and protein sources offers further benefits. By addressing nutritional deficiencies through protein intake, women may experience better overall well-being during this challenging time.
While we examined various dietary strategies, the role of protein stands out as particularly beneficial and can be integrated with other treatments. This combined approach enhances maternal comfort and contributes positively to fetal health, ensuring a healthier pregnancy journey.
9
Nausea alleviation
Most Useful Review
1 people found this helpful
After trying it for about a month, I can confirm the nausea I frequently experience, especially in the morning, has vanished. I find it best to consume it with yoghurt, alone in small amounts, or in salads. It's a delightful addition to my diet, and I plan to continue using and repurchasing it.
Pelvic Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
Cystitis relief noted
Most Useful Review
Pumpkin seeds are beneficial for eye health, particularly for those who frequently suffer from cystitis. Since incorporating them into my diet, I have been free from the associated pelvic pain I experienced for years. My father expressed gratitude, and now a teacher I know, who has cataracts, has also benefited, delaying surgery as his eyesight improved. I consume pumpkin seeds daily, and they have made a significant difference.
Arthritis details
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.4
USERS' SCORE
Good
Based on 3 Reviews
8.4
9
In our exploration of how certain natural compounds can impact rheumatoid arthritis (RA), we focused on the total flavonoids derived from Schltr., specifically identifying the effects of quercetin. Our research employed various methods, including cellular and animal models, to examine how these compounds inhibit TNF-α, a key player in inflammation and joint deterioration.
We discovered that quercetin stands out among several compounds, demonstrating a strong ability to reduce TNF-α activity. This reduction corresponds with decreased cellular injury and apoptosis in our models, showcasing quercetin's potential as a protective agent against RA symptoms. Through advanced techniques such as molecular docking and thermal profiling, we verified that quercetin binds to TNF-α, eventually diminishing the inflammatory processes related to arthritis.
The findings suggest that quercetin plays a significant role in suppressing the TNF-α/NF-κB signaling pathway, which is crucial in the development of RA. By blocking certain inflammatory responses, quercetin appears to mitigate pain and joint damage, positioning it as a hopeful candidate for RA treatment. Overall, our investigation highlights quercetin's promising properties as a natural anti-inflammatory agent for those suffering from arthritis.
We discovered that quercetin stands out among several compounds, demonstrating a strong ability to reduce TNF-α activity. This reduction corresponds with decreased cellular injury and apoptosis in our models, showcasing quercetin's potential as a protective agent against RA symptoms. Through advanced techniques such as molecular docking and thermal profiling, we verified that quercetin binds to TNF-α, eventually diminishing the inflammatory processes related to arthritis.
The findings suggest that quercetin plays a significant role in suppressing the TNF-α/NF-κB signaling pathway, which is crucial in the development of RA. By blocking certain inflammatory responses, quercetin appears to mitigate pain and joint damage, positioning it as a hopeful candidate for RA treatment. Overall, our investigation highlights quercetin's promising properties as a natural anti-inflammatory agent for those suffering from arthritis.
9
Beneficial for arthritis
Most Useful Review
1 people found this helpful
The quality is excellent. I have repurchased pumpkin seeds numerous times due to their anti-inflammatory effects, which benefit my periodontal disease and arthritis. They are natural and healthy, making them a long-time staple in my diet.
Bone Pain details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.3
9
Regulates blood sugar
Most Useful Review
3 people found this helpful
The benefits of pumpkin seeds are well-documented, particularly when unroasted. They contain a significant amount of zinc, aiding in bone health and potentially regulating blood sugar levels. They've also been found to slow ageing and improve the condition of hair and skin. I wholeheartedly recommend this product for its multiple health benefits, including its positive effects on bone pain.
Heart Disease details
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.6
USERS' SCORE
Good
Based on 10 Reviews
8.3
9
We examined the potential of Maresin 1 (MaR 1), a compound known for its powerful anti-inflammatory and antioxidant properties, to combat heart ischemia/reperfusion injury (IRI). Conducting experiments on both mice and neonatal rat ventricle myocytes, we assessed how MaR 1 influences the cell death process known as pyroptosis, which is linked to IRI.
Our study revealed that administering MaR 1 before inducing IRI significantly reduced heart damage by lowering the size of heart infarcts, curbing cell death, and decreasing inflammation. The treatment led to notable improvements in heart function by acting on a signaling pathway that includes proteins like SIRT1 and HMGB-1.
In laboratory experiments, MaR 1 not only enhanced cell survival but also lessened harmful enzyme activities associated with heart damage. Moreover, when we used a SIRT1 inhibitor, it became clear that the protective effects of MaR 1 were closely tied to this pathway. This suggests that MaR 1 could offer a promising new avenue for treating cardiac IRI by targeting and reducing inflammation and cell death.
Our study revealed that administering MaR 1 before inducing IRI significantly reduced heart damage by lowering the size of heart infarcts, curbing cell death, and decreasing inflammation. The treatment led to notable improvements in heart function by acting on a signaling pathway that includes proteins like SIRT1 and HMGB-1.
In laboratory experiments, MaR 1 not only enhanced cell survival but also lessened harmful enzyme activities associated with heart damage. Moreover, when we used a SIRT1 inhibitor, it became clear that the protective effects of MaR 1 were closely tied to this pathway. This suggests that MaR 1 could offer a promising new avenue for treating cardiac IRI by targeting and reducing inflammation and cell death.
8
Bone and skin health
Most Useful Review
10 people found this helpful
Pumpkin seeds are fantastic! They enhance bone health and assist with heart disease due to their healthy fats and magnesium. I soak them overnight for better consumption.
Autoimmune Disorder details
SCIENTIFIC SCORE
Moderately Effective
Based on 8 Researches
8.4
USERS' SCORE
Good
Based on 2 Reviews
8.2
9
Targeted HS delivery alleviates RA
We explored a new strategy to treat rheumatoid arthritis (RA) by using nanoparticles to deliver hydrogen sulfide (HS) directly to affected joints. Our research focused on how effectively these nanoparticles, called NaHS@Cy5@MS@SP, could target specific cells involved in inflammation and tissue damage in RA. By slowly releasing HS in the synovium, we aimed to combat the negative effects of inflammation caused by fibroblast-like synoviocytes (FLSs).
Throughout our investigations, we observed that the nanoparticles not only increased levels of HS but also boosted the activity of an enzyme linked to its production. This intervention showed promising results, as it significantly reduced inflammation and proliferation of FLSs in laboratory settings. In mice with arthritis, those treated with the nanoparticles experienced reduced joint swelling and less damage to their bones and cartilage compared to those receiving conventional HS treatment.
Additionally, we confirmed that the nanoparticles were effective in shutting down the Hedgehog signaling pathway, which is known for promoting excessive cellular growth and inflammation in RA. Our findings support the idea that delivering HS in a targeted manner can improve treatment outcomes, offering hope for more effective therapies for RA moving forward.
Throughout our investigations, we observed that the nanoparticles not only increased levels of HS but also boosted the activity of an enzyme linked to its production. This intervention showed promising results, as it significantly reduced inflammation and proliferation of FLSs in laboratory settings. In mice with arthritis, those treated with the nanoparticles experienced reduced joint swelling and less damage to their bones and cartilage compared to those receiving conventional HS treatment.
Additionally, we confirmed that the nanoparticles were effective in shutting down the Hedgehog signaling pathway, which is known for promoting excessive cellular growth and inflammation in RA. Our findings support the idea that delivering HS in a targeted manner can improve treatment outcomes, offering hope for more effective therapies for RA moving forward.
7.5
Healthy breakfast
Most Useful Review
2 people found this helpful
Tasty and high quality. I’ve ordered these pumpkin seeds for myself and my mother before. She enjoys them every morning for breakfast, finding them very healthy. I use them as part of a women's seed cycle, and they taste great as a snack or in bread. They have been beneficial for managing my autoimmune disorder.
Osteoporosis details
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.7
USERS' SCORE
Good
Based on 7 Reviews
8.2
8
We explored how a specific protein, Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), influences the development of bone marrow mesenchymal stem cells (BMSCs) into bone-forming cells, especially in the context of osteoporosis (OP). Our aim was to uncover the molecular mechanisms that contribute to this transformation and possibly identify new treatment routes for OP.
We conducted a series of experiments that included analyzing mRNA expression levels and protein detection through various methods. Through techniques like alkaline phosphatase staining and Alizarin Red staining, we evaluated how well BMSCs differentiated into bone-forming cells. Our findings revealed that KLK4—a protein crucial for bone formation—was underexpressed in OP patients but significantly increased in successfully differentiated BMSCs.
Importantly, we observed that IGF2BP3 enhances the expression of KLK4, thereby promoting the osteogenic differentiation of the BMSCs. When KLK4 levels were increased, they could counteract the negative effects seen when IGF2BP3 was downregulated. These results highlight the significant role IGF2BP3 plays in supporting BMSC development into bone-forming cells, presenting a promising target for osteoporosis treatment.
We conducted a series of experiments that included analyzing mRNA expression levels and protein detection through various methods. Through techniques like alkaline phosphatase staining and Alizarin Red staining, we evaluated how well BMSCs differentiated into bone-forming cells. Our findings revealed that KLK4—a protein crucial for bone formation—was underexpressed in OP patients but significantly increased in successfully differentiated BMSCs.
Importantly, we observed that IGF2BP3 enhances the expression of KLK4, thereby promoting the osteogenic differentiation of the BMSCs. When KLK4 levels were increased, they could counteract the negative effects seen when IGF2BP3 was downregulated. These results highlight the significant role IGF2BP3 plays in supporting BMSC development into bone-forming cells, presenting a promising target for osteoporosis treatment.
9
Bone density support
Most Useful Review
The benefits of pumpkin seeds for bones are significant; magnesium, calcium, and phosphorus increase bone density and reduce osteoporosis risk in women. The quality, taste, and ingredients surpass those in stores, and the self-sealing package contains 454 grams. However, it's not safe for infants, as it can cause discomfort due to its protein and iron content.
Sleep Apnea details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.2
7.5
Improved sleep quality
Most Useful Review
1 people found this helpful
One of the products that significantly helped with my stomach issues and psychological state. I felt a transformation in my wellbeing. The taste is pleasantly sweet, and it aids those suffering from insomnia at night due to its magnesium content, which promotes comfortable sleep.
Cancer details
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.2
USERS' SCORE
Good
Based on 4 Reviews
8.1
9
We explored how specific changes to the METTL14 protein affect cancer, particularly in acute myeloid leukemia (AML). By examining the RG-rich region of METTL14, we discovered that a special form of arginine methylation called symmetric dimethylation, specifically at positions R425 and R445, plays a vital role in enhancing its function.
Our research revealed that this modification not only improves the activity of the METTL3:METTL14 complex but also influences which genes get expressed in cancer cells. We found that the presence of symmetric dimethylarginines helps the complex deposit a crucial chemical mark, known as m6A, on RNA, which is essential for the regulation of gene activity.
Furthermore, we conducted a series of experiments that indicated a potential therapeutic angle in targeting the METTL3 and PRMT5 proteins. When both are inhibited, we observed a significant drop in the expression of genes important for AML cell growth, hinting at new possibilities for treating this challenging cancer. Overall, this study highlights the intricate relationship between protein modifications and cancer biology, emphasizing the potential for more targeted approaches in therapy.
Our research revealed that this modification not only improves the activity of the METTL3:METTL14 complex but also influences which genes get expressed in cancer cells. We found that the presence of symmetric dimethylarginines helps the complex deposit a crucial chemical mark, known as m6A, on RNA, which is essential for the regulation of gene activity.
Furthermore, we conducted a series of experiments that indicated a potential therapeutic angle in targeting the METTL3 and PRMT5 proteins. When both are inhibited, we observed a significant drop in the expression of genes important for AML cell growth, hinting at new possibilities for treating this challenging cancer. Overall, this study highlights the intricate relationship between protein modifications and cancer biology, emphasizing the potential for more targeted approaches in therapy.
7.5
Supports cancer treatment
Most Useful Review
5 people found this helpful
I ordered pumpkin seeds for the first time and found them to be of excellent quality. They are small, clean, and loved by my children. I give them daily due to their beneficial composition, which includes high protein and healthy fats. Regular consumption is believed to help combat cancer, boost immunity, and improve overall health without side effects. Additionally, they may assist with various ailments and are rich in essential vitamins and minerals. I really enjoyed them and will definitely repurchase.
Hair Loss details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 14 Reviews
8
7.5
Effective against baldness
Most Useful Review
7 people found this helpful
It is beautiful, tastes sweet, and is beneficial for health. It contains Amika 3, which is useful for hair loss. I consume it daily as it has components that protect against genetic baldness. Eating it with sunflower seeds boosts its benefits. I highly recommend it and will definitely repurchase.
Heart Attack details
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8
USERS' SCORE
Good
Based on 6 Reviews
8
9
We aimed to uncover how the proteins VEGFA and bFGF can support heart recovery following a heart attack, and we did this by enhancing human adipose-derived stem cells (hADSCs) with modified mRNA. These proteins are known to play a role in improving blood flow and reducing cell death, both vital for effective healing.
By modifying the hADSCs to overexpress these proteins, we sought to improve their ability to support the heart during such a critical time. Importantly, our approach involved using a new technique that enables the hADSCs to produce these growth factors in a timed, efficient manner. This modification not only led to better survival of the transplanted cells but also promoted stable formation of new blood vessels at the site of injury.
We observed that the infused hADSCs improved overall heart function and electrical activity, suggesting a robust response to the proteins we introduced. The results indicate that the combination of these engineered stem cells and the proteins could substantially enhance recovery after a heart attack, paving the way for new treatments for heart diseases caused by ischemia.
By modifying the hADSCs to overexpress these proteins, we sought to improve their ability to support the heart during such a critical time. Importantly, our approach involved using a new technique that enables the hADSCs to produce these growth factors in a timed, efficient manner. This modification not only led to better survival of the transplanted cells but also promoted stable formation of new blood vessels at the site of injury.
We observed that the infused hADSCs improved overall heart function and electrical activity, suggesting a robust response to the proteins we introduced. The results indicate that the combination of these engineered stem cells and the proteins could substantially enhance recovery after a heart attack, paving the way for new treatments for heart diseases caused by ischemia.
8
Promotes heart health
Most Useful Review
Excellent product! Pumpkin seeds are a delightful, crunchy snack that enhances my diet. They offer many health benefits, including heart health and digestion improvement. I recommend them for their rich nutrients and great taste.
Urinary Tract Infection details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 11 Reviews
8
9
Prevents infections
Most Useful Review
Tasty and fresh, I find pumpkin seeds excellent for preventing infections in children. I eat them too, as they are very beneficial. I highly recommend them!
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6.5
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.9
5
We aimed to understand how immunoadsorption therapy, which removes certain proteins from the blood, affects individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) following a COVID-19 infection.
Our study focused on 12 post-COVID patients experiencingME/CFS symptoms, heightened levels of specific autoantibodies, and neurological issues. We found that after receiving immunoadsorption therapy, there was a marked decrease in these troublesome autoantibodies associated with the autonomic nervous system.
Additionally, the therapy led to reduced levels of pro-inflammatory cytokines—substances involved in the body's immune response—which correlated with the presence of spike proteins in some patients. Despite these changes, we noted that, thirty days after therapy, while there were improvements in neuropsychological function and some physical strength, the self-reported symptoms and overall scores on ME/CFS questionnaires did not show significant improvement.
Therefore, while immunoadsorption therapy showed promise in altering certain immune markers, it did not lead to a substantial improvement in the patients' overall experience of ME/CFS.
Our study focused on 12 post-COVID patients experiencingME/CFS symptoms, heightened levels of specific autoantibodies, and neurological issues. We found that after receiving immunoadsorption therapy, there was a marked decrease in these troublesome autoantibodies associated with the autonomic nervous system.
Additionally, the therapy led to reduced levels of pro-inflammatory cytokines—substances involved in the body's immune response—which correlated with the presence of spike proteins in some patients. Despite these changes, we noted that, thirty days after therapy, while there were improvements in neuropsychological function and some physical strength, the self-reported symptoms and overall scores on ME/CFS questionnaires did not show significant improvement.
Therefore, while immunoadsorption therapy showed promise in altering certain immune markers, it did not lead to a substantial improvement in the patients' overall experience of ME/CFS.
7.5
Fatigue reduction observed
Most Useful Review
I ordered these pumpkin seeds from iHerb and am very satisfied! This is my first time buying this brand, and they are large, fresh, and unsalted. After a week, I noticed reduced fatigue and improved mood, which is beneficial considering my chronic fatigue syndrome. I use them in salads and as snacks. The packaging is convenient, and the price is nice, especially on offer. I highly recommend them for a healthy and tasty option!
Knee Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.9
9
CNP may ease knee osteoarthritis
We explored the potential of C-type natriuretic peptide (CNP) as a treatment for knee pain and osteoarthritis. This peptide was tested through intraarticular injections in a rat model of knee arthritis to assess its impact on cartilage degradation and persistent pain.
Our analysis revealed that CNP appears to work by targeting specific pathways in the body. Notably, we found that CNP negatively affected the IL6-STAT3 signaling pathway, which is known to contribute to inflammation and pain in the knees. Rather than interfering with other inflammatory signals, CNP selectively inhibited the mechanism that usually leads to increased pain and degradation of joint cartilage.
The findings suggest that by suppressing the expression of VEGFa, a protein associated with inflammation, CNP could provide relief from knee pain. We believe this positions CNP as an exciting candidate for further development as a disease-modifying anti-osteoarthritis drug (DMOAD). With its ability to reduce pain and protect cartilage, CNP shows promise as an innovative approach to managing knee osteoarthritis.
Our analysis revealed that CNP appears to work by targeting specific pathways in the body. Notably, we found that CNP negatively affected the IL6-STAT3 signaling pathway, which is known to contribute to inflammation and pain in the knees. Rather than interfering with other inflammatory signals, CNP selectively inhibited the mechanism that usually leads to increased pain and degradation of joint cartilage.
The findings suggest that by suppressing the expression of VEGFa, a protein associated with inflammation, CNP could provide relief from knee pain. We believe this positions CNP as an exciting candidate for further development as a disease-modifying anti-osteoarthritis drug (DMOAD). With its ability to reduce pain and protect cartilage, CNP shows promise as an innovative approach to managing knee osteoarthritis.
9
Cystitis relief
Most Useful Review
Pumpkin seeds are beneficial for eye health and have helped me with my knee pain, particularly cystitis, which I suffered from for years. Since I started consuming them consistently, I've been pain-free. I even recommended them to a colleague with cataracts, and he postponed surgery due to improved eyesight.
Prostate Cancer details
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.1
USERS' SCORE
Moderately Good
Based on 13 Reviews
7.8
9
We explored the potential of Toosendanin (TSN) as a treatment for prostate cancer (PCa) in our recent investigation. By examining the effects of TSN on prostate cancer cells, specifically DU145 and LNCaP, we observed notable changes in cell behaviors. TSN treatment significantly reduced cell proliferation, migration, and invasion, while enhancing apoptosis—essentially pushing cancer cells towards a self-destructive path.
Our analysis further showed that TSN promotes a type of cell death known as ferroptosis and encourages M1 polarization, which is a process that can help recruit immune cells to fight cancer. We dug deeper into the mechanisms at play, discovering that Toosendanin lowers the levels of a protein called USP39, which is linked to the growth and stability of another protein called PLK1. This suggests that TSN might halt cancer progression by disrupting this harmful interplay.
In our studies, we also employed various techniques, including flow cytometry and western blotting, to confirm our findings. At the end of our research, we confirmed that TSN not only effectively slows down tumor growth but does so by targeting the USP39/PLK1 pathway. Altogether, these insights provide valuable information about how TSN could serve as a promising candidate in the battle against prostate cancer.
Our analysis further showed that TSN promotes a type of cell death known as ferroptosis and encourages M1 polarization, which is a process that can help recruit immune cells to fight cancer. We dug deeper into the mechanisms at play, discovering that Toosendanin lowers the levels of a protein called USP39, which is linked to the growth and stability of another protein called PLK1. This suggests that TSN might halt cancer progression by disrupting this harmful interplay.
In our studies, we also employed various techniques, including flow cytometry and western blotting, to confirm our findings. At the end of our research, we confirmed that TSN not only effectively slows down tumor growth but does so by targeting the USP39/PLK1 pathway. Altogether, these insights provide valuable information about how TSN could serve as a promising candidate in the battle against prostate cancer.
9
Prostate cancer protection
Most Useful Review
Rich in iron and protein, I consume a handful of pumpkin seeds between meals. They also contain zinc, selenium, kelp, and copper, which I believe help protect my prostate cancer.
Allergies details
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.4
8
We explored the potential of recombinant phospholipase A5, also known as Ves v 5, to improve the diagnosis of yellow jacket venom allergies. Our study involved seven individuals, including those who had allergic reactions and those who did not. By isolating serum samples from these participants, we assessed their reactions to both bee venom and the recombinant allergens.
The production of Ves v 5 was successfully carried out in Escherichia coli, leading to the creation of soluble proteins that we then purified. We performed various tests to evaluate these proteins' functionality. This included assessing their biochemical characteristics and how well they interacted with the immune system.
Our findings highlighted the significant role of Ves v 5 in allergic reactions to hymenoptera venoms. The results suggest that recombinant proteins can be a promising alternative for diagnosing these allergies, moving away from traditional methods that rely on whole venom extracts. Ultimately, allergen-specific therapies could provide more effective and tailored treatment options for those prone to these allergies.
The production of Ves v 5 was successfully carried out in Escherichia coli, leading to the creation of soluble proteins that we then purified. We performed various tests to evaluate these proteins' functionality. This included assessing their biochemical characteristics and how well they interacted with the immune system.
Our findings highlighted the significant role of Ves v 5 in allergic reactions to hymenoptera venoms. The results suggest that recombinant proteins can be a promising alternative for diagnosing these allergies, moving away from traditional methods that rely on whole venom extracts. Ultimately, allergen-specific therapies could provide more effective and tailored treatment options for those prone to these allergies.
9
Effective for allergies
Most Useful Review
Mumtaz The quality is excellent, and the ingredients do not cause any allergies; its taste is very pleasant. I use it daily, and the size is excellent. The package lasts for two months and is beneficial for increasing iron. I find it useful for those on a diet or exercising, and I use it twice with a protein recipe and refreshing mix. Thank you.
Celiac details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 3 Reviews
7.1
9
Safe option noted
Most Useful Review
As a celiac, I can safely use this product. It has a good taste and is a healthy option for my diet.
Diarrhea details
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.3
USERS' SCORE
Medium or Average
Based on 4 Reviews
6.1
9
We explored the impact of p23-specific IgY antibodies on diarrhea caused by a zoonotic enteroparasite in newborn calves. This research aimed to see if these antibodies could effectively reduce the duration and severity of diarrhea, which is a significant issue in dairy and beef farming.
In our study, we used eight newborn calves and divided them into two groups. Four calves received a treatment containing specific IgY from immunized hens, while the other four had regular milk. After orally infecting all calves with a significant number of oocysts, we carefully monitored their health for 21 days.
Our findings revealed that calves treated with the p23-specific IgY had a remarkable reduction in the duration of diarrhea—from 7.5 days to just 3.5 days. They also showed a significant decrease in the duration of oocyst shedding. Although we observed some delays in the onset and severity of diarrhea, these changes were not statistically significant.
Overall, this study indicates that p23-specific IgY antibodies present a promising option for managing neonatal diarrhea in calves. This treatment could offer a non-invasive method to improve calf health and reduce economic losses for farmers.
In our study, we used eight newborn calves and divided them into two groups. Four calves received a treatment containing specific IgY from immunized hens, while the other four had regular milk. After orally infecting all calves with a significant number of oocysts, we carefully monitored their health for 21 days.
Our findings revealed that calves treated with the p23-specific IgY had a remarkable reduction in the duration of diarrhea—from 7.5 days to just 3.5 days. They also showed a significant decrease in the duration of oocyst shedding. Although we observed some delays in the onset and severity of diarrhea, these changes were not statistically significant.
Overall, this study indicates that p23-specific IgY antibodies present a promising option for managing neonatal diarrhea in calves. This treatment could offer a non-invasive method to improve calf health and reduce economic losses for farmers.
0
Unsafe for infants
Most Useful Review
Pumpkin seeds are beneficial for bone health due to their magnesium and calcium content. The taste and quality are superb, better than in shops. However, they are not safe for infants, as they can lead to pain, vomiting, and diarrhoea.
