Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.6
USERS' SCORE
Good
Based on 29 Reviews
8.1
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Selenium (elemental)(from 40 mg L-Selenomethionine)
200 mcg
364%
Top Medical Research Studies
8
We explored the effects of selenium supplementation in patients suffering from Hashimoto thyroiditis (HT), a leading cause of hypothyroidism. By analyzing multiple randomized controlled trials, we aimed to see how selenium might impact thyroid function, particularly focusing on thyroid-stimulating hormone (TSH) levels and thyroid antibodies.
Our analysis included results from 35 studies, where we observed that selenium supplementation led to a notable decrease in TSH levels among patients not undergoing thyroid hormone replacement therapy. This suggests that selenium may help manage thyroid function in specific populations.
Additionally, we found that selenium also reduced levels of thyroid peroxidase antibodies (TPOAb) and malondialdehyde (MDA), which indicates improved thyroid health and reduced oxidative stress. Interestingly, we observed that these benefits occurred irrespective of whether patients were receiving thyroid hormone therapy.
However, we did not find significant changes in other thyroid hormones or immune markers, indicating that while selenium can be effective in some areas, its benefits may not extend across all measures of thyroid health. Overall, our findings support the safe use of selenium in lowering TSH and certain antibodies in HT patients not on hormone therapy.
Our analysis included results from 35 studies, where we observed that selenium supplementation led to a notable decrease in TSH levels among patients not undergoing thyroid hormone replacement therapy. This suggests that selenium may help manage thyroid function in specific populations.
Additionally, we found that selenium also reduced levels of thyroid peroxidase antibodies (TPOAb) and malondialdehyde (MDA), which indicates improved thyroid health and reduced oxidative stress. Interestingly, we observed that these benefits occurred irrespective of whether patients were receiving thyroid hormone therapy.
However, we did not find significant changes in other thyroid hormones or immune markers, indicating that while selenium can be effective in some areas, its benefits may not extend across all measures of thyroid health. Overall, our findings support the safe use of selenium in lowering TSH and certain antibodies in HT patients not on hormone therapy.
Read More
9
We conducted a double-blinded, randomized controlled trial to investigate how selenium affects individuals with autoimmune hypothyroidism. In our study, we divided 144 patients into two groups, one receiving a combination of levothyroxine (a common thyroid treatment) and selenium, while the other group was given a placebo along with the same thyroid medication. This design allowed us to effectively measure the results and make a fair comparison between the two groups.
After three months of treatment, we observed some interesting changes. The group that took selenium showed a significant reduction in anti-Tg antibodies—markers associated with thyroid autoimmunity—compared to the placebo group. We also found that their TSH levels decreased significantly, while their free T4 levels increased. This suggests that selenium not only helps lower immune system activity against the thyroid but also supports overall thyroid function.
Our findings suggest that incorporating selenium into the treatment plan for autoimmune hypothyroidism could be beneficial for patients. While this doesn't isolate selenium’s effects completely, as it was taken alongside levothyroxine, the results indicate its potential in managing thyroid health effectively.
After three months of treatment, we observed some interesting changes. The group that took selenium showed a significant reduction in anti-Tg antibodies—markers associated with thyroid autoimmunity—compared to the placebo group. We also found that their TSH levels decreased significantly, while their free T4 levels increased. This suggests that selenium not only helps lower immune system activity against the thyroid but also supports overall thyroid function.
Our findings suggest that incorporating selenium into the treatment plan for autoimmune hypothyroidism could be beneficial for patients. While this doesn't isolate selenium’s effects completely, as it was taken alongside levothyroxine, the results indicate its potential in managing thyroid health effectively.
Read More
8
We delved into the impact of nano-selenium on hypothyroidism, particularly how it might alleviate related oxidative stress in the liver and kidneys. In the study, rats were divided into different groups, including a control group and those treated with propylthiouracil (PTU) to induce hypothyroidism. Some of the hypothyroid rats also received varying doses of nano-selenium to assess its effects.
Over a six-week period, we measured indicators of liver and kidney function, such as specific enzyme levels and markers for oxidative damage. Results showed that hypothyroidism significantly increased levels of harmful substances while decreasing beneficial ones. However, when nano-selenium was administered, we observed a noticeable improvement in these key indicators.
Overall, the presence of nano-selenium appeared to protect against the damaging effects of hypothyroidism, helping to restore balance in oxidative stress levels. This suggests that selenium may hold promise as a supportive treatment for liver and kidney health in individuals with thyroid disorders. Future research will help us understand the specific mechanisms behind these positive effects.
Over a six-week period, we measured indicators of liver and kidney function, such as specific enzyme levels and markers for oxidative damage. Results showed that hypothyroidism significantly increased levels of harmful substances while decreasing beneficial ones. However, when nano-selenium was administered, we observed a noticeable improvement in these key indicators.
Overall, the presence of nano-selenium appeared to protect against the damaging effects of hypothyroidism, helping to restore balance in oxidative stress levels. This suggests that selenium may hold promise as a supportive treatment for liver and kidney health in individuals with thyroid disorders. Future research will help us understand the specific mechanisms behind these positive effects.
Read More
Most Useful Reviews
9
Restored balance
198 people found this helpful
I have congenital hypothyroidism, which only manifested severe symptoms during menopause—lethargy, drowsiness, forgetfulness, and irritability. Upon my endocrinologist's advice, I started taking selenium. My well-being has dramatically improved; my menstrual cycle is back to normal, memory has returned, and I feel calm and balanced. It's evident that bioadditives are vital for thyroid function, and completing a full course of them was crucial.
Read More
10
Hypothyroidism remission
128 people found this helpful
Selenium has a remarkably positive impact on thyroid function. I combined it with vitamin E and inositol, leading my hypothyroidism into remission—my TSH dropped from 14 to 1.8 in just five months. I strongly encourage others to support their thyroid with selenium!
Read More
10
Energy and weight loss
35 people found this helpful
Selenium is one of the TOP 3 powerful antioxidants and essential for thyroid hormones to function. I was constantly lethargic, apathetic, and overweight, but upon discovering I had hypothyroidism, I started taking selenium with natural iodine and L-tyrosine. Over six months, my metabolism and hormones normalised, my energy improved dramatically, and I lost weight, alleviating a host of other ailments. I continue to take it regularly.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.6
- All Researches
9
We conducted a double-blinded, randomized controlled trial to investigate how selenium affects individuals with autoimmune hypothyroidism. In our study, we divided 144 patients into two groups, one receiving a combination of levothyroxine (a common thyroid treatment) and selenium, while the other group was given a placebo along with the same thyroid medication. This design allowed us to effectively measure the results and make a fair comparison between the two groups.
After three months of treatment, we observed some interesting changes. The group that took selenium showed a significant reduction in anti-Tg antibodies—markers associated with thyroid autoimmunity—compared to the placebo group. We also found that their TSH levels decreased significantly, while their free T4 levels increased. This suggests that selenium not only helps lower immune system activity against the thyroid but also supports overall thyroid function.
Our findings suggest that incorporating selenium into the treatment plan for autoimmune hypothyroidism could be beneficial for patients. While this doesn't isolate selenium’s effects completely, as it was taken alongside levothyroxine, the results indicate its potential in managing thyroid health effectively.
After three months of treatment, we observed some interesting changes. The group that took selenium showed a significant reduction in anti-Tg antibodies—markers associated with thyroid autoimmunity—compared to the placebo group. We also found that their TSH levels decreased significantly, while their free T4 levels increased. This suggests that selenium not only helps lower immune system activity against the thyroid but also supports overall thyroid function.
Our findings suggest that incorporating selenium into the treatment plan for autoimmune hypothyroidism could be beneficial for patients. While this doesn't isolate selenium’s effects completely, as it was taken alongside levothyroxine, the results indicate its potential in managing thyroid health effectively.
Read More
9
Selenium aids subclinical hypothyroidism
We approached the intriguing question of whether selenium, when combined with myo-inositol, could help those dealing with subclinical hypothyroidism. This study involved 148 women of reproductive age, who had their thyroid stimulating hormone (TSH) levels monitored over a six-month period while taking daily supplements.
Throughout the study, we observed substantial improvements in TSH levels, as well as reductions in autoantibody titers, which are markers of thyroid autoimmune activity. Participants also reported better management of symptoms typically associated with hypothyroidism, including more regular menstrual cycles and lower cholesterol levels. Remarkably, these benefits appeared alongside the treatment quite consistently.
Overall, the findings suggest that incorporating selenium and myo-inositol into the treatment plan for subclinical hypothyroidism could be quite beneficial. This combination may not only help stabilize thyroid function but could also improve the quality of life for women affected by this condition. The study holds promise for those seeking alternative options to manage their thyroid health effectively.
Throughout the study, we observed substantial improvements in TSH levels, as well as reductions in autoantibody titers, which are markers of thyroid autoimmune activity. Participants also reported better management of symptoms typically associated with hypothyroidism, including more regular menstrual cycles and lower cholesterol levels. Remarkably, these benefits appeared alongside the treatment quite consistently.
Overall, the findings suggest that incorporating selenium and myo-inositol into the treatment plan for subclinical hypothyroidism could be quite beneficial. This combination may not only help stabilize thyroid function but could also improve the quality of life for women affected by this condition. The study holds promise for those seeking alternative options to manage their thyroid health effectively.
Read More
8
Selenium and myo-inositol efficacy
We explored the impact of selenium supplementation on patients with autoimmune thyroiditis, particularly focusing on its effectiveness in restoring normal thyroid function. The study compared the effects of selenium alone against a combination therapy of selenium and myo-inositol (referred to as MI + Se).
Through a systematic review of three studies involving 288 participants, we observed that the combined treatment of selenium and myo-inositol resulted in a notable decrease in thyroid-stimulating hormone (TSH) levels. This suggests that combining these two supplements may enhance the restoring of thyroid function better than selenium alone.
However, while we noted significant reductions in TSH and thyroglobulin antibodies, other measures like TPO antibodies, T3, and T4 levels showed minimal or no significant changes. This indicates that while the MI + Se treatment could help in some areas, more extensive research is necessary to fully understand its effectiveness and to perhaps confirm these findings with larger, long-term studies.
Through a systematic review of three studies involving 288 participants, we observed that the combined treatment of selenium and myo-inositol resulted in a notable decrease in thyroid-stimulating hormone (TSH) levels. This suggests that combining these two supplements may enhance the restoring of thyroid function better than selenium alone.
However, while we noted significant reductions in TSH and thyroglobulin antibodies, other measures like TPO antibodies, T3, and T4 levels showed minimal or no significant changes. This indicates that while the MI + Se treatment could help in some areas, more extensive research is necessary to fully understand its effectiveness and to perhaps confirm these findings with larger, long-term studies.
Read More
8
We investigated how selenium affects thyroid function in older Chinese adults, focusing particularly on its potential impact on hypothyroidism. Our study included participants aged 65 and older, who provided samples of their fingernails and whole blood for analysis. We specifically looked at hormone levels, including thyroid stimulating hormone (TSH) and various forms of thyroxine, to assess thyroid health.
Our findings revealed a strong positive association between selenium levels in the blood and fingernails, suggesting that higher selenium status is linked with lower TSH levels. We observed that participants in higher selenium quartiles had lower TSH, which is typically associated with less risk of hypothyroidism. For instance, those with the highest selenium levels showed a reduced odds ratio for hypothyroidism.
However, our results also highlighted a complex relationship; while higher selenium levels seemed to lower the risk of hypothyroidism, they were simultaneously linked with an increased risk of hyperthyroidism. This dual effect suggests that selenium status also plays a role in thyroid dysfunctions, with both positive and negative implications for thyroid health.
In summary, higher selenium levels are associated with lower TSH levels and may reduce the risk of hypothyroidism, but they also pose a higher risk for hyperthyroidism in this older population. This study emphasizes the intricate balance of nutrients like selenium in managing thyroid health, particularly among aging adults.
Our findings revealed a strong positive association between selenium levels in the blood and fingernails, suggesting that higher selenium status is linked with lower TSH levels. We observed that participants in higher selenium quartiles had lower TSH, which is typically associated with less risk of hypothyroidism. For instance, those with the highest selenium levels showed a reduced odds ratio for hypothyroidism.
However, our results also highlighted a complex relationship; while higher selenium levels seemed to lower the risk of hypothyroidism, they were simultaneously linked with an increased risk of hyperthyroidism. This dual effect suggests that selenium status also plays a role in thyroid dysfunctions, with both positive and negative implications for thyroid health.
In summary, higher selenium levels are associated with lower TSH levels and may reduce the risk of hypothyroidism, but they also pose a higher risk for hyperthyroidism in this older population. This study emphasizes the intricate balance of nutrients like selenium in managing thyroid health, particularly among aging adults.
Read More
8
We observed the effects of selenium and zinc deficiencies on thyroid health in a particular case involving a 50-year-old man. This individual had undergone intestinal surgery, leaving him with a significant reduction in his small intestine. As a result, he was reliant on total parenteral nutrition (TPN) without trace element supplements for about six weeks.
During this period, lab tests indicated that his thyroid-stimulating hormone (TSH) levels were elevated, along with high free thyroxine (FT4) and low free triiodothyronine (FT3) levels—an unusual pattern that raised suspicion of selenium deficiency. After starting selenium supplementation, we were pleased to note an improvement: his FT3 levels increased, and FT4 levels returned to normal ranges, although TSH still showed some temporary elevation.
We considered that zinc deficiency could also play a role in this thyroid dysfunction. After introducing zinc into his treatment plan, we noticed a normalization of his overall thyroid function. This highlights the importance of evaluating both selenium and zinc levels when addressing thyroid health, particularly in patients on TPN.
Overall, while selenium supplementation showed significant improvement in the case, the role of zinc was also critical in fully resolving the thyroid dysfunction.
During this period, lab tests indicated that his thyroid-stimulating hormone (TSH) levels were elevated, along with high free thyroxine (FT4) and low free triiodothyronine (FT3) levels—an unusual pattern that raised suspicion of selenium deficiency. After starting selenium supplementation, we were pleased to note an improvement: his FT3 levels increased, and FT4 levels returned to normal ranges, although TSH still showed some temporary elevation.
We considered that zinc deficiency could also play a role in this thyroid dysfunction. After introducing zinc into his treatment plan, we noticed a normalization of his overall thyroid function. This highlights the importance of evaluating both selenium and zinc levels when addressing thyroid health, particularly in patients on TPN.
Overall, while selenium supplementation showed significant improvement in the case, the role of zinc was also critical in fully resolving the thyroid dysfunction.
Read More
User Reviews
USERS' SCORE
Good
Based on 29 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Restored balance
198 people found this helpful
I have congenital hypothyroidism, which only manifested severe symptoms during menopause—lethargy, drowsiness, forgetfulness, and irritability. Upon my endocrinologist's advice, I started taking selenium. My well-being has dramatically improved; my menstrual cycle is back to normal, memory has returned, and I feel calm and balanced. It's evident that bioadditives are vital for thyroid function, and completing a full course of them was crucial.
Read More
10
Hypothyroidism remission
128 people found this helpful
Selenium has a remarkably positive impact on thyroid function. I combined it with vitamin E and inositol, leading my hypothyroidism into remission—my TSH dropped from 14 to 1.8 in just five months. I strongly encourage others to support their thyroid with selenium!
Read More
10
Energy and weight loss
35 people found this helpful
Selenium is one of the TOP 3 powerful antioxidants and essential for thyroid hormones to function. I was constantly lethargic, apathetic, and overweight, but upon discovering I had hypothyroidism, I started taking selenium with natural iodine and L-tyrosine. Over six months, my metabolism and hormones normalised, my energy improved dramatically, and I lost weight, alleviating a host of other ailments. I continue to take it regularly.
Read More
10
Avoid radical solutions
11 people found this helpful
I faced severe hypothyroidism issues, including thyroid nodules. Doctors recommended removal, but I chose to seek alternatives. They often overlook nutrients like iodine and selenium. I did extensive research and alongside detoxification, I took iodine, selenium, and zinc, leading my nodules to disappear and my blood tests to improve. With the right nutrients, I believe healing is possible without extreme medical interventions.
Read More
9
Pain relief in joints
11 people found this helpful
For me, selenium has been fantastic. It alleviated pain in my small joints and improved my kidney problems related to hypothyroidism. After starting selenium, I can now walk for hours without discomfort, whereas previously I felt a strong desire to sit down after just an hour.
Read More
Frequently Asked Questions
10
Hypothyroidism remission
128 people found this helpful
Selenium has a remarkably positive impact on thyroid function. I combined it with vitamin E and inositol, leading my hypothyroidism into remission—my TSH dropped from 14 to 1.8 in just five months. I strongly encourage others to support their thyroid with selenium!
9
Restored balance
198 people found this helpful
I have congenital hypothyroidism, which only manifested severe symptoms during menopause—lethargy, drowsiness, forgetfulness, and irritability. Upon my endocrinologist's advice, I started taking selenium. My well-being has dramatically improved; my menstrual cycle is back to normal, memory has returned, and I feel calm and balanced. It's evident that bioadditives are vital for thyroid function, and completing a full course of them was crucial.
7.5
Effective for inflammation
3 people found this helpful
Excellent and very useful for inflammation; the benefit is noticeable from the first use, with sufficient quantity. Minerals are vital for the body and beneficial for symptoms of hypothyroidism, with a doctor's advice. I noticed results by the second month. An excellent combination, and I will order again due to its high quality.
10
Energy and weight loss
35 people found this helpful
Selenium is one of the TOP 3 powerful antioxidants and essential for thyroid hormones to function. I was constantly lethargic, apathetic, and overweight, but upon discovering I had hypothyroidism, I started taking selenium with natural iodine and L-tyrosine. Over six months, my metabolism and hormones normalised, my energy improved dramatically, and I lost weight, alleviating a host of other ailments. I continue to take it regularly.
9
Seborrheic dermatitis improvement
3 people found this helpful
The doctor prescribed selenium alongside other vitamins due to my subclinical hypothyroidism. A miracle occurred; my dandruff and seborrheic dermatitis have cleared, and hair loss has reversed. The combination is key, although the taste is unpleasant.
7.5
TPO antibodies reduced
2 people found this helpful
This is my first time purchasing NOW Selenium supplements, and I take it for my hypothyroidism, as studies indicate selenium can reduce TPO antibodies and alleviate symptoms. The Selenomethionine form is highly regarded. As I don't consume enough selenium-rich foods, taking this supplement during flu season feels beneficial. I value its absence of allergens and find capsules gentler on my stomach, reinforcing my trust in NOW supplements.
9
Excellent analysis reduction
8 people found this helpful
I will always accept In hypothyroidism, I take a course of 1-2 months of selenium separately from iodine and then kelp. The effect is excellent on analysis-reduction of TSH.
7.5
Helpful for hypothyroidism
1 people found this helpful
A good preparation with selenium in a chelated form and good digestibility. You can take 200 micrograms regularly, particularly if living in areas with poor selenium content. The value for money at Now Foods is consistently excellent. I recommend it! I take it alongside potassium iodide, and it aids with hypothyroidism. If you're not hesitant, put ♥ ️
7.5
Enhanced wellbeing
4 people found this helpful
I have low thyroxine levels due to hypothyroidism, causing symptoms like fatigue, dry skin, and sensitivity to cold. After several months of taking selenium with Nascent Iodine, my thyroxine levels have improved. I'm cautious about balanced dosages, particularly around goitrogenic foods, to maintain steady levels without experiencing adverse symptoms.
6
Improved joint health
204 people found this helpful
Selenium is an essential mineral that supports the endocrine, immune, and reproductive systems. Known for its antioxidant properties, it helps protect the body from free radicals and aids in normal cell growth. I take one capsule daily after breakfast. Since I started taking selenium, I’ve noticed significant improvements in the pain in my small joints, leg muscles, kidneys (urolithiasis), and thyroid gland (hypothyroidism). Now, I can walk for hours without heaviness in my legs.
9
Reduced antibodies observed
2 people found this helpful
I have hypothyroidism, and following my endocrinologist's advice, I began taking selenium to lower antibodies, which did decrease. I took it with other medications. Anyone with thyroid issues should consider this as their first remedy. I always keep it in my medicine cabinet.
8
We explored the effects of selenium supplementation in patients suffering from Hashimoto thyroiditis (HT), a leading cause of hypothyroidism. By analyzing multiple randomized controlled trials, we aimed to see how selenium might impact thyroid function, particularly focusing on thyroid-stimulating hormone (TSH) levels and thyroid antibodies.
Our analysis included results from 35 studies, where we observed that selenium supplementation led to a notable decrease in TSH levels among patients not undergoing thyroid hormone replacement therapy. This suggests that selenium may help manage thyroid function in specific populations.
Additionally, we found that selenium also reduced levels of thyroid peroxidase antibodies (TPOAb) and malondialdehyde (MDA), which indicates improved thyroid health and reduced oxidative stress. Interestingly, we observed that these benefits occurred irrespective of whether patients were receiving thyroid hormone therapy.
However, we did not find significant changes in other thyroid hormones or immune markers, indicating that while selenium can be effective in some areas, its benefits may not extend across all measures of thyroid health. Overall, our findings support the safe use of selenium in lowering TSH and certain antibodies in HT patients not on hormone therapy.
Our analysis included results from 35 studies, where we observed that selenium supplementation led to a notable decrease in TSH levels among patients not undergoing thyroid hormone replacement therapy. This suggests that selenium may help manage thyroid function in specific populations.
Additionally, we found that selenium also reduced levels of thyroid peroxidase antibodies (TPOAb) and malondialdehyde (MDA), which indicates improved thyroid health and reduced oxidative stress. Interestingly, we observed that these benefits occurred irrespective of whether patients were receiving thyroid hormone therapy.
However, we did not find significant changes in other thyroid hormones or immune markers, indicating that while selenium can be effective in some areas, its benefits may not extend across all measures of thyroid health. Overall, our findings support the safe use of selenium in lowering TSH and certain antibodies in HT patients not on hormone therapy.
9
Selenium aids subclinical hypothyroidism
We approached the intriguing question of whether selenium, when combined with myo-inositol, could help those dealing with subclinical hypothyroidism. This study involved 148 women of reproductive age, who had their thyroid stimulating hormone (TSH) levels monitored over a six-month period while taking daily supplements.
Throughout the study, we observed substantial improvements in TSH levels, as well as reductions in autoantibody titers, which are markers of thyroid autoimmune activity. Participants also reported better management of symptoms typically associated with hypothyroidism, including more regular menstrual cycles and lower cholesterol levels. Remarkably, these benefits appeared alongside the treatment quite consistently.
Overall, the findings suggest that incorporating selenium and myo-inositol into the treatment plan for subclinical hypothyroidism could be quite beneficial. This combination may not only help stabilize thyroid function but could also improve the quality of life for women affected by this condition. The study holds promise for those seeking alternative options to manage their thyroid health effectively.
Throughout the study, we observed substantial improvements in TSH levels, as well as reductions in autoantibody titers, which are markers of thyroid autoimmune activity. Participants also reported better management of symptoms typically associated with hypothyroidism, including more regular menstrual cycles and lower cholesterol levels. Remarkably, these benefits appeared alongside the treatment quite consistently.
Overall, the findings suggest that incorporating selenium and myo-inositol into the treatment plan for subclinical hypothyroidism could be quite beneficial. This combination may not only help stabilize thyroid function but could also improve the quality of life for women affected by this condition. The study holds promise for those seeking alternative options to manage their thyroid health effectively.
8
Selenium and myo-inositol efficacy
We explored the impact of selenium supplementation on patients with autoimmune thyroiditis, particularly focusing on its effectiveness in restoring normal thyroid function. The study compared the effects of selenium alone against a combination therapy of selenium and myo-inositol (referred to as MI + Se).
Through a systematic review of three studies involving 288 participants, we observed that the combined treatment of selenium and myo-inositol resulted in a notable decrease in thyroid-stimulating hormone (TSH) levels. This suggests that combining these two supplements may enhance the restoring of thyroid function better than selenium alone.
However, while we noted significant reductions in TSH and thyroglobulin antibodies, other measures like TPO antibodies, T3, and T4 levels showed minimal or no significant changes. This indicates that while the MI + Se treatment could help in some areas, more extensive research is necessary to fully understand its effectiveness and to perhaps confirm these findings with larger, long-term studies.
Through a systematic review of three studies involving 288 participants, we observed that the combined treatment of selenium and myo-inositol resulted in a notable decrease in thyroid-stimulating hormone (TSH) levels. This suggests that combining these two supplements may enhance the restoring of thyroid function better than selenium alone.
However, while we noted significant reductions in TSH and thyroglobulin antibodies, other measures like TPO antibodies, T3, and T4 levels showed minimal or no significant changes. This indicates that while the MI + Se treatment could help in some areas, more extensive research is necessary to fully understand its effectiveness and to perhaps confirm these findings with larger, long-term studies.
3
We conducted a study to determine if selenium supplementation could enhance the quality of life (QoL) for patients suffering from autoimmune thyroiditis. In a robust clinical trial involving 412 participants who were already receiving levothyroxine treatment, we set up a double-blind, randomized control design. This means that neither the participants nor the researchers knew who was receiving selenium and who was on a placebo, ensuring that our observations were as unbiased as possible.
Over 12 months, participants were given either 200 μg of selenium or a placebo daily. We assessed their quality of life multiple times using a questionnaire designed specifically for thyroid-related issues. While participants showed improvements in their QoL during the trial, we found no significant differences between the two groups after one year.
Interestingly, while selenium supplementation did lead to lower thyroid peroxidase antibody levels, it did not impact levothyroxine dosage or the balance of thyroid hormones in the body. Ultimately, both selenium and placebo groups experienced comparable improvements, indicating that selenium supplementation did not provide additional benefits beyond the placebo effect.
Over 12 months, participants were given either 200 μg of selenium or a placebo daily. We assessed their quality of life multiple times using a questionnaire designed specifically for thyroid-related issues. While participants showed improvements in their QoL during the trial, we found no significant differences between the two groups after one year.
Interestingly, while selenium supplementation did lead to lower thyroid peroxidase antibody levels, it did not impact levothyroxine dosage or the balance of thyroid hormones in the body. Ultimately, both selenium and placebo groups experienced comparable improvements, indicating that selenium supplementation did not provide additional benefits beyond the placebo effect.
References
- Nikkhah M, Vafa M, Abiri B, Golgiri F, Sarbakhsh P, et al. The Effect of Some Micronutrients Multi-Supplementation on Thyroid Function, Metabolic Features and Quality of Life in Patients Treating With Levothyroxine and Vitamin D: A Double-blind, Randomized Controlled Trial. Med J Islam Repub Iran. 2024;38:133. 10.47176/mjiri.38.133
- Zuhair V, Sheikh AT, Shafi N, Babar A, Khan A, et al. Role of Supplementation with Selenium and Myo-Inositol Versus Selenium Alone in Patients of Autoimmune Thyroiditis: A Systematic Review and Meta-Analysis. Clin Med Insights Endocrinol Diabetes. 2024;17:11795514241300998. 10.1177/11795514241300998
- Li F, Su L, Shao R, Luo J, Chen Y, et al. Selenium Status Associates with Thyroid Hormone and Thyroid Dysfunction in Older Chinese Adults. Biol Trace Elem Res. 2025;203:1413. 10.1007/s12011-024-04286-2
- AkbariRad M, Mazloum Khorasani Z, Beizae B, Ayatollahi H, Emadzadeh M, et al. Effect of selenium on anti-Tg antibody in patients with autoimmune hypothyroidism: A randomized controlled trial. Caspian J Intern Med. 2024;15:340. 10.22088/cjim.15.2.340
- Nagano K, Motomura Y, Bando H, Yamamoto M, Kanie K, et al. Thyroid dysfunction due to trace element deficiency-not only selenium but also zinc. Hormones (Athens). 2024;23:675. 10.1007/s42000-024-00550-1
- Wang S, Chen P, He Y, Wei J, Tian L, et al. A follow-up study on factors affecting the recovery of patients with hypothyroidism in different selenium environments. BMC Endocr Disord. 2024;24:14. 10.1186/s12902-024-01536-1
- El-Shaer RAA, Ibrahim S, Hewady PM, Atef MM, El-Deeb OS, et al. Selenium protects against nesfatin-1 modulation of the hypothalamic-pituitary-testicular axis during hypothyroidism in male rats. Physiol Rep. 2024;12:e15923. 10.14814/phy2.15923
- Huwiler VV, Maissen-Abgottspon S, Stanga Z, Mühlebach S, Trepp R, et al. Selenium Supplementation in Patients with Hashimoto Thyroiditis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Thyroid. 2024;34:295. 10.1089/thy.2023.0556
- Larsen C, Winther KH, Cramon PK, Rasmussen ÅK, Feldt-Rasmusssen U, et al. Selenium supplementation and placebo are equally effective in improving quality of life in patients with hypothyroidism. Eur Thyroid J. 2024;13. 10.1530/ETJ-23-0175
- Kubiak K, Szmidt MK, Kaluza J, Zylka A, Sicinska E. Do Dietary Supplements Affect Inflammation, Oxidative Stress, and Antioxidant Status in Adults with Hypothyroidism or Hashimoto's Disease?-A Systematic Review of Controlled Trials. Antioxidants (Basel). 2023;12. 10.3390/antiox12101798
- Hosseini M, Behehsti F, Marefati N, Anaeigoudari A. Nano-selenium relieved hepatic and renal oxidative damage in hypothyroid rats. Physiol Rep. 2023;11:e15682. 10.14814/phy2.15682
- Wróblewski M, Wróblewska J, Nuszkiewicz J, Pawłowska M, Wesołowski R, et al. The Role of Selected Trace Elements in Oxidoreductive Homeostasis in Patients with Thyroid Diseases. Int J Mol Sci. 2023;24. 10.3390/ijms24054840
- Lu L, Huang Z, Wang X, Chen J. Interaction Between Dietary Selenium and Zinc Intakes on Hypothyroidism. Biol Trace Elem Res. 2023;201:4667. 10.1007/s12011-023-03563-w
- Payer J, Jackuliak P, Kužma M, Džupon M, Vaňuga P. Supplementation with myo-inositol and Selenium improves the clinical conditions and biochemical features of women with or at risk for subclinical hypothyroidism. Front Endocrinol (Lausanne). 2022;13:1067029. 10.3389/fendo.2022.1067029
- Hojjati Fard F, Sabzi F, Marefati N, Vafaee F, Beheshti F, et al. Nanoselenium improved learning, memory, and brain-derived neurotrophic factor and attenuated nitric oxide, and oxidative stress in the brain of juvenile hypothyroid rats. Metab Brain Dis. 2022;37:2719. 10.1007/s11011-022-01073-7
- Paparo SR, Ferrari SM, Patrizio A, Elia G, Ragusa F, et al. Myoinositol in Autoimmune Thyroiditis. Front Endocrinol (Lausanne). 2022;13:930756. 10.3389/fendo.2022.930756
- Berisha-Muharremi V, Tahirbegolli B, Phypers R, Hanna R. Efficacy of Combined Photobiomodulation Therapy with Supplements versus Supplements alone in Restoring Thyroid Gland Homeostasis in Hashimoto Thyroiditis: A Clinical Feasibility Parallel Trial with 6-Months Follow-Up. J Pers Med. 2023;13. 10.3390/jpm13081274
